The network for 'organ senescence' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organ senescence

The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. An example of this process is found in Arabidopsis thaliana.

NameDescriptionProbabilityFunc Analog Organism
A3galt2alpha 1,3-galactosyltransferase 20.114
Fapfibroblast activation protein, alpha0.114
Btg2BTG family, member 20.111
Egr1early growth response 10.109
Tgfb1i1transforming growth factor beta 1 induced transcript 10.064
Edn1endothelin 10.061
Wisp2WNT1 inducible signaling pathway protein 20.048
FosFBJ osteosarcoma oncogene0.045
Cpxm2carboxypeptidase X (M14 family), member 20.040
Snai1snail homolog 1 (Drosophila)0.038
Junbjun B proto-oncogene0.036
Actg2actin, gamma 2, smooth muscle, enteric0.032
Cyr61cysteine-rich, angiogenic inducer, 610.021
Mustn1musculoskeletal, embryonic nuclear protein 10.021
Gprc5aG protein-coupled receptor, family C, group 5, member A0.019
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.017
Cspg4chondroitin sulfate proteoglycan 40.016
Nrsn1neurensin 10.015
RGD1561143similar to cell surface receptor FDFACT0.014
Nr4a1nuclear receptor subfamily 4, group A, member 10.014
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.014
Megf6multiple EGF-like-domains 60.014
Fibinfin bud initiation factor homolog (zebrafish)0.014
Ctgfconnective tissue growth factor0.014
Clec11aC-type lectin domain family 11, member a0.013
Zfp36zinc finger protein 360.013
Col8a1collagen, type VIII, alpha 10.012
RGD1310371similar to RIKEN cDNA 1700026D080.012
Rwdd1RWD domain containing 10.012
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.012
Thbs4thrombospondin 40.012
Ccdc8coiled-coil domain containing 80.011
Bace1beta-site APP cleaving enzyme 10.011
Olfml2bolfactomedin-like 2B0.011
Slit3slit homolog 3 (Drosophila)0.010
Npr2natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism