The network for 'regulation of cardiac muscle contraction by calcium ion signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cardiac muscle contraction by calcium ion signaling

Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.

NameDescriptionProbabilityFunc Analog Organism
Casq2calsequestrin 2 (cardiac muscle)0.647
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.350
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.329
Asphaspartate-beta-hydroxylase0.310
Ldb3LIM domain binding 30.229
Actc1actin, alpha, cardiac muscle 10.221
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.179
Klrk1killer cell lectin-like receptor subfamily K, member 10.136
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.129
Smpxsmall muscle protein, X-linked0.119
CdonCdon homolog (mouse)0.111
Myl1myosin, light chain 10.109
Pygmphosphorylase, glycogen, muscle0.104
Ckmcreatine kinase, muscle0.098
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.091
Csrp3cysteine and glycine-rich protein 30.081
Utrnutrophin0.079
Phka1phosphorylase kinase, alpha 10.078
Lnpepleucyl/cystinyl aminopeptidase0.074
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.072
Mybpc1myosin binding protein C, slow type0.071
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.064
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.063
Myo9amyosin IXA0.061
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.060
Sh3bgrSH3 domain binding glutamic acid-rich protein0.055
Pgam2phosphoglycerate mutase 2 (muscle)0.053
Nek9NIMA (never in mitosis gene a)- related kinase 90.052
Slc26a2solute carrier family 26 (sulfate transporter), member 20.051
Pdlim3PDZ and LIM domain 30.051
Cav3caveolin 30.050
Cyth1cytohesin 10.046
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.046
Calcrlcalcitonin receptor-like0.044
Atxn3ataxin 30.043
RhagRh-associated glycoprotein0.042
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.042
Syt7synaptotagmin VII0.040
Capn6calpain 60.040
Myoz1myozenin 10.040
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.039
Inpp4binositol polyphosphate-4-phosphatase, type II0.039
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.039
Nptxrneuronal pentraxin receptor0.037
Padi2peptidyl arginine deiminase, type II0.037
Flt1FMS-related tyrosine kinase 10.035
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.035
Nf1neurofibromin 10.034
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.032
Itpr1inositol 1,4,5-triphosphate receptor, type 10.032
Unc5bunc-5 homolog B (C. elegans)0.031
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.027
Mylk2myosin light chain kinase 20.027
Fryfurry homolog (Drosophila)0.027
Tgfb2transforming growth factor, beta 20.027
Actn2actinin alpha 20.026
Kcne1potassium voltage-gated channel, Isk-related family, member 10.026
Irs1insulin receptor substrate 10.026
Nexnnexilin (F actin binding protein)0.026
Lims1LIM and senescent cell antigen-like domains 10.025
Megf6multiple EGF-like-domains 60.025
Trim72tripartite motif-containing 720.024
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.024
P2ry1purinergic receptor P2Y, G-protein coupled, 10.023
Mbmyoglobin0.022
Dmddystrophin0.022
Myom1myomesin 10.021
Tmem38atransmembrane protein 38a0.021
Grpgastrin releasing peptide0.021
Wapwhey acidic protein0.021
Prkaa2protein kinase, AMP-activated, alpha 2 catalytic subunit0.020
Myocmyocilin0.020
Tnnt3troponin T type 3 (skeletal, fast)0.020
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.020
Akap6A kinase (PRKA) anchor protein 60.020
Rasa2RAS p21 protein activator 20.019
Pacs1phosphofurin acidic cluster sorting protein 10.019
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.019
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.019
Fgf14fibroblast growth factor 140.019
Inpp5jinositol polyphosphate-5-phosphatase J0.018
Gabra2gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 20.018
Pik3r3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.018
Hoxa4homeo box A40.017
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.017
Pgrprogesterone receptor0.017
Tnni1troponin I type 1 (skeletal, slow)0.017
Prrx1paired related homeobox 10.017
Stc1stanniocalcin 10.017
Unc45bunc-45 homolog B (C. elegans)0.017
Sspnsarcospan0.016
Nrxn1neurexin 10.016
Agtr2angiotensin II receptor, type 20.016
Rpl3lribosomal protein L3-like0.016
Ank3ankyrin 3, node of Ranvier0.016
Car4carbonic anhydrase 40.016
Inhbainhibin beta-A0.016
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.016
Arandrogen receptor0.016
Sptbn1spectrin, beta, non-erythrocytic 10.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.981
DTNAdystrobrevin, alpha0.941
PKD1polycystic kidney disease 1 (autosomal dominant)0.845
MEF2Amyocyte enhancer factor 2A0.531
SPTBspectrin, beta, erythrocytic0.441
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.356
TTNtitin0.354
SYNMsynemin, intermediate filament protein0.337
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.296
EHD1EH-domain containing 10.289
MEF2Cmyocyte enhancer factor 2C0.216
AKAP6A kinase (PRKA) anchor protein 60.125
DTNBdystrobrevin, beta0.102
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.101
MIF4GDMIF4G domain containing0.068
TRPC1transient receptor potential cation channel, subfamily C, member 10.065
UTRNutrophin0.064
NCOR1nuclear receptor corepressor 10.063
KIF1Ckinesin family member 1C0.059
ACTN2actinin, alpha 20.056
RHAGRh-associated glycoprotein0.051
YAP1Yes-associated protein 10.048
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.047
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.039
SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)0.036
CANXcalnexin0.036
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.035
ANK2ankyrin 2, neuronal0.031
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.031
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.027
LDB3LIM domain binding 30.027
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.027
NDRG2NDRG family member 20.025
MYOZ2myozenin 20.025
SLNsarcolipin0.024
CKMcreatine kinase, muscle0.024
SMPXsmall muscle protein, X-linked0.022
MECP2methyl CpG binding protein 2 (Rett syndrome)0.021
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.021
MYL4myosin, light chain 4, alkali; atrial, embryonic0.020
TNNI1troponin I type 1 (skeletal, slow)0.020
TNNC1troponin C type 1 (slow)0.020
DDAH2dimethylarginine dimethylaminohydrolase 20.019
SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)0.018
MYL2myosin, light chain 2, regulatory, cardiac, slow0.018
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.018
TMEM47transmembrane protein 470.017
DIAPH1diaphanous homolog 1 (Drosophila)0.016
ALBalbumin0.016
ZMYND11zinc finger, MYND-type containing 110.016
TIAM1T-cell lymphoma invasion and metastasis 10.016
MDM4Mdm4 p53 binding protein homolog (mouse)0.016
MYH7myosin, heavy chain 7, cardiac muscle, beta0.015
TSC2tuberous sclerosis 20.015
MYL1myosin, light chain 1, alkali; skeletal, fast0.015
PAMpeptidylglycine alpha-amidating monooxygenase0.014
CASQ1calsequestrin 1 (fast-twitch, skeletal muscle)0.014
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.014
HDAC9histone deacetylase 90.014
DMDdystrophin0.013
PYGMphosphorylase, glycogen, muscle0.013
TNNC2troponin C type 2 (fast)0.013
BCL6B-cell CLL/lymphoma 60.012
ARandrogen receptor0.012
MYBPC2myosin binding protein C, fast type0.012
HDAC5histone deacetylase 50.012
CAV3caveolin 30.012
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.012
ACTC1actin, alpha, cardiac muscle 10.012
CDC25Bcell division cycle 25 homolog B (S. pombe)0.012
TNNT3troponin T type 3 (skeletal, fast)0.012
MYBPC1myosin binding protein C, slow type0.011
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.011
ATF2activating transcription factor 20.011
IRS1insulin receptor substrate 10.011
HIPK2homeodomain interacting protein kinase 20.011
RPL3Lribosomal protein L3-like0.011
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.010
TNIKTRAF2 and NCK interacting kinase0.010
MYH2myosin, heavy chain 2, skeletal muscle, adult0.010
ATXN1ataxin 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mef2dmyocyte enhancer factor 2D0.995
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.901
Casq2calsequestrin 20.790
Hrchistidine rich calcium binding protein0.789
Ldb3LIM domain binding 30.644
Ryr2ryanodine receptor 2, cardiac0.627
Pkd1polycystic kidney disease 1 homolog0.613
Ttntitin0.374
Mef2cmyocyte enhancer factor 2C0.373
Srpk3serine/arginine-rich protein specific kinase 30.304
Actn2actinin alpha 20.296
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.289
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.261
Gja1gap junction protein, alpha 10.225
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.219
Dag1dystroglycan 10.216
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.210
Casq1calsequestrin 10.208
Pygmmuscle glycogen phosphorylase0.189
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.155
Myom2myomesin 20.151
Mybpc3myosin binding protein C, cardiac0.124
Ncor2nuclear receptor co-repressor 20.099
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.097
Spna1spectrin alpha 10.093
Myl1myosin, light polypeptide 10.084
Myom1myomesin 10.080
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.078
Tcaptitin-cap0.076
Desdesmin0.074
Actc1actin, alpha, cardiac muscle 10.071
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.070
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.067
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.060
Vegfavascular endothelial growth factor A0.060
Dtnadystrobrevin alpha0.058
Ank1ankyrin 1, erythroid0.057
Capn3calpain 30.053
Scn5asodium channel, voltage-gated, type V, alpha0.052
Smyd1SET and MYND domain containing 10.051
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.049
Alpk3alpha-kinase 30.047
Myl3myosin, light polypeptide 30.047
Dctn1dynactin 10.046
Xirp1xin actin-binding repeat containing 10.046
Spnb1spectrin beta 10.044
Ckmcreatine kinase, muscle0.043
Mef2amyocyte enhancer factor 2A0.043
Frmd5FERM domain containing 50.039
Nrapnebulin-related anchoring protein0.039
Lphn1latrophilin 10.038
Invsinversin0.037
Nos1nitric oxide synthase 1, neuronal0.037
Tnnt3troponin T3, skeletal, fast0.037
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.034
Epas1endothelial PAS domain protein 10.034
Hdac4histone deacetylase 40.034
Zfp651zinc finger protein 6510.034
Phka1phosphorylase kinase alpha 10.033
Tspo2translocator protein 20.032
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.032
Ckmt2creatine kinase, mitochondrial 20.031
Per3period homolog 3 (Drosophila)0.030
Dmpkdystrophia myotonica-protein kinase0.028
Limch1LIM and calponin homology domains 10.028
Fktnfukutin0.028
Tnnc2troponin C2, fast0.027
Popdc2popeye domain containing 20.026
Snta1syntrophin, acidic 10.026
Myocdmyocardin0.024
Myoz1myozenin 10.024
Col19a1collagen, type XIX, alpha 10.024
Prnpprion protein0.024
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.024
Skiski sarcoma viral oncogene homolog (avian)0.024
Kcna7potassium voltage-gated channel, shaker-related subfamily, member 70.023
Tjp1tight junction protein 10.023
Tcf4transcription factor 40.023
Scn1bsodium channel, voltage-gated, type I, beta0.023
Pdlim3PDZ and LIM domain 30.022
Tnnt2troponin T2, cardiac0.022
Trim25tripartite motif-containing 250.022
Hbb-b1hemoglobin, beta adult major chain0.022
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.022
Sgcbsarcoglycan, beta (dystrophin-associated glycoprotein)0.021
Nr3c1nuclear receptor subfamily 3, group C, member 10.021
Tnni1troponin I, skeletal, slow 10.021
Efnb3ephrin B30.021
Spnb2spectrin beta 20.020
Hrh2histamine receptor H20.020
Plp1proteolipid protein (myelin) 10.020
Csrp3cysteine and glycine-rich protein 30.020
Dlg4discs, large homolog 4 (Drosophila)0.020
Largelike-glycosyltransferase0.019
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.019
Kitlkit ligand0.019
Ypel3yippee-like 3 (Drosophila)0.018
Mpripmyosin phosphatase Rho interacting protein0.018
Rtn2reticulon 2 (Z-band associated protein)0.018
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism