The network for 'positive regulation of heart rate' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of heart rate

Any process that activates or increases the frequency or rate of heart contraction.

NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.277
Oprk1opioid receptor, kappa 10.074
Ednraendothelin receptor type A0.058
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.050
Olr287olfactory receptor 2870.042
Lim2lens intrinsic membrane protein 20.039
Hrh2histamine receptor H 20.036
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.035
Ctsjcathepsin J0.033
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.031
Csf1colony stimulating factor 1 (macrophage)0.028
Agtr1aangiotensin II receptor, type 1a0.027
Hcrtr2hypocretin (orexin) receptor 20.022
Kiss1rKISS1 receptor0.021
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.021
Fgf14fibroblast growth factor 140.021
Htr65-hydroxytryptamine (serotonin) receptor 60.021
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.020
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.020
Gpr26G protein-coupled receptor 260.019
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.019
Olr226olfactory receptor 2260.019
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.018
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.017
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.017
Arandrogen receptor0.017
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.016
Csrnp2cysteine-serine-rich nuclear protein 20.016
Olr416olfactory receptor 4160.015
Giprgastric inhibitory polypeptide receptor0.015
Hrh3histamine receptor H30.015
Dsppdentin sialophosphoprotein0.015
Aqp5aquaporin 50.015
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.015
Smgbneonatal submandibular gland protein B0.015
Bcl2l10BCL2-like 10 (apoptosis facilitator)0.015
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.014
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.014
Krt34keratin 340.014
Mmp13matrix metallopeptidase 130.014
Fgf7fibroblast growth factor 70.013
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.013
Nkx2-1NK2 homeobox 10.012
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.012
Ccbp2chemokine binding protein 20.012
Kcnh6potassium voltage-gated channel, subfamily H (eag-related), member 60.012
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.012
Slc14a2solute carrier family 14 (urea transporter), member 20.012
Sstr2somatostatin receptor 20.012
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.012
Slc18a1solute carrier family 18 (vesicular monoamine), member 10.012
Grm8glutamate receptor, metabotropic 80.011
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.011
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.011
Gfra2GDNF family receptor alpha 20.011
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.011
RGD1564327similar to integrin alpha 80.011
Olr1082olfactory receptor 10820.010
Dccdeleted in colorectal carcinoma0.010
Iappislet amyloid polypeptide0.010
Cntn3contactin 3 (plasmacytoma associated)0.010
Testintestin gene0.010
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.010
Cgaglycoprotein hormones, alpha polypeptide0.010
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.999
SNTG2syntrophin, gamma 20.982
AKAP6A kinase (PRKA) anchor protein 60.590
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.290
PTPN3protein tyrosine phosphatase, non-receptor type 30.072
FKBP1BFK506 binding protein 1B, 12.6 kDa0.027
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.027
FGF18fibroblast growth factor 180.026
TBX5T-box 50.025
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.020
ESRRBestrogen-related receptor beta0.019
DAB1disabled homolog 1 (Drosophila)0.018
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.017
SEZ6Lseizure related 6 homolog (mouse)-like0.017
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.017
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.016
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.016
DLG4discs, large homolog 4 (Drosophila)0.015
CASQ2calsequestrin 2 (cardiac muscle)0.015
IL17Binterleukin 17B0.015
KRT14keratin 140.015
TNNC2troponin C type 2 (fast)0.014
VIPvasoactive intestinal peptide0.014
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.014
RIT2Ras-like without CAAX 20.014
AKIP1A kinase (PRKA) interacting protein 10.014
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.013
PAX3paired box 30.013
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.013
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.013
TEFthyrotrophic embryonic factor0.013
GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.013
DSCAML1Down syndrome cell adhesion molecule like 10.013
CHRNA4cholinergic receptor, nicotinic, alpha 40.013
WNT11wingless-type MMTV integration site family, member 110.013
BCL2L10BCL2-like 10 (apoptosis facilitator)0.012
HIF3Ahypoxia inducible factor 3, alpha subunit0.012
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.012
LBX1ladybird homeobox 10.012
GRIK3glutamate receptor, ionotropic, kainate 30.012
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.012
LDB3LIM domain binding 30.012
POU4F3POU class 4 homeobox 30.012
KRT13keratin 130.012
SLC6A1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.011
APOC3apolipoprotein C-III0.011
FOXL1forkhead box L10.011
GJA3gap junction protein, alpha 3, 46kDa0.011
GRIA1glutamate receptor, ionotropic, AMPA 10.011
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.011
PCDHB11protocadherin beta 110.011
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.011
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.011
ACTN2actinin, alpha 20.011
P2RX6purinergic receptor P2X, ligand-gated ion channel, 60.010
GJD2gap junction protein, delta 2, 36kDa0.010
SSTR1somatostatin receptor 10.010
CHGBchromogranin B (secretogranin 1)0.010
PGM5phosphoglucomutase 50.010
ADRA1Dadrenergic, alpha-1D-, receptor0.010
WNT7Awingless-type MMTV integration site family, member 7A0.010
CAV3caveolin 30.010
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.010
CRHBPcorticotropin releasing hormone binding protein0.010
LRRN2leucine rich repeat neuronal 20.010
ANKRD1ankyrin repeat domain 1 (cardiac muscle)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.954
Scn5asodium channel, voltage-gated, type V, alpha0.930
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.921
Cckbrcholecystokinin B receptor0.884
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.875
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.852
Tbx5T-box 50.717
Hand1heart and neural crest derivatives expressed transcript 10.650
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.649
Adrb1adrenergic receptor, beta 10.614
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.590
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.505
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.441
Sstr1somatostatin receptor 10.435
Lhx6LIM homeobox protein 60.423
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.395
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.393
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.376
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.373
Hand2heart and neural crest derivatives expressed transcript 20.338
Smyd1SET and MYND domain containing 10.336
Grm2glutamate receptor, metabotropic 20.333
Drd2dopamine receptor D20.324
Chrm1cholinergic receptor, muscarinic 1, CNS0.318
Ryr2ryanodine receptor 2, cardiac0.293
Crhr2corticotropin releasing hormone receptor 20.286
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.282
Sstr4somatostatin receptor 40.271
Adra2cadrenergic receptor, alpha 2c0.268
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.267
Crhr1corticotropin releasing hormone receptor 10.246
Tbx3T-box 30.227
Efnb2ephrin B20.218
Adrb3adrenergic receptor, beta 30.211
Gja5gap junction protein, alpha 50.180
Gata4GATA binding protein 40.175
Adra1aadrenergic receptor, alpha 1a0.172
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.162
ND6NADH dehydrogenase subunit 60.162
Hey2hairy/enhancer-of-split related with YRPW motif 20.160
Pnpla2patatin-like phospholipase domain containing 20.158
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.150
Kcns2K+ voltage-gated channel, subfamily S, 20.145
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.144
Adrb2adrenergic receptor, beta 20.128
Htr45 hydroxytryptamine (serotonin) receptor 40.125
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.124
Chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.123
Krtap5-1keratin associated protein 5-10.112
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.112
Chrna10cholinergic receptor, nicotinic, alpha polypeptide 100.111
Cacng2calcium channel, voltage-dependent, gamma subunit 20.100
Chrna4cholinergic receptor, nicotinic, alpha polypeptide 40.097
Stx1bsyntaxin 1B0.095
Kcnk3potassium channel, subfamily K, member 30.093
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.088
Kcnk4potassium channel, subfamily K, member 40.087
Mas1MAS1 oncogene0.087
Pgrprogesterone receptor0.080
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.077
Grid1glutamate receptor, ionotropic, delta 10.074
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.073
Cacng5calcium channel, voltage-dependent, gamma subunit 50.068
Smr2submaxillary gland androgen regulated protein 20.068
Gsx1GS homeobox 10.067
Kifc2kinesin family member C20.067
Glra1glycine receptor, alpha 1 subunit0.066
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.065
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.062
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.061
Galr1galanin receptor 10.061
Pramel7preferentially expressed antigen in melanoma like 70.060
Gjd3gap junction protein, delta 30.060
Chrngcholinergic receptor, nicotinic, gamma polypeptide0.060
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.060
Oprk1opioid receptor, kappa 10.059
Gpr12G-protein coupled receptor 120.059
Scn1asodium channel, voltage-gated, type I, alpha0.059
Neto1neuropilin (NRP) and tolloid (TLL)-like 10.057
ErasES cell-expressed Ras0.056
Mpzmyelin protein zero0.053
Neurod2neurogenic differentiation 20.053
Prox1prospero-related homeobox 10.052
Cldn26claudin 260.051
Gpr45G protein-coupled receptor 450.051
Uts2rurotensin 2 receptor0.051
Msx1homeobox, msh-like 10.050
Syt3synaptotagmin III0.050
Drd4dopamine receptor D40.048
Hey1hairy/enhancer-of-split related with YRPW motif 10.048
Cntn2contactin 20.047
Arpp21cyclic AMP-regulated phosphoprotein, 210.047
Oprl1opioid receptor-like 10.046
Sfrp5secreted frizzled-related sequence protein 50.045
Clcn1chloride channel 10.044
Gjc2gap junction protein, gamma 20.044
Mobpmyelin-associated oligodendrocytic basic protein0.044
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism