The network for 'artery smooth muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

artery smooth muscle contraction

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.

NameDescriptionProbabilityFunc Analog Organism
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.794
Ahsgalpha-2-HS-glycoprotein0.394
Apohapolipoprotein H (beta-2-glycoprotein I)0.303
Albalbumin0.288
Rup2urinary protein 20.211
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.207
RGD1565859RGD15658590.155
LOC299282Serine protease inhibitor0.140
Agxt2alanine-glyoxylate aminotransferase 20.126
Apoa5apolipoprotein A-V0.123
Prss2protease, serine, 20.113
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.112
A3galt2alpha 1,3-galactosyltransferase 20.110
Il1rninterleukin 1 receptor antagonist0.110
Procprotein C0.109
Cgaglycoprotein hormones, alpha polypeptide0.105
Phkg1phosphorylase kinase, gamma 10.098
Apcsamyloid P component, serum0.096
Gucy2fguanylate cyclase 2F0.094
Olr1413olfactory receptor 14130.093
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.092
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.081
Nrg1neuregulin 10.079
Sftpa1surfactant protein A10.077
Tacr2tachykinin receptor 20.073
Cpb1carboxypeptidase B1 (tissue)0.069
Esr1estrogen receptor 10.067
Spink1serine peptidase inhibitor, Kazal type 10.064
RorbRAR-related orphan receptor B0.061
Olr416olfactory receptor 4160.061
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.061
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.060
Figfc-fos induced growth factor0.059
Smad3SMAD family member 30.056
Syt8synaptotagmin VIII0.055
Cxcr5chemokine (C-X-C motif) receptor 50.054
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.054
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.050
Gng7guanine nucleotide binding protein (G protein), gamma 70.050
Agtr1aangiotensin II receptor, type 1a0.050
Fosl1fos-like antigen 10.047
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.047
Gcgroup specific component0.046
Lifleukemia inhibitory factor0.046
Pemtphosphatidylethanolamine N-methyltransferase0.045
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.043
Dmgdhdimethylglycine dehydrogenase0.043
Adra2cadrenergic, alpha-2C-, receptor0.043
Tnp2transition protein 20.043
Lsm6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.042
Csf3colony stimulating factor 3 (granulocyte)0.039
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.039
Oprd1opioid receptor, delta 10.039
Ttc36tetratricopeptide repeat domain 360.038
C8bcomplement component 8, beta polypeptide0.038
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.038
Pla2g5phospholipase A2, group V0.038
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.038
Testintestin gene0.038
Apoa2apolipoprotein A-II0.038
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.037
Hipk3homeodomain interacting protein kinase 30.036
Serpinb5serpin peptidase inhibitor, clade B (ovalbumin), member 50.036
Azgp1alpha-2-glycoprotein 1, zinc-binding0.036
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.035
Hnmthistamine N-methyltransferase0.035
Mchr1melanin-concentrating hormone receptor 10.035
Fgf14fibroblast growth factor 140.034
Pdha2pyruvate dehydrogenase (lipoamide) alpha 20.034
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.033
Pcsk1proprotein convertase subtilisin/kexin type 10.033
Ccr2chemokine (C-C motif) receptor 20.033
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.033
Igf2insulin-like growth factor 20.031
Gria1glutamate receptor, ionotropic, AMPA 10.030
Pde1bphosphodiesterase 1B, calmodulin-dependent0.030
Ngfnerve growth factor (beta polypeptide)0.030
Vcsa1variable coding sequence A10.030
Asgr2asialoglycoprotein receptor 20.029
Grm6glutamate receptor, metabotropic 60.029
Galgalanin prepropeptide0.028
Necab1N-terminal EF-hand calcium binding protein 10.028
Col10a1collagen, type X, alpha 10.028
Kiss1rKISS1 receptor0.028
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.027
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.027
Odf4outer dense fiber of sperm tails 40.027
Aqp8aquaporin 80.027
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.027
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.026
Bhlha15basic helix-loop-helix family, member a150.026
Foxi2forkhead box I20.026
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.026
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.026
Kynukynureninase (L-kynurenine hydrolase)0.026
Fabp1fatty acid binding protein 1, liver0.026
Gjb5gap junction protein, beta 50.026
Smosmoothened homolog (Drosophila)0.025
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.025
Afpalpha-fetoprotein0.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
UBQLN4ubiquilin 40.478
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.410
EDN1endothelin 10.313
PIP4K2Bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.210
GKAP1G kinase anchoring protein 10.166
CAV1caveolin 1, caveolae protein, 22kDa0.139
SPARCL1SPARC-like 1 (hevin)0.118
CEND1cell cycle exit and neuronal differentiation 10.108
MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 60.096
EDNRAendothelin receptor type A0.093
DCNdecorin0.085
PTNpleiotrophin0.081
PAX2paired box 20.075
RGS4regulator of G-protein signaling 40.070
CAV2caveolin 20.065
COL4A1collagen, type IV, alpha 10.057
ITPRIPL1inositol 1,4,5-trisphosphate receptor interacting protein-like 10.052
PCDH17protocadherin 170.051
GABRDgamma-aminobutyric acid (GABA) A receptor, delta0.048
EGR4early growth response 40.044
CCDC134coiled-coil domain containing 1340.042
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.041
COL8A1collagen, type VIII, alpha 10.038
ROBO2roundabout, axon guidance receptor, homolog 2 (Drosophila)0.037
ZNF205zinc finger protein 2050.037
SLC1A6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.036
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.036
AGTR1angiotensin II receptor, type 10.035
SCAF1SR-related CTD-associated factor 10.035
HK2hexokinase 20.034
SFRP1secreted frizzled-related protein 10.034
ZG16Bzymogen granule protein 16 homolog B (rat)0.034
ANKRD13Dankyrin repeat domain 13 family, member D0.033
ELTD1EGF, latrophilin and seven transmembrane domain containing 10.033
SCG2secretogranin II0.032
CDH5cadherin 5, type 2 (vascular endothelium)0.031
SPAG8sperm associated antigen 80.031
NPPAnatriuretic peptide A0.031
ERP27endoplasmic reticulum protein 270.031
SCG5secretogranin V (7B2 protein)0.030
ACCN1amiloride-sensitive cation channel 1, neuronal0.030
PICK1protein interacting with PRKCA 10.029
FKBP2FK506 binding protein 2, 13kDa0.029
CDH6cadherin 6, type 2, K-cadherin (fetal kidney)0.027
MCHR1melanin-concentrating hormone receptor 10.027
ADAM33ADAM metallopeptidase domain 330.027
LPPR4lipid phosphate phosphatase-related protein type 40.027
NPHP1nephronophthisis 1 (juvenile)0.026
EDNRBendothelin receptor type B0.026
CCDC14coiled-coil domain containing 140.026
HRKharakiri, BCL2 interacting protein (contains only BH3 domain)0.026
VGFVGF nerve growth factor inducible0.025
ASPNasporin0.024
NELL1NEL-like 1 (chicken)0.024
NID1nidogen 10.024
NOTCH2NLnotch 2 N-terminal like0.024
ENPEPglutamyl aminopeptidase (aminopeptidase A)0.024
VIPvasoactive intestinal peptide0.022
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.022
KLHDC5kelch domain containing 50.022
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.022
WNT7Awingless-type MMTV integration site family, member 7A0.022
CDHR5cadherin-related family member 50.021
JPH3junctophilin 30.021
PCDH8protocadherin 80.020
FABP