The network for 'lymphocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte proliferation

The expansion of a lymphocyte population by cell division.

NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.629
RT1-Db1RT1 class II, locus Db10.420
RT1-BbRT1 class II, locus Bb0.327
RT1-BaRT1 class II, locus Ba0.288
Anxa2annexin A20.275
Cd37CD37 molecule0.251
Cd2Cd2 molecule0.240
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.223
Hckhemopoietic cell kinase0.205
Casp1caspase 10.163
Inpp5dinositol polyphosphate-5-phosphatase D0.128
Il10interleukin 100.126
RT1-DMbRT1 class II, locus DMb0.089
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.088
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.084
Il1r1interleukin 1 receptor, type I0.080
RT1-DMaRT1 class II, locus DMa0.078
Cd247Cd247 molecule0.077
Ciitaclass II, major histocompatibility complex, transactivator0.074
Olr1654olfactory receptor 16540.069
Fgfr2fibroblast growth factor receptor 20.067
Gpr20G protein-coupled receptor 200.059
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.059
Cd53Cd53 molecule0.059
Prpg1proline-rich proteoglycan 10.055
Cd4Cd4 molecule0.050
Nkg7natural killer cell group 7 sequence0.048
Ptafrplatelet-activating factor receptor0.048
Il2rbinterleukin 2 receptor, beta0.046
Cd44Cd44 molecule0.045
Il4interleukin 40.043
Ptprcprotein tyrosine phosphatase, receptor type, C0.043
Scp2sterol carrier protein 20.043
Gzmkgranzyme K0.043
Ptpn6protein tyrosine phosphatase, non-receptor type 60.040
Cfpcomplement factor properdin0.039
Cd38CD38 molecule0.039
Zbp1Z-DNA binding protein 10.037
Nr5a2nuclear receptor subfamily 5, group A, member 20.037
Flt1FMS-related tyrosine kinase 10.036
Psme2proteasome (prosome, macropain) activator subunit 20.035
Ptger4prostaglandin E receptor 4 (subtype EP4)0.034
Plauplasminogen activator, urokinase0.034
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.033
Ctsbcathepsin B0.033
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.032
Ccr5chemokine (C-C motif) receptor 50.032
Prr13proline rich 130.032
Hsph1heat shock 105/110 protein 10.031
Gpr182G protein-coupled receptor 1820.031
Syt8synaptotagmin VIII0.031
Fgbfibrinogen beta chain0.031
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.030
Tgfbr2transforming growth factor, beta receptor II0.029
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.029
Metmet proto-oncogene0.028
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.028
Arhgap4Rho GTPase activating protein 40.027
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.026
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.026
Slc15a3solute carrier family 15, member 30.026
Rassf5Ras association (RalGDS/AF-6) domain family member 50.026
Ripk3receptor-interacting serine-threonine kinase 30.026
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.026
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.025
Mmp10matrix metallopeptidase 100.025
Il1binterleukin 1 beta0.025
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.025
Mvpmajor vault protein0.024
Ccr2chemokine (C-C motif) receptor 20.024
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.024
UST4rintegral membrane transport protein UST4r0.024
Il1rninterleukin 1 receptor antagonist0.024
RGD1559588similar to cell surface receptor FDFACT0.024
BidBH3 interacting domain death agonist0.024
Bcl2B-cell CLL/lymphoma 20.024
Btnl8butyrophilin-like 80.024
Olaholeoyl-ACP hydrolase0.023
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.023
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.023
Tp53tumor protein p530.023
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.023
Aif1allograft inflammatory factor 10.022
F2rl2coagulation factor II (thrombin) receptor-like 20.022
Man2b1mannosidase, alpha, class 2B, member 10.022
Tas2r123taste receptor, type 2, member 1230.022
Itpr2inositol 1,4,5-triphosphate receptor, type 20.022
C1qbcomplement component 1, q subcomponent, B chain0.022
Il1rl1interleukin 1 receptor-like 10.022
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.022
Laptm5lysosomal protein transmembrane 50.021
Lef1lymphoid enhancer binding factor 10.021
Kcnk13potassium channel, subfamily K, member 130.021
Mov10Moloney leukemia virus 100.021
Gfapglial fibrillary acidic protein0.021
Napsanapsin A aspartic peptidase0.020
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ptch2patched 20.373
foxd3forkhead box D30.290
lef1lymphocyte enhancer binding factor 10.229
mmp9matrix metalloproteinase 90.216
kitakit receptor a0.174
pitx2paired-like homeodomain transcription factor 20.104
tlr3toll-like receptor 30.099
bmp2bbone morphogenetic protein 2b0.098
runx2arunt-related transcription factor 2a0.097
bmp1abone morphogenetic protein 1a0.092
osr1odd-skipped related 1 (Drosophila)0.084
ifnphi1interferon phi 10.084
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.083
tmem144btransmembrane protein 144b0.082
cdx4caudal type homeo box transcription factor 40.079
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.077
fgf8afibroblast growth factor 8 a0.076
sulf2lsulfatase 2, like0.073
rag1recombination activating gene 10.071
tbpTATA box binding protein0.071
tnfatumor necrosis factor a (TNF superfamily, member 2)0.071
pax7bpaired box gene 7b0.070
gmpsguanine monphosphate synthetase0.070
rcn1reticulocalbin 1, EF-hand calcium binding domain0.069
cdh1cadherin 1, epithelial0.069
gpr126G protein-coupled receptor 1260.067
disc1disrupted in schizophrenia 10.066
trpm7transient receptor potential cation channel, subfamily M, member 70.066
myod1myogenic differentiation 10.065
emx2empty spiracles homeobox 20.064
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.064
stc1lstanniocalcin 1, like0.063
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.062
lrrc33leucine rich repeat containing 330.062
LOC100003514protein kinase C alpha type-like0.062
bmp6bone morphogenetic protein 60.061
ahcyS-adenosylhomocysteine hydrolase0.061
mmp15bmatrix metallopeptidase 15b0.060
tfectranscription factor EC0.059
hbaa1hemoglobin alpha adult-10.059
alkanaplastic lymphoma kinase (Ki-1)0.059
nap1l1nucleosome assembly protein 1, like 10.058
lgals2alectin, galactoside-binding, soluble, 2a0.057
alcamaactivated leukocyte cell adhesion molecule a0.057
msxcmuscle segment homeobox C0.057
foxp1bforkhead box P1b0.057
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.056
cxcr4bchemokine (C-X-C motif), receptor 4b0.056
axin2axin 2 (conductin, axil)0.056
ddr2bdiscoidin domain receptor family, member 2b0.055
cpoxcoproporphyrinogen oxidase0.054
ap2m1aadaptor-related protein complex 2, mu 1 subunit, a0.053
tlr2toll-like receptor 20.053
gli1GLI-Kruppel family member 10.052
cmybtranscription factor cmyb0.050
hspa5heat shock protein 50.050
b3gnt7UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 70.050
ugt1b1UDP glucuronosyltransferase 1 family, polypeptide B10.048
bocbrother of CDO0.048
col10a1collagen, type X, alpha 10.047
syngr1asynaptogyrin 1a0.046
gmfgglia maturation factor, gamma0.046
her6hairy-related 60.046
eya2eyes absent homolog 2 (Drosophila)0.046
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.046
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.046
ptk2.1protein tyrosine kinase 2a0.046
prps1aphosphoribosyl pyrophosphate synthetase 1A0.045
angptl1angiopoietin-like 10.045
nrp2bneuropilin 2b0.045
tm9sf3transmembrane 9 superfamily member 30.045
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.044
ocrloculocerebrorenal syndrome of Lowe0.044
scn1asodium channel, voltage-gated, type I, alpha0.044
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.044
irak4interleukin-1 receptor-associated kinase 40.044
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.044
foxa2forkhead box A20.044
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.043
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.043
impdh1binosine 5'-phosphate dehydrogenase 1b0.043
lmo4aLIM domain only 4a0.043
fgf20afibroblast growth factor 20a0.043
aldh1a2aldehyde dehydrogenase 1 family, member A20.042
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.042
tie1endothelium-specific receptor tyrosine kinase 10.042
plagl2pleiomorphic adenoma gene-like 20.041
fgf3fibroblast growth factor 30.041
efna2ephrin A20.040
oprd1bopioid receptor, delta 1b0.040
sim2single-minded homolog 2 (Drosophila)0.040
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.993
SYKspleen tyrosine kinase0.969
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.968
PTPN6protein tyrosine phosphatase, non-receptor type 60.963
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.926
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.923
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.916
HLA-Bmajor histocompatibility complex, class I, B0.916
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.909
FGFR2fibroblast growth factor receptor 20.909
PTPN1protein tyrosine phosphatase, non-receptor type 10.900
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.898
BCL2B-cell CLL/lymphoma 20.891
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.891
GRB2growth factor receptor-bound protein 20.860
IL2RGinterleukin 2 receptor, gamma0.851
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.830
HLA-DMBmajor histocompatibility complex, class II, DM beta0.829
CD80CD80 molecule0.826
CD247CD247 molecule0.807
HLA-Gmajor histocompatibility complex, class I, G0.784
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.784
BCL2L1BCL2-like 10.780
HLA-Fmajor histocompatibility complex, class I, F0.770
TANKTRAF family member-associated NFKB activator0.767
ABI1abl-interactor 10.761
HLA-Cmajor histocompatibility complex, class I, C0.760
IL2RBinterleukin 2 receptor, beta0.751
CCR7chemokine (C-C motif) receptor 70.727
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.714
HLA-Amajor histocompatibility complex, class I, A0.693
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.679
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.671
TRAF1TNF receptor-associated factor 10.667
ICAM1intercellular adhesion molecule 10.657
BTN3A3butyrophilin, subfamily 3, member A30.644
RB1retinoblastoma 10.618
SOCS3suppressor of cytokine signaling 30.612
SHC1SHC (Src homology 2 domain containing) transforming protein 10.599
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.596
IL10RAinterleukin 10 receptor, alpha0.595
CD2CD2 molecule0.584
CD86CD86 molecule0.571
CCR5chemokine (C-C motif) receptor 50.570
SIGLEC7sialic acid binding Ig-like lectin 70.545
PSEN1presenilin 10.524
IRAK1interleukin-1 receptor-associated kinase 10.509
RUNX1runt-related transcription factor 10.499
BIRC3baculoviral IAP repeat containing 30.496
BTN3A1butyrophilin, subfamily 3, member A10.494
CDK6cyclin-dependent kinase 60.488
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.477
LTAlymphotoxin alpha (TNF superfamily, member 1)0.469
CCL5chemokine (C-C motif) ligand 50.465
HLA-DRB5major histocompatibility complex, class II, DR beta 50.456
HLA-Emajor histocompatibility complex, class I, E0.454
CTLA4cytotoxic T-lymphocyte-associated protein 40.446
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.443
IRF4interferon regulatory factor 40.438
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.423
IL4Rinterleukin 4 receptor0.415
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.398
BRCA1breast cancer 1, early onset0.385
SOS1son of sevenless homolog 1 (Drosophila)0.385
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.376
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.372
BTN3A2butyrophilin, subfamily 3, member A20.358
INSRinsulin receptor0.356
TFF1trefoil factor 10.331
HLA-DPB1major histocompatibility complex, class II, DP beta 10.330
CD1CCD1c molecule0.323
SQSTM1sequestosome 10.318
TAL1T-cell acute lymphocytic leukemia 10.317
CXCL9chemokine (C-X-C motif) ligand 90.316
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.316
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.308
EGFRepidermal growth factor receptor0.302
FLNAfilamin A, alpha0.294
HIPK2homeodomain interacting protein kinase 20.293
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.292
SMAD4SMAD family member 40.291
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.281
HLA-DRB4major histocompatibility complex, class II, DR beta 40.272
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.269
TICAM2toll-like receptor adaptor molecule 20.268
PTPRCprotein tyrosine phosphatase, receptor type, C0.268
EP300E1A binding protein p3000.267
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.264
CD19CD19 molecule0.264
PRKCBprotein kinase C, beta0.262
LATlinker for activation of T cells0.256
CD28CD28 molecule0.255
FCN1ficolin (collagen/fibrinogen domain containing) 10.250
MDM2Mdm2 p53 binding protein homolog (mouse)0.248
SMAD7SMAD family member 70.245
PAX3paired box 30.243
CCL4chemokine (C-C motif) ligand 40.242
IL1R1interleukin 1 receptor, type I0.237
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.997
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.996
Ikzf1IKAROS family zinc finger 10.995
Ctnnb1catenin (cadherin associated protein), beta 10.990
Cd40CD40 antigen0.989
Cd19CD19 antigen0.983
Efnb2ephrin B20.981
Tlr4toll-like receptor 40.975
Ptenphosphatase and tensin homolog0.969
Tnfaip3tumor necrosis factor, alpha-induced protein 30.967
Foxp3forkhead box P30.964
Bcl2B-cell leukemia/lymphoma 20.964
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.959
Tgfb1transforming growth factor, beta 10.957
Ccr2chemokine (C-C motif) receptor 20.955
Lyz2lysozyme 20.948
Tnftumor necrosis factor0.940
Map3k14mitogen-activated protein kinase kinase kinase 140.937
Hif1ahypoxia inducible factor 1, alpha subunit0.934
Zeb1zinc finger E-box binding homeobox 10.930
Gli3GLI-Kruppel family member GLI30.917
Ptpn6protein tyrosine phosphatase, non-receptor type 60.916
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.915
Clec4nC-type lectin domain family 4, member n0.910
Cxcr4chemokine (C-X-C motif) receptor 40.910
Leprleptin receptor0.904
Nr3c1nuclear receptor subfamily 3, group C, member 10.895
Birc3baculoviral IAP repeat-containing 30.882
Pdcd1programmed cell death 10.880
Casp4caspase 4, apoptosis-related cysteine peptidase0.855
Ighimmunoglobulin heavy chain complex0.851
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.850
CblCasitas B-lineage lymphoma0.850
Ifnginterferon gamma0.849
Ntf3neurotrophin 30.846
Grb2growth factor receptor bound protein 20.842
Prkcdprotein kinase C, delta0.839
Cdkn1bcyclin-dependent kinase inhibitor 1B0.833
Itgb1integrin beta 1 (fibronectin receptor beta)0.833
Rag2recombination activating gene 20.830
Prf1perforin 1 (pore forming protein)0.819
Il10interleukin 100.815
Gli2GLI-Kruppel family member GLI20.810
Kitkit oncogene0.792
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.791
Fgfr2fibroblast growth factor receptor 20.791
Hes1hairy and enhancer of split 1 (Drosophila)0.788
Traf6TNF receptor-associated factor 60.779
Ikzf3IKAROS family zinc finger 30.761
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.760
Il4interleukin 40.758
Ccr7chemokine (C-C motif) receptor 70.750
Cd28CD28 antigen0.750
Inpp5dinositol polyphosphate-5-phosphatase D0.749
C3ar1complement component 3a receptor 10.744
Rag1recombination activating gene 10.729
Casp8caspase 80.729
Tgfb2transforming growth factor, beta 20.727
Itga3integrin alpha 30.725
Ikbkginhibitor of kappaB kinase gamma0.724
Map3k7mitogen-activated protein kinase kinase kinase 70.723
Irf5interferon regulatory factor 50.721
Trp63transformation related protein 630.715
Emx1empty spiracles homolog 1 (Drosophila)0.703
Foxn1forkhead box N10.697
Traf2TNF receptor-associated factor 20.690
FaslFas ligand (TNF superfamily, member 6)0.688
Grb10growth factor receptor bound protein 100.682
Cd4CD4 antigen0.670
Socs1suppressor of cytokine signaling 10.667
Il10rainterleukin 10 receptor, alpha0.663
Smad4MAD homolog 4 (Drosophila)0.658
FasFas (TNF receptor superfamily member 6)0.655
Foxc1forkhead box C10.649
Irf8interferon regulatory factor 80.642
Cd80CD80 antigen0.631
Irf4interferon regulatory factor 40.629
Sfpi1SFFV proviral integration 10.619
Vav1vav 1 oncogene0.615
Csf1colony stimulating factor 1 (macrophage)0.610
Sox4SRY-box containing gene 40.608
Itgaxintegrin alpha X0.604
WasWiskott-Aldrich syndrome homolog (human)0.599
Ephb2Eph receptor B20.598
Cdk4cyclin-dependent kinase 40.590
Gpr132G protein-coupled receptor 1320.588
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.586
Dok1docking protein 10.585
Prdm1PR domain containing 1, with ZNF domain0.585
Fzd4frizzled homolog 4 (Drosophila)0.585
Ccr6chemokine (C-C motif) receptor 60.584
Sh2d2aSH2 domain protein 2A0.584
Cd6CD6 antigen0.579
Cd72CD72 antigen0.574
Card11caspase recruitment domain family, member 110.574
Latlinker for activation of T cells0.570
Ptprcprotein tyrosine phosphatase, receptor type, C0.570
Nf1neurofibromatosis 10.565
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.563
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism