The network for 'positive regulation of protein secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.

NameDescriptionProbabilityFunc Analog Organism
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.163
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.130
Il1binterleukin 1 beta0.103
Ccr2chemokine (C-C motif) receptor 20.081
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.079
Svs1seminal vesicle secretory protein 10.077
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.069
Adora2aadenosine A2a receptor0.057
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.052
Gzmkgranzyme K0.048
Adora3adenosine A3 receptor0.046
Adra2aadrenergic, alpha-2A-, receptor0.041
Cd247Cd247 molecule0.039
Casp1caspase 10.037
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.037
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.036
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.035
Il8rbinterleukin 8 receptor, beta0.035
Ccnd3cyclin D30.035
Oprk1opioid receptor, kappa 10.034
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.034
Cd4Cd4 molecule0.034
PycardPYD and CARD domain containing0.034
Stat6signal transducer and activator of transcription 60.033
Tlr4toll-like receptor 40.032
Fgfr2fibroblast growth factor receptor 20.032
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.030
Grm6glutamate receptor, metabotropic 60.030
Ptger2prostaglandin E receptor 2 (subtype EP2)0.029
Olr1500olfactory receptor 15000.029
Pftk1PFTAIRE protein kinase 10.029
Hist1h1ahistone cluster 1, H1a0.028
Acp5acid phosphatase 5, tartrate resistant0.027
Plauplasminogen activator, urokinase0.027
Fgfr1Fibroblast growth factor receptor 10.027
Olr1082olfactory receptor 10820.027
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.026
Ptpn18protein tyrosine phosphatase, non-receptor type 180.026
Reg3aregenerating islet-derived 3 alpha0.026
Trhr2thyrotropin releasing hormone receptor 20.025
Matkmegakaryocyte-associated tyrosine kinase0.024
Mmp12matrix metallopeptidase 120.024
RT1-BaRT1 class II, locus Ba0.024
Ptgs1prostaglandin-endoperoxide synthase 10.024
Tgfbr2transforming growth factor, beta receptor II0.023
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.023
Alpialkaline phosphatase, intestinal0.023
Egfrepidermal growth factor receptor0.022
Il2rginterleukin 2 receptor, gamma0.022
Ptafrplatelet-activating factor receptor0.022
Lpllipoprotein lipase0.022
Hpcal4hippocalcin-like 40.022
Cckbrcholecystokinin B receptor0.021
Ptpn6protein tyrosine phosphatase, non-receptor type 60.021
Bdkrb2bradykinin receptor B20.021
Cxcl10chemokine (C-X-C motif) ligand 100.021
Gdnfglial cell derived neurotrophic factor0.020
CamkvCaM kinase-like vesicle-associated0.020
Cd53Cd53 molecule0.020
Edn1endothelin 10.020
Slit1slit homolog 1 (Drosophila)0.020
Cd8bCD8b molecule0.020
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.020
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.020
Col10a1collagen, type X, alpha 10.020
Gfi1growth factor independent 1 transcription repressor0.019
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.019
Cxcr5chemokine (C-X-C motif) receptor 50.019
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.019
Cskc-src tyrosine kinase0.019
Ccl4chemokine (C-C motif) ligand 40.018
Il6interleukin 60.018
Ccr5chemokine (C-C motif) receptor 50.018
Serp1stress-associated endoplasmic reticulum protein 10.017
Il2rbinterleukin 2 receptor, beta0.017
Adam17ADAM metallopeptidase domain 170.017
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.017
Chrna7cholinergic receptor, nicotinic, alpha 70.017
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.017
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.016
Myo1bmyosin Ib0.016
Il9rinterleukin 9 receptor0.016
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.016
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.016
Grm7glutamate receptor, metabotropic 70.016
Ccdc102acoiled-coil domain containing 102A0.016
Cdk4cyclin-dependent kinase 40.016
Selpselectin P0.016
Crhbpcorticotropin releasing hormone binding protein0.016
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.016
Ptprcprotein tyrosine phosphatase, receptor type, C0.016
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.015
Ctsccathepsin C0.015
Syngr2synaptogyrin 20.015
Cfpcomplement factor properdin0.015
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.015
Lgals9lectin, galactoside-binding, soluble, 90.015
Il1r1interleukin 1 receptor, type I0.015
Glp2rglucagon-like peptide 2 receptor0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cg25CCollagen type IV0.652
ImpIGF-II mRNA-binding protein0.259
G-oalpha47AG protein oalpha 47A0.170
mewmultiple edematous wings0.170
CHOp24CG3564 gene product from transcript CG3564-RA0.149
imdimmune deficiency0.114
swshort wing0.093
wbwing blister0.087
myoglianinCG1838 gene product from transcript CG1838-RD0.083
Pvf1PDGF- and VEGF-related factor 10.082
locolocomotion defects0.069
Patr-1Protein associated with topo II related - 10.060
BG4CG12297 gene product from transcript CG12297-RA0.058
trioCG18214 gene product from transcript CG18214-RA0.054
Socs36ESuppressor of cytokine signaling at 36E0.054
cdicenter divider0.048
RASSF8CG5053 gene product from transcript CG5053-RA0.043
CtBPC-terminal Binding Protein0.040
zfh1Zn finger homeodomain 10.040
Gef26CG9491 gene product from transcript CG9491-RB0.039
SplySphingosine-1-phosphate lyase0.038
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.037
AlyCG1101 gene product from transcript CG1101-RA0.036
EloAElongin A0.035
CG9053CG9053 gene product from transcript CG9053-RA0.034
reporeversed polarity0.034
CatsupCatecholamines up0.032
Kr-h1Kruppel homolog 10.032
CG5027CG5027 gene product from transcript CG5027-RA0.032
wuhoCG15897 gene product from transcript CG15897-RA0.031
Wnt2Wnt oncogene analog 20.030
Ext2CG8433 gene product from transcript CG8433-RA0.028
Tfb5CG42373 gene product from transcript CG42373-RB0.027
CG18005CG18005 gene product from transcript CG18005-RA0.026
edlETS-domain lacking0.026
oafout at first0.025
pex2peroxin 20.025
MrtfMyocardin-related transcription factor0.021
Tre1trapped in endoderm-10.021
drkdownstream of receptor kinase0.020
katanin-60katanin 600.020
Xe7CG2179 gene product from transcript CG2179-RA0.019
Cad99CCG31009 gene product from transcript CG31009-RB0.018
alphaTub84Balpha-Tubulin at 84B0.018
Smg5CG8954 gene product from transcript CG8954-RA0.018
bambag of marbles0.018
l(2)05510lethal (2) 055100.017
Pka-R2cAMP-dependent protein kinase R20.017
Ptp10DProtein tyrosine phosphatase 10D0.016
CG5382CG5382 gene product from transcript CG5382-RB0.016
unc-104CG8566 gene product from transcript CG8566-RB0.015
CG31211CG31211 gene product from transcript CG31211-RB0.015
slboslow border cells0.014
CG7607CG7607 gene product from transcript CG7607-RA0.014
rtGEFrho-type guanine exchange factor0.013
HmgsHMG Coenzyme A synthase0.013
CG3371CG3371 gene product from transcript CG3371-RA0.012
Eip71CDEcdysone-induced protein 28/29kD0.012
CG15124CG15124 gene product from transcript CG15124-RA0.012
CG7830CG7830 gene product from transcript CG7830-RA0.011
Ras64BRas oncogene at 64B0.011
CG11275CG11275 gene product from transcript CG11275-RA0.011
lqfliquid facets0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.810
BTN3A2butyrophilin, subfamily 3, member A20.709
CD80CD80 molecule0.700
NLRC4NLR family, CARD domain containing 40.677
CTLA4cytotoxic T-lymphocyte-associated protein 40.571
BTN3A3butyrophilin, subfamily 3, member A30.515
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.475
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.419
LRP1low density lipoprotein receptor-related protein 10.367
BTN3A1butyrophilin, subfamily 3, member A10.347
FGAfibrinogen alpha chain0.337
ANGangiogenin, ribonuclease, RNase A family, 50.314
ABI2abl-interactor 20.278
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.275
CDH5cadherin 5, type 2 (vascular endothelium)0.269
CCR2chemokine (C-C motif) receptor 20.259
FGBfibrinogen beta chain0.259
NRP1neuropilin 10.258
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.254
BCAR1breast cancer anti-estrogen resistance 10.238
COL4A1collagen, type IV, alpha 10.225
TAL1T-cell acute lymphocytic leukemia 10.204
TUBA1Ctubulin, alpha 1c0.193
IL10RAinterleukin 10 receptor, alpha0.190
IL1R1interleukin 1 receptor, type I0.155
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.146
APPamyloid beta (A4) precursor protein0.143
LATlinker for activation of T cells0.140
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.126
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.126
FSTL1follistatin-like 10.122
TGFB1transforming growth factor, beta 10.119
SEC24DSEC24 family, member D (S. cerevisiae)0.119
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.116
IRAK3interleukin-1 receptor-associated kinase 30.114
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.111
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.110
RNASE4ribonuclease, RNase A family, 40.108
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.101
DRD2dopamine receptor D20.098
CCL4chemokine (C-C motif) ligand 40.098
CCR1chemokine (C-C motif) receptor 10.097
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.097
FYNFYN oncogene related to SRC, FGR, YES0.097
EGFRepidermal growth factor receptor0.094
SETD8SET domain containing (lysine methyltransferase) 80.090
CCL8chemokine (C-C motif) ligand 80.089
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.086
TLR2toll-like receptor 20.084
IL10interleukin 100.084
AP2B1adaptor-related protein complex 2, beta 1 subunit0.078
ENO1enolase 1, (alpha)0.077
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.075
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.075
FGGfibrinogen gamma chain0.073
FGFR1fibroblast growth factor receptor 10.072
IL4interleukin 40.072
PGFplacental growth factor0.071
CRPC-reactive protein, pentraxin-related0.069
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.068
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.066
C5AR1complement component 5a receptor 10.066
APOEapolipoprotein E0.065
TRAF1TNF receptor-associated factor 10.065
FGL2fibrinogen-like 20.063
PTPRBprotein tyrosine phosphatase, receptor type, B0.062
SOS1son of sevenless homolog 1 (Drosophila)0.062
BTN2A2butyrophilin, subfamily 2, member A20.059
SH3KBP1SH3-domain kinase binding protein 10.058
CXCL2chemokine (C-X-C motif) ligand 20.057
DLG1discs, large homolog 1 (Drosophila)0.055
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.055
TMEM173transmembrane protein 1730.055
SYKspleen tyrosine kinase0.053
CCR5chemokine (C-C motif) receptor 50.052
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.052
IFI16interferon, gamma-inducible protein 160.052
HCKhemopoietic cell kinase0.051
KLRC3killer cell lectin-like receptor subfamily C, member 30.051
RIPK2receptor-interacting serine-threonine kinase 20.050
IGFBP3insulin-like growth factor binding protein 30.050
MEFVMediterranean fever0.049
CAV1caveolin 1, caveolae protein, 22kDa0.049
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.049
FLT4fms-related tyrosine kinase 40.048
FPR1formyl peptide receptor 10.048
TNFRSF9tumor necrosis factor receptor superfamily, member 90.047
GBP5guanylate binding protein 50.046
TRAF5TNF receptor-associated factor 50.045
CD93CD93 molecule0.045
CAV2caveolin 20.044
CFHcomplement factor H0.044
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.043
IGFBP5insulin-like growth factor binding protein 50.043
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Il1r1interleukin 1 receptor, type I0.985
Tlr4toll-like receptor 40.968
Casp4caspase 4, apoptosis-related cysteine peptidase0.964
Ccl2chemokine (C-C motif) ligand 20.896
Clec4dC-type lectin domain family 4, member d0.857
Casp1caspase 10.846
Il1binterleukin 1 beta0.796
C3ar1complement component 3a receptor 10.753
Nos2nitric oxide synthase 2, inducible0.709
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.708
FasFas (TNF receptor superfamily member 6)0.702
Ccr2chemokine (C-C motif) receptor 20.695
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.604
Ren1renin 1 structural0.593
Leprleptin receptor0.579
Il1rl1interleukin 1 receptor-like 10.571
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.557
Agtr1aangiotensin II receptor, type 1a0.519
Pdcd1programmed cell death 10.503
Il10interleukin 100.494
Il1rninterleukin 1 receptor antagonist0.491
Msr1macrophage scavenger receptor 10.470
Cd4CD4 antigen0.450
Ccl8chemokine (C-C motif) ligand 80.422
Cd28CD28 antigen0.421
Gbp5guanylate binding protein 50.419
Ccr1chemokine (C-C motif) receptor 10.408
Mmp12matrix metallopeptidase 120.406
Pax2paired box gene 20.404
Il10rainterleukin 10 receptor, alpha0.384
Cd80CD80 antigen0.382
Ptgirprostaglandin I receptor (IP)0.380
Cd33CD33 antigen0.357
MefvMediterranean fever0.356
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.329
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.325
Cd209bCD209b antigen0.324
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.320
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.315
Gpr33G protein-coupled receptor 330.311
Il2rbinterleukin 2 receptor, beta chain0.302
Itgaxintegrin alpha X0.300
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.282
Cybbcytochrome b-245, beta polypeptide0.271
Ncr1natural cytotoxicity triggering receptor 10.266
AF251705cDNA sequence AF2517050.255
BlkB lymphoid kinase0.254
Nlrp3NLR family, pyrin domain containing 30.254
Atp7aATPase, Cu++ transporting, alpha polypeptide0.242
Ccl12chemokine (C-C motif) ligand 120.238
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.233
Npy2rneuropeptide Y receptor Y20.229
Rbpjlrecombination signal binding protein for immunoglobulin kappa J region-like0.227
Ccl22chemokine (C-C motif) ligand 220.224
Cd44CD44 antigen0.218
PycardPYD and CARD domain containing0.218
Htr45 hydroxytryptamine (serotonin) receptor 40.210
Klrg1killer cell lectin-like receptor subfamily G, member 10.209
Ccl17chemokine (C-C motif) ligand 170.202
Cd14CD14 antigen0.199
Csf1rcolony stimulating factor 1 receptor0.193
Crhr1corticotropin releasing hormone receptor 10.191
Pax8paired box gene 80.187
Batf3basic leucine zipper transcription factor, ATF-like 30.183
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.183
FaslFas ligand (TNF superfamily, member 6)0.182
Ccl24chemokine (C-C motif) ligand 240.182
Fcgr1Fc receptor, IgG, high affinity I0.181
Il18r1interleukin 18 receptor 10.180
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.179
1100001G20RikRIKEN cDNA 1100001G20 gene0.179
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.177
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.177
Flt3FMS-like tyrosine kinase 30.177
Cx3cr1chemokine (C-X3-C) receptor 10.175
Tgfbr1transforming growth factor, beta receptor I0.172
Wt1Wilms tumor 1 homolog0.171
Stat6signal transducer and activator of transcription 60.171
Fbn1fibrillin 10.171
BtkBruton agammaglobulinemia tyrosine kinase0.170
Tnftumor necrosis factor0.170
Sstr4somatostatin receptor 40.169
Clec4eC-type lectin domain family 4, member e0.167
H2-DMb2histocompatibility 2, class II, locus Mb20.166
Fgf23fibroblast growth factor 230.163
Tbxas1thromboxane A synthase 1, platelet0.160
Tlr2toll-like receptor 20.160
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.159
Adra2cadrenergic receptor, alpha 2c0.157
Wnt10bwingless related MMTV integration site 10b0.157
Ccl7chemokine (C-C motif) ligand 70.156
Cd5CD5 antigen0.156
Ltalymphotoxin A0.156
Clec7aC-type lectin domain family 7, member a0.150
Selpselectin, platelet0.150
Gm11428predicted gene 114280.150
Cd40CD40 antigen0.149
Gcgrglucagon receptor0.148
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism