The network for 'astrocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

astrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

NameDescriptionProbabilityFunc Analog Organism
S100a10S100 calcium binding protein A100.620
Anxa2annexin A20.521
S100a4S100 calcium-binding protein A40.334
Anxa1annexin A10.290
S100a6S100 calcium binding protein A60.278
Lgals3lectin, galactoside-binding, soluble, 30.267
Timp1TIMP metallopeptidase inhibitor 10.216
S100a9S100 calcium binding protein A90.187
S100a8S100 calcium binding protein A80.183
Mt1ametallothionein 1a0.156
Anxa5annexin A50.136
Vimvimentin0.132
S100a11S100 calcium binding protein A11 (calizzarin)0.128
Mgpmatrix Gla protein0.120
Cd63Cd63 molecule0.072
Lgals1lectin, galactoside-binding, soluble, 10.065
A2malpha-2-macroglobulin0.043
Ifitm3interferon induced transmembrane protein 30.036
Tspotranslocator protein0.032
Cripcysteine-rich intestinal protein0.031
Capn2calpain 20.030
AhnakAHNAK nucleoprotein0.028
Magmyelin-associated glycoprotein0.027
Cd9CD9 molecule0.027
Gabrr2gamma-aminobutyric acid (GABA) receptor, rho 20.026
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.025
Loxlysyl oxidase0.024
Klk6kallikrein related-peptidase 60.023
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.023
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.023
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.022
Mbpmyelin basic protein0.022
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.022
Acanaggrecan0.021
Unc5bunc-5 homolog B (C. elegans)0.020
Fn1fibronectin 10.020
Arpc1bactin related protein 2/3 complex, subunit 1B0.020
Ppypancreatic polypeptide0.019
Ccl2chemokine (C-C motif) ligand 20.018
Ednrbendothelin receptor type B0.018
Cd151CD151 molecule (Raph blood group)0.018
Pmp22peripheral myelin protein 220.017
Taglntransgelin0.016
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.016
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.015
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.015
Ddr1discoidin domain receptor tyrosine kinase 10.015
Plekhb1pleckstrin homology domain containing, family B (evectins) member 10.014
Olig1oligodendrocyte transcription factor 10.014
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.014
Tnftumor necrosis factor (TNF superfamily, member 2)0.014
Pllpplasma membrane proteolipid (plasmolipin)0.014
Ppyr1pancreatic polypeptide receptor 10.013
Ecel1endothelin converting enzyme-like 10.013
Gja1gap junction protein, alpha 10.013
Gna11guanine nucleotide binding protein, alpha 110.013
Znf532zinc finger protein 5320.012
Tmod2tropomodulin 20.012
Fxyd1FXYD domain-containing ion transport regulator 10.012
Hmox1heme oxygenase (decycling) 10.012
Sox10SRY (sex determining region Y)-box 100.011
Cryaacrystallin, alpha A0.011
Sncgsynuclein, gamma (breast cancer-specific protein 1)0.011
Grip2glutamate receptor interacting protein 20.011
LOC290595hypothetical gene supported by AF1520020.011
Il12binterleukin 12B0.011
Spp1secreted phosphoprotein 10.011
Plp2proteolipid protein 2 (colonic epithelium-enriched)0.011
Apodapolipoprotein D0.011
Myd88myeloid differentiation primary response gene 880.011
Dnm1dynamin 10.011
Acheacetylcholinesterase0.010
Cstbcystatin B (stefin B)0.010
Gfapglial fibrillary acidic protein0.010
GperG protein-coupled estrogen receptor 10.010
Mrgprx3MAS-related GPR, member X30.010
Drd2dopamine receptor D20.010
Msx2msh homeobox 20.010
Sfrp4secreted frizzled-related protein 40.010
Arhgap23Rho GTPase activating protein 230.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dlddeltaD0.955
dladeltaA0.951
shhasonic hedgehog a0.936
ascl1aachaete-scute complex-like 1a (Drosophila)0.936
fgf8afibroblast growth factor 8 a0.934
sox3SRY-box containing gene 30.931
chdchordin0.906
bmp2bbone morphogenetic protein 2b0.901
ndr2nodal-related 20.901
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.865
cdh2cadherin 2, neuronal0.865
mdkbmidkine-related growth factor b0.836
olig2oligodendrocyte lineage transcription factor 20.768
flhfloating head0.768
lfnglunatic fringe homolog0.765
mpzmyelin protein zero0.744
plp1aproteolipid protein 1a0.732
nr2e1nuclear receptor subfamily 2, group E, member 10.719
mbpmyelin basic protein0.705
sox9aSRY-box containing gene 9a0.694
otpborthopedia homolog b0.659
notch1anotch homolog 1a0.626
foxn4forkhead box N40.617
pou3f1POU class 3 homeobox 10.614
dbx1adeveloping brain homeobox 1a0.610
osr1odd-skipped related 1 (Drosophila)0.605
scn1basodium channel, voltage-gated, type I, beta a0.586
col15a1bcollagen, type XV, alpha 1b0.572
neurodneurogenic differentiation0.544
pax2apaired box gene 2a0.523
gata1aGATA binding protein 1a0.522
lingo1bleucine rich repeat and Ig domain containing 1b0.514
aldh1a2aldehyde dehydrogenase 1 family, member A20.492
pax6apaired box gene 6a0.486
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.449
sox19aSRY-box containing gene 19a0.426
mibmind bomb0.420
gli1GLI-Kruppel family member 10.409
shhbsonic hedgehog b0.401
aplnrbapelin receptor b0.401
cdx4caudal type homeo box transcription factor 40.401
foxg1aforkhead box G1a0.394
lhx1aLIM homeobox 1a0.391
mecomMDS1 and EVI1 complex locus0.385
sox1aSRY-box containing gene 1a0.382
ascl1bachaete-scute complex-like 1b (Drosophila)0.381
gscgoosecoid0.378
her12hairy-related 120.372
gdf6agrowth differentiation factor 6a0.351
zic4zic family member 40.348
emx3empty spiracles homeobox 30.336
her6hairy-related 60.317
arnt2aryl hydrocarbon receptor nuclear translocator 20.314
tp53tumor protein p530.312
fzd8afrizzled homolog 8a0.312
insm1binsulinoma-associated 1b0.298
cdh5cadherin 50.292
mdkamidkine-related growth factor0.282
arxaristaless related homeobox0.275
tal1T-cell acute lymphocytic leukemia 10.265
osr2odd-skipped related 2 (Drosophila)0.258
dmrt2adoublesex and mab-3 related transcription factor 2a0.255
vsx2visual system homeobox 20.249
stmn1bstathmin 1b0.244
coe2coe20.239
il6rinterleukin 6 receptor0.237
irx3airoquois homeobox protein 3a0.222
hey1hairy/enhancer-of-split related with YRPW motif 10.220
ripk2receptor-interacting serine-threonine kinase 20.219
hnf1baHNF1 homeobox Ba0.219
notch3notch homolog 30.214
nr2f1bnuclear receptor subfamily 2, group F, member 1b0.213
sox2SRY-box containing gene 20.212
tnfrsfatumor necrosis factor receptor superfamily, member a0.211
pcnaproliferating cell nuclear antigen0.211
fgf3fibroblast growth factor 30.209
emx2empty spiracles homeobox 20.205
robo3roundabout homolog 30.203
alcambactivated leukocyte cell adhesion molecule b0.203
gpm6abglycoprotein M6Ab0.197
sfrp5secreted frizzled-related protein 50.196
her4.2hairy-related 4.20.195
klf4Kruppel-like factor 40.190
sox17SRY-box containing gene 170.188
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.187
her15.1hairy and enhancer of split-related 15.10.182
hhexhematopoietically expressed homeobox0.174
dlbdeltaB0.173
nkx6.1NK6 transcription factor related, locus 1 (Drosophila)0.172
tuba1ltubulin, alpha 1, like0.170
socs3asuppressor of cytokine signaling 3a0.167
lmo2LIM domain only 2 (rhombotin-like 1)0.163
spry2sprouty homolog 20.162
tbx16T-box gene 160.161
her8ahairy-related 8a0.151
klf4aKruppel-like transcription factor 4a0.149
tbx20T-box 200.145
foxe3forkhead box E30.144
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.143
tbx1T-box 10.143
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.976
RIN3Ras and Rab interactor 30.951
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.950
SOX10SRY (sex determining region Y)-box 100.947
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.929
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.879
EGFRepidermal growth factor receptor0.835
PAX3paired box 30.771
DRD2dopamine receptor D20.756
ALBalbumin0.737
JAG1jagged 10.719
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.691
BMPR1Abone morphogenetic protein receptor, type IA0.672
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.669
