The network for 'positive regulation of response to stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

NameDescriptionProbabilityFunc Analog Organism
F13a1coagulation factor XIII, A1 polypeptide0.841
Prrx1paired related homeobox 10.785
Slco2b1solute carrier organic anion transporter family, member 2b10.738
Jak1Janus kinase 10.712
Cd14CD14 molecule0.688
Bcanbrevican0.664
Runx1runt-related transcription factor 10.664
Ccl4chemokine (C-C motif) ligand 40.622
Vom2r27vomeronasal 2 receptor, 270.622
Fgfr2fibroblast growth factor receptor 20.617
Cd4Cd4 molecule0.612
Agtr1aangiotensin II receptor, type 1a0.609
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.577
Il6interleukin 60.568
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.563
Itgamintegrin, alpha M0.555
S100a8S100 calcium binding protein A80.543
Adora2aadenosine A2a receptor0.539
Cpceruloplasmin0.535
Bcl2B-cell CLL/lymphoma 20.530
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.529
Mca32mast cell antigen 320.524
Vcanversican0.522
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.516
Arl11ADP-ribosylation factor-like 110.506
Socs3suppressor of cytokine signaling 30.506
RGD1310262hypothetical LOC3046500.501
Ptafrplatelet-activating factor receptor0.495
Il12binterleukin 12B0.495
Smad7SMAD family member 70.494
Ifnginterferon gamma0.486
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.475
Htr75-hydroxytryptamine (serotonin) receptor 70.463
Creb1cAMP responsive element binding protein 10.462
Notch3Notch homolog 3 (Drosophila)0.454
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.452
Fgf16fibroblast growth factor 160.448
Metmet proto-oncogene0.447
Lgals5lectin, galactose binding, soluble 50.437
Scarb1scavenger receptor class B, member 10.436
Egfrepidermal growth factor receptor0.435
Nfibnuclear factor I/B0.434
Cd8aCD8a molecule0.434
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.425
Il4rainterleukin 4 receptor, alpha0.423
Mapk1mitogen activated protein kinase 10.423
Pzppregnancy-zone protein0.421
Calcbcalcitonin-related polypeptide, beta0.421
Sellselectin L0.419
Ccl2chemokine (C-C motif) ligand 20.417
Nrp2neuropilin 20.415
Mc4rmelanocortin 4 receptor0.411
Ncanneurocan0.409
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.407
Prp15proline-rich protein 150.403
Tcf21transcription factor 210.402
Gja5gap junction protein, alpha 50.400
Fshbfollicle stimulating hormone, beta polypeptide0.399
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.397
Stat3signal transducer and activator of transcription 30.396
Mapk9mitogen-activated protein kinase 90.396
Ncr1natural cytotoxicity triggering receptor 10.393
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.386
Mmp12matrix metallopeptidase 120.385
Olr226olfactory receptor 2260.379
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.377
Sstr5somatostatin receptor 50.373
Adarb2adenosine deaminase, RNA-specific, B20.373
Insrrinsulin receptor-related receptor0.372
Prkchprotein kinase C, eta0.372
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.370
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.370
Bdkrb2bradykinin receptor B20.370
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.366
Phkg1phosphorylase kinase, gamma 10.363
Ccl20chemokine (C-C motif) ligand 200.362
Il9rinterleukin 9 receptor0.361
Gcgroup specific component0.361
Hyal2hyaluronoglucosaminidase 20.360
Fgafibrinogen alpha chain0.360
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.356
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.356
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.354
Itpr2inositol 1,4,5-triphosphate receptor, type 20.354
Barhl2BarH-like homeobox 20.353
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.348
Tgfbr2transforming growth factor, beta receptor II0.347
Il1r1interleukin 1 receptor, type I0.347
S1pr2sphingosine-1-phosphate receptor 20.347
Gpr6G protein-coupled receptor 60.347
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.338
Tpc1808tropic 18080.337
Ifitm3interferon induced transmembrane protein 30.336
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.335
Msnmoesin0.335
Nrxn1neurexin 10.326
Olr416olfactory receptor 4160.325
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.324
Cxcl13chemokine (C-X-C motif) ligand 130.321
Foxs1forkhead box S10.321
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.848
sma-6Protein SMA-60.365
let-60Protein LET-600.334
lmn-1Protein LMN-10.330
daf-12Protein DAF-120.322
lag-1Protein LAG-10.310
prp-21Protein PRP-210.302
daf-11Protein DAF-110.296
sma-1Protein SMA-10.276
lin-36Protein LIN-360.271
msp-36Protein MSP-360.270
vab-3Protein VAB-30.259
sem-5Protein SEM-50.256
mpk-1Protein MPK-10.248
unc-9Protein UNC-90.244
daf-2Protein DAF-20.239
cki-2Protein CKI-20.238
ifg-1Protein IFG-10.231
unc-40Protein UNC-400.229
pha-4Protein PHA-40.227
fkh-2Protein FKH-20.225
eor-1Protein EOR-10.215
uig-1Protein UIG-10.211
hnd-1Protein HND-10.209
ten-1Protein TEN-10.203
hmg-1.2Protein HMG-1.20.194
eya-1Protein EYA-10.193
imp-2Protein IMP-20.179
cdc-42Protein CDC-420.178
let-756Protein LET-7560.176
bar-1Protein BAR-10.163
inx-3Protein INX-30.161
itr-1Protein ITR-10.159
ida-1Protein IDA-10.157
H06I04.1Protein H06I04.10.146
msp-78Protein MSP-780.145
unc-43Protein UNC-430.142
sup-12Protein SUP-120.142
pmp-3Protein PMP-30.140
feh-1Protein FEH-10.136
egl-46Protein EGL-460.133
odr-3Protein ODR-30.133
pkg-1Protein PKG-10.131
lin-45Protein LIN-450.127
T28F4.1Protein T28F4.10.124
elt-6Protein ELT-60.121
zfp-3Protein ZFP-30.121
tag-343Protein TAG-3430.119
pmt-1Protein PMT-10.116
mab-31Protein MAB-310.112
C14C10.5Protein C14C10.50.112
sek-1Protein SEK-10.112
msp-152Protein MSP-1520.112
tps-1Protein TPS-10.110
che-3Protein CHE-30.108
cst-1Protein CST-10.107
brp-1Protein BRP-10.107
msp-50Protein MSP-500.106
ldb-1Protein LDB-10.106
msp-76Protein MSP-760.103
mtm-3Protein MTM-30.101
unc-120Protein UNC-1200.101
trim-9Protein TRIM-90.096
tbb-4Protein TBB-40.096
CELE_F47G4.4Protein F47G4.40.095
msp-40Protein MSP-400.095
unc-32Protein UNC-320.094
vps-11Protein VPS-110.091
ZK742.2Protein ZK742.20.091
gsy-1Protein GSY-10.087
R90.1Protein R90.10.087
kin-10Protein KIN-100.087
msp-3Protein MSP-30.086
C05D11.7Protein C05D11.70.086
msp-74Protein MSP-740.085
klp-7Protein KLP-70.083
ntl-4Protein NTL-40.082
M02B1.3Protein M02B1.30.082
toe-4Protein TOE-40.081
nhr-6Protein NHR-60.078
lin-59Protein LIN-590.078
eps-8Protein EPS-80.078
B0361.6Protein B0361.60.078
osm-6Protein OSM-60.076
pry-1Protein PRY-10.076
vav-1Protein VAV-10.076
apr-1Protein APR-10.075
msp-77Protein MSP-770.074
osm-3Protein OSM-30.074
elt-3Protein ELT-30.074
mat-3Protein MAT-30.074
lin-12Protein LIN-120.072
sel-8Protein SEL-80.072
pqn-44Protein PQN-440.072
ZK546.3Protein ZK546.30.071
che-13Protein CHE-130.070
msp-38Protein MSP-380.070
dkf-1Protein DKF-10.070
msp-45Protein MSP-450.070
egl-27Protein EGL-270.069
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.957
pkd2polycystic kidney disease 20.892
sox32SRY-box containing gene 320.859
fgf8afibroblast growth factor 8 a0.761
bmp2bbone morphogenetic protein 2b0.754
pax2apaired box gene 2a0.706
shhasonic hedgehog a0.704
sulf1sulfatase 10.677
fn1fibronectin 10.662
dharmadharma0.653
evx1even-skipped homeobox 10.602
cxcr4bchemokine (C-X-C motif), receptor 4b0.591
bmp2abone morphogenetic protein 2a0.571
brd4bromodomain containing 40.557
gli2aGLI-Kruppel family member GLI2a0.557
acvr1lactivin A receptor, type I like0.556
chdchordin0.535
trpm7transient receptor potential cation channel, subfamily M, member 70.534
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.524
gdf6agrowth differentiation factor 6a0.456
pcdh18bprotocadherin 18b0.449
tbx16T-box gene 160.437
ndr2nodal-related 20.424
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.360
dkk1bdickkopf 1b0.353
bmp4bone morphogenetic protein 40.347
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.344
spry4sprouty (Drosophila) homolog 40.339
gli1GLI-Kruppel family member 10.339
hey1hairy/enhancer-of-split related with YRPW motif 10.335
nrp2bneuropilin 2b0.324
brd2abromodomain-containing 2a0.317
nlgn2bneuroligin 2b0.311
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.310
dlddeltaD0.308
fzd7afrizzled homolog 7a0.293
runx3runt-related transcription factor 30.285
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.282
axin1axin 10.275
cdh2cadherin 2, neuronal0.274
kif17kinesin family member 170.270
lhx2bLIM homeobox 2b0.264
sparcsecreted acidic cysteine rich glycoprotein0.262
ptch1patched 10.250
jag1bjagged 1b0.246
angptl2angiopoietin-like 20.242
podxlpodocalyxin-like0.238
otpaorthopedia homolog a0.229
dlx5adistal-less homeobox gene 5a0.227
col5a2lcollagen, type V, alpha 2-like0.226
foxp2forkhead box P20.225
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.222
irx2airoquois homeobox protein 2, a0.220
ift88intraflagellar transport 88 homolog0.219
sox9bSRY-box containing gene 9b0.217
mcoln1mucolipin 10.216
gata5GATA-binding protein 50.207
disp1dispatched homolog 1 (Drosophila)0.203
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.202
tbx1T-box 10.202
postnperiostin, osteoblast specific factor0.200
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.199
ntlano tail a0.198
prrx1apaired related homeobox 1a0.197
wnt2bbwingless-type MMTV integration site family, member 2Bb0.191
fras1Fraser syndrome 10.191
crestincrestin0.190
flt4fms-related tyrosine kinase 40.185
scribscribbled homolog (Drosophila)0.183
sf3b1splicing factor 3b, subunit 10.179
esr2aestrogen receptor 2a0.176
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.175
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.174
ptgs1prostaglandin-endoperoxide synthase 10.173
ptpraprotein tyrosine phosphatase, receptor type, A0.173
rargaretinoic acid receptor gamma a0.171
bmpr1aabone morphogenetic protein receptor, type 1aa0.171
dag1dystroglycan 10.171
plcg1phospholipase C, gamma 10.169
cpceruloplasmin0.166
atp2b1aATPase, Ca++ transporting, plasma membrane 1a0.161
wnt8awingless-type MMTV integration site family, member 8a0.161
sox9aSRY-box containing gene 9a0.158
wnt5bwingless-type MMTV integration site family, member 5b0.158
notch2notch homolog 20.157
jag2jagged 20.155
col1a1acollagen, type I, alpha 1a0.153
paqr7bprogestin and adipoQ receptor family member VII, b0.151
alcambactivated leukocyte cell adhesion molecule b0.150
mmp9matrix metalloproteinase 90.147
satb2SATB homeobox 20.146
dusp6dual specificity phosphatase 60.145
irx4airoquois homeobox protein 4a0.144
lef1lymphocyte enhancer binding factor 10.142
bbc3BCL2 binding component 30.141
dzip1DAZ interacting protein 10.139
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.139
tgfb1atransforming growth factor, beta 1a0.138
ef1aelongation factor 1-alpha0.138
mxtx2mix-type homeobox gene 20.138
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
InRInsulin-like receptor0.957
fzfrizzled0.926
Stat92ESignal-transducer and activator of transcription protein at 92E0.923
dmdiminutive0.920
S6kRPS6-p70-protein kinase0.916
spasspastin0.908
stcksteamer duck0.876
rutrutabaga0.875
CaMKIICalcium/calmodulin-dependent protein kinase II0.870
TBPHCG10327 gene product from transcript CG10327-RC0.857
drkdownstream of receptor kinase0.855
SNF1ASNF1A/AMP-activated protein kinase0.849
PtenCG5671 gene product from transcript CG5671-RB0.845
Ras85DRas oncogene at 85D0.844
Pi3K92ECG4141 gene product from transcript CG4141-RB0.842
Sin3ACG8815 gene product from transcript CG8815-RC0.830
SmoxSmad on X0.817
GugGrunge0.810
PvrPDGF- and VEGF-receptor related0.807
DadDaughters against dpp0.801
Sir2CG5216 gene product from transcript CG5216-RA0.794
Lis-1Lissencephaly-10.789
RelRelish0.776
Mef2Myocyte enhancer factor 20.772
pntpointed0.762
p38bCG7393 gene product from transcript CG7393-RA0.759
slmbsupernumerary limbs0.754
Atg1Autophagy-specific gene 10.754
shishibire0.746
domedomeless0.740
Pp2B-14DProtein phosphatase 2B at 14D0.737
EcREcdysone receptor0.733
UbqnUbiquilin0.719
sflsulfateless0.709
Sema-1aCG18405 gene product from transcript CG18405-RD0.690
grogroucho0.674
foxoforkhead box, sub-group O0.661
Src64BSrc oncogene at 64B0.660
MadMothers against dpp0.660
e(y)3enhancer of yellow 30.641
emcextra macrochaetae0.638
Fmr1CG6203 gene product from transcript CG6203-RC0.634
TlToll0.634
ChcClathrin heavy chain0.630
ttvtout-velu0.629
atoatonal0.628
osoutstretched0.627
Akt1CG4006 gene product from transcript CG4006-RA0.626
rprreaper0.624
keykenny0.616
PsnPresenilin0.613
DptBDiptericin B0.606
Sra-1specifically Rac1-associated protein 10.600
ykiyorkie0.598
PGRP-LCPeptidoglycan recognition protein LC0.596
rdxroadkill0.595
arrarrow0.589
ushu-shaped0.577
sdscalloped0.573
AlkCG8250 gene product from transcript CG8250-RA0.571
hthhomothorax0.570
notnon-stop0.570
ewgerect wing0.567
Tak1TGF-beta activated kinase 10.562
bratbrain tumor0.560
ecdecdysoneless0.558
Bin1Bicoid interacting protein 10.553
kaykayak0.552
RhebCG1081 gene product from transcript CG1081-RA0.546
Arp66BActin-related protein 66B0.544
pucpuckered0.525
Ced-12CG5336 gene product from transcript CG5336-RA0.518
eveeven skipped0.517
SosSon of sevenless0.517
Btk29ABtk family kinase at 29A0.511
bazbazooka0.506
BEAF-32Boundary element-associated factor of 32kD0.502
Nrx-IVNeurexin IV0.502
binbiniou0.498
Caf1Chromatin assembly factor 1 subunit0.496
tumtumbleweed0.495
RalaRas-related protein0.490
p53CG33336 gene product from transcript CG33336-RB0.487
E(spl)Enhancer of split0.485
Vap-33-1CG5014 gene product from transcript CG5014-RB0.482
PknProtein kinase related to protein kinase N0.474
Ube3aUbiquitin protein ligase E3A0.473
mbcmyoblast city0.468
rhorhomboid0.466
POSHPlenty of SH3s0.465
Cp190Centrosomal protein 190kD0.462
Ntf-2Nuclear transport factor-20.461
brmbrahma0.461
shgshotgun0.458
Vps35Vacuolar protein sorting 350.457
eIF-4EEukaryotic initiation factor 4E0.452
CkIIalphaCasein kinase II alpha subunit0.451
kiskismet0.447
modSPmodular serine protease0.444
Taf4TBP-associated factor 40.437
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SSK2Ssk2p0.793
PTC1Ptc1p0.538
PRK1Prk1p0.402
SLT2Slt2p0.399
VPS27Vps27p0.361
ENA5Ena5p0.315
TOR1Tor1p0.310
BCY1Bcy1p0.294
NBP2Nbp2p0.250
ERP4Erp4p0.234
MIG1Mig1p0.224
TRA1Tra1p0.202
FAR11Far11p0.196
YPT1Ypt1p0.189
YAK1Yak1p0.188
TPK1Tpk1p0.169
MYO5Myo5p0.168
SLG1Slg1p0.159
HST1Hst1p0.151
RGD1Rgd1p0.139
SNF5Snf5p0.137
STE5Ste5p0.126
YOR1Yor1p0.121
BEM3Bem3p0.119
PPH3Pph3p0.117
KSP1Ksp1p0.115
GAT2Gat2p0.113
ARP2Arp2p0.107
IZH4Izh4p0.105
KOG1Kog1p0.102
AKL1Akl1p0.098
YKR015Chypothetical protein0.098
PHO80Pho80p0.092
MIG2Mig2p0.090
PBS2Pbs2p0.085
ATG13Atg13p0.083
OLE1Ole1p0.083
BMH1Bmh1p0.082
CNS1Cns1p0.078
RTG3Rtg3p0.076
STE4Ste4p0.075
MMR1Mmr1p0.075
SSK1Ssk1p0.071
CLB3Clb3p0.070
CLA4Cla4p0.070
HUA2Hua2p0.069
RFX1Rfx1p0.067
PPH22Pph22p0.066
FAR1Far1p0.065
SNT1Snt1p0.063
HHT1Hht1p0.063
SLA2Sla2p0.062
EAF5Eaf5p0.061
DNF3Dnf3p0.060
TPK2Tpk2p0.060
HOS4Hos4p0.060
RHO1Rho1p0.059
CRZ1Crz1p0.058
GAL7Gal7p0.057
TOR2Tor2p0.057
FUS3Fus3p0.056
SEC1Sec1p0.055
GPB2Gpb2p0.055
BCK1Bck1p0.054
MIG3Mig3p0.054
MSO1Mso1p0.053
GLN3Gln3p0.052
CSR2Csr2p0.052
CDC55Cdc55p0.052
PPH21Pph21p0.051
MMS22Mms22p0.051
PCL2Pcl2p0.050
ROM2Rom2p0.050
GCN2Gcn2p0.048
MSS4Mss4p0.048
OSH7Osh7p0.048
PIB2Pib2p0.047
SRP54Srp54p0.046
STP22Stp22p0.046
URA8Ura8p0.045
GPR1Gpr1p0.045
EPL1Epl1p0.043
SWI1Swi1p0.042
LYS5Lys5p0.042
MKT1Mkt1p0.042
FAP1Fap1p0.041
GIC1Gic1p0.041
ISW1Isw1p0.040
TIP41Tip41p0.040
STE23Ste23p0.040
ARK1Ark1p0.040
TBS1Tbs1p0.040
CTR9Ctr9p0.039
STE20Ste20p0.039
SWI5Swi5p0.039
SPT15Spt15p0.039
UGP1Ugp1p0.039
LCB4Lcb4p0.038
TPO4Tpo4p0.038
ENA2Ena2p0.038