The network for 'negative regulation of epidermal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of epidermal cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HOXB5homeobox B50.999
RNPS1RNA binding protein S1, serine-rich domain0.999
EEDembryonic ectoderm development0.976
SRSF6serine/arginine-rich splicing factor 60.940
BMPR1Abone morphogenetic protein receptor, type IA0.936
HOXB7homeobox B70.928
HOXB6homeobox B60.901
HOXA10homeobox A100.885
SRSF4serine/arginine-rich splicing factor 40.878
TRA2Btransformer 2 beta homolog (Drosophila)0.868
HOXA5homeobox A50.810
HOXB3homeobox B30.750
SUZ12suppressor of zeste 12 homolog (Drosophila)0.730
HOXA7homeobox A70.715
HOXA11homeobox A110.659
PRPF38APRP38 pre-mRNA processing factor 38 (yeast) domain containing A0.608
HOXB9homeobox B90.568
HOXA4homeobox A40.472
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.466
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.425
HOXA6homeobox A60.414
SREK1splicing regulatory glutamine/lysine-rich protein 10.408
SRSF2serine/arginine-rich splicing factor 20.371
HOXC6homeobox C60.369
KRT5keratin 50.353
HOXC10homeobox C100.336
FUSfused in sarcoma0.331
SRRM2serine/arginine repetitive matrix 20.326
CABLES1Cdk5 and Abl enzyme substrate 10.303
SRSF7serine/arginine-rich splicing factor 70.288
HOXA2homeobox A20.287
HNRNPA1heterogeneous nuclear ribonucleoprotein A10.287
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.247
U2AF1U2 small nuclear RNA auxiliary factor 10.236
FSTL1follistatin-like 10.222
RBBP4retinoblastoma binding protein 40.191
NR4A1nuclear receptor subfamily 4, group A, member 10.179
SRRM1serine/arginine repetitive matrix 10.169
HOXC4homeobox C40.140
SATB2SATB homeobox 20.134
NOTCH1notch 10.128
HOXA3homeobox A30.121
BBS10Bardet-Biedl syndrome 100.115
MSX1msh homeobox 10.110
HOXA1homeobox A10.106
KRT15keratin 150.097
TOE1target of EGR1, member 1 (nuclear)0.095
MAT2Amethionine adenosyltransferase II, alpha0.094
HOXB4homeobox B40.093
HOXB2homeobox B20.090
HOXC5homeobox C50.080
H3F3BH3 histone, family 3B (H3.3B)0.075
CSNK1Ecasein kinase 1, epsilon0.070
HOXC13homeobox C130.068
HOXC11homeobox C110.067
HOXC8homeobox C80.066
UHRF1ubiquitin-like with PHD and ring finger domains 10.065
SFPQsplicing factor proline/glutamine-rich0.064
HOXD10homeobox D100.061
HOXC9homeobox C90.060
NXF1nuclear RNA export factor 10.057
DNMT1DNA (cytosine-5-)-methyltransferase 10.053
CCNL1cyclin L10.050
KRT6Ckeratin 6C0.050
NOTCH3notch 30.043
HOXA13homeobox A130.041
TMSB4Xthymosin beta 4, X-linked0.038
NOGnoggin0.037
ZFYVE9zinc finger, FYVE domain containing 90.036
JAG1jagged 10.035
ASXL1additional sex combs like 1 (Drosophila)0.033
HES2hairy and enhancer of split 2 (Drosophila)0.033
TARDBPTAR DNA binding protein0.031
BMP4bone morphogenetic protein 40.028
SF3A2splicing factor 3a, subunit 2, 66kDa0.028
EWSR1Ewing sarcoma breakpoint region 10.025
DLX2distal-less homeobox 20.024
HOXB8homeobox B80.024
HNRNPMheterogeneous nuclear ribonucleoprotein M0.024
ZNF431zinc finger protein 4310.024
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.023
CCND1cyclin D10.023
OTPorthopedia homeobox0.023
FXYD3FXYD domain containing ion transport regulator 30.023
EFNA1ephrin-A10.021
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble0.020
FOXL1forkhead box L10.020
CCNE1cyclin E10.019
HOXD9homeobox D90.019
ACACAacetyl-CoA carboxylase alpha0.019
BMPR1Bbone morphogenetic protein receptor, type IB0.019
PITX2paired-like homeodomain 20.019
PDX1pancreatic and duodenal homeobox 10.019
PRSS8protease, serine, 80.019
DLX5distal-less homeobox 50.019
GRHL2grainyhead-like 2 (Drosophila)0.019
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.018
HOXD8homeobox D80.018
TAF15TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa0.017
HOXD3homeobox D30.017
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.999
Shhsonic hedgehog0.989
Dll1delta-like 1 (Drosophila)0.961
Eya1eyes absent 1 homolog (Drosophila)0.953
Fgfr2fibroblast growth factor receptor 20.940
Gli3GLI-Kruppel family member GLI30.934
Psen1presenilin 10.923
Jag1jagged 10.921
Chd7chromodomain helicase DNA binding protein 70.921
Fgfr1fibroblast growth factor receptor 10.899
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.853
Sox2SRY-box containing gene 20.837
Emx1empty spiracles homolog 1 (Drosophila)0.798
Rb1retinoblastoma 10.728
Foxg1forkhead box G10.672
Hes1hairy and enhancer of split 1 (Drosophila)0.665
Pax3paired box gene 30.627
Vangl2vang-like 2 (van gogh, Drosophila)0.590
Foxc1forkhead box C10.582
Otx2orthodenticle homolog 2 (Drosophila)0.546
Ctnnb1catenin (cadherin associated protein), beta 10.523
Emx2empty spiracles homolog 2 (Drosophila)0.427
Notch2Notch gene homolog 2 (Drosophila)0.414
Nognoggin0.400
Efnb2ephrin B20.348
Prrx1paired related homeobox 10.330
Cdkn1bcyclin-dependent kinase inhibitor 1B0.272
Jag2jagged 20.263
Jarid2jumonji, AT rich interactive domain 20.234
Tgfb2transforming growth factor, beta 20.232
Ptenphosphatase and tensin homolog0.231
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.215
Tcfap2atranscription factor AP-2, alpha0.209
Fgf8fibroblast growth factor 80.202
Wnt3awingless-related MMTV integration site 3A0.194
Pitx2paired-like homeodomain transcription factor 20.183
Dlx5distal-less homeobox 50.169
Sox9SRY-box containing gene 90.161
Foxc2forkhead box C20.161
Smosmoothened homolog (Drosophila)0.146
Stk38serine/threonine kinase 380.142
Pax6paired box gene 60.140
Bmp4bone morphogenetic protein 40.139
Trp73transformation related protein 730.125
Gli2GLI-Kruppel family member GLI20.119
Hand1heart and neural crest derivatives expressed transcript 10.108
Ptk7PTK7 protein tyrosine kinase 70.100
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.100
Prrx2paired related homeobox 20.095
Ptf1apancreas specific transcription factor, 1a0.094
Fgfr3fibroblast growth factor receptor 30.091
Zg16zymogen granule protein 160.091
Zeb1zinc finger E-box binding homeobox 10.089
Trp63transformation related protein 630.079
Bmp7bone morphogenetic protein 70.077
2210010C04RikRIKEN cDNA 2210010C04 gene0.076
Cdx2caudal type homeobox 20.064
Tbx1T-box 10.061
Lrp6low density lipoprotein receptor-related protein 60.061
Rbbp4retinoblastoma binding protein 40.059
Fgf10fibroblast growth factor 100.058
Hand2heart and neural crest derivatives expressed transcript 20.058
Gscgoosecoid homeobox0.058
Reg2regenerating islet-derived 20.053
Meox2mesenchyme homeobox 20.053
Reg3bregenerating islet-derived 3 beta0.044
Ins1insulin I0.044
Ror2receptor tyrosine kinase-like orphan receptor 20.042
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.041
Hes5hairy and enhancer of split 5 (Drosophila)0.040
Egfrepidermal growth factor receptor0.039
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.037
Gata4GATA binding protein 40.037
Cpa1carboxypeptidase A10.036
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.036
Gbx2gastrulation brain homeobox 20.035
Sycnsyncollin0.034
Ins2insulin II0.034
Lef1lymphoid enhancer binding factor 10.034
Mtf2metal response element binding transcription factor 20.032
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.031
Reg3dregenerating islet-derived 3 delta0.028
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.028
Hoxa13homeobox A130.027
Tbx3T-box 30.027
Pax9paired box gene 90.027
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.027
Sp6trans-acting transcription factor 60.026
Hes3hairy and enhancer of split 3 (Drosophila)0.026
Gata3GATA binding protein 30.024
Fgf15fibroblast growth factor 150.024
Engendoglin0.023
Srrm4serine/arginine repetitive matrix 40.023
Efnb1ephrin B10.023
Suz12suppressor of zeste 12 homolog (Drosophila)0.023
Reg3aregenerating islet-derived 3 alpha0.023
Ptch1patched homolog 10.023
Pax1paired box gene 10.022
Reg1regenerating islet-derived 10.022
Ctrb1chymotrypsinogen B10.022
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism