The network for 'establishment of neuroblast polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of neuroblast polarity

The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.

NameDescriptionProbabilityFunc Analog Organism
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.318
Arl13bADP-ribosylation factor-like 13B0.099
Eif4heukaryotic translation initiation factor 4H0.058
Cdc42cell division cycle 42 (GTP binding protein)0.050
Capza2capping protein (actin filament) muscle Z-line, alpha 20.046
Tulp1tubby like protein 10.045
Fkbp1aFK506 binding protein 1a0.043
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.043
Sod2superoxide dismutase 2, mitochondrial0.042
Mylk2myosin light chain kinase 20.036
Zfp706zinc finger protein 7060.032
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.030
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.028
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.026
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.020
Rab10RAB10, member RAS oncogene family0.019
RGD1564163similar to RIKEN cDNA 1700025K230.018
March8membrane-associated ring finger (C3HC4) 80.018
Prlhprolactin releasing hormone0.017
Seltselenoprotein T0.016
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.016
RhdRh blood group, D antigen0.015
Hrnbp3hexaribonucleotide binding protein 30.015
Nlgn3neuroligin 30.015
Nedd4neural precursor cell expressed, developmentally down-regulated 40.014
Ptp4a2protein tyrosine phosphatase 4a20.014
Chd6chromodomain helicase DNA binding protein 60.013
Dgkgdiacylglycerol kinase, gamma0.012
Nrxn3neurexin 30.012
Lhx1LIM homeobox 10.011
Syn1synapsin I0.011
Slc45a1solute carrier family 45, member 10.011
Nxph1neurexophilin 10.010
Rtn4reticulon 40.010
Tmem67transmembrane protein 670.010
Cdc25acell division cycle 25 homolog A (S. pombe)0.010
Myt1lmyelin transcription factor 1-like0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cdc42CG12530 gene product from transcript CG12530-RA0.931
Rho1CG8416 gene product from transcript CG8416-RB0.713
Rab11Rab-protein 110.580
Rab5Rab-protein 50.218
sqhspaghetti squash0.081
Eb1CG3265 gene product from transcript CG3265-RF0.074
RalaRas-related protein0.063
Arf79FADP ribosylation factor 79F0.055
Sop2Suppressor of profilin 20.049
par-1CG8201 gene product from transcript CG8201-RA0.044
Syx7Syntaxin 70.029
Vrp1Verprolin 10.028
DlicDynein light intermediate chain0.026
Vap-33-1CG5014 gene product from transcript CG5014-RB0.026
ctpcut up0.025
MrtfMyocardin-related transcription factor0.023
Arf51FADP ribosylation factor 51F0.018
RhoGDICG7823 gene product from transcript CG7823-RA0.017
Arp66BActin-related protein 66B0.013
ChcClathrin heavy chain0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PRKCZprotein kinase C, zeta0.999
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.956
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.821
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.704
LLGL1lethal giant larvae homolog 1 (Drosophila)0.348
LLGL2lethal giant larvae homolog 2 (Drosophila)0.336
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.316
PRKCIprotein kinase C, iota0.311
IQGAP1IQ motif containing GTPase activating protein 10.234
NUMBnumb homolog (Drosophila)0.137
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.089
TNK2tyrosine kinase, non-receptor, 20.086
PAK3p21 protein (Cdc42/Rac)-activated kinase 30.085
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.075
CCDC115coiled-coil domain containing 1150.075
RPP14ribonuclease P/MRP 14kDa subunit0.049
INSRinsulin receptor0.049
TMSB4Xthymosin beta 4, X-linked0.049
NTF4neurotrophin 40.045
ZNF71zinc finger protein 710.043
BAIAP2BAI1-associated protein 20.042
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.042
TRIP10thyroid hormone receptor interactor 100.042
LATlinker for activation of T cells0.041
F11RF11 receptor0.038
NMT2N-myristoyltransferase 20.038
WIPF1WAS/WASL interacting protein family, member 10.036
PLCG1phospholipase C, gamma 10.032
IQGAP2IQ motif containing GTPase activating protein 20.030
BCAR1breast cancer anti-estrogen resistance 10.029
VHLvon Hippel-Lindau tumor suppressor0.029
PAK7p21 protein (Cdc42/Rac)-activated kinase 70.028
SHC3SHC (Src homology 2 domain containing) transforming protein 30.026
SQSTM1sequestosome 10.023
PTPN1protein tyrosine phosphatase, non-receptor type 10.022
CDH5cadherin 5, type 2 (vascular endothelium)0.019
GHRgrowth hormone receptor0.016
LRCH1leucine-rich repeats and calponin homology (CH) domain containing 10.016
NCF2neutrophil cytosolic factor 20.014
PAK4p21 protein (Cdc42/Rac)-activated kinase 40.013
FGFR1fibroblast growth factor receptor 10.013
CDC42EP2CDC42 effector protein (Rho GTPase binding) 20.012
BADBCL2-associated agonist of cell death0.011
LRCH3leucine-rich repeats and calponin homology (CH) domain containing 30.010
WASLWiskott-Aldrich syndrome-like0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI30.999
Pax2paired box gene 20.997
Fgfr2fibroblast growth factor receptor 20.996
Ntf3neurotrophin 30.992
Eya1eyes absent 1 homolog (Drosophila)0.990
Bdnfbrain derived neurotrophic factor0.985
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.979
Prrx1paired related homeobox 10.960
Fgf9fibroblast growth factor 90.933
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.931
Gli2GLI-Kruppel family member GLI20.925
Pax3paired box gene 30.922
Hoxa1homeobox A10.908
Tbx10T-box 100.903
Fgf8fibroblast growth factor 80.887
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.887
Foxg1forkhead box G10.885
Twist2twist homolog 2 (Drosophila)0.878
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.874
Fgfr3fibroblast growth factor receptor 30.870
Foxc1forkhead box C10.804
Fgf10fibroblast growth factor 100.803
Jag1jagged 10.788
Wnt5awingless-related MMTV integration site 5A0.747
Zeb1zinc finger E-box binding homeobox 10.723
Isl1ISL1 transcription factor, LIM/homeodomain0.711
Sox9SRY-box containing gene 90.689
Retret proto-oncogene0.676
Hand2heart and neural crest derivatives expressed transcript 20.627
Pthlhparathyroid hormone-like peptide0.606
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.566
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.563
Sox2SRY-box containing gene 20.557
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.534
Pou4f3POU domain, class 4, transcription factor 30.533
Dlx5distal-less homeobox 50.529
Gbx2gastrulation brain homeobox 20.524
Tcf21transcription factor 210.519
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.482
Lmx1aLIM homeobox transcription factor 1 alpha0.470
Msx2homeobox, msh-like 20.468
Vangl2vang-like 2 (van gogh, Drosophila)0.460
Nkx2-1NK2 homeobox 10.453
Fgf3fibroblast growth factor 30.445
Tcfap2atranscription factor AP-2, alpha0.445
Tbx15T-box 150.440
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.437
Tgfb2transforming growth factor, beta 20.418
Fgf14fibroblast growth factor 140.415
Pax6paired box gene 60.401
Zfpm2zinc finger protein, multitype 20.379
Bmp4bone morphogenetic protein 40.378
Foxc2forkhead box C20.373
Tbx1T-box 10.360
Phox2apaired-like homeobox 2a0.358
Meox2mesenchyme homeobox 20.345
Trp63transformation related protein 630.338
Chd7chromodomain helicase DNA binding protein 70.318
Alx4aristaless-like homeobox 40.314
Hoxd13homeobox D130.310
Chrngcholinergic receptor, nicotinic, gamma polypeptide0.309
Nrg1neuregulin 10.309
Otx2orthodenticle homolog 2 (Drosophila)0.308
Rac1RAS-related C3 botulinum substrate 10.302
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.296
Bmp5bone morphogenetic protein 50.291
Hoxa11homeobox A110.289
Gscgoosecoid homeobox0.289
Sox11SRY-box containing gene 110.278
Tbx3T-box 30.251
Ror2receptor tyrosine kinase-like orphan receptor 20.245
Shc3src homology 2 domain-containing transforming protein C30.230
Epha3Eph receptor A30.229
Sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.221
Hoxd11homeobox D110.219
Hmx3H6 homeobox 30.212
Phox2bpaired-like homeobox 2b0.211
Btbd17BTB (POZ) domain containing 170.208
Gata3GATA binding protein 30.208
Runx2runt related transcription factor 20.207
Ptpn11protein tyrosine phosphatase, non-receptor type 110.206
Rarbretinoic acid receptor, beta0.202
Gli1GLI-Kruppel family member GLI10.196
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.192
Tgfbr3transforming growth factor, beta receptor III0.187
Bmp2bone morphogenetic protein 20.183
Gja1gap junction protein, alpha 10.181
Ctnnb1catenin (cadherin associated protein), beta 10.181
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.167
Pbx1pre B-cell leukemia transcription factor 10.157
Cntn4contactin 40.141
Pou3f4POU domain, class 3, transcription factor 40.140
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.139
Prrx2paired related homeobox 20.137
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.136
Gdf11growth differentiation factor 110.133
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism