The network for 'histamine secretion by mast cell' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histamine secretion by mast cell

The regulated release of histamine by a mast cell or group of mast cells.

NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.798
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.796
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.684
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.478
Morf4l2mortality factor 4 like 20.428
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.322
Calm1calmodulin 10.253
Pgam1phosphoglycerate mutase 1 (brain)0.238
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.208
Fkbp1aFK506 binding protein 1a0.193
Calm2calmodulin 20.181
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.176
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.135
Tuba1ctubulin, alpha 1C0.127
Tpm3tropomyosin 3, gamma0.118
Actr3ARP3 actin-related protein 3 homolog (yeast)0.110
Sirpasignal-regulatory protein alpha0.103
Cfl1cofilin 1, non-muscle0.089
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.068
Cltcclathrin, heavy chain (Hc)0.062
ZwintZW10 interactor0.060
Eif4heukaryotic translation initiation factor 4H0.060
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.055
Tubb2atubulin, beta 2a0.055
Il1binterleukin 1 beta0.054
Appamyloid beta (A4) precursor protein0.045
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.041
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.041
Rab6aRAB6A, member RAS oncogene family0.038
Il2rginterleukin 2 receptor, gamma0.037
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.037
Dock8dedicator of cytokinesis 80.036
Stmn1stathmin 10.036
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.035
Cd37CD37 molecule0.035
Mpripmyosin phosphatase Rho interacting protein0.033
Inpp5dinositol polyphosphate-5-phosphatase D0.031
Hnrpdheterogeneous nuclear ribonucleoprotein D0.025
Hsph1heat shock 105/110 protein 10.025
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.024
Wdr1WD repeat domain 10.024
Nckap1NCK-associated protein 10.023
Hspa8heat shock protein 80.020
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.020
Gnb1guanine nucleotide binding protein (G protein), beta polypeptide 10.020
Cfpcomplement factor properdin0.020
BidBH3 interacting domain death agonist0.019
Il2rbinterleukin 2 receptor, beta0.019
Ptafrplatelet-activating factor receptor0.019
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.018
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.018
Sykspleen tyrosine kinase0.018
Parp14poly (ADP-ribose) polymerase family, member 140.018
Pitpnaphosphatidylinositol transfer protein, alpha0.017
Rhobras homolog gene family, member B0.017
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.016
Ahcyl1adenosylhomocysteinase-like 10.016
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.015
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.015
Prkcdprotein kinase C, delta0.015
Prnpprion protein0.014
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.014
Cd247Cd247 molecule0.014
Casp1caspase 10.014
Actg1actin, gamma 10.013
Caprin1cell cycle associated protein 10.013
RGD1311493similar to CG13379-PA0.013
Cxcr3chemokine (C-X-C motif) receptor 30.013
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.012
Ly86lymphocyte antigen 860.012
Ube2v1ubiquitin-conjugating enzyme E2 variant 10.012
Mect1mucoepidermoid carcinoma translocated 10.012
Klhl6kelch-like 6 (Drosophila)0.012
Brafv-raf murine sarcoma viral oncogene homolog B10.012
Socs5suppressor of cytokine signaling 50.012
Ptprcprotein tyrosine phosphatase, receptor type, C0.012
Plauplasminogen activator, urokinase0.011
Dnase1l3deoxyribonuclease 1-like 30.011
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.011
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.011
Bak1BCL2-antagonist/killer 10.011
Cpecarboxypeptidase E0.011
Tspan3tetraspanin 30.011
Cd22CD22 molecule0.011
Muc1mucin 1, cell surface associated0.011
Pfkpphosphofructokinase, platelet0.011
Tmed2transmembrane emp24 domain trafficking protein 20.011
Arhgap4Rho GTPase activating protein 40.010
Ralgdsral guanine nucleotide dissociation stimulator0.010
Dpysl2dihydropyrimidinase-like 20.010
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.010
Nedd4neural precursor cell expressed, developmentally down-regulated 40.010
Arhgap25Rho GTPase activating protein 250.010
TcrbT-cell receptor beta chain0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ighimmunoglobulin heavy chain complex0.618
MefvMediterranean fever0.581
Cd19CD19 antigen0.155
Ptpn6protein tyrosine phosphatase, non-receptor type 60.126
Inpp5dinositol polyphosphate-5-phosphatase D0.107
Cd40CD40 antigen0.089
BlnkB-cell linker0.070
Il4interleukin 40.065
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.048
Kitkit oncogene0.048
Ikzf1IKAROS family zinc finger 10.038
Ifnginterferon gamma0.036
Ptenphosphatase and tensin homolog0.032
Siglecesialic acid binding Ig-like lectin E0.031
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.030
Msr1macrophage scavenger receptor 10.027
Trpv1transient receptor potential cation channel, subfamily V, member 10.026
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.021
Eporerythropoietin receptor0.020
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.018
Ikzf3IKAROS family zinc finger 30.016
Fcgr4Fc receptor, IgG, low affinity IV0.014
Cd300lbCD300 antigen like family member B0.014
Trem3triggering receptor expressed on myeloid cells 30.014
Irg1immunoresponsive gene 10.014
Dok3docking protein 30.014
Cd33CD33 antigen0.013
Clec4dC-type lectin domain family 4, member d0.013
Il1rninterleukin 1 receptor antagonist0.012
Hcsthematopoietic cell signal transducer0.011
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.011
Tnftumor necrosis factor0.010
Fpr1formyl peptide receptor 10.010
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.010
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.010
Tmprss2transmembrane protease, serine 20.010
Apobrapolipoprotein B receptor0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism