The network for 'regulation of leukocyte mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of leukocyte mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.

NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.610
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.069
Cxcl10chemokine (C-X-C motif) ligand 100.067
Klrd1killer cell lectin-like receptor, subfamily D, member 10.058
RT1-CE12RT1 class I, locus CE120.057
Hsph1heat shock 105/110 protein 10.057
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.047
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.044
Gzmbgranzyme B0.044
Nkg7natural killer cell group 7 sequence0.040
Sellselectin L0.039
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.036
Il1binterleukin 1 beta0.035
Mmp12matrix metallopeptidase 120.034
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.029
Slfn2schlafen 20.026
Prf1perforin 1 (pore forming protein)0.025
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.025
Hspb1heat shock protein 10.022
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.021
Oasl2'-5'-oligoadenylate synthetase-like0.019
Plaurplasminogen activator, urokinase receptor0.017
Il6interleukin 60.017
Gzmkgranzyme K0.017
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.016
Il7rinterleukin 7 receptor0.015
Il2rbinterleukin 2 receptor, beta0.014
F2rl1coagulation factor II (thrombin) receptor-like 10.013
Cd14CD14 molecule0.013
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.012
Neurl3neuralized homolog 3 (Drosophila)0.012
Oas1a2'-5' oligoadenylate synthetase 1A0.011
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.011
RT1-S3RT1 class Ib, locus S30.011
Casp1caspase 10.011
Ccl4chemokine (C-C motif) ligand 40.011
Ccr2chemokine (C-C motif) receptor 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
lrrc33leucine rich repeat containing 330.255
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.050
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.033
defbl3defensin, beta-like 30.033
coro1acoronin, actin binding protein, 1A0.032
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.027
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b0.024
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.024
c1qccomplement component 1, q subcomponent, C chain0.020
itln3intelectin 30.020
nitr8novel immune-type receptor 80.020
etnk1ethanolamine kinase 10.019
itln1intelectin 10.019
LOC567405novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)0.018
gmfgglia maturation factor, gamma0.018
g6pdglucose-6-phosphate dehydrogenase0.017
grnagranulin a0.017
styk1serine/threonine/tyrosine kinase 10.016
tbpTATA box binding protein0.016
arpc1bactin related protein 2/3 complex, subunit 1B0.016
c3ccomplement component c3c0.015
cx34.4connexin 34.40.015
bsdc1BSD domain containing 10.015
pcsk2proprotein convertase subtilisin/kexin type 20.015
illr1immune-related, lectin-like receptor 10.015
irf11interferon regulatory factor 110.015
psmb9aproteasome (prosome, macropain) subunit, beta type, 9a0.014
figlafactor in the germline alpha0.014
cd74CD74 molecule, major histocompatibility complex, class II invariant chain0.014
rhogbras homolog gene family, member Gb0.014
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.014
c1qbcomplement component 1, q subcomponent, B chain0.014
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.014
cxcr3.2chemokine (C-X-C motif) receptor 3.20.014
smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.013
nitr4anovel immune-type receptor 4a0.013
c3bcomplement component c3b0.013
fxr2fragile X mental retardation, autosomal homolog 20.013
tlr22toll-like receptor 220.013
ptk6aPTK6 protein tyrosine kinase 6a0.013
ddr2bdiscoidin domain receptor family, member 2b0.013
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.013
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.013
col5a3collagen, type V, alpha 30.013
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.013
bbs4Bardet-Biedl syndrome 40.012
sppl3signal peptide peptidase 30.012
cul1bcullin 1b0.012
LOC555739serine/threonine-protein kinase LMTK1-like0.012
ptprebprotein tyrosine phosphatase, receptor type, E, b0.012
nitr12novel immune-type receptor 120.012
fhl2bfour and a half LIM domains 2b0.012
foxp3aforkhead box P3a0.012
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.012
slc12a10.1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.10.012
cyp2n13cytochrome P450, family 2, subfamily N, polypeptide 130.011
trim25tripartite motif-containing 250.011
piguphosphatidylinositol glycan anchor biosynthesis, class U0.011
edarectodysplasin A receptor0.011
wacaWW domain containing adaptor with coiled-coil a0.011
gpr143G protein-coupled receptor 1430.011
syngr1asynaptogyrin 1a0.011
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.011
ggnbp2gametogenetin binding protein 20.011
dmrt1doublesex and mab-3 related transcription factor 10.011
pkzprotein kinase containing Z-DNA binding domains0.011
ythdf3YTH domain family 30.011
LOC794786interferon-induced protein with tetratricopeptide repeats 1-like0.011
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.011
pth1bparathyroid hormone 1b0.011
npy4rneuropeptide Y receptor Y40.011
illr3immune-related, lectin-like receptor 30.011
stat1bsignal transducer and activator of transcription 1b0.011
npy7rneuropeptide Y receptor Y70.011
dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.010
slc22a7asolute carrier family 22 (organic anion transporter), member 7a0.010
tlr4bbtoll-like receptor 4b, duplicate b0.010
lrrfip1aleucine rich repeat (in FLII) interacting protein 1a0.010
il12bbinterleukin 12B, b0.010
cd40lgCD40 ligand0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Amajor histocompatibility complex, class I, A0.998
HLA-Gmajor histocompatibility complex, class I, G0.916
HLA-Cmajor histocompatibility complex, class I, C0.901
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.878
HLA-Fmajor histocompatibility complex, class I, F0.878
HLA-Bmajor histocompatibility complex, class I, B0.742
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.559
IL8interleukin 80.549
CXCL3chemokine (C-X-C motif) ligand 30.475
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.470
TAPBPTAP binding protein (tapasin)0.445
HLA-Emajor histocompatibility complex, class I, E0.435
IL2RBinterleukin 2 receptor, beta0.397
CXCL2chemokine (C-X-C motif) ligand 20.378
CCR5chemokine (C-C motif) receptor 50.309
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.293
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.268
SLAMF1signaling lymphocytic activation molecule family member 10.256
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.230
CCL5chemokine (C-C motif) ligand 50.230
CD84CD84 molecule0.213
CAV1caveolin 1, caveolae protein, 22kDa0.161
IL1Binterleukin 1, beta0.159
CCR1chemokine (C-C motif) receptor 10.144
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.142
ARRB1arrestin, beta 10.139
CCL4chemokine (C-C motif) ligand 40.137
KLRD1killer cell lectin-like receptor subfamily D, member 10.135
CXCL9chemokine (C-X-C motif) ligand 90.128
CCL13chemokine (C-C motif) ligand 130.109
IFNGinterferon, gamma0.106
IL6interleukin 6 (interferon, beta 2)0.100
GBAglucosidase, beta, acid0.100
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.097
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.092
PTPN6protein tyrosine phosphatase, non-receptor type 60.087
CASP8caspase 8, apoptosis-related cysteine peptidase0.080
IDEinsulin-degrading enzyme0.079
DPP4dipeptidyl-peptidase 40.074
IL23Ainterleukin 23, alpha subunit p190.069
CCR7chemokine (C-C motif) receptor 70.069
ITM2Bintegral membrane protein 2B0.065
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.063
CCL8chemokine (C-C motif) ligand 80.058
CCL2chemokine (C-C motif) ligand 20.057
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.055
CCL20chemokine (C-C motif) ligand 200.054
CCL7chemokine (C-C motif) ligand 70.054
RAB14RAB14, member RAS oncogene family0.054
PVRL4poliovirus receptor-related 40.046
KLRK1killer cell lectin-like receptor subfamily K, member 10.046
PTPN1protein tyrosine phosphatase, non-receptor type 10.045
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.037
BCL2A1BCL2-related protein A10.032
FASLGFas ligand (TNF superfamily, member 6)0.032
CCR4chemokine (C-C motif) receptor 40.029
INSRinsulin receptor0.029
CXCL5chemokine (C-X-C motif) ligand 50.029
GZMKgranzyme K (granzyme 3; tryptase II)0.028
KLRC3killer cell lectin-like receptor subfamily C, member 30.028
GPR171G protein-coupled receptor 1710.028
CH25Hcholesterol 25-hydroxylase0.027
CD163CD163 molecule0.026
TNFtumor necrosis factor0.026
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.023
TLR2toll-like receptor 20.023
IL10interleukin 100.023
CXCL10chemokine (C-X-C motif) ligand 100.022
PILRApaired immunoglobin-like type 2 receptor alpha0.022
FPR3formyl peptide receptor 30.022
NLRP3NLR family, pyrin domain containing 30.020
VCAM1vascular cell adhesion molecule 10.020
HK3hexokinase 3 (white cell)0.020
CCR2chemokine (C-C motif) receptor 20.020
CD8ACD8a molecule0.019
KLRC2killer cell lectin-like receptor subfamily C, member 20.019
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.019
CXCL13chemokine (C-X-C motif) ligand 130.018
MMP12matrix metallopeptidase 12 (macrophage elastase)0.018
GNSglucosamine (N-acetyl)-6-sulfatase0.018
CD22CD22 molecule0.018
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.018
SIGLEC7sialic acid binding Ig-like lectin 70.017
CD3GCD3g molecule, gamma (CD3-TCR complex)0.017
VAMP4vesicle-associated membrane protein 40.017
CCL19chemokine (C-C motif) ligand 190.016
IL7Rinterleukin 7 receptor0.016
TRAF1TNF receptor-associated factor 10.016
BIRC3baculoviral IAP repeat containing 30.016
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.016
STAP2signal transducing adaptor family member 20.016
SLAMF8SLAM family member 80.015
CXCL11chemokine (C-X-C motif) ligand 110.015
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.015
SELEselectin E0.015
TREM1triggering receptor expressed on myeloid cells 10.015
IL18RAPinterleukin 18 receptor accessory protein0.015
AQP9aquaporin 90.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
B2mbeta-2 microglobulin1.000
H2-K1histocompatibility 2, K1, K region1.000
H2-D1histocompatibility 2, D region locus 10.999
Klrk1killer cell lectin-like receptor subfamily K, member 10.997
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.995
TapbpTAP binding protein0.992
Klra9killer cell lectin-like receptor subfamily A, member 90.982
Klrc1killer cell lectin-like receptor subfamily C, member 10.964
FynFyn proto-oncogene0.961
Slamf1signaling lymphocytic activation molecule family member 10.960
FaslFas ligand (TNF superfamily, member 6)0.917
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.911
H2-Q7histocompatibility 2, Q region locus 70.898
Gzmkgranzyme K0.854
Il2rginterleukin 2 receptor, gamma chain0.812
Stat5bsignal transducer and activator of transcription 5B0.796
Gzmbgranzyme B0.787
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.786
Xcl1chemokine (C motif) ligand 10.764
Pnp2purine-nucleoside phosphorylase 20.726
H2-Q8histocompatibility 2, Q region locus 80.640
Gzmagranzyme A0.621
Klrd1killer cell lectin-like receptor, subfamily D, member 10.602
Il18rapinterleukin 18 receptor accessory protein0.549
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.537
H2-Q6histocompatibility 2, Q region locus 60.534
Casp8caspase 80.498
Stat5asignal transducer and activator of transcription 5A0.469
Arrb1arrestin, beta 10.456
Ncr1natural cytotoxicity triggering receptor 10.441
Il6interleukin 60.421
Lcklymphocyte protein tyrosine kinase0.418
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.408
Spna1spectrin alpha 10.344
Irf9interferon regulatory factor 90.333
Ctswcathepsin W0.315
Icosinducible T-cell co-stimulator0.308
ItkIL2-inducible T-cell kinase0.296
H2-Q5histocompatibility 2, Q region locus 50.295
Cd160CD160 antigen0.257
Lair1leukocyte-associated Ig-like receptor 10.244
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.228
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.223
Cd247CD247 antigen0.214
Ccr3chemokine (C-C motif) receptor 30.205
Il2rainterleukin 2 receptor, alpha chain0.187
Ccl5chemokine (C-C motif) ligand 50.175
Klrg1killer cell lectin-like receptor subfamily G, member 10.173
Stat3signal transducer and activator of transcription 30.168
Cd244CD244 natural killer cell receptor 2B40.168
Il2rbinterleukin 2 receptor, beta chain0.164
Sh2d1b1SH2 domain protein 1B10.160
Ccr1chemokine (C-C motif) receptor 10.158
Itm2bintegral membrane protein 2B0.154
Cd47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)0.151
Ciitaclass II transactivator0.133
Ubdubiquitin D0.131
C920025E04RikRIKEN cDNA C920025E04 gene0.128
Itga4integrin alpha 40.122
Nkg7natural killer cell group 7 sequence0.120
Sh2d2aSH2 domain protein 2A0.118
Slamf7SLAM family member 70.118
Jak2Janus kinase 20.116
H2-M3histocompatibility 2, M region locus 30.110
Il1rninterleukin 1 receptor antagonist0.106
Map3k8mitogen-activated protein kinase kinase kinase 80.104
Ms4a4bmembrane-spanning 4-domains, subfamily A, member 4B0.103
Aoahacyloxyacyl hydrolase0.102
Parp14poly (ADP-ribose) polymerase family, member 140.098
Ccl4chemokine (C-C motif) ligand 40.096
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.095
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.093
Lgals8lectin, galactose binding, soluble 80.093
Il18r1interleukin 18 receptor 10.093
FybFYN binding protein0.092
Klre1killer cell lectin-like receptor family E member 10.089
Il4rainterleukin 4 receptor, alpha0.088
C2complement component 2 (within H-2S)0.085
Il12rb1interleukin 12 receptor, beta 10.085
Cxcl5chemokine (C-X-C motif) ligand 50.085
Klra3killer cell lectin-like receptor, subfamily A, member 30.085
Il2interleukin 20.083
Klrb1fkiller cell lectin-like receptor subfamily B member 1F0.082
Trim21tripartite motif-containing 210.082
Selpselectin, platelet0.080
F2rl2coagulation factor II (thrombin) receptor-like 20.080
Klra2killer cell lectin-like receptor, subfamily A, member 20.079
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.075
Cd7CD7 antigen0.074
Ctla4cytotoxic T-lymphocyte-associated protein 40.074
Irg1immunoresponsive gene 10.073
Mcpt8mast cell protease 80.070
H2-Blhistocompatibility 2, blastocyst0.070
Ccl3chemokine (C-C motif) ligand 30.069
Plbd2phospholipase B domain containing 20.069
Latlinker for activation of T cells0.069
Ctsbcathepsin B0.068
H2-M2histocompatibility 2, M region locus 20.066
TxkTXK tyrosine kinase0.066
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism