The network for 'tetrahydrofolate metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tetrahydrofolate metabolic process

The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

NameDescriptionProbabilityFunc Analog Organism
Dhfrdihydrofolate reductase0.312
Unguracil-DNA glycosylase0.155
Top2atopoisomerase (DNA) II alpha0.138
Ccnb1cyclin B10.134
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.127
Rbp2retinol binding protein 2, cellular0.123
Hn1lhematological and neurological expressed 1-like0.118
Cenpicentromere protein I0.111
Rad51cRad51 homolog c (S. cerevisiae)0.089
Mcm5minichromosome maintenance complex component 50.081
Acsm3acyl-CoA synthetase medium-chain family member 30.076
Shmt1serine hydroxymethyltransferase 1 (soluble)0.073
Ccne1cyclin E10.068
Pola1polymerase (DNA directed), alpha 10.066
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.065
Pctpphosphatidylcholine transfer protein0.060
Casp7caspase 70.059
Fert2fer (fms/fps related) protein kinase, testis specific 20.058
Tk1thymidine kinase 1, soluble0.053
Ns5atp9NS5A (hepatitis C virus) transactivated protein 90.052
Rpa2replication protein A20.050
Nolc1nucleolar and coiled-body phosphoprotein 10.049
Mcm2minichromosome maintenance complex component 20.045
Bmp7bone morphogenetic protein 70.044
Mtr5-methyltetrahydrofolate-homocysteine methyltransferase0.043
Tymsthymidylate synthetase0.042
Timelesstimeless homolog (Drosophila)0.042
Chek1CHK1 checkpoint homolog (S. pombe)0.042
Aldobaldolase B, fructose-bisphosphate0.041
Mcm4minichromosome maintenance complex component 40.041
Josd2Josephin domain containing 20.040
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.037
Aldh18a1aldehyde dehydrogenase 18 family, member A10.033
Creb1cAMP responsive element binding protein 10.033
Hmmrhyaluronan mediated motility receptor (RHAMM)0.032
Hnf1aHNF1 homeobox A0.030
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.030
Sf3b3splicing factor 3b, subunit 30.029
Slc19a1solute carrier family 19 (folate transporter), member 10.028
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.027
Atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.027
Nup62nucleoporin 620.027
Gcgroup specific component0.027
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.027
Gcgrglucagon receptor0.026
Brca1breast cancer 10.026
Vps45vacuolar protein sorting 45 homolog (S. cerevisiae)0.026
Nhlrc2NHL repeat containing 20.026
Slco2a1solute carrier organic anion transporter family, member 2a10.026
Acacbacetyl-Coenzyme A carboxylase beta0.026
LOC689399hypothetical protein LOC6893990.025
RGD1304693similar to CG14803-PA0.025
Hat1histone acetyltransferase 10.025
Ces1ccarboxylesterase 1C0.025
Cpsf3cleavage and polyadenylation specificity factor 30.024
Asnsasparagine synthetase0.023
Polr1bpolymerase (RNA) I polypeptide B0.023
Lmnb1lamin B10.023
Apoc4apolipoprotein C-IV0.023
Shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.023
Prim2primase, DNA, polypeptide 20.022
Fen1flap structure-specific endonuclease 10.022
RestRE1-silencing transcription factor0.021
Nup155nucleoporin 1550.021
Eif2b2eukaryotic translation initiation factor 2B, subunit 2 beta0.021
RGD1309437similar to RIKEN cDNA 2610528E230.020
Thoc6THO complex 6 homolog (Drosophila)0.020
Hnf4ahepatocyte nuclear factor 4, alpha0.019
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.019
FasFas (TNF receptor superfamily, member 6)0.019
Gnmtglycine N-methyltransferase0.019
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.018
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.018
Haus4HAUS augmin-like complex, subunit 40.018
Agpsalkylglycerone phosphate synthase0.018
Gins1GINS complex subunit 1 (Psf1 homolog)0.018
Brca2breast cancer 20.017
Prim1DNA primase, p49 subunit0.017
Olr59olfactory receptor 590.017
Smcr7lSmith-Magenis syndrome chromosome region, candidate 7-like (human)0.017
Nlrp6NLR family, pyrin domain containing 60.016
Phgdhphosphoglycerate dehydrogenase0.016
Irf2interferon regulatory factor 20.016
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.016
Lnpepleucyl/cystinyl aminopeptidase0.016
Gulogulonolactone (L-) oxidase0.016
Ppp1r3bprotein phosphatase 1, regulatory (inhibitor) subunit 3B0.015
Aspgasparaginase homolog (S. cerevisiae)0.015
Ezh2enhancer of zeste homolog 2 (Drosophila)0.015
Gspt1G1 to S phase transition 10.015
Atxn3ataxin 30.015
Mcm3minichromosome maintenance complex component 30.015
Aimp2aminoacyl tRNA synthetase complex-interacting multifunctional protein 20.015
Fbp1fructose-1,6-bisphosphatase 10.015
Dio1deiodinase, iodothyronine, type I0.015
Msh2mutS homolog 2 (E. coli)0.015
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism