The network for 'positive regulation of cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
Bcl2B-cell CLL/lymphoma 20.906
Jak1Janus kinase 10.529
Marcksmyristoylated alanine rich protein kinase C substrate0.449
Il6interleukin 60.437
Rap1bRAP1B, member of RAS oncogene family0.402
Fgfr2fibroblast growth factor receptor 20.401
Hspb1heat shock protein 10.375
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.365
Adora2aadenosine A2a receptor0.356
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.350
Grm5glutamate receptor, metabotropic 50.342
Nek9NIMA (never in mitosis gene a)- related kinase 90.341
Edn1endothelin 10.333
Tgfbr2transforming growth factor, beta receptor II0.305
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.305
Selpselectin P0.304
Adam17ADAM metallopeptidase domain 170.298
Fn1fibronectin 10.298
Creb1cAMP responsive element binding protein 10.294
Dab2disabled homolog 2 (Drosophila)0.293
Smad7SMAD family member 70.289
Dll3delta-like 3 (Drosophila)0.287
Ccr5chemokine (C-C motif) receptor 50.276
Ccl4chemokine (C-C motif) ligand 40.274
Bmp6bone morphogenetic protein 60.273
Slit3slit homolog 3 (Drosophila)0.271
Prrx1paired related homeobox 10.268
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.267
Iappislet amyloid polypeptide0.264
Rhobras homolog gene family, member B0.263
Il1r1interleukin 1 receptor, type I0.261
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.258
Dnase1l3deoxyribonuclease 1-like 30.253
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.243
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.234
Trim47tripartite motif-containing 470.233
Cd4Cd4 molecule0.233
Cxcl2chemokine (C-X-C motif) ligand 20.232
Ednrbendothelin receptor type B0.228
Pebp1phosphatidylethanolamine binding protein 10.224
Tgfbr3transforming growth factor, beta receptor III0.223
Gja1gap junction protein, alpha 10.221
Irs1insulin receptor substrate 10.219
Cxcl10chemokine (C-X-C motif) ligand 100.218
Calcrlcalcitonin receptor-like0.214
Dusp6dual specificity phosphatase 60.207
Fgf7fibroblast growth factor 70.206
Gja3gap junction protein, alpha 30.206
UncxUNC homeobox0.203
Wt1Wilms tumor 10.203
Itgamintegrin, alpha M0.200
Muskmuscle, skeletal, receptor tyrosine kinase0.198
Tmod2tropomodulin 20.198
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.197
Tnftumor necrosis factor (TNF superfamily, member 2)0.197
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.196
Adrb2adrenergic, beta-2-, receptor, surface0.195
Errfi1ERBB receptor feedback inhibitor 10.192
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.191
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.184
Mapk1mitogen activated protein kinase 10.184
Cd80Cd80 molecule0.184
Tgm1transglutaminase 1, K polypeptide0.182
Testintestin gene0.181
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.180
Foxd1forkhead box D10.180
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.177
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.175
Pecam1platelet/endothelial cell adhesion molecule 10.175
Mapre1microtubule-associated protein, RP/EB family, member 10.173
Gata6GATA binding protein 60.173
RT1-BaRT1 class II, locus Ba0.172
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.171
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.170
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.169
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.167
Gja6gap junction protein, alpha 60.166
Pdia4protein disulfide isomerase family A, member 40.166
Homer3homer homolog 3 (Drosophila)0.166
Nxph3neurexophilin 30.165
Ptprqprotein tyrosine phosphatase, receptor type, Q0.165
Glra1glycine receptor, alpha 10.165
Itgb4integrin, beta 40.164
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.163
Ehfets homologous factor0.162
Doc2bdouble C2-like domains, beta0.162
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.160
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.160
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.159
Casp3caspase 30.159
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.157
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.157
Otx1orthodenticle homeobox 10.156
Mpripmyosin phosphatase Rho interacting protein0.156
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.155
Gdf11growth differentiation factor 110.154
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hlh-2Protein HLH-20.489
elt-6Protein ELT-60.373
egl-18Protein EGL-180.292
unc-73Protein UNC-730.229
ceh-20Protein CEH-200.213
pha-4Protein PHA-40.169
bar-1Protein BAR-10.145
nhr-67Protein NHR-670.131
cye-1Protein CYE-10.131
egl-15Protein EGL-150.122
unc-9Protein UNC-90.102
lin-17Protein LIN-170.090
mab-31Protein MAB-310.082
cam-1Protein CAM-10.075
let-60Protein LET-600.075
egl-46Protein EGL-460.075
unc-62Protein UNC-620.073
ten-1Protein TEN-10.070
egl-27Protein EGL-270.066
eor-2Protein EOR-20.062
ifc-2Protein IFC-20.061
ret-1Protein RET-10.060
egl-13Protein EGL-130.056
vab-3Protein VAB-30.055
cst-1Protein CST-10.054
cki-2Protein CKI-20.048
daf-2Protein DAF-20.047
goa-1Protein GOA-10.047
daf-12Protein DAF-120.046
sax-3Protein SAX-30.045
sas-5Protein SAS-50.042
sem-5Protein SEM-50.039
lin-32Protein LIN-320.038
hnd-1Protein HND-10.037
ajm-1Protein AJM-10.036
egl-44Protein EGL-440.035
syg-2Protein SYG-20.033
egl-30Protein EGL-300.033
skp-1Protein SKP-10.032
lin-59Protein LIN-590.030
par-2Protein PAR-20.030
unc-60Protein UNC-600.029
par-5Protein PAR-50.029
D1044.2Protein D1044.20.028
mpk-1Protein MPK-10.027
lit-1Protein LIT-10.027
npp-22Protein NPP-220.027
zyg-9Protein ZYG-90.026
cst-2Protein CST-20.026
hlh-1Protein HLH-10.026
alx-1Protein ALX-10.026
tmc-2Protein TMC-20.025
etr-1Protein ETR-10.025
brf-1Protein BRF-10.025
unc-32Protein UNC-320.025
egl-5Protein EGL-50.024
mab-5Protein MAB-50.024
cnd-1Protein CND-10.024
mig-5Protein MIG-50.023
inx-3Protein INX-30.023
scc-1Protein SCC-10.022
F21A10.2Protein F21A10.20.022
pry-1Protein PRY-10.021
unc-6Protein UNC-60.021
tsp-12Protein TSP-120.021
smp-1Protein SMP-10.021
pat-3Protein PAT-30.020
fkh-2Protein FKH-20.020
sur-2Protein SUR-20.020
R10E12.2Protein R10E12.20.019
let-607Protein LET-6070.019
magu-2Protein MAGU-20.018
pbrm-1Protein PBRM-10.018
F41C3.8Protein F41C3.80.018
ras-1Protein RAS-10.018
nhr-25Protein NHR-250.018
C34D10.2Protein C34D10.20.018
mom-2Protein MOM-20.017
soc-2Protein SOC-20.017
nhr-6Protein NHR-60.016
sdz-28Protein SDZ-280.016
tag-353Protein TAG-3530.016
CELE_C01G6.5Protein C01G6.50.016
unc-5Protein UNC-50.016
pmk-3Protein PMK-30.016
T28F4.1Protein T28F4.10.016
unc-86Protein UNC-860.015
ddr-2Protein DDR-20.015
ina-1Protein INA-10.015
fcp-1Protein FCP-10.015
hmg-1.2Protein HMG-1.20.015
dcp-66Protein DCP-660.015
K08E3.5Protein K08E3.50.015
daf-4Protein DAF-40.014
kal-1Protein KAL-10.014
par-6Protein PAR-60.014
sel-7Protein SEL-70.014
crm-1Protein CRM-10.014
cdh-3Protein CDH-30.014
mig-2Protein MIG-20.013
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
neurodneurogenic differentiation0.849
gli1GLI-Kruppel family member 10.779
ascl1aachaete-scute complex-like 1a (Drosophila)0.757
fgf8afibroblast growth factor 8 a0.568
fgf10afibroblast growth factor 10a0.524
copebcore promoter element binding protein0.494
gata6GATA-binding protein 60.427
col2a1acollagen type II, alpha-1a0.414
tp53tumor protein p530.409
bmp2bbone morphogenetic protein 2b0.404
alcamaactivated leukocyte cell adhesion molecule a0.396
slit3slit (Drosophila) homolog 30.390
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.372
metmet proto-oncogene (hepatocyte growth factor receptor)0.371
pax2apaired box gene 2a0.356
gata2aGATA-binding protein 2a0.351
myod1myogenic differentiation 10.339
tbx1T-box 10.301
spry4sprouty (Drosophila) homolog 40.291
mycamyelocytomatosis oncogene a0.274
nrg2aneuregulin 2a0.256
runx2arunt-related transcription factor 2a0.245
rargaretinoic acid receptor gamma a0.237
dusp6dual specificity phosphatase 60.232
foxa2forkhead box A20.228
bmp4bone morphogenetic protein 40.222
neo1neogenin 10.216
shhasonic hedgehog a0.212
pbx1apre-B-cell leukemia transcription factor 1a0.207
myf5myogenic factor 50.204
fn1fibronectin 10.192
dccdeleted in colorectal carcinoma0.188
msxcmuscle segment homeobox C0.183
wnt1wingless-type MMTV integration site family, member 10.177
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.175
notch3notch homolog 30.171
bhlhe22basic helix-loop-helix family, member e220.171
kdrlkinase insert domain receptor like0.168
gata3GATA-binding protein 30.161
cdh2cadherin 2, neuronal0.159
ptf1apancreas specific transcription factor, 1a0.157
irx3airoquois homeobox protein 3a0.150
wnt11rwingless-type MMTV integration site family, member 11, related0.148
lmx1b.1LIM homeobox transcription factor 1, beta 10.145
fgf3fibroblast growth factor 30.141
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.139
atoh1aatonal homolog 1a0.135
diaph2diaphanous homolog 2 (Drosophila)0.135
scinlascinderin like a0.135
foxp1bforkhead box P1b0.134
fgfr4fibroblast growth factor receptor 40.134
gdf6agrowth differentiation factor 6a0.133
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.132
lef1lymphocyte enhancer binding factor 10.130
tpm4tropomyosin 40.130
egr1early growth response 10.126
sfrp1asecreted frizzled-related protein 1a0.120
lama4laminin, alpha 40.119
tcf12transcription factor 120.118
her6hairy-related 60.117
ptch2patched 20.116
evx1even-skipped homeobox 10.114
gro1groucho 10.113
eng2bengrailed 2b0.112
dkk1bdickkopf 1b0.109
dll4delta-like 4 (Drosophila)0.107
efnb2aephrin B2a0.107
dlx5adistal-less homeobox gene 5a0.106
vcanbversican b0.104
osr1odd-skipped related 1 (Drosophila)0.104
bmperBMP binding endothelial regulator0.104
tgfbitransforming growth factor, beta-induced0.100
sulf1sulfatase 10.099
foxd3forkhead box D30.097
bocbrother of CDO0.096
pax6apaired box gene 6a0.096
atp1a3aATPase, Na+/K+ transporting, alpha 3a polypeptide0.095
vdravitamin D receptor a0.094
wnt8bwingless-type MMTV integration site family, member 8b0.094
wnt4awingless-type MMTV integration site family, member 4a0.094
alcambactivated leukocyte cell adhesion molecule b0.094
tcf7transcription factor 7 (T-cell specific, HMG-box)0.093
nrp2bneuropilin 2b0.092
tbx18T-box 180.092
otpborthopedia homolog b0.092
yrkYes-related kinase0.091
phox2apaired-like homeobox 2a0.091
sox11aSRY-box containing gene 11a0.090
runx1runt-related transcription factor 10.090
otx5orthodenticle homolog 50.087
ihhaIndian hedgehog homolog a0.085
flhfloating head0.083
tfectranscription factor EC0.083
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.082
dmrt2adoublesex and mab-3 related transcription factor 2a0.080
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.754
Pi3K92ECG4141 gene product from transcript CG4141-RB0.750
TBPHCG10327 gene product from transcript CG10327-RC0.732
mbcmyoblast city0.707
InRInsulin-like receptor0.689
aopanterior open0.656
numbCG3779 gene product from transcript CG3779-RB0.627
foxoforkhead box, sub-group O0.574
EcREcdysone receptor0.562
robo3CG5423 gene product from transcript CG5423-RA0.536
E(spl)Enhancer of split0.512
MadMothers against dpp0.487
Rac2CG8556 gene product from transcript CG8556-RA0.484
l(2)gllethal (2) giant larvae0.448
phlpole hole0.413
Dsp1Dorsal switch protein 10.396
zfh1Zn finger homeodomain 10.393
Rac1CG2248 gene product from transcript CG2248-RA0.350
AtpalphaNa pump alpha subunit0.319
HLHm5E(spl) region transcript m50.291
Ced-12CG5336 gene product from transcript CG5336-RA0.290
HLHm7E(spl) region transcript m70.275
Pk61CProtein kinase 61C0.255
abd-Aabdominal A0.250
Wnt4Wnt oncogene analog 40.246
PvrPDGF- and VEGF-receptor related0.246
HLHmdeltaE(spl) region transcript mdelta0.246
SosSon of sevenless0.230
S6kRPS6-p70-protein kinase0.227
Wnt5Wnt oncogene analog 50.221
HLHmbetaE(spl) region transcript mbeta0.219
vvlventral veins lacking0.218
ctpcut up0.211
Su(H)Suppressor of Hairless0.210
shotshort stop0.204
HLHmgammaE(spl) region transcript mgamma0.204
CaMKIICalcium/calmodulin-dependent protein kinase II0.201
CG11347CG11347 gene product from transcript CG11347-RE0.200
Tsc1CG6147 gene product from transcript CG6147-RA0.190
EgfrEpidermal growth factor receptor0.185
AlkCG8250 gene product from transcript CG8250-RA0.184
gcmglial cells missing0.177
fz2frizzled 20.175
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.170
Gp150CG5820 gene product from transcript CG5820-RA0.155
Tab2TAK1-associated binding protein 20.149
Fmr1CG6203 gene product from transcript CG6203-RC0.148
DadDaughters against dpp0.141
fasfaint sausage0.139
Src42ASrc oncogene at 42A0.139
jebjelly belly0.138
eyaeyes absent0.137
rawCG12437 gene product from transcript CG12437-RB0.132
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
CREBBPCREB binding protein1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.998
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.998
TP53tumor protein p530.998
SMAD3SMAD family member 30.997
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.995
EGFRepidermal growth factor receptor0.994
SMAD7SMAD family member 70.993
BCAR1breast cancer anti-estrogen resistance 10.992
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.990
FYNFYN oncogene related to SRC, FGR, YES0.990
NOTCH1notch 10.988
SMAD2SMAD family member 20.988
TAL1T-cell acute lymphocytic leukemia 10.988
JUNjun proto-oncogene0.984
SRFserum response factor (c-fos serum response element-binding transcription factor)0.984
SMAD4SMAD family member 40.983
NCOR2nuclear receptor corepressor 20.970
MDM2Mdm2 p53 binding protein homolog (mouse)0.968
FOSFBJ murine osteosarcoma viral oncogene homolog0.949
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.949
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.947
PMLpromyelocytic leukemia0.946
RUNX1runt-related transcription factor 10.945
ARandrogen receptor0.944
NCOA1nuclear receptor coactivator 10.944
CASP3caspase 3, apoptosis-related cysteine peptidase0.944
MYOD1myogenic differentiation 10.938
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.935
SMAD9SMAD family member 90.935
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.934
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.934
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.933
SHC1SHC (Src homology 2 domain containing) transforming protein 10.930
SOCS3suppressor of cytokine signaling 30.910
TRAF1TNF receptor-associated factor 10.897
GRB2growth factor receptor-bound protein 20.896
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.894
ATXN1ataxin 10.892
FGFR2fibroblast growth factor receptor 20.865
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.861
STK3serine/threonine kinase 30.861
S100BS100 calcium binding protein B0.861
NCOR1nuclear receptor corepressor 10.859
NCK1NCK adaptor protein 10.855
PTPN6protein tyrosine phosphatase, non-receptor type 60.851
JAG1jagged 10.837
RASSF5Ras association (RalGDS/AF-6) domain family member 50.829
DUSP1dual specificity phosphatase 10.828
BIRC3baculoviral IAP repeat containing 30.828
FBLN1fibulin 10.823
SIRT1sirtuin 10.811
FASFas (TNF receptor superfamily, member 6)0.799
YAP1Yes-associated protein 10.793
HCKhemopoietic cell kinase0.790
SKIv-ski sarcoma viral oncogene homolog (avian)0.789
HDAC1histone deacetylase 10.788
LCKlymphocyte-specific protein tyrosine kinase0.785
NME2non-metastatic cells 2, protein (NM23B) expressed in0.780
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.776
BHLHE40basic helix-loop-helix family, member e400.772
EGR1early growth response 10.770
METmet proto-oncogene (hepatocyte growth factor receptor)0.768
CFLARCASP8 and FADD-like apoptosis regulator0.764
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.760
FHL2four and a half LIM domains 20.759
CDK6cyclin-dependent kinase 60.752
SMURF1SMAD specific E3 ubiquitin protein ligase 10.749
NCOA2nuclear receptor coactivator 20.749
AKT1v-akt murine thymoma viral oncogene homolog 10.744
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.738
SMAD1SMAD family member 10.737
NR4A1nuclear receptor subfamily 4, group A, member 10.732
TRAF6TNF receptor-associated factor 60.731
NTRK3neurotrophic tyrosine kinase, receptor, type 30.713
STAT5Asignal transducer and activator of transcription 5A0.712
COL1A1collagen, type I, alpha 10.711
SMURF2SMAD specific E3 ubiquitin protein ligase 20.709
HLA-Amajor histocompatibility complex, class I, A0.705
IL4Rinterleukin 4 receptor0.705
EPORerythropoietin receptor0.704
HDAC2histone deacetylase 20.699
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.690
XIAPX-linked inhibitor of apoptosis0.690
CCR5chemokine (C-C motif) receptor 50.686
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.679
PDX1pancreatic and duodenal homeobox 10.674
LATlinker for activation of T cells0.674
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.666
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.666
HDAC4histone deacetylase 40.664
S100A6S100 calcium binding protein A60.663
HLA-Cmajor histocompatibility complex, class I, C0.658
IL1Binterleukin 1, beta0.658
HLA-Bmajor histocompatibility complex, class I, B0.650
EP300E1A binding protein p3000.642
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism