The network for 'branched chain amino acid catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

branched chain amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.

NameDescriptionProbabilityFunc Analog Organism
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.592
Gcdhglutaryl-Coenzyme A dehydrogenase0.469
Mutmethylmalonyl-Coenzyme A mutase0.311
Ivdisovaleryl coenzyme A dehydrogenase0.293
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.230
Pccapropionyl-coenzyme A carboxylase, alpha polypeptide0.215
Suclg2succinate-CoA ligase, GDP-forming, beta subunit0.213
Adkadenosine kinase0.190
Isoc1isochorismatase domain containing 10.117
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.095
Nntnicotinamide nucleotide transhydrogenase0.095
Nfs1NFS1 nitrogen fixation 1 homolog (S. cerevisiae)0.090
Scp2sterol carrier protein 20.076
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.076
RGD1303003homolog of zebrafish ES10.065
Acat1acetyl-coenzyme A acetyltransferase 10.060
Bckdhbbranched chain keto acid dehydrogenase E1, beta polypeptide0.054
Adhfe1alcohol dehydrogenase, iron containing, 10.049
Ghrgrowth hormone receptor0.041
Hibadh3-hydroxyisobutyrate dehydrogenase0.040
Aldh2aldehyde dehydrogenase 2 family (mitochondrial)0.038
Acadsbacyl-Coenzyme A dehydrogenase, short/branched chain0.037
Mccc1methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)0.034
Pccbpropionyl coenzyme A carboxylase, beta polypeptide0.034
Etfdhelectron-transferring-flavoprotein dehydrogenase0.031
Pxmp2peroxisomal membrane protein 20.029
Nfianuclear factor I/A0.024
Aldh9a1aldehyde dehydrogenase 9 family, member A10.024
Idh3gisocitrate dehydrogenase 3 (NAD), gamma0.020
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.020
Ubxn6UBX domain protein 60.019
Dhtkd1dehydrogenase E1 and transketolase domain containing 10.019
Klf15Kruppel-like factor 150.019
Gstk1glutathione S-transferase kappa 10.019
Pecrperoxisomal trans-2-enoyl-CoA reductase0.018
Suoxsulfite oxidase0.018
LOC100361841kynurenine aminotransferase III-like0.017
FastkFas-activated serine/threonine kinase0.017
Josd2Josephin domain containing 20.017
Gstm7glutathione S-transferase, mu 70.017
Glud1glutamate dehydrogenase 10.017
Abhd14babhydrolase domain containing 14b0.015
Acsl1acyl-CoA synthetase long-chain family member 10.014
Eif2b2eukaryotic translation initiation factor 2B, subunit 2 beta0.013
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.013
Cabc1chaperone, ABC1 activity of bc1 complex homolog (S. pombe)0.012
Pdk2pyruvate dehydrogenase kinase, isozyme 20.012
Slc25a13solute carrier family 25, member 13 (citrin)0.012
Aldh4a1aldehyde dehydrogenase 4 family, member A10.012
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.011
Tecrtrans-2,3-enoyl-CoA reductase0.011
Pdhxpyruvate dehydrogenase complex, component X0.010
Mtus1mitochondrial tumor suppressor 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ECH1enoyl CoA hydratase 1, peroxisomal0.616
BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide0.443
HADHhydroxyacyl-CoA dehydrogenase0.211
MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha)0.124
ALDH6A1aldehyde dehydrogenase 6 family, member A10.115
BCKDKbranched chain ketoacid dehydrogenase kinase0.081
C21orf33chromosome 21 open reading frame 330.078
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.068
CPT2carnitine palmitoyltransferase 20.035
SUCLG2succinate-CoA ligase, GDP-forming, beta subunit0.029
GCDHglutaryl-CoA dehydrogenase0.028
PHYHphytanoyl-CoA 2-hydroxylase0.025
DHTKD1dehydrogenase E1 and transketolase domain containing 10.020
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.015
TRAPPC6Atrafficking protein particle complex 6A0.014
NNTnicotinamide nucleotide transhydrogenase0.012
ACADSBacyl-CoA dehydrogenase, short/branched chain0.011
ALDOAaldolase A, fructose-bisphosphate0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dbtdihydrolipoamide branched chain transacylase E20.478
Ivdisovaleryl coenzyme A dehydrogenase0.336
Mutmethylmalonyl-Coenzyme A mutase0.147
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.146
Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase)0.131
Gcdhglutaryl-Coenzyme A dehydrogenase0.083
Acad11acyl-Coenzyme A dehydrogenase family, member 110.059
Hibadh3-hydroxyisobutyrate dehydrogenase0.057
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.053
Scp2sterol carrier protein 2, liver0.038
Etfaelectron transferring flavoprotein, alpha polypeptide0.037
Chpt1choline phosphotransferase 10.032
Sirt3sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)0.027
Suclg2succinate-Coenzyme A ligase, GDP-forming, beta subunit0.025
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.024
Gstk1glutathione S-transferase kappa 10.024
Entpd5ectonucleoside triphosphate diphosphohydrolase 50.023
Pccbpropionyl Coenzyme A carboxylase, beta polypeptide0.022
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.021
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.019
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.017
Cbr1carbonyl reductase 10.016
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.014
Hsdl2hydroxysteroid dehydrogenase like 20.013
Acad8acyl-Coenzyme A dehydrogenase family, member 80.013
Ehhadhenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase0.013
Ccbl2cysteine conjugate-beta lyase 20.012
Hadhhydroxyacyl-Coenzyme A dehydrogenase0.012
Gnpatglyceronephosphate O-acyltransferase0.011
H2-Ke6H2-K region expressed gene 60.011
Qdprquinoid dihydropteridine reductase0.011
Pex7peroxisomal biogenesis factor 70.011
Clyblcitrate lyase beta like0.011
Acadsbacyl-Coenzyme A dehydrogenase, short/branched chain0.010
Phyhphytanoyl-CoA hydroxylase0.010
Hrsp12heat-responsive protein 120.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism