The network for 'regulation of osteoblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

NameDescriptionProbabilityFunc Analog Organism
Timp3TIMP metallopeptidase inhibitor 30.550
Nedd4neural precursor cell expressed, developmentally down-regulated 40.539
Id3inhibitor of DNA binding 30.267
Fgfr2fibroblast growth factor receptor 20.200
Nraddneurotrophin receptor associated death domain0.179
Id1inhibitor of DNA binding 10.160
Itpr2inositol 1,4,5-triphosphate receptor, type 20.156
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.155
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.112
Ptpn14protein tyrosine phosphatase, non-receptor type 140.108
Col12a1collagen, type XII, alpha 10.088
Nr2f2nuclear receptor subfamily 2, group F, member 20.086
Cald1caldesmon 10.074
Bmp3bone morphogenetic protein 30.069
Cpdcarboxypeptidase D0.064
Foxe3forkhead box E30.064
Acvr1activin A receptor, type I0.063
Sod3superoxide dismutase 3, extracellular0.063
Fgfr1Fibroblast growth factor receptor 10.060
Cpxm2carboxypeptidase X (M14 family), member 20.058
Wnt5awingless-type MMTV integration site family, member 5A0.057
Bcl2B-cell CLL/lymphoma 20.056
Actc1actin, alpha, cardiac muscle 10.052
Grm5glutamate receptor, metabotropic 50.051
Znf503zinc finger protein 5030.050
Arhgap28Rho GTPase activating protein 280.049
Igfbp5insulin-like growth factor binding protein 50.049
Jubjub, ajuba homolog (Xenopus laevis)0.046
Ednrbendothelin receptor type B0.044
Mmp23matrix metallopeptidase 230.044
Ppicpeptidylprolyl isomerase C0.043
Twist2twist homolog 2 (Drosophila)0.042
Sox4SRY (sex determining region Y)-box 40.040
Slit3slit homolog 3 (Drosophila)0.040
Nfianuclear factor I/A0.039
Bmp4bone morphogenetic protein 40.039
Sc65synaptonemal complex protein SC650.037
Sox13SRY (sex determining region Y)-box 130.036
Agtr1aangiotensin II receptor, type 1a0.034
Crtapcartilage associated protein0.034
Emp1epithelial membrane protein 10.034
Tcf12transcription factor 120.034
Errfi1ERBB receptor feedback inhibitor 10.033
Hapln1hyaluronan and proteoglycan link protein 10.031
Leprleptin receptor0.031
Vcanversican0.030
Tead3TEA domain family member 30.030
Smad7SMAD family member 70.029
Chrngcholinergic receptor, nicotinic, gamma0.028
Madcam1mucosal vascular addressin cell adhesion molecule 10.027
Smosmoothened homolog (Drosophila)0.027
Ptpn1protein tyrosine phosphatase, non-receptor type 10.026
Igfbp2insulin-like growth factor binding protein 20.025
Glg1golgi apparatus protein 10.025
Appamyloid beta (A4) precursor protein0.024
Olfml2aolfactomedin-like 2A0.024
Adrb1adrenergic, beta-1-, receptor0.024
Lamc1laminin, gamma 10.024
Epha2Eph receptor A20.024
RbpmsRNA binding protein with multiple splicing0.024
Efemp2EGF-containing fibulin-like extracellular matrix protein 20.023
Gdf11growth differentiation factor 110.022
FcgrtFc fragment of IgG, receptor, transporter, alpha0.022
Mid1midline 10.022
Notch2Notch homolog 2 (Drosophila)0.022
Jak1Janus kinase 10.022
Col6a3procollagen, type VI, alpha 30.021
Svep1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.021
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.021
Fgf10fibroblast growth factor 100.021
Calcrlcalcitonin receptor-like0.021
PawrPRKC, apoptosis, WT1, regulator0.021
Tnmdtenomodulin0.020
Irs1insulin receptor substrate 10.020
Nek9NIMA (never in mitosis gene a)- related kinase 90.020
Hes1hairy and enhancer of split 1 (Drosophila)0.019
Bhlhe40basic helix-loop-helix family, member e400.019
Cxcl12chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)0.019
Myocmyocilin0.019
Ppap2bphosphatidic acid phosphatase type 2B0.019
Mcammelanoma cell adhesion molecule0.018
Fstl3follistatin-like 3 (secreted glycoprotein)0.018
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.018
Sgcesarcoglycan, epsilon0.018
Col4a5collagen, type IV, alpha 50.018
Tgfb3transforming growth factor, beta 30.018
Asphaspartate-beta-hydroxylase0.018
Vom2r44vomeronasal 2 receptor 440.017
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.017
Cav1caveolin 1, caveolae protein0.017
Tcf3transcription factor 30.017
Nfibnuclear factor I/B0.017
Foxd1forkhead box D10.016
Spta1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.016
Six1SIX homeobox 10.016
Agtr2angiotensin II receptor, type 20.016
Cd9CD9 molecule0.016
Ascl1achaete-scute complex homolog 1 (Drosophila)0.016
Meox2mesenchyme homeobox 20.016
Ltb4rleukotriene B4 receptor0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD4SMAD family member 40.998
SMAD2SMAD family member 20.997
SMAD7SMAD family member 70.996
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.995
CREBBPCREB binding protein0.995
SMAD3SMAD family member 30.992
SKILSKI-like oncogene0.985
FBLN1fibulin 10.953
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.908
CAV1caveolin 1, caveolae protein, 22kDa0.857
LAMC1laminin, gamma 1 (formerly LAMB2)0.814
SMAD1SMAD family member 10.791
PAX3paired box 30.730
YAP1Yes-associated protein 10.717
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.685
SMURF2SMAD specific E3 ubiquitin protein ligase 20.627
SNX9sorting nexin 90.604
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.602
SP1Sp1 transcription factor0.598
JAG1jagged 10.593
ATF3activating transcription factor 30.566
JUNjun proto-oncogene0.554
NOTCH3notch 30.550
HIPK2homeodomain interacting protein kinase 20.531
FKBP1AFK506 binding protein 1A, 12kDa0.529
ENGendoglin0.523
FGFR1fibroblast growth factor receptor 10.511
SKIv-ski sarcoma viral oncogene homolog (avian)0.490
POU3F2POU class 3 homeobox 20.457
HLA-Bmajor histocompatibility complex, class I, B0.442
BMP2bone morphogenetic protein 20.429
BMPR1Abone morphogenetic protein receptor, type IA0.401
NCK2NCK adaptor protein 20.394
FSTL1follistatin-like 10.387
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.384
JUPjunction plakoglobin0.375
NOTCH1notch 10.363
BMPR1Bbone morphogenetic protein receptor, type IB0.353
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.353
FGFR2fibroblast growth factor receptor 20.349
SMAD5SMAD family member 50.343
IFITM1interferon induced transmembrane protein 1 (9-27)0.338
PTPN12protein tyrosine phosphatase, non-receptor type 120.335
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.310
NCOR1nuclear receptor corepressor 10.308
CXXC5CXXC finger protein 50.286
BMP7bone morphogenetic protein 70.279
AXIN1axin 10.273
TGFB1transforming growth factor, beta 10.262
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.259
GDF5growth differentiation factor 50.258
CCND1cyclin D10.257
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.256
PTPN1protein tyrosine phosphatase, non-receptor type 10.242
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.232
SOCS3suppressor of cytokine signaling 30.222
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.219
BCAR1breast cancer anti-estrogen resistance 10.214
IFITM2interferon induced transmembrane protein 2 (1-8D)0.206
JUBjub, ajuba homolog (Xenopus laevis)0.203
FGF1fibroblast growth factor 1 (acidic)0.196
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.185
S100A4S100 calcium binding protein A40.178
WWOXWW domain containing oxidoreductase0.178
ESR1estrogen receptor 10.170
UHRF2ubiquitin-like with PHD and ring finger domains 20.166
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.162
ADAM15ADAM metallopeptidase domain 150.161
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.160
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.159
ARandrogen receptor0.158
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.155
SMOsmoothened homolog (Drosophila)0.152
FN1fibronectin 10.149
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.149
BMP4bone morphogenetic protein 40.147
IFITM3interferon induced transmembrane protein 3 (1-8U)0.144
SETD7SET domain containing (lysine methyltransferase) 70.139
SFRP1secreted frizzled-related protein 10.139
NRP1neuropilin 10.134
EP300E1A binding protein p3000.132
WNT3Awingless-type MMTV integration site family, member 3A0.131
BMP1bone morphogenetic protein 10.126
TM4SF1transmembrane 4 L six family member 10.125
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein0.122
AMOTL2angiomotin like 20.122
DCNdecorin0.116
TGFB3transforming growth factor, beta 30.114
SMAD6SMAD family member 60.114
NOGnoggin0.113
MMP14matrix metallopeptidase 14 (membrane-inserted)0.113
RUNX2runt-related transcription factor 20.112
EGR1early growth response 10.111
TGFBR1transforming growth factor, beta receptor 10.108
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.102
IGF2Rinsulin-like growth factor 2 receptor0.101
WWP2WW domain containing E3 ubiquitin protein ligase 20.097
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.097
SMURF1SMAD specific E3 ubiquitin protein ligase 10.096
SQSTM1sequestosome 10.094
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.998
Pax3paired box gene 30.994
Fgfr1fibroblast growth factor receptor 10.990
Shhsonic hedgehog0.986
Ctnnb1catenin (cadherin associated protein), beta 10.983
Bmp4bone morphogenetic protein 40.978
Notch1Notch gene homolog 1 (Drosophila)0.978
Ptenphosphatase and tensin homolog0.976
Otx2orthodenticle homolog 2 (Drosophila)0.974
Foxc1forkhead box C10.969
Trp53transformation related protein 530.965
Smad4MAD homolog 4 (Drosophila)0.959
Nodalnodal0.950
Fgf8fibroblast growth factor 80.943
Tgfb2transforming growth factor, beta 20.942
Smad3MAD homolog 3 (Drosophila)0.939
Runx2runt related transcription factor 20.929
Sox9SRY-box containing gene 90.912
Gata4GATA binding protein 40.901
Vegfavascular endothelial growth factor A0.889
Nognoggin0.879
Hand2heart and neural crest derivatives expressed transcript 20.866
Hes1hairy and enhancer of split 1 (Drosophila)0.862
Pthlhparathyroid hormone-like peptide0.857
Bmp7bone morphogenetic protein 70.851
Prrx1paired related homeobox 10.841
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.836
Gli3GLI-Kruppel family member GLI30.828
Mdm2transformed mouse 3T3 cell double minute 20.828
Msx1homeobox, msh-like 10.826
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.819
Smad6MAD homolog 6 (Drosophila)0.819
Ptf1apancreas specific transcription factor, 1a0.818
Ror2receptor tyrosine kinase-like orphan receptor 20.818
Csf1colony stimulating factor 1 (macrophage)0.801
Ptpn11protein tyrosine phosphatase, non-receptor type 110.796
Fgfr3fibroblast growth factor receptor 30.788
Neurod1neurogenic differentiation 10.778
Ascl1achaete-scute complex homolog 1 (Drosophila)0.774
Smosmoothened homolog (Drosophila)0.772
Dlx5distal-less homeobox 50.770
Rargretinoic acid receptor, gamma0.755
Acvr1activin A receptor, type 10.741
Hand1heart and neural crest derivatives expressed transcript 10.731
Prrx2paired related homeobox 20.703
Bmpr1abone morphogenetic protein receptor, type 1A0.692
Mef2dmyocyte enhancer factor 2D0.679
Apcadenomatosis polyposis coli0.677
Ltblymphotoxin B0.675
Pax2paired box gene 20.655
Ntf3neurotrophin 30.654
Gpc3glypican 30.648
Msx2homeobox, msh-like 20.640
Pax8paired box gene 80.619
Gli2GLI-Kruppel family member GLI20.613
Nos3nitric oxide synthase 3, endothelial cell0.602
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.598
Tnftumor necrosis factor0.586
Pax6paired box gene 60.586
Jag1jagged 10.577
Gata3GATA binding protein 30.576
Pitx2paired-like homeodomain transcription factor 20.575
Leprleptin receptor0.575
Fgf18fibroblast growth factor 180.566
Zic3zinc finger protein of the cerebellum 30.564
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.551
Smad2MAD homolog 2 (Drosophila)0.551
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.550
Wnt4wingless-related MMTV integration site 40.541
Eya1eyes absent 1 homolog (Drosophila)0.531
Id3inhibitor of DNA binding 30.528
Itgb1integrin beta 1 (fibronectin receptor beta)0.519
Alx4aristaless-like homeobox 40.510
Id1inhibitor of DNA binding 10.508
Ncoa3nuclear receptor coactivator 30.506
Adra2aadrenergic receptor, alpha 2a0.493
Foxc2forkhead box C20.488
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.486
Tbx3T-box 30.471
Hoxd13homeobox D130.468
Ptgs2prostaglandin-endoperoxide synthase 20.461
Rarbretinoic acid receptor, beta0.461
Snai1snail homolog 1 (Drosophila)0.459
Twist2twist homolog 2 (Drosophila)0.448
Lhx1LIM homeobox protein 10.436
Dll1delta-like 1 (Drosophila)0.432
Twist1twist homolog 1 (Drosophila)0.431
Thrathyroid hormone receptor alpha0.424
Hoxa2homeobox A20.424
Mndalmyeloid nuclear differentiation antigen like0.424
Zfpm2zinc finger protein, multitype 20.420
Adam17a disintegrin and metallopeptidase domain 170.419
Tgfb1transforming growth factor, beta 10.417
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.415
Hey1hairy/enhancer-of-split related with YRPW motif 10.411
Tcfap2atranscription factor AP-2, alpha0.411
Vdrvitamin D receptor0.408
En1engrailed 10.408
Gscgoosecoid homeobox0.405
Dkk1dickkopf homolog 1 (Xenopus laevis)0.403
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism