The network for 'bone resorption' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

bone resorption

The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.

NameDescriptionProbabilityFunc Analog Organism
Rhogras homolog gene family, member G (rho G)0.030
Plauplasminogen activator, urokinase0.027
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.025
Nos3nitric oxide synthase 3, endothelial cell0.024
Cd53Cd53 molecule0.022
Plekpleckstrin0.020
AxlAxl receptor tyrosine kinase0.018
Fkbp1aFK506 binding protein 1a0.017
Aldobaldolase B, fructose-bisphosphate0.016
Ifi30interferon gamma inducible protein 300.015
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.015
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.015
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.015
Laptm5lysosomal protein transmembrane 50.015
Ptk2bPTK2B protein tyrosine kinase 2 beta0.014
Gpnmbglycoprotein (transmembrane) nmb0.014
Reg3bregenerating islet-derived 3 beta0.014
Ccr5chemokine (C-C motif) receptor 50.014
Klhl6kelch-like 6 (Drosophila)0.013
Cd2Cd2 molecule0.013
Il1binterleukin 1 beta0.013
Tmbim6transmembrane BAX inhibitor motif containing 60.013
Testintestin gene0.013
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.013
Lamp2lysosomal-associated membrane protein 20.013
RT1-DMaRT1 class II, locus DMa0.013
Psd4pleckstrin and Sec7 domain containing 40.013
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.013
Cotl1coactosin-like 1 (Dictyostelium)0.013
Col12a1collagen, type XII, alpha 10.012
Lst1leukocyte specific transcript 10.012
Inpp5dinositol polyphosphate-5-phosphatase D0.012
Vom1r102vomeronasal 1 receptor 1020.012
Aspgasparaginase homolog (S. cerevisiae)0.011
Sellselectin L0.011
Cd37CD37 molecule0.011
Dazap2DAZ associated protein 20.011
Arl11ADP-ribosylation factor-like 110.011
Vat1vesicle amine transport protein 1 homolog (T californica)0.011
Glp2rglucagon-like peptide 2 receptor0.011
Rtn4reticulon 40.011
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.011
Gpr182G protein-coupled receptor 1820.011
Icam2intercellular adhesion molecule 20.010
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.010
C1qbcomplement component 1, q subcomponent, B chain0.010
Tas2r105taste receptor, type 2, member 1050.010
Sstr5somatostatin receptor 50.010
Tlr7toll-like receptor 70.010
Cnr2cannabinoid receptor 2 (macrophage)0.010
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CFLARCASP8 and FADD-like apoptosis regulator0.105
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.089
FYNFYN oncogene related to SRC, FGR, YES0.061
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.051
SH3KBP1SH3-domain kinase binding protein 10.044
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.043
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.041
PSAPprosaposin0.024
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.021
CTSAcathepsin A0.021
CASP8caspase 8, apoptosis-related cysteine peptidase0.020
GRNgranulin0.019
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.018
NRP1neuropilin 10.016
CTSDcathepsin D0.014
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.013
PTK2PTK2 protein tyrosine kinase 20.013
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.013
SRCIN1SRC kinase signaling inhibitor 10.013
SHC1SHC (Src homology 2 domain containing) transforming protein 10.012
FADDFas (TNFRSF6)-associated via death domain0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.954
Csf1colony stimulating factor 1 (macrophage)0.951
Col1a1collagen, type I, alpha 10.903
Cd40CD40 antigen0.841
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.840
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.774
BtkBruton agammaglobulinemia tyrosine kinase0.708
Fgfr2fibroblast growth factor receptor 20.691
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.647
Ighimmunoglobulin heavy chain complex0.590
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.564
Ltblymphotoxin B0.562
Agtr2angiotensin II receptor, type 20.536
Ppargperoxisome proliferator activated receptor gamma0.527
Pou2af1POU domain, class 2, associating factor 10.503
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.485
Ikzf1IKAROS family zinc finger 10.454
Loxlysyl oxidase0.452
Fbn1fibrillin 10.452
Mc5rmelanocortin 5 receptor0.435
Klklotho0.403
Ltbp2latent transforming growth factor beta binding protein 20.397
Elnelastin0.396
Cd19CD19 antigen0.395
Itgb3integrin beta 30.391
Inpp5dinositol polyphosphate-5-phosphatase D0.391
Map3k14mitogen-activated protein kinase kinase kinase 140.379
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.349
Fgfr3fibroblast growth factor receptor 30.336
Acvrl1activin A receptor, type II-like 10.324
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.323
Ptenphosphatase and tensin homolog0.316
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.297
Adam17a disintegrin and metallopeptidase domain 170.297
Nr3c1nuclear receptor subfamily 3, group C, member 10.295
Gja1gap junction protein, alpha 10.293
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.287
Egfrepidermal growth factor receptor0.280
Crhr1corticotropin releasing hormone receptor 10.277
Dok1docking protein 10.274
Hspg2perlecan (heparan sulfate proteoglycan 2)0.270
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.264
Itgb2lintegrin beta 2-like0.257
Ptpn11protein tyrosine phosphatase, non-receptor type 110.252
Tgfb2transforming growth factor, beta 20.248
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.245
Grb2growth factor receptor bound protein 20.235
Esr1estrogen receptor 1 (alpha)0.235
Nos3nitric oxide synthase 3, endothelial cell0.230
Pthlhparathyroid hormone-like peptide0.222
Apoeapolipoprotein E0.215
Kcns2K+ voltage-gated channel, subfamily S, 20.212
Bmp4bone morphogenetic protein 40.209
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.205
SrcRous sarcoma oncogene0.203
Il7interleukin 70.199
Pax8paired box gene 80.196
Ctskcathepsin K0.193
Tnfaip3tumor necrosis factor, alpha-induced protein 30.193
Nr5a1nuclear receptor subfamily 5, group A, member 10.187
FynFyn proto-oncogene0.185
S1pr2sphingosine-1-phosphate receptor 20.185
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.182
Retret proto-oncogene0.176
Jag1jagged 10.174
Pdgfbplatelet derived growth factor, B polypeptide0.173
Arandrogen receptor0.171
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.171
Hic1hypermethylated in cancer 10.168
Pnpla2patatin-like phospholipase domain containing 20.163
Tgfatransforming growth factor alpha0.163
Il4interleukin 40.161
Gp5glycoprotein 5 (platelet)0.158
WasWiskott-Aldrich syndrome homolog (human)0.155
Cxcr5chemokine (C-X-C motif) receptor 50.155
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.155
BlnkB-cell linker0.154
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.149
Dok2docking protein 20.148
Vegfavascular endothelial growth factor A0.148
Pax1paired box gene 10.145
Cav1caveolin 1, caveolae protein0.142
Birc3baculoviral IAP repeat-containing 30.141
Pecam1platelet/endothelial cell adhesion molecule 10.136
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.134
Bglapbone gamma carboxyglutamate protein0.134
Fgf10fibroblast growth factor 100.132
Cd22CD22 antigen0.130
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.130
Ptk2PTK2 protein tyrosine kinase 20.129
Edaectodysplasin-A0.129
Abp1amiloride binding protein 1 (amine oxidase, copper-containing)0.128
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.127
Lepleptin0.126
Ccr6chemokine (C-C motif) receptor 60.124
Tnftumor necrosis factor0.124
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.123
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.118
Tgfbr3transforming growth factor, beta receptor III0.118
Htr75-hydroxytryptamine (serotonin) receptor 70.118
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism