The network for 'response to nitrosative stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to nitrosative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.

NameDescriptionProbabilityFunc Analog Organism
Gstm1glutathione S-transferase mu 11.000
Ephx1epoxide hydrolase 1, microsomal0.871
Gstm2glutathione S-transferase mu 20.754
Gsta3glutathione S-transferase A30.551
Txnrd1thioredoxin reductase 10.293
Selenbp1selenium binding protein 10.189
Serp1stress-associated endoplasmic reticulum protein 10.141
Gstm7glutathione S-transferase, mu 70.117
Hibadh3-hydroxyisobutyrate dehydrogenase0.094
Gstm5glutathione S-transferase, mu 50.070
Cyb5r3cytochrome b5 reductase 30.066
Gsrglutathione reductase0.061
Rab11aRAB11a, member RAS oncogene family0.046
Egr1early growth response 10.043
Gclmglutamate cysteine ligase, modifier subunit0.041
Cyb5acytochrome b5 type A (microsomal)0.033
Prdx6peroxiredoxin 60.031
Pdk2pyruvate dehydrogenase kinase, isozyme 20.028
Nqo1NAD(P)H dehydrogenase, quinone 10.027
Gstp1glutathione S-transferase pi 10.027
Fahd2afumarylacetoacetate hydrolase domain containing 2A0.025
Gsta4glutathione S-transferase alpha 40.025
Gclcglutamate-cysteine ligase, catalytic subunit0.024
Coq3coenzyme Q3 homolog, methyltransferase (S. cerevisiae)0.024
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.023
Mgst1microsomal glutathione S-transferase 10.022
Paicsphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase0.022
Tmem218transmembrane protein 2180.021
Nenfneuron derived neurotrophic factor0.020
Wdr61WD repeat domain 610.018
Pgrmc1progesterone receptor membrane component 10.017
Slc40a1solute carrier family 39 (iron-regulated transporter), member 10.017
S100a1S100 calcium binding protein A10.017
Aadacarylacetamide deacetylase (esterase)0.016
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.016
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.016
Pecrperoxisomal trans-2-enoyl-CoA reductase0.016
Dusp1dual specificity phosphatase 10.015
Acot12acyl-CoA thioesterase 120.014
Catcatalase0.013
RGD1564114similar to FLJ46082 protein0.013
Exosc7exosome component 70.012
UST4rintegral membrane transport protein UST4r0.012
Pxmp2peroxisomal membrane protein 20.012
Pde6dphosphodiesterase 6D, cGMP-specific, rod, delta0.011
Hao2hydroxyacid oxidase 2 (long chain)0.011
Pirpirin (iron-binding nuclear protein)0.011
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.011
Cetn2centrin, EF-hand protein, 20.011
Fxyd1FXYD domain-containing ion transport regulator 10.011
Aldocaldolase C, fructose-bisphosphate0.011
Aldh2aldehyde dehydrogenase 2 family (mitochondrial)0.010
Mrpl36mitochondrial ribosomal protein L360.010
Rdh10retinol dehydrogenase 10 (all-trans)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPK1mitogen-activated protein kinase 11.000
GSTM1glutathione S-transferase mu 11.000
MAPK14mitogen-activated protein kinase 141.000
GSTM2glutathione S-transferase mu 2 (muscle)1.000
GSTM4glutathione S-transferase mu 41.000
MAP2K1mitogen-activated protein kinase kinase 11.000
MAPK3mitogen-activated protein kinase 31.000
DUSP3dual specificity phosphatase 30.997
DUSP1dual specificity phosphatase 10.990
PTPRRprotein tyrosine phosphatase, receptor type, R0.983
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.965
PEA15phosphoprotein enriched in astrocytes 150.959
DUSP5dual specificity phosphatase 50.909
PTPN7protein tyrosine phosphatase, non-receptor type 70.831
DUSP6dual specificity phosphatase 60.814
DUSP7dual specificity phosphatase 70.812
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.789
GSTM3glutathione S-transferase mu 3 (brain)0.713
MAP2K4mitogen-activated protein kinase kinase 40.618
PTPRJprotein tyrosine phosphatase, receptor type, J0.576
ARHGAP9Rho GTPase activating protein 90.507
MBPmyelin basic protein0.416
ATF3activating transcription factor 30.412
IER3immediate early response 30.378
ZFP36L1zinc finger protein 36, C3H type-like 10.374
FOSFBJ murine osteosarcoma viral oncogene homolog0.337
MAPK8mitogen-activated protein kinase 80.308
ATF2activating transcription factor 20.305
PHLDA1pleckstrin homology-like domain, family A, member 10.298
MKNK2MAP kinase interacting serine/threonine kinase 20.261
MTPNmyotrophin0.255
BHLHE40basic helix-loop-helix family, member e400.237
KLF6Kruppel-like factor 60.172
MAP2K3mitogen-activated protein kinase kinase 30.161
MAP2K6mitogen-activated protein kinase kinase 60.131
TRIB1tribbles homolog 1 (Drosophila)0.128
DUSP4dual specificity phosphatase 40.127
IER5immediate early response 50.117
CSDAcold shock domain protein A0.093
BCL2B-cell CLL/lymphoma 20.092
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.084
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.080
IQGAP1IQ motif containing GTPase activating protein 10.070
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.066
EGR1early growth response 10.064
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.056
HADHhydroxyacyl-CoA dehydrogenase0.056
CASP8caspase 8, apoptosis-related cysteine peptidase0.044
RB1retinoblastoma 10.044
ELK1ELK1, member of ETS oncogene family0.043
MKNK1MAP kinase interacting serine/threonine kinase 10.042
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.039
MAPK11mitogen-activated protein kinase 110.039
JUNjun proto-oncogene0.032
NR4A2nuclear receptor subfamily 4, group A, member 20.030
LCKlymphocyte-specific protein tyrosine kinase0.029
IER2immediate early response 20.026
FAM48Afamily with sequence similarity 48, member A0.026
HBEGFheparin-binding EGF-like growth factor0.025
DUSP16dual specificity phosphatase 160.024
TNIP1TNFAIP3 interacting protein 10.024
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.022
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.020
RPS6KA4ribosomal protein S6 kinase, 90kDa, polypeptide 40.019
DUSP9dual specificity phosphatase 90.019
CRYZcrystallin, zeta (quinone reductase)0.016
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.013
GHRgrowth hormone receptor0.013
PDCD6IPprogrammed cell death 6 interacting protein0.012
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.012
RHOBras homolog gene family, member B0.011
NFIL3nuclear factor, interleukin 3 regulated0.011
AHRaryl hydrocarbon receptor0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gstm1glutathione S-transferase, mu 11.000
Adh1alcohol dehydrogenase 1 (class I)0.985
Gstm2glutathione S-transferase, mu 20.980
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.876
Gsta3glutathione S-transferase, alpha 30.868
Gstm6glutathione S-transferase, mu 60.679
Cyp2f2cytochrome P450, family 2, subfamily f, polypeptide 20.617
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.573
Gstm3glutathione S-transferase, mu 30.545
Inmtindolethylamine N-methyltransferase0.459
Gstt1glutathione S-transferase, theta 10.382
Ces1dcarboxylesterase 1D0.294
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.193
Fmo1flavin containing monooxygenase 10.165
Aldh1a7aldehyde dehydrogenase family 1, subfamily A70.116
Ephx1epoxide hydrolase 1, microsomal0.116
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.111
Fxyd1FXYD domain-containing ion transport regulator 10.108
Gsta4glutathione S-transferase, alpha 40.100
Gstm4glutathione S-transferase, mu 40.100
Gstk1glutathione S-transferase kappa 10.068
Mapk1mitogen-activated protein kinase 10.067
Sult1a1sulfotransferase family 1A, phenol-preferring, member 10.064
Ttrtransthyretin0.056
Tstthiosulfate sulfurtransferase, mitochondrial0.055
Pon1paraoxonase 10.052
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 20.052
Slc22a18solute carrier family 22 (organic cation transporter), member 180.051
Sult1d1sulfotransferase family 1D, member 10.048
Aldh1a1aldehyde dehydrogenase family 1, subfamily A10.041
Pxmp2peroxisomal membrane protein 20.040
Iydiodotyrosine deiodinase0.039
Gstp1glutathione S-transferase, pi 10.038
Aldh2aldehyde dehydrogenase 2, mitochondrial0.037
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.036
Selenbp1selenium binding protein 10.035
Rarres2retinoic acid receptor responder (tazarotene induced) 20.033
Fmo5flavin containing monooxygenase 50.031
Rbp4retinol binding protein 4, plasma0.031
Hpgdhydroxyprostaglandin dehydrogenase 15 (NAD)0.030
Cd59aCD59a antigen0.029
Fmo2flavin containing monooxygenase 20.028
Cyp2d22cytochrome P450, family 2, subfamily d, polypeptide 220.028
Grb7growth factor receptor bound protein 70.027
Tmem205transmembrane protein 2050.026
Nqo1NAD(P)H dehydrogenase, quinone 10.026
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.026
Sordsorbitol dehydrogenase0.025
Fmo3flavin containing monooxygenase 30.023
Aox1aldehyde oxidase 10.022
Cmblcarboxymethylenebutenolidase-like (Pseudomonas)0.022
Ier2immediate early response 20.020
Thnsl2threonine synthase-like 2 (bacterial)0.019
Acy3aspartoacylase (aminoacylase) 30.018
Ces2gcarboxylesterase 2G0.018
Abhd14babhydrolase domain containing 14b0.018
Echdc3enoyl Coenzyme A hydratase domain containing 30.018
Copz2coatomer protein complex, subunit zeta 20.017
Khkketohexokinase0.017
Bcl10B-cell leukemia/lymphoma 100.017
Slc22a1solute carrier family 22 (organic cation transporter), member 10.017
Cyb5cytochrome b-50.017
Galmgalactose mutarotase0.017
Aassaminoadipate-semialdehyde synthase0.016
Itih2inter-alpha trypsin inhibitor, heavy chain 20.016
Cbr2carbonyl reductase 20.016
Bphlbiphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)0.016
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.015
Ephx2epoxide hydrolase 2, cytoplasmic0.015
Omdosteomodulin0.015
Adhfe1alcohol dehydrogenase, iron containing, 10.014
Mettl7a1methyltransferase like 7A10.014
Upb1ureidopropionase, beta0.013
Apoc1apolipoprotein C-I0.013
Cmtm8CKLF-like MARVEL transmembrane domain containing 80.013
Dpyddihydropyrimidine dehydrogenase0.012
Gstm7glutathione S-transferase, mu 70.012
Tcea3transcription elongation factor A (SII), 30.012
Hint2histidine triad nucleotide binding protein 20.012
Pcbd1pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 10.012
Acox2acyl-Coenzyme A oxidase 2, branched chain0.011
Atp5c1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.011
Gnmtglycine N-methyltransferase0.011
Bbox1butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)0.011
Pparaperoxisome proliferator activated receptor alpha0.011
Ndrg2N-myc downstream regulated gene 20.011
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.011
Ces1ecarboxylesterase 1E0.011
Gm3776predicted gene 37760.011
Gstt3glutathione S-transferase, theta 30.010
Gpld1glycosylphosphatidylinositol specific phospholipase D10.010
Thrspthyroid hormone responsive SPOT14 homolog (Rattus)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MIG2Mig2p0.196
CSR2Csr2p0.109
HAL5Hal5p0.096
YKR075Chypothetical protein0.089
MIG1Mig1p0.076
MIG3Mig3p0.075
DAL81Dal81p0.074
VHS1Vhs1p0.063
ROX1Rox1p0.056
GLN3Gln3p0.055
LYS5Lys5p0.054
YPL014Whypothetical protein0.052
MOT3Mot3p0.052
RTG3Rtg3p0.051
VID24Vid24p0.049
RGS2Rgs2p0.047
NUP157Nup157p0.040
GIP2Gip2p0.039
GAT2Gat2p0.039
CAT8Cat8p0.039
HXT3Hxt3p0.038
SKS1Sks1p0.038
TYE7Tye7p0.038
CUP9Cup9p0.038
YPR157Whypothetical protein0.038
SAK1Sak1p0.037
TPO2Tpo2p0.036
ERV2Erv2p0.034
FAA2Faa2p0.033
RPN4Rpn4p0.033
MGA1Mga1p0.032
YKL187Chypothetical protein0.032
SMP1Smp1p0.032
HSF1Hsf1p0.032
YIR035Chypothetical protein0.031
NTO1Nto1p0.029
OPY2Opy2p0.029
ZAP1Zap1p0.029
POG1Pog1p0.028
SRD1Srd1p0.028
PCT1Pct1p0.027
TBS1Tbs1p0.027
HOR2Hor2p0.027
PHO12Pho12p0.027
LEU2Leu2p0.027
IRC8Irc8p0.027
RPI1Rpi1p0.026
YLR264C-Ahypothetical protein0.026
NRG2Nrg2p0.026
KIC1Kic1p0.026
CBK1Cbk1p0.026
ICS2Ics2p0.026
YOL038C-Ahypothetical protein0.025
TOS3Tos3p0.025
FMP48Fmp48p0.025
SWC7Swc7p0.025
FOL2Fol2p0.024
CUP1-1Cup1-1p0.024
HAL1Hal1p0.024
YPR013Chypothetical protein0.024
ARP10Arp10p0.024
YPL216Whypothetical protein0.024
YJL218Whypothetical protein0.024
IRC23Irc23p0.024
ACE2Ace2p0.023
YLR162Whypothetical protein0.023
YAR068Whypothetical protein0.023
MER1Mer1p0.023
YNR014Whypothetical protein0.023
HPF1Hpf1p0.023
YMR317Whypothetical protein0.023
TIP1Tip1p0.023
CHA1Cha1p0.023
PCL2Pcl2p0.023
YIR042Chypothetical protein0.023
AGP2Agp2p0.023
ECM22Ecm22p0.022
MDM1Mdm1p0.022
ARE2Are2p0.022
SOR2Sor2p0.022
ARG8Arg8p0.022
FMT1Fmt1p0.022
ATP6Atp6p0.022
SFL1Sfl1p0.022
NRG1Nrg1p0.022
STL1Stl1p0.022
YOR385Whypothetical protein0.021
YAR066Whypothetical protein0.021
AUA1Aua1p0.021
DSE3Dse3p0.021
ICY1Icy1p0.021
SPL2Spl2p0.021
VAC7Vac7p0.021
YMR295Chypothetical protein0.021
PMD1Pmd1p0.021
BRE4Bre4p0.021
DCS2Dcs2p0.021
SWI1Swi1p0.021
YBR013Chypothetical protein0.021
IES1Ies1p0.021