BCAR1breast cancer anti-estrogen resistance 10.667
GRB2growth factor receptor-bound protein 20.604
MAXMYC associated factor X0.554
PLATplasminogen activator, tissue0.524
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.506
IL1RAPinterleukin 1 receptor accessory protein0.491
BMP7bone morphogenetic protein 70.482
IL1R1interleukin 1 receptor, type I0.442
DNM1dynamin 10.431
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.429
SHC1SHC (Src homology 2 domain containing) transforming protein 10.410
SYNJ1synaptojanin 10.387
CHD3chromodomain helicase DNA binding protein 30.351
NOTCH3notch 30.339
CAPN1calpain 1, (mu/I) large subunit0.330
FGF1fibroblast growth factor 1 (acidic)0.321
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.313
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.272
EIF2B4eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa0.252
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.252
NR4A1nuclear receptor subfamily 4, group A, member 10.251
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.242
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.237
KIAA0408KIAA04080.231
JAK2Janus kinase 20.230
JAK1Janus kinase 10.224
OLIG2oligodendrocyte lineage transcription factor 20.209
SKIv-ski sarcoma viral oncogene homolog (avian)0.209
RIN1Ras and Rab interactor 10.207
GATA2GATA binding protein 20.204
SNX9sorting nexin 90.188
IFNGR1interferon gamma receptor 10.187
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.172
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.167
FGAfibrinogen alpha chain0.158
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.151
RUNX1runt-related transcription factor 10.129
FSTL1follistatin-like 10.129
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.126
F3coagulation factor III (thromboplastin, tissue factor)0.124
ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix protein0.120
MAML1mastermind-like 1 (Drosophila)0.120
NECAB2N-terminal EF-hand calcium binding protein 20.119
ADORA1adenosine A1 receptor0.117
FGFR2fibroblast growth factor receptor 20.113
SOX2SRY (sex determining region Y)-box 20.111
IGF1Rinsulin-like growth factor 1 receptor0.107
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.106
GFAPglial fibrillary acidic protein0.102
GHRgrowth hormone receptor0.102
SOX11SRY (sex determining region Y)-box 110.102
SNRNP200small nuclear ribonucleoprotein 200kDa (U5)0.098
BMP2bone morphogenetic protein 20.092
LIFRleukemia inhibitory factor receptor alpha0.091
ABI2abl-interactor 20.090
EP300E1A binding protein p3000.086
CDK6cyclin-dependent kinase 60.086
POU3F2POU class 3 homeobox 20.085
SEPT4septin 40.084
PHLDA1pleckstrin homology-like domain, family A, member 10.084
OSMRoncostatin M receptor0.081
NAMPTnicotinamide phosphoribosyltransferase0.080
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.080
GRB7growth factor receptor-bound protein 70.078
CFBcomplement factor B0.074
U2AF1U2 small nuclear RNA auxiliary factor 10.074
TENC1tensin like C1 domain containing phosphatase (tensin 2)0.073
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.073
NR4A3nuclear receptor subfamily 4, group A, member 30.071
TAL1T-cell acute lymphocytic leukemia 10.071
SPRR2Asmall proline-rich protein 2A0.071
CRPC-reactive protein, pentraxin-related0.071
SOS1son of sevenless homolog 1 (Drosophila)0.071
STAT1signal transducer and activator of transcription 1, 91kDa0.071
AHSGalpha-2-HS-glycoprotein0.070
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.067
ITSN1intersectin 1 (SH3 domain protein)0.063
STAT5Asignal transducer and activator of transcription 5A0.062
LHX2LIM homeobox 20.062
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.061
PLCG1phospholipase C, gamma 10.061
DIS3L2DIS3 mitotic control homolog (S. cerevisiae)-like 20.061
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.059
ORM1orosomucoid 10.058
PXNpaxillin0.057
NCANneurocan0.057
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax3paired box gene 31.000
Emx1empty spiracles homolog 1 (Drosophila)0.999
Otx2orthodenticle homolog 2 (Drosophila)0.999
Fgfr2fibroblast growth factor receptor 20.996
Hand2heart and neural crest derivatives expressed transcript 20.996
Hand1heart and neural crest derivatives expressed transcript 10.996
Gli3GLI-Kruppel family member GLI30.995
Sox9SRY-box containing gene 90.993
Pax6paired box gene 60.989
Fgf8fibroblast growth factor 80.986
Fgfr1fibroblast growth factor receptor 10.983
Gli2GLI-Kruppel family member GLI20.975
Sox2SRY-box containing gene 20.975
Isl1ISL1 transcription factor, LIM/homeodomain0.974
Ascl1achaete-scute complex homolog 1 (Drosophila)0.956
Nognoggin0.951
En1engrailed 10.917
Pax2paired box gene 20.915
Tcfap2atranscription factor AP-2, alpha0.900
Smosmoothened homolog (Drosophila)0.894
Rararetinoic acid receptor, alpha0.873
Nodalnodal0.859
Gbx2gastrulation brain homeobox 20.856
Neurod1neurogenic differentiation 10.844
Alx4aristaless-like homeobox 40.842
Neurog2neurogenin 20.832
Eya1eyes absent 1 homolog (Drosophila)0.832
Foxc1forkhead box C10.819
Prrx1paired related homeobox 10.801
Dlx5distal-less homeobox 50.778
Ntf3neurotrophin 30.775
Msx1homeobox, msh-like 10.774
Notch1Notch gene homolog 1 (Drosophila)0.762
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.760
Itgb1integrin beta 1 (fibronectin receptor beta)0.753
Pax1paired box gene 10.721
Retret proto-oncogene0.707
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.683
Atoh7atonal homolog 7 (Drosophila)0.683
Gata4GATA binding protein 40.679
Emx2empty spiracles homolog 2 (Drosophila)0.673
Meox2mesenchyme homeobox 20.656
Trp53transformation related protein 530.654
Id3inhibitor of DNA binding 30.654
Bmp4bone morphogenetic protein 40.633
Lamc1laminin, gamma 10.630
Rargretinoic acid receptor, gamma0.623
Gscgoosecoid homeobox0.623
Foxc2forkhead box C20.622
Lmx1bLIM homeobox transcription factor 1 beta0.613
Ptch1patched homolog 10.593
Sox3SRY-box containing gene 30.588
Foxg1forkhead box G10.583
Sox10SRY-box containing gene 100.563
Fgf10fibroblast growth factor 100.561
Tlx3T-cell leukemia, homeobox 30.559
Pbx1pre B-cell leukemia transcription factor 10.528
Hes1hairy and enhancer of split 1 (Drosophila)0.517
Nhlh1nescient helix loop helix 10.516
Id1inhibitor of DNA binding 10.515
Lhx5LIM homeobox protein 50.480
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.479
Col2a1collagen, type II, alpha 10.460
Onecut1one cut domain, family member 10.459
Zic3zinc finger protein of the cerebellum 30.455
Rspo2R-spondin 2 homolog (Xenopus laevis)0.453
Ptf1apancreas specific transcription factor, 1a0.449
Insm1insulinoma-associated 10.447
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.444
Hes5hairy and enhancer of split 5 (Drosophila)0.437
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.431
Neurog3neurogenin 30.431
Neurog1neurogenin 10.414
Tcf4transcription factor 40.409
Dlx1distal-less homeobox 10.406
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.404
Chrdchordin0.403
Hoxc5homeobox C50.396
Chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.390
Alx3aristaless-like homeobox 30.387
Hoxa1homeobox A10.372
Ptenphosphatase and tensin homolog0.370
Tcf21transcription factor 210.368
Hoxd3homeobox D30.367
Fgf17fibroblast growth factor 170.363
Tgfb2transforming growth factor, beta 20.359
Vegfavascular endothelial growth factor A0.359
Ror2receptor tyrosine kinase-like orphan receptor 20.354
Sox11SRY-box containing gene 110.348
Vangl2vang-like 2 (van gogh, Drosophila)0.346
Glra1glycine receptor, alpha 1 subunit0.339
Lmx1aLIM homeobox transcription factor 1 alpha0.338
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.337
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.327
Foxd2forkhead box D20.327
Vax1ventral anterior homeobox containing gene 10.326
Prrx2paired related homeobox 20.323
Hoxd11homeobox D110.322
Wnt6wingless-related MMTV integration site 60.320
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism