The network for 'natural killer cell activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

natural killer cell activation involved in immune response

The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GBAglucosidase, beta, acid0.878
GNSglucosamine (N-acetyl)-6-sulfatase0.783
SNAP23synaptosomal-associated protein, 23kDa0.719
MLPHmelanophilin0.227
RABEP1rabaptin, RAB GTPase binding effector protein 10.156
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.080
CCNKcyclin K0.063
IFNA4interferon, alpha 40.060
NCSTNnicastrin0.060
RAB14RAB14, member RAS oncogene family0.059
IFNA16interferon, alpha 160.055
IFNA17interferon, alpha 170.055
CLINT1clathrin interactor 10.052
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.047
SYNRGsynergin, gamma0.044
IFNA10interferon, alpha 100.041
TM9SF2transmembrane 9 superfamily member 20.040
RNF13ring finger protein 130.039
IFNA21interferon, alpha 210.038
IFNA14interferon, alpha 140.035
OCRLoculocerebrorenal syndrome of Lowe0.034
OSTM1osteopetrosis associated transmembrane protein 10.033
CREG1cellular repressor of E1A-stimulated genes 10.032
CTSAcathepsin A0.031
CTBSchitobiase, di-N-acetyl-0.030
MYO5Amyosin VA (heavy chain 12, myoxin)0.029
OSBPL11oxysterol binding protein-like 110.024
MFSD1major facilitator superfamily domain containing 10.024
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.023
SLMAPsarcolemma associated protein0.022
CYLC1cylicin, basic protein of sperm head cytoskeleton 10.022
NECAP1NECAP endocytosis associated 10.022
IFNA13interferon, alpha 130.021
LAMP1lysosomal-associated membrane protein 10.020
C6orf10chromosome 6 open reading frame 100.018
YTHDF3YTH domain family, member 30.018
IGF2Rinsulin-like growth factor 2 receptor0.016
LAPTM4Alysosomal protein transmembrane 4 alpha0.016
IFNA7interferon, alpha 70.015
CTAGE1cutaneous T-cell lymphoma-associated antigen 10.015
TGOLN2trans-golgi network protein 20.014
SPO11SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)0.014
TNFRSF21tumor necrosis factor receptor superfamily, member 210.013
CD46CD46 molecule, complement regulatory protein0.013
OR2B2olfactory receptor, family 2, subfamily B, member 20.013
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.013
OR52A1olfactory receptor, family 52, subfamily A, member 10.013
SEC22BSEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)0.013
HTN1histatin 10.013
ARL6IP5ADP-ribosylation-like factor 6 interacting protein 50.013
PGCPplasma glutamate carboxypeptidase0.012
IFNA5interferon, alpha 50.012
LEPROTleptin receptor overlapping transcript0.012
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.012
PSEN1presenilin 10.012
SLC31A2solute carrier family 31 (copper transporters), member 20.012
TAS2R16taste receptor, type 2, member 160.012
STATHstatherin0.012
TAS2R7taste receptor, type 2, member 70.012
TMC6transmembrane channel-like 60.012
CDK5RAP3CDK5 regulatory subunit associated protein 30.012
CLDN17claudin 170.012
AFMafamin0.012
MAGT1magnesium transporter 10.012
LECT2leukocyte cell-derived chemotaxin 20.011
TAF6LTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa0.011
KRTAP4-7keratin associated protein 4-70.011
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.011
IL13RA1interleukin 13 receptor, alpha 10.011
LUZP4leucine zipper protein 40.011
IL21interleukin 210.011
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.011
RRHretinal pigment epithelium-derived rhodopsin homolog0.011
RAB9ARAB9A, member RAS oncogene family0.011
TAS2R8taste receptor, type 2, member 80.010
ANXA4annexin A40.010
SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 10.010
OR6A2olfactory receptor, family 6, subfamily A, member 20.010
SYTL1synaptotagmin-like 10.010
COLEC10collectin sub-family member 10 (C-type lectin)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sytl5synaptotagmin-like 50.984
Rab27aRAB27A, member RAS oncogene family0.975
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.930
Stx11syntaxin 110.853
Mlphmelanophilin0.829
Prf1perforin 1 (pore forming protein)0.785
Ctsbcathepsin B0.698
Lystlysosomal trafficking regulator0.509
Ctsdcathepsin D0.349
anonagouti0.311
Plbd2phospholipase B domain containing 20.306
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.245
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.199
Stat1signal transducer and activator of transcription 10.148
Sprr2ksmall proline-rich protein 2K0.147
Ifna2interferon alpha 20.135
Ifna1interferon alpha 10.106
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.099
Ifna12interferon alpha 120.085
Adam1aa disintegrin and metallopeptidase domain 1a0.084
Ap1m1adaptor-related protein complex AP-1, mu subunit 10.062
Lamp2lysosomal-associated membrane protein 20.056
Smr3asubmaxillary gland androgen regulated protein 3A0.055
Pla2g1bphospholipase A2, group IB, pancreas0.055
Sprr2ismall proline-rich protein 2I0.049
Hps6Hermansky-Pudlak syndrome 60.046
Ifnabinterferon alpha B0.046
Grngranulin0.046
Prp2proline rich protein 20.043
Pldnpallidin0.043
Chiachitinase, acidic0.041
Tshbthyroid stimulating hormone, beta subunit0.038
Ifna9interferon alpha 90.038
Gm12597predicted gene 125970.037
Sytl3synaptotagmin-like 30.035
Tspo2translocator protein 20.031
Hexahexosaminidase A0.029
Zanzonadhesin0.027
Atp6v0cATPase, H+ transporting, lysosomal V0 subunit C0.027
Pax4paired box gene 40.027
Itgb2lintegrin beta 2-like0.026
Omt2boocyte maturation, beta0.026
Klk1b1kallikrein 1-related peptidase b10.026
Igf2rinsulin-like growth factor 2 receptor0.025
Itln1intelectin 1 (galactofuranose binding)0.024
Csn1s1casein alpha s10.024
Prlprolactin0.022
Gabra6gamma-aminobutyric acid (GABA) A receptor, subunit alpha 60.020
Tcn2transcobalamin 20.020
Reg3gregenerating islet-derived 3 gamma0.019
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.019
Mbl1mannose-binding lectin (protein A) 10.018
Akr1a4aldo-keto reductase family 1, member A4 (aldehyde reductase)0.017
Sprr2dsmall proline-rich protein 2D0.017
Cand1cullin associated and neddylation disassociated 10.017
Olfr49olfactory receptor 490.017
Prl8a6prolactin family 8, subfamily a, member 60.016
Mpomyeloperoxidase0.016
Gckglucokinase0.015
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.015
Agap2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.015
Vpreb1pre-B lymphocyte gene 10.015
Nr6a1nuclear receptor subfamily 6, group A, member 10.014
Olfr1509olfactory receptor 15090.014
Vmn1r13vomeronasal 1 receptor 130.014
Car1carbonic anhydrase 10.013
Ostm1osteopetrosis associated transmembrane protein 10.013
Sox14SRY-box containing gene 140.012
Ngpneutrophilic granule protein0.012
Pigrpolymeric immunoglobulin receptor0.012
Ctsgcathepsin G0.012
Gp1baglycoprotein 1b, alpha polypeptide0.012
Muc13mucin 13, epithelial transmembrane0.012
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.012
Lcn2lipocalin 20.012
Pde6gphosphodiesterase 6G, cGMP-specific, rod, gamma0.011
Galr3galanin receptor 30.011
Gm12185predicted gene 121850.011
Hcsthematopoietic cell signal transducer0.011
Rab37RAB37, member of RAS oncogene family0.011
Slc2a8solute carrier family 2, (facilitated glucose transporter), member 80.011
Crygdcrystallin, gamma D0.011
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.011
Cst7cystatin F (leukocystatin)0.011
Cltcclathrin, heavy polypeptide (Hc)0.011
G6pd2glucose-6-phosphate dehydrogenase 20.011
Tcl1b3T-cell leukemia/lymphoma 1B, 30.011
Acppacid phosphatase, prostate0.011
RragcRas-related GTP binding C0.010
Spi15serine protease inhibitor 150.010
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.010
Gnsglucosamine (N-acetyl)-6-sulfatase0.010
Ctsacathepsin A0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism