The network for 'negative regulation of mrna metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mrna metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process.

NameDescriptionProbabilityFunc Analog Organism
TardbpTAR DNA binding protein0.047
Sfrs2splicing factor, arginine/serine-rich 20.043
Sfrs1splicing factor, arginine/serine-rich 10.025
Hnrph1heterogeneous nuclear ribonucleoprotein H10.019
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.017
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.015
Hnrnprheterogeneous nuclear ribonucleoprotein R0.014
Hdac1histone deacetylase 10.011
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.384
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.368
si:dkey-250d21.1si:dkey-250d21.10.322
nhp2NHP2 ribonucleoprotein homolog (yeast)0.203
sf3b4splicing factor 3b, subunit 40.198
ssbSjogren syndrome antigen B (autoantigen La)0.138
snrpcsmall nuclear ribonucleoprotein polypeptide C0.096
ybx1Y box binding protein 10.085
srsf11serine/arginine-rich splicing factor 110.079
prpf39PRP39 pre-mRNA processing factor 39 homolog (yeast)0.078
snrnp70small nuclear ribonucleoprotein 70 (U1)0.077
zgc:86598zgc:865980.076
cx43.4connexin 43.40.069
snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.067
hmga1ahigh mobility group AT-hook 1a0.062
zgc:92194zgc:921940.049
polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.049
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.048
hnrnpmheterogeneous nuclear ribonucleoprotein M0.048
eef2beukaryotic translation elongation factor 2b0.048
setbSET translocation (myeloid leukemia-associated) B0.046
ilf3binterleukin enhancer binding factor 3b0.045
ctnnb1catenin (cadherin-associated protein), beta 10.044
ck2bcasein kinase 2 beta0.044
zgc:112425zgc:1124250.043
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.043
huwe1HECT, UBA and WWE domain containing 10.041
si:dkey-67c22.2si:dkey-67c22.20.039
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.037
kpnb1karyopherin (importin) beta 10.037
prpf8pre-mRNA processing factor 80.037
snrpd3lsmall nuclear ribonucleoprotein D3 polypeptide, like0.035
matr3lmatrin 3-like0.033
cpsf6cleavage and polyadenylation specific factor 60.031
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.031
sf1splicing factor 10.031
srsf1aserine/arginine-rich splicing factor 1a0.030
glra4aglycine receptor, alpha 4a0.029
zgc:64040zgc:640400.029
rbm39aRNA binding motif protein 39a0.029
nrxn1aneurexin 1a0.029
yap1Yes-associated protein 10.028
pespescadillo0.028
ranras-related nuclear protein0.027
nucks1anuclear casein kinase and cyclin-dependent kinase substrate 1a0.026
ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39b0.026
ewsr1bEwing sarcoma breakpoint region 1b0.026
safbscaffold attachment factor B0.025
ftsjFtsJ homolog 3 (E. coli)0.025
zgc:136930zgc:1369300.025
rbmxRNA binding motif protein, X-linked0.025
zgc:158363zgc:1583630.024
npm4nucleophosmin/nucleoplasmin, 40.024
h2afvlH2A histone family, member V, like0.024
zgc:77407zgc:774070.023
slc43a1asolute carrier family 43, member 1a0.023
luc7lLUC7-like (S. cerevisiae)0.023
ilf2interleukin enhancer binding factor 20.022
erfEts2 repressor factor0.022
lsm14abLSM14 homolog Ab (SCD6, S. cerevisiae)0.022
mtr5-methyltetrahydrofolate-homocysteine methyltransferase0.021
cherpcalcium homeostasis endoplasmic reticulum protein0.021
zgc:110682zgc:1106820.021
foxc1aforkhead box C1a0.021
nolc1nucleolar and coiled-body phosphoprotein 10.021
alas2aminolevulinate, delta-, synthetase 20.020
srsf2serine/arginine-rich splicing factor 20.020
akap8lA kinase (PRKA) anchor protein 8-like0.020
rtn1areticulon 1a0.020
eif4ebp3leukaryotic translation initiation factor 4E binding protein 3, like0.020
gatad2aGATA zinc finger domain containing 2A0.020
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.020
caprin1acell cycle associated protein 1a0.019
ddx39aaDEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa0.019
eftud2elongation factor Tu GTP binding domain containing 20.019
rplp0ribosomal protein, large, P00.019
mthfd1methylenetetrahydrofolate dehydrogenase (NADP+ dependent)0.019
wu:fb58e05wu:fb58e050.019
rbm4.2RNA binding motif protein 4.20.019
pa2g4aproliferation-associated 2G4, a0.018
nupl1nucleoporin like 10.018
ldb1bLIM-domain binding factor 1b0.018
zgc:66100zgc:661000.018
rpl3ribosomal protein L30.018
adssladenylosuccinate synthase, like0.018
smu1smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)0.018
zgc:77262zgc:772620.018
actn4actinin, alpha 40.018
wnt3wingless-type MMTV integration site family, member 30.018
srsf5aserine/arginine-rich splicing factor 5a0.018
nr2f6anuclear receptor subfamily 2, group F, member 6a0.017
fancbFanconi anemia, complementation group B0.017
sept8aseptin 8a0.017
ranbp1RAN binding protein 10.017
puf60apoly-U binding splicing factor a0.017
abcg2cATP-binding cassette, sub-family G (WHITE), member 2c0.017
slc30a4solute carrier family 30 (zinc transporter), member 40.017
polr3glapolymerase (RNA) III (DNA directed) polypeptide G like a0.017
rer1RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)0.017
vamp3vesicle-associated membrane protein 3 (cellubrevin)0.017
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DlDelta0.041
HHairless0.018
EgfrEpidermal growth factor receptor0.015
Ras85DRas oncogene at 85D0.013
saxsaxophone0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
U2AF2U2 small nuclear RNA auxiliary factor 20.879
PABPC1poly(A) binding protein, cytoplasmic 10.840
RNPS1RNA binding protein S1, serine-rich domain0.813
PTBP1polypyrimidine tract binding protein 10.694
HNRNPA1heterogeneous nuclear ribonucleoprotein A10.672
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.557
TRA2Btransformer 2 beta homolog (Drosophila)0.508
SRSF1serine/arginine-rich splicing factor 10.506
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.495
SRSF6serine/arginine-rich splicing factor 60.488
PCBP1poly(rC) binding protein 10.420
SRRM1serine/arginine repetitive matrix 10.420
SRSF2serine/arginine-rich splicing factor 20.349
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.305
PCBP2poly(rC) binding protein 20.257
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.250
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.240
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.204
QKIquaking homolog, KH domain RNA binding (mouse)0.153
HNRNPKheterogeneous nuclear ribonucleoprotein K0.148
SRSF3serine/arginine-rich splicing factor 30.142
PTBP2polypyrimidine tract binding protein 20.138
SRSF9serine/arginine-rich splicing factor 90.134
CPEB4cytoplasmic polyadenylation element binding protein 40.122
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.100
U2AF1U2 small nuclear RNA auxiliary factor 10.092
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.091
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.089
HNRNPFheterogeneous nuclear ribonucleoprotein F0.089
SRRTserrate RNA effector molecule homolog (Arabidopsis)0.074
HNRNPH2heterogeneous nuclear ribonucleoprotein H2 (H')0.073
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.064
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.053
SNRPAsmall nuclear ribonucleoprotein polypeptide A0.050
USP22ubiquitin specific peptidase 220.049
SRPK2SRSF protein kinase 20.039
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.038
PNNpinin, desmosome associated protein0.037
SRSF4serine/arginine-rich splicing factor 40.035
RALYRNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))0.035
RBM39RNA binding motif protein 390.033
TARDBPTAR DNA binding protein0.032
SRPK1SRSF protein kinase 10.028
CPEB3cytoplasmic polyadenylation element binding protein 30.027
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.027
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.026
SRSF7serine/arginine-rich splicing factor 70.026
HNRPDLheterogeneous nuclear ribonucleoprotein D-like0.025
DCAF7DDB1 and CUL4 associated factor 70.025
RBM17RNA binding motif protein 170.024
CLK2CDC-like kinase 20.023
SREK1splicing regulatory glutamine/lysine-rich protein 10.021
SRSF5serine/arginine-rich splicing factor 50.020
MAT2Amethionine adenosyltransferase II, alpha0.019
CELF1CUGBP, Elav-like family member 10.019
RBM23RNA binding motif protein 230.018
SUGP1SURP and G patch domain containing 10.017
ILF3interleukin enhancer binding factor 3, 90kDa0.017
C19orf43chromosome 19 open reading frame 430.016
RBMXRNA binding motif protein, X-linked0.016
CARM1coactivator-associated arginine methyltransferase 10.015
PABPN1poly(A) binding protein, nuclear 10.015
FBXO33F-box protein 330.015
CIRBPcold inducible RNA binding protein0.014
PPM1Gprotein phosphatase, Mg2+/Mn2+ dependent, 1G0.013
PABPC3poly(A) binding protein, cytoplasmic 30.013
SMU1smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)0.012
BANF1barrier to autointegration factor 10.012
PRCCpapillary renal cell carcinoma (translocation-associated)0.012
LARP1La ribonucleoprotein domain family, member 10.011
RBM4RNA binding motif protein 40.011
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.011
DHX38DEAH (Asp-Glu-Ala-His) box polypeptide 380.010
NXF1nuclear RNA export factor 10.010
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.406
Pabpn1poly(A) binding protein, nuclear 10.216
Trim28tripartite motif-containing 280.211
Srsf6serine/arginine-rich splicing factor 60.198
Srsf2serine/arginine-rich splicing factor 20.192
TardbpTAR DNA binding protein0.180
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.171
Hnrnpa3heterogeneous nuclear ribonucleoprotein A30.149
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.107
Srsf1serine/arginine-rich splicing factor 10.099
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.098
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.090
Ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.080
SetSET nuclear oncogene0.080
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.059
Hnrnpmheterogeneous nuclear ribonucleoprotein M0.045
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.044
Ewsr1Ewing sarcoma breakpoint region 10.043
Srsf11serine/arginine-rich splicing factor 110.042
Matr3matrin 30.041
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.041
Ctbp1C-terminal binding protein 10.038
Ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.036
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.035
Ptmaprothymosin alpha0.033
Pcbp1poly(rC) binding protein 10.030
Raver2ribonucleoprotein, PTB-binding 20.030
Tra2atransformer 2 alpha homolog (Drosophila)0.028
Tra2btransformer 2 beta homolog (Drosophila)0.028
Safbscaffold attachment factor B0.027
Srsf3serine/arginine-rich splicing factor 30.026
Srsf7serine/arginine-rich splicing factor 70.023
Akr1c13aldo-keto reductase family 1, member C130.021
Akr1c12aldo-keto reductase family 1, member C120.021
Akap8A kinase (PRKA) anchor protein 80.021
Hmgn1high mobility group nucleosomal binding domain 10.019
Sp3trans-acting transcription factor 30.019
Ptges3prostaglandin E synthase 3 (cytosolic)0.018
Prpf38bPRP38 pre-mRNA processing factor 38 (yeast) domain containing B0.018
Taf1dTATA box binding protein (Tbp)-associated factor, RNA polymerase I, D0.017
Acin1apoptotic chromatin condensation inducer 10.017
Rbm14RNA binding motif protein 140.017
CtcfCCCTC-binding factor0.016
Sf3a2splicing factor 3a, subunit 20.016
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 90.016
Prpf39PRP39 pre-mRNA processing factor 39 homolog (yeast)0.016
Nononon-POU-domain-containing, octamer binding protein0.016
Srsf4serine/arginine-rich splicing factor 40.015
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.015
Safb2scaffold attachment factor B20.014
Fusfusion, derived from t(12;16) malignant liposarcoma (human)0.014
Raver1ribonucleoprotein, PTB-binding 10.014
2500003M10RikRIKEN cDNA 2500003M10 gene0.013
Timm10translocase of inner mitochondrial membrane 10 homolog (yeast)0.013
Impdh2inosine 5'-phosphate dehydrogenase 20.013
2310036O22RikRIKEN cDNA 2310036O22 gene0.012
Gcfc1GC-rich sequence DNA-binding factor 10.011
Npm1nucleophosmin 10.011
Luc7l3LUC7-like 3 (S. cerevisiae)0.011
Eif2c2eukaryotic translation initiation factor 2C, 20.011
Nxf1nuclear RNA export factor 1 homolog (S. cerevisiae)0.011
Pnnpinin0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
UBI4Ubi4p0.256
RIM11Rim11p0.018
SSD1Ssd1p0.014
TPS2Tps2p0.014
UBP15Ubp15p0.014
SSE2Sse2p0.011
ATG3Atg3p0.010