The network for 'negative regulation of cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell development

Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.374
Fgfr2fibroblast growth factor receptor 20.354
Anxa5annexin A50.284
Pxdnperoxidasin homolog (Drosophila)0.269
S100a6S100 calcium binding protein A60.248
Nr4a3nuclear receptor subfamily 4, group A, member 30.234
Arf1ADP-ribosylation factor 10.208
Rararetinoic acid receptor, alpha0.202
Cd9CD9 molecule0.198
Twist2twist homolog 2 (Drosophila)0.197
Aqp4aquaporin 40.196
Ascl1achaete-scute complex homolog 1 (Drosophila)0.193
LOC100362824caveolin 2-like0.187
Accn2amiloride-sensitive cation channel 2, neuronal0.180
Gata3GATA binding protein 30.179
S100a11S100 calcium binding protein A11 (calizzarin)0.172
Nr4a2nuclear receptor subfamily 4, group A, member 20.162
Ageradvanced glycosylation end product-specific receptor0.159
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.150
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.147
Robo1roundabout homolog 1 (Drosophila)0.142
Lgals5lectin, galactose binding, soluble 50.141
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.135
Hes5hairy and enhancer of split 5 (Drosophila)0.134
Rhoaras homolog gene family, member A0.133
S100a10S100 calcium binding protein A100.127
Irf2interferon regulatory factor 20.126
Pex5lperoxisomal biogenesis factor 5-like0.123
Timp3TIMP metallopeptidase inhibitor 30.121
Hist1h1dhistone cluster 1, H1d0.121
Sv2asynaptic vesicle glycoprotein 2a0.118
Tcf4transcription factor 40.117
Tgfbr2transforming growth factor, beta receptor II0.114
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.114
Nedd4neural precursor cell expressed, developmentally down-regulated 40.112
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.112
Slc22a1solute carrier family 22 (organic cation transporter), member 10.110
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.105
Fut2fucosyltransferase 2 (secretor status included)0.105
Bex4brain expressed, X-linked 40.104
Hsp90b1heat shock protein 90, beta, member 10.102
Ndnnecdin homolog (mouse)0.100
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.100
Marcksmyristoylated alanine rich protein kinase C substrate0.100
Magmyelin-associated glycoprotein0.098
Rab7aRAB7A, member RAS oncogene family0.096
Igfbp5insulin-like growth factor binding protein 50.096
Lgals9lectin, galactoside-binding, soluble, 90.094
Sgsm1small G protein signaling modulator 10.092
Dchs1dachsous 1 (Drosophila)0.091
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.090
Rxraretinoid X receptor alpha0.089
Lzts1leucine zipper, putative tumor suppressor 10.089
Nr2c2nuclear receptor subfamily 2, group C, member 20.088
RragaRas-related GTP binding A0.086
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.084
Calcrcalcitonin receptor0.084
Ehd2EH-domain containing 20.083
Adcy8adenylate cyclase 8 (brain)0.083
Hspb1heat shock protein 10.083
Arhgap1Rho GTPase activating protein 10.082
Cishcytokine inducible SH2-containing protein0.082
Otx1orthodenticle homeobox 10.080
Vcpvalosin-containing protein0.080
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.080
Sprr1alsmall proline-rich protein 1A-like0.079
Igf2rinsulin-like growth factor 2 receptor0.078
Hoxa1homeo box A10.078
Ecel1endothelin converting enzyme-like 10.078
Myo1cmyosin IC0.076
Unc5bunc-5 homolog B (C. elegans)0.076
Fgfr1Fibroblast growth factor receptor 10.076
St18suppression of tumorigenicity 180.075
Stat6signal transducer and activator of transcription 60.075
Dab2disabled homolog 2 (Drosophila)0.074
Rtn1reticulon 10.073
Arnt2aryl hydrocarbon receptor nuclear translocator 20.073
Egr3early growth response 30.073
Syt9synaptotagmin IX0.072
Onecut1one cut homeobox 10.072
Foxa3forkhead box A30.072
Anxa1annexin A10.070
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.070
Pnmal2PNMA-like 20.070
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.069
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.069
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.069
Scamp2secretory carrier membrane protein 20.069
Galr3galanin receptor 30.068
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.068
Gna15guanine nucleotide binding protein, alpha 150.068
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.067
Cpecarboxypeptidase E0.067
Notch1Notch homolog 1, translocation-associated (Drosophila)0.067
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.023
vab-3Protein VAB-30.019
inx-3Protein INX-30.018
pha-4Protein PHA-40.015
unc-7Protein UNC-70.015
pry-1Protein PRY-10.012
mec-2Protein MEC-20.012
unc-70Protein UNC-700.011
cam-1Protein CAM-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
alcamaactivated leukocyte cell adhesion molecule a0.846
phox2apaired-like homeobox 2a0.735
pax6apaired box gene 6a0.535
tbx16T-box gene 160.527
notch3notch homolog 30.526
jag2jagged 20.498
ascl1aachaete-scute complex-like 1a (Drosophila)0.483
neo1neogenin 10.470
fgfr2fibroblast growth factor receptor 20.444
neurod4neurogenic differentiation 40.269
sox2SRY-box containing gene 20.267
foxa1forkhead box A10.262
nog1noggin 10.261
otx1borthodenticle homolog 1b0.260
fgf3fibroblast growth factor 30.232
dlx3bdistal-less homeobox gene 3b0.218
foxa3forkhead box A30.209
jag1bjagged 1b0.208
fgfr4fibroblast growth factor receptor 40.204
otx2orthodenticle homolog 20.201
shhbsonic hedgehog b0.199
bmp2abone morphogenetic protein 2a0.188
foxd3forkhead box D30.181
ptf1apancreas specific transcription factor, 1a0.180
bmp2bbone morphogenetic protein 2b0.179
pou3f3bPOU class 3 homeobox 3b0.172
gli1GLI-Kruppel family member 10.164
robo2roundabout homolog 20.155
her12hairy-related 120.148
shhasonic hedgehog a0.143
lhx1aLIM homeobox 1a0.142
flhfloating head0.136
hgfbhepatocyte growth factor b0.125
zic1zic family member 1 (odd-paired homolog, Drosophila)0.119
bocbrother of CDO0.118
mnx1motor neuron and pancreas homeobox 10.116
fzd10frizzled homolog 100.115
foxa2forkhead box A20.115
fzd7afrizzled homolog 7a0.114
wnt5bwingless-type MMTV integration site family, member 5b0.113
frem3Fras1 related extracellular matrix 30.110
otpborthopedia homolog b0.110
foxi1forkhead box I10.110
nr2e1nuclear receptor subfamily 2, group E, member 10.104
notch1anotch homolog 1a0.101
her15.1hairy and enhancer of split-related 15.10.100
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.094
tbx2bT-box 2b0.093
meis2.2myeloid ecotropic viral integration site 2.20.093
fzd5frizzled homolog 50.089
tbx6T-box gene 60.089
wnt11rwingless-type MMTV integration site family, member 11, related0.088
irx1airoquois homeobox protein 1, a0.087
fgf8afibroblast growth factor 8 a0.087
efnb1ephrin B10.086
nrp2bneuropilin 2b0.086
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.084
ptgs1prostaglandin-endoperoxide synthase 10.084
irx5airoquois homeobox protein 5a0.082
nav3neuron navigator 30.080
irx3biroquois homeobox protein 3b0.078
atoh1batonal homolog 1b0.077
sox3SRY-box containing gene 30.074
neurog1neurogenin 10.074
nf1aneurofibromin 1a0.073
cfl2lcofilin 2, like0.072
sfrp5secreted frizzled-related protein 50.072
dccdeleted in colorectal carcinoma0.068
nrarpanotch-regulated ankyrin repeat protein a0.067
gata2aGATA-binding protein 2a0.067
ndr2nodal-related 20.066
vsx2visual system homeobox 20.065
cdx4caudal type homeo box transcription factor 40.064
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.064
irx1biroquois homeobox protein 1, b0.064
metmet proto-oncogene (hepatocyte growth factor receptor)0.062
gdf6agrowth differentiation factor 6a0.061
dlx4bdistal-less homeobox gene 4b0.061
barhl2BarH-like 20.061
rad21RAD21 homolog (S. pombe)0.061
fzd8bfrizzled homolog 8b0.060
sox10SRY-box containing gene 100.060
hnf1baHNF1 homeobox Ba0.058
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.058
gata1aGATA binding protein 1a0.057
fezf2FEZ family zinc finger 20.056
fzd8afrizzled homolog 8a0.056
gbx1gastrulation brain homeobox 10.056
fgfr3fibroblast growth factor receptor 30.054
msxemuscle segment homeobox E0.054
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.054
insm1ainsulinoma-associated 1a0.053
olfm1aolfactomedin 1a0.053
msgn1mesogenin 10.051
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.991
EgfrEpidermal growth factor receptor0.932
cicubitus interruptus0.777
ph-ppolyhomeotic proximal0.748
TBPHCG10327 gene product from transcript CG10327-RC0.744
HLHmdeltaE(spl) region transcript mdelta0.705
MadMothers against dpp0.694
sosine oculis0.677
Akt1CG4006 gene product from transcript CG4006-RA0.665
HLHmgammaE(spl) region transcript mgamma0.656
Pi3K92ECG4141 gene product from transcript CG4141-RB0.584
MED11Mediator complex subunit 110.571
ik2IkappaB kinase-like 20.565
norpAno receptor potential A0.515
m4E(spl) region transcript m40.476
MED27Mediator complex subunit 270.466
Ten-aTenascin accessory0.463
HLHm7E(spl) region transcript m70.438
MED6Mediator complex subunit 60.413
MED31Mediator complex subunit 310.387
Wnt5Wnt oncogene analog 50.386
cdicenter divider0.375
HLHmbetaE(spl) region transcript mbeta0.368
Stat92ESignal-transducer and activator of transcription protein at 92E0.346
toytwin of eyeless0.332
ftz-f1ftz transcription factor 10.332
HLHm5E(spl) region transcript m50.317
TomTwin of m40.300
Arr2Arrestin 20.297
Su(H)Suppressor of Hairless0.282
slp1sloppy paired 10.269
faffat facets0.257
argosCG4531 gene product from transcript CG4531-RA0.245
myoglianinCG1838 gene product from transcript CG1838-RD0.237
Plc21CPhospholipase C at 21C0.224
lblladybird late0.217
HLHm3E(spl) region transcript m30.215
slmbsupernumerary limbs0.208
malphaE(spl) region transcript malpha0.207
m2E(spl) region transcript m20.182
vvlventral veins lacking0.181
trptransient receptor potential0.181
trolterribly reduced optic lobes0.177
CG12424CG12424 gene product from transcript CG12424-RC0.177
salmspalt major0.163
phlpole hole0.158
Fas1Fasciclin 10.156
gbbglass bottom boat0.156
ninaEneither inactivation nor afterpotential E0.156
CG5794CG5794 gene product from transcript CG5794-RB0.152
gfAgiant fibre A0.152
hydhyperplastic discs0.148
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JAG1jagged 10.903
CCT8chaperonin containing TCP1, subunit 8 (theta)0.853
NOTCH1notch 10.832
CCT4chaperonin containing TCP1, subunit 4 (delta)0.728
BBS10Bardet-Biedl syndrome 100.703
APPamyloid beta (A4) precursor protein0.696
ZMYND11zinc finger, MYND-type containing 110.624
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.620
ARID1AAT rich interactive domain 1A (SWI-like)0.615
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.609
HDAC2histone deacetylase 20.600
PBX1pre-B-cell leukemia homeobox 10.582
YAP1Yes-associated protein 10.569
FGF1fibroblast growth factor 1 (acidic)0.559
FBXW11F-box and WD repeat domain containing 110.518
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.467
MMP14matrix metallopeptidase 14 (membrane-inserted)0.451
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.431
NOTCH3notch 30.424
PAX3paired box 30.411
CDK8cyclin-dependent kinase 80.411
NKX2-1NK2 homeobox 10.384
HDAC1histone deacetylase 10.350
BMP7bone morphogenetic protein 70.347
TGFB1transforming growth factor, beta 10.347
NGFRnerve growth factor receptor0.334
PTPN6protein tyrosine phosphatase, non-receptor type 60.323
GSK3Bglycogen synthase kinase 3 beta0.318
SOX1SRY (sex determining region Y)-box 10.315
NR4A1nuclear receptor subfamily 4, group A, member 10.306
FGFR2fibroblast growth factor receptor 20.301
SMAD4SMAD family member 40.294
POU3F2POU class 3 homeobox 20.292
BMP2bone morphogenetic protein 20.290
TCP1t-complex 10.287
C2orf65chromosome 2 open reading frame 650.241
SP1Sp1 transcription factor0.239
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.232
SIN3ASIN3 homolog A, transcription regulator (yeast)0.230
SMAD1SMAD family member 10.227
PPP2R2Cprotein phosphatase 2, regulatory subunit B, gamma0.227
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.226
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.217
SFRP1secreted frizzled-related protein 10.217
TP73tumor protein p730.212
FBLN1fibulin 10.203
FYNFYN oncogene related to SRC, FGR, YES0.202
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.198
FGF8fibroblast growth factor 8 (androgen-induced)0.194
BTRCbeta-transducin repeat containing0.191
PILRApaired immunoglobin-like type 2 receptor alpha0.187
MEIS1Meis homeobox 10.180
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.179
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.177
PAX8paired box 80.176
PDX1pancreatic and duodenal homeobox 10.171
WNT1wingless-type MMTV integration site family, member 10.170
RNF11ring finger protein 110.170
TBX5T-box 50.166
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.166
LRP1low density lipoprotein receptor-related protein 10.163
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.161
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.156
SOCS1suppressor of cytokine signaling 10.154
VEGFAvascular endothelial growth factor A0.149
GRB7growth factor receptor-bound protein 70.149
RB1CC1RB1-inducible coiled-coil 10.147
IL1R1interleukin 1 receptor, type I0.145
POU5F1POU class 5 homeobox 10.143
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.139
SMAD7SMAD family member 70.137
CCT7chaperonin containing TCP1, subunit 7 (eta)0.136
MED15mediator complex subunit 150.136
NEDD4neural precursor cell expressed, developmentally down-regulated 40.134
CHDHcholine dehydrogenase0.123
IMMTinner membrane protein, mitochondrial0.119
TGFB3transforming growth factor, beta 30.116
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.115
TCF4transcription factor 40.115
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.112
JAG2jagged 20.111
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.110
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.110
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.109
FGFR1fibroblast growth factor receptor 10.108
FGF4fibroblast growth factor 40.106
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.104
OLIG2oligodendrocyte lineage transcription factor 20.104
FZD8frizzled homolog 8 (Drosophila)0.103
NEDD9neural precursor cell expressed, developmentally down-regulated 90.101
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.101
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.100
PSEN2presenilin 2 (Alzheimer disease 4)0.099
DLL1delta-like 1 (Drosophila)0.097
GATA4GATA binding protein 40.096
FOXD3forkhead box D30.095
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Foxc1forkhead box C11.000
Pax3paired box gene 31.000
Hand2heart and neural crest derivatives expressed transcript 20.998
Bmp7bone morphogenetic protein 70.997
Eya1eyes absent 1 homolog (Drosophila)0.994
Psen1presenilin 10.994
Pax2paired box gene 20.993
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.992
Fgf8fibroblast growth factor 80.990
Foxc2forkhead box C20.986
Msx1homeobox, msh-like 10.986
Emx1empty spiracles homolog 1 (Drosophila)0.985
Hand1heart and neural crest derivatives expressed transcript 10.982
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.981
Gli2GLI-Kruppel family member GLI20.980
Sox9SRY-box containing gene 90.979
Pbx1pre B-cell leukemia transcription factor 10.978
Smad3MAD homolog 3 (Drosophila)0.975
Rspo2R-spondin 2 homolog (Xenopus laevis)0.966
Wnt3awingless-related MMTV integration site 3A0.965
Emx2empty spiracles homolog 2 (Drosophila)0.964
Bmp4bone morphogenetic protein 40.963
Pitx2paired-like homeodomain transcription factor 20.961
Tcfap2atranscription factor AP-2, alpha0.960
Dlx5distal-less homeobox 50.957
Pou3f3POU domain, class 3, transcription factor 30.952
Ednraendothelin receptor type A0.947
Isl1ISL1 transcription factor, LIM/homeodomain0.939
Fgfr1fibroblast growth factor receptor 10.939
Sox2SRY-box containing gene 20.938
Gscgoosecoid homeobox0.933
Hoxd13homeobox D130.929
Prrx2paired related homeobox 20.925
Apcadenomatosis polyposis coli0.925
Meox2mesenchyme homeobox 20.922
Tbx1T-box 10.914
Tbx3T-box 30.911
Efnb2ephrin B20.910
Smosmoothened homolog (Drosophila)0.908
Notch1Notch gene homolog 1 (Drosophila)0.886
Epha4Eph receptor A40.886
Hes1hairy and enhancer of split 1 (Drosophila)0.869
Foxa2forkhead box A20.863
Prrx1paired related homeobox 10.862
Tlx3T-cell leukemia, homeobox 30.858
Lef1lymphoid enhancer binding factor 10.854
Pax9paired box gene 90.851
Gbx2gastrulation brain homeobox 20.845
Hoxa13homeobox A130.844
Tgfb2transforming growth factor, beta 20.843
Appamyloid beta (A4) precursor protein0.839
Gdf5growth differentiation factor 50.837
Foxg1forkhead box G10.837
Zeb1zinc finger E-box binding homeobox 10.835
Ephb3Eph receptor B30.825
Acvr1activin A receptor, type 10.821
Pax6paired box gene 60.819
Msx2homeobox, msh-like 20.817
Rargretinoic acid receptor, gamma0.809
Dll4delta-like 4 (Drosophila)0.802
Sall4sal-like 4 (Drosophila)0.796
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.792
Ephb2Eph receptor B20.790
Smad6MAD homolog 6 (Drosophila)0.790
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.785
Nos3nitric oxide synthase 3, endothelial cell0.771
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.770
Alx4aristaless-like homeobox 40.768
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.767
Lhx3LIM homeobox protein 30.764
Rarbretinoic acid receptor, beta0.763
Hoxd11homeobox D110.761
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.759
Jag1jagged 10.755
Dccdeleted in colorectal carcinoma0.746
Neurog2neurogenin 20.744
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.741
Id1inhibitor of DNA binding 10.737
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.731
Ror2receptor tyrosine kinase-like orphan receptor 20.729
Hoxa1homeobox A10.726
Sox17SRY-box containing gene 170.726
Ptpn11protein tyrosine phosphatase, non-receptor type 110.724
Klk1b5kallikrein 1-related peptidase b50.722
UncxUNC homeobox0.715
Nkx3-2NK3 homeobox 20.711
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.700
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.698
Fgf3fibroblast growth factor 30.691
Fgf10fibroblast growth factor 100.691
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.683
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism