The network for 'arachidonic acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

arachidonic acid metabolic process

The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.

NameDescriptionProbabilityFunc Analog Organism
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.902
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.825
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.762
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.725
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.560
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.509
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.461
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.458
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.457
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.430
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.407
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.401
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.389
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.360
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.358
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.331
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.319
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.283
LOC100365112carboxylesterase-like0.243
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.217
Fdxrferredoxin reductase0.208
Crygfcrystallin, gamma F0.188
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.181
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.155
Apobapolipoprotein B0.148
Olr1701olfactory receptor 17010.145
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.144
Cyp2b15cytochrome P450, family 2, subfamily b, polypeptide 150.143
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.140
Rxrgretinoid X receptor gamma0.125
LOC494499LOC494499 protein0.120
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.092
Adh1alcohol dehydrogenase 1 (class I)0.090
Fads2fatty acid desaturase 20.090
Haao3-hydroxyanthranilate 3,4-dioxygenase0.087
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.086
Ppardperoxisome proliferator-activated receptor delta0.084
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.080
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.077
Gckrglucokinase (hexokinase 4) regulator0.075
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.073
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.072
L3mbtl3l(3)mbt-like 3 (Drosophila)0.071
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.067
Aqp9aquaporin 90.066
A1i3alpha-1-inhibitor III0.065
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.064
Fasnfatty acid synthase0.062
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.059
Cyp2b21cytochrome P450, family 2, subfamily b, polypeptide 210.057
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.055
Slc22a7solute carrier family 22 (organic anion transporter), member 70.055
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.054
Dhfrdihydrofolate reductase0.047
LOC293989cytochrome P450-like0.046
Mosc1MOCO sulphurase C-terminal domain containing 10.046
Cyp2d1cytochrome P450, family 2, subfamily d, polypeptide 10.044
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.043
Dpysdihydropyrimidinase0.039
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.039
Dhcr77-dehydrocholesterol reductase0.037
Rag1recombination activating gene 10.035
Ces1ecarboxylesterase 1E0.035
Ces1ccarboxylesterase 1C0.034
Cd46CD46 molecule, complement regulatory protein0.032
Mettl7bmethyltransferase like 7B0.030
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.029
Il8rainterleukin 8 receptor, alpha0.029
Olr59olfactory receptor 590.029
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.029
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.029
RT1-M5RT1 class Ib, locus M50.029
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.028
Akr1c18aldo-keto reductase family 1, member C180.028
Cst8cystatin 8 (cystatin-related epididymal specific)0.027
Gcm1glial cells missing homolog 1 (Drosophila)0.027
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.027
Otcornithine carbamoyltransferase0.027
Cps1carbamoyl-phosphate synthetase 10.026
Fads1fatty acid desaturase 10.026
Olr837olfactory receptor 8370.026
Olr1346olfactory receptor 13460.026
Il1rl2interleukin 1 receptor-like 20.025
Fmo1flavin containing monooxygenase 10.025
Gja5gap junction protein, alpha 50.024
Pparaperoxisome proliferator activated receptor alpha0.023
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.022
Qpctglutaminyl-peptide cyclotransferase0.021
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.021
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.021
RhagRh-associated glycoprotein0.021
Gsta5glutathione S-transferase Yc2 subunit0.020
Selpselectin P0.020
Srd5a1steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)0.020
Apoa2apolipoprotein A-II0.020
Fgfr4fibroblast growth factor receptor 40.019
Slc9a2solute carrier family 9 (sodium/hydrogen exchanger), member 20.019
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.019
Olr1469olfactory receptor Olr14690.019
Gsta2glutathione S-transferase A20.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPK1mitogen-activated protein kinase 10.998
DHCR77-dehydrocholesterol reductase0.998
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.996
COTL1coactosin-like 1 (Dictyostelium)0.987
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.986
DUSP1dual specificity phosphatase 10.970
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.887
MAPK14mitogen-activated protein kinase 140.843
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.724
FADS2fatty acid desaturase 20.637
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.520
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.473
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.459
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.406
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.316
DUSP3dual specificity phosphatase 30.246
C8Bcomplement component 8, beta polypeptide0.207
IL8interleukin 80.169
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.128
MAP2K1mitogen-activated protein kinase kinase 10.127
PTPRJprotein tyrosine phosphatase, receptor type, J0.125
RPS6KA4ribosomal protein S6 kinase, 90kDa, polypeptide 40.110
GLYATglycine-N-acyltransferase0.105
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.101
ALOX12Barachidonate 12-lipoxygenase, 12R type0.101
PEA15phosphoprotein enriched in astrocytes 150.097
ADH6alcohol dehydrogenase 6 (class V)0.091
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.085
KNG1kininogen 10.081
CXCL2chemokine (C-X-C motif) ligand 20.080
OTCornithine carbamoyltransferase0.080
ALOXE3arachidonate lipoxygenase 30.080
MAT1Amethionine adenosyltransferase I, alpha0.077
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.069
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.067
F9coagulation factor IX0.066
C8Acomplement component 8, alpha polypeptide0.066
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.066
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 90.065
CXCL3chemokine (C-X-C motif) ligand 30.058
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.058
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.057
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.056
DAOD-amino-acid oxidase0.056
HRGhistidine-rich glycoprotein0.055
KRT5keratin 50.055
FETUBfetuin B0.052
TNFAIP6tumor necrosis factor, alpha-induced protein 60.051
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.050
BHMTbetaine--homocysteine S-methyltransferase0.048
AGXT2alanine--glyoxylate aminotransferase 20.048
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.047
CFHR4complement factor H-related 40.046
DAPK1death-associated protein kinase 10.045
HALhistidine ammonia-lyase0.044
PLAURplasminogen activator, urokinase receptor0.044
LAMC3laminin, gamma 30.043
CRPC-reactive protein, pentraxin-related0.043
ELK1ELK1, member of ETS oncogene family0.042
ALDOBaldolase B, fructose-bisphosphate0.041
IL1Binterleukin 1, beta0.040
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.039
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.038
C6complement component 60.035
AADACarylacetamide deacetylase (esterase)0.035
RPS6KA2ribosomal protein S6 kinase, 90kDa, polypeptide 20.035
MASP2mannan-binding lectin serine peptidase 20.034
PLGplasminogen0.034
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.033
ZNF219zinc finger protein 2190.033
G6PCglucose-6-phosphatase, catalytic subunit0.032
NAMPTnicotinamide phosphoribosyltransferase0.032
SCAND1SCAN domain containing 10.032
FMO4flavin containing monooxygenase 40.031
DPYSdihydropyrimidinase0.031
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.031
GBA3glucosidase, beta, acid 3 (cytosolic)0.030
GPLD1glycosylphosphatidylinositol specific phospholipase D10.030
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.030
FABP1fatty acid binding protein 1, liver0.029
GSTA3glutathione S-transferase alpha 30.029
HAO1hydroxyacid oxidase (glycolate oxidase) 10.028
ALOX5AParachidonate 5-lipoxygenase-activating protein0.028
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.027
TGM1transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)0.027
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.025
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 30.025
IER3immediate early response 30.024
CTSBcathepsin B0.024
GNA13guanine nucleotide binding protein (G protein), alpha 130.023
RDH16retinol dehydrogenase 16 (all-trans)0.023
KLK13kallikrein-related peptidase 130.023
LPAlipoprotein, Lp(a)0.022
XDHxanthine dehydrogenase0.022
PLA2G4Aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.022
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.021
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.021
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.021
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.021
NR1I3nuclear receptor subfamily 1, group I, member 30.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.834
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.811
Cps1carbamoyl-phosphate synthetase 10.782
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.675
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.611
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.507
F9coagulation factor IX0.473
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.467
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.419
Otcornithine transcarbamylase0.369
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.365
Mup5major urinary protein 50.349
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.272
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.265
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.254
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.250
Akr1c6aldo-keto reductase family 1, member C60.237
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.221
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.218
Tattyrosine aminotransferase0.208
CrpC-reactive protein, pentraxin-related0.205
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.202
Apoc4apolipoprotein C-IV0.201
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.197
Hrghistidine-rich glycoprotein0.191
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.187
Aadacarylacetamide deacetylase (esterase)0.168
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.163
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.158
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.156
Sult1d1sulfotransferase family 1D, member 10.149
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.149
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.146
Sult1b1sulfotransferase family 1B, member 10.138
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.123
G6pcglucose-6-phosphatase, catalytic0.123
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.120
Krtap6-1keratin associated protein 6-10.120
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.118
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.115
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.114
Nr1i2nuclear receptor subfamily 1, group I, member 20.113
Cml2camello-like 20.111
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.110
Keg1kidney expressed gene 10.107
Fmo3flavin containing monooxygenase 30.100
Cyp2c68cytochrome P450, family 2, subfamily c, polypeptide 680.098
Mbl2mannose-binding lectin (protein C) 20.095
Azgp1alpha-2-glycoprotein 1, zinc0.094
Alox5aparachidonate 5-lipoxygenase activating protein0.094
F13bcoagulation factor XIII, beta subunit0.093
Inhbcinhibin beta-C0.088
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.084
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.081
Cyp2b13cytochrome P450, family 2, subfamily b, polypeptide 130.079
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.079
Slco1b2solute carrier organic anion transporter family, member 1b20.075
Dmgdhdimethylglycine dehydrogenase precursor0.075
Albalbumin0.072
Lect2leukocyte cell-derived chemotaxin 20.072
C9complement component 90.071
Aldobaldolase B, fructose-bisphosphate0.070
Rdh7retinol dehydrogenase 70.067
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.065
Ces2acarboxylesterase 2A0.064
Ces1ccarboxylesterase 1C0.063
Nr1i3nuclear receptor subfamily 1, group I, member 30.062
Tdo2tryptophan 2,3-dioxygenase0.057
Hgdhomogentisate 1, 2-dioxygenase0.056
Cyp2f2cytochrome P450, family 2, subfamily f, polypeptide 20.049
Ces3acarboxylesterase 3A0.049
Cyp4a12acytochrome P450, family 4, subfamily a, polypeptide 12a0.048
Cyp4a31cytochrome P450, family 4, subfamily a, polypeptide 310.045
Ugt3a2UDP glycosyltransferases 3 family, polypeptide A20.045
Csn1s1casein alpha s10.044
Acot12acyl-CoA thioesterase 120.044
Glyatglycine-N-acyltransferase0.043
Akr1d1aldo-keto reductase family 1, member D10.043
F2coagulation factor II0.043
Mup3major urinary protein 30.042
Pigrpolymeric immunoglobulin receptor0.042
Pon1paraoxonase 10.041
Pplperiplakin0.040
Bhmtbetaine-homocysteine methyltransferase0.039
Cfhr1complement factor H-related 10.039
Slc22a1solute carrier family 22 (organic cation transporter), member 10.038
Gcgroup specific component0.038
Upp2uridine phosphorylase 20.038
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.038
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.037
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 20.037
Cfhr2complement factor H-related 20.036
Casp14caspase 140.036
Apobapolipoprotein B0.036
Prlrprolactin receptor0.036
Apcsserum amyloid P-component0.036
Mbl1mannose-binding lectin (protein A) 10.035
Asgr2asialoglycoprotein receptor 20.035
Mettl7bmethyltransferase like 7B0.035
Agmatagmatine ureohydrolase (agmatinase)0.033
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism