The network for 'smad protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

smad protein import into nucleus

The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

NameDescriptionProbabilityFunc Analog Organism
LOC100359498ribosomal protein L35a-like0.035
Uba52ubiquitin A-52 residue ribosomal protein fusion product 10.029
Rpl27ribosomal protein L270.027
FauFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed0.023
Atp5eATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit0.021
Rps10ribosomal protein S100.021
LOC10036049160S ribosomal protein L13-like0.021
Rps21ribosomal protein S210.020
Rpl18aribosomal protein L18A0.020
RGD1304704similar to Hypothetical protein CGI-990.019
Rpl26ribosomal protein L260.019
Rpl10aribosomal protein L10A0.019
Rps26ribosomal protein S260.019
Rpl19ribosomal protein L190.019
Rpl35ribosomal protein L350.018
Uqcr11ubiquinol-cytochrome c reductase, complex III subunit XI0.018
Rpsaribosomal protein SA0.018
Rps15ribosomal protein S150.018
Rpl31ribosomal protein L310.018
Tceb1transcription elongation factor B (SIII), polypeptide 10.018
Rpl29ribosomal protein L290.017
Rpl13aribosomal protein L13A0.017
Rps12ribosomal protein S120.017
Rps11ribosomal protein S110.017
Rpl34ribosomal protein L340.016
Rps16ribosomal protein S160.016
Rps7ribosomal protein S70.016
Rpl36aribosomal protein L36a0.015
Gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2 like 10.015
Rps14ribosomal protein S140.015
Rpl27aribosomal protein L27a0.015
Rps8ribosomal protein S80.015
Rpl17ribosomal protein L170.014
LOC499782similar to 60S ribosomal protein L120.014
Rps27aribosomal protein S27a0.014
Ndufa2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 20.014
Rpl37ribosomal protein L370.014
Rps19ribosomal protein S190.014
Rps15aribosomal protein S15a0.014
Rpl38ribosomal protein L380.013
Rpl18ribosomal protein L180.013
Rpl4ribosomal protein L40.013
Rpl15ribosomal protein L150.013
Rps3aribosomal protein S3a0.013
Rps20ribosomal protein S200.013
Rps5ribosomal protein S50.013
Rpl22ribosomal protein L220.013
Tceb2transcription elongation factor B (SIII), polypeptide 20.013
Churc1churchill domain containing 10.013
Rps23ribosomal protein S230.013
Flnafilamin A, alpha0.013
LOC100362298ribosomal protein S18-like0.013
Rps25ribosomal protein s250.013
Rps6ribosomal protein S60.012
S100a11S100 calcium binding protein A11 (calizzarin)0.012
Rpl28ribosomal protein L280.012
Rpl23aribosomal protein L23a0.012
Rps17ribosomal protein S170.012
Rpl11ribosomal protein L110.012
Ndufb2NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 20.012
Rps4xribosomal protein S4, X-linked0.012
Rpl23ribosomal protein L230.012
Rpl6ribosomal protein L60.012
Rpl21ribosomal protein L210.011
Mrpl23mitochondrial ribosomal protein L230.011
Rplp1ribosomal protein, large, P10.011
Rps27ribosomal protein S270.011
Rpl5ribosomal protein L50.011
Rps28ribosomal protein S280.011
Rpl8ribosomal protein L80.011
Rpl41ribosomal protein L410.011
Rpl9ribosomal protein L90.011
RGD1306917similar to RIKEN cDNA 2900010M230.011
Tomm6translocase of outer mitochondrial membrane 6 homolog (yeast)0.011
Rpl3ribosomal protein L30.011
Rpl36alribosomal protein L36a-like0.011
Rpl10ribosomal protein L100.010
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.010
LOC688869similar to cytochrome c oxidase, subunit VIb polypeptide 10.010
Atp5j2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Nup214Nucleoporin 2140.782
MadMothers against dpp0.334
Nup98Nucleoporin 980.191
DadDaughters against dpp0.105
enokenoki mushroom0.088
PNUTSCG33526 gene product from transcript CG33526-RD0.082
Nup160Nucleoporin 1600.082
Bap170Brahma associated protein 170kD0.065
Pi3K92ECG4141 gene product from transcript CG4141-RB0.046
SmoxSmad on X0.046
myoglianinCG1838 gene product from transcript CG1838-RD0.039
Mcm2Minichromosome maintenance 20.036
hipkhomeodomain interacting protein kinase0.035
CG8709CG8709 gene product from transcript CG8709-RK0.035
highikaru genki0.032
Nopp140CG7421 gene product from transcript CG7421-RB0.032
FBX011FBX011 ortholog0.032
EgfrEpidermal growth factor receptor0.032
CG5857CG5857 gene product from transcript CG5857-RA0.031
Prp19CG5519 gene product from transcript CG5519-RA0.028
kibrakibra ortholog0.027
Nup154Nucleoporin 1540.026
Stat92ESignal-transducer and activator of transcription protein at 92E0.024
Su(H)Suppressor of Hairless0.023
CG10080CG10080 gene product from transcript CG10080-RA0.023
MEP-1CG1244 gene product from transcript CG1244-RG0.022
Mat89BaMaternal transcript 89Ba0.019
mib1mind bomb 10.019
CG4849CG4849 gene product from transcript CG4849-RA0.018
Akt1CG4006 gene product from transcript CG4006-RA0.018
InRInsulin-like receptor0.017
Tango14Transport and Golgi organization 140.017
CG9776CG9776 gene product from transcript CG9776-RA0.016
CG5931CG5931 gene product from transcript CG5931-RA0.015
Mef2Myocyte enhancer factor 20.015
RnrLRibonucleoside diphosphate reductase large subunit0.014
Nup133Nucleoporin 1330.014
CG12084CG12084 gene product from transcript CG12084-RA0.014
Rpn2CG11888 gene product from transcript CG11888-RA0.014
trpmltransient receptor potential mucolipin0.013
nop5CG10206 gene product from transcript CG10206-RA0.013
CG6905CG6905 gene product from transcript CG6905-RA0.013
gbbglass bottom boat0.012
l(3)L1231lethal (3) L12310.012
Nup107Nucleoporin 1070.012
Uba1Ubiquitin activating enzyme 10.012
bin3bicoid-interacting protein 30.012
eIF-4BEukaryotic initiation factor 4B0.012
escextra sexcombs0.012
Rab5Rab-protein 50.011
ManfMesencephalic astrocyte-derived neurotrophic factor0.011
CG16941CG16941 gene product from transcript CG16941-RA0.011
Bj1Bj1 protein0.010
CG2931CG2931 gene product from transcript CG2931-RA0.010
Bre1CG10542 gene product from transcript CG10542-RA0.010
lidlittle imaginal discs0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.998
TGFB1transforming growth factor, beta 10.981
KPNB1karyopherin (importin) beta 10.876
SP1Sp1 transcription factor0.861
BMPR1Abone morphogenetic protein receptor, type IA0.858
BMP2bone morphogenetic protein 20.766
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.761
FOSFBJ murine osteosarcoma viral oncogene homolog0.615
NUP85nucleoporin 85kDa0.542
AHCTF1AT hook containing transcription factor 10.512
NUP153nucleoporin 153kDa0.500
JUNjun proto-oncogene0.447
FSTL1follistatin-like 10.427
SOX10SRY (sex determining region Y)-box 100.381
BMPR1Bbone morphogenetic protein receptor, type IB0.376
SMAD7SMAD family member 70.279
SMURF2SMAD specific E3 ubiquitin protein ligase 20.249
WWP2WW domain containing E3 ubiquitin protein ligase 20.249
NUP133nucleoporin 133kDa0.245
SMAD2SMAD family member 20.241
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.221
SMAD3SMAD family member 30.221
GDF5growth differentiation factor 50.189
FOXD3forkhead box D30.124
BMP4bone morphogenetic protein 40.108
ZFYVE9zinc finger, FYVE domain containing 90.096
NRP1neuropilin 10.075
JDP2Jun dimerization protein 20.074
SOX2SRY (sex determining region Y)-box 20.065
APCadenomatous polyposis coli0.057
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.049
ATF3activating transcription factor 30.048
TGFBR1transforming growth factor, beta receptor 10.047
TGFB3transforming growth factor, beta 30.044
ACVR1activin A receptor, type I0.042
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.037
SEC31ASEC31 homolog A (S. cerevisiae)0.036
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.033
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.033
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.032
NUP98nucleoporin 98kDa0.031
NLKnemo-like kinase0.025
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.025
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.024
BTRCbeta-transducin repeat containing0.024
AMOTL1angiomotin like 10.023
NUP160nucleoporin 160kDa0.021
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.020
MYO6myosin VI0.020
QKIquaking homolog, KH domain RNA binding (mouse)0.020
DUSP1dual specificity phosphatase 10.019
PRKG1protein kinase, cGMP-dependent, type I0.018
TUBA1Ctubulin, alpha 1c0.018
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.018
HEYLhairy/enhancer-of-split related with YRPW motif-like0.017
PTPN14protein tyrosine phosphatase, non-receptor type 140.016
CHD6chromodomain helicase DNA binding protein 60.016
NXF1nuclear RNA export factor 10.016
SKILSKI-like oncogene0.016
DAZAP2DAZ associated protein 20.016
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.016
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.016
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.015
ERBB2IPerbb2 interacting protein0.015
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.015
C19orf10chromosome 19 open reading frame 100.015
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.015
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.015
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.015
ACVR2Bactivin A receptor, type IIB0.014
RUNX1runt-related transcription factor 10.014
TPRtranslocated promoter region (to activated MET oncogene)0.014
E2F3E2F transcription factor 30.014
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.013
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.013
CKAP5cytoskeleton associated protein 50.012
SMAD4SMAD family member 40.012
CALD1caldesmon 10.011
IER2immediate early response 20.011
SENP1SUMO1/sentrin specific peptidase 10.011
SOX21SRY (sex determining region Y)-box 210.011
MAPK8mitogen-activated protein kinase 80.011
HIPK2homeodomain interacting protein kinase 20.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Smad4MAD homolog 4 (Drosophila)0.856
Smad3MAD homolog 3 (Drosophila)0.442
Smad1MAD homolog 1 (Drosophila)0.327
Trp53transformation related protein 530.254
Axin1axin 10.201
Ctnnb1catenin (cadherin associated protein), beta 10.192
Apcadenomatosis polyposis coli0.151
Tgfbr2transforming growth factor, beta receptor II0.134
Acvr1activin A receptor, type 10.129
Yap1yes-associated protein 10.103
Map3k7mitogen-activated protein kinase kinase kinase 70.065
Vegfavascular endothelial growth factor A0.064
Smad2MAD homolog 2 (Drosophila)0.060
Smad7MAD homolog 7 (Drosophila)0.056
Foxc1forkhead box C10.048
Ptenphosphatase and tensin homolog0.044
Erbb2ipErbb2 interacting protein0.043
Bmpr1abone morphogenetic protein receptor, type 1A0.040
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.036
Gsk3bglycogen synthase kinase 3 beta0.022
Thbs1thrombospondin 10.020
Prkg1protein kinase, cGMP-dependent, type I0.020
Il6stinterleukin 6 signal transducer0.019
Smad6MAD homolog 6 (Drosophila)0.019
Kitlkit ligand0.019
Col1a1collagen, type I, alpha 10.017
Tgfb2transforming growth factor, beta 20.016
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.016
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.015
Meox2mesenchyme homeobox 20.014
Stk11serine/threonine kinase 110.013
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.013
Smurf1SMAD specific E3 ubiquitin protein ligase 10.012
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.012
BrafBraf transforming gene0.012
Fgfr1fibroblast growth factor receptor 10.012
Ece1endothelin converting enzyme 10.011
Stat3signal transducer and activator of transcription 30.011
Tgfbr1transforming growth factor, beta receptor I0.011
Tgfb1transforming growth factor, beta 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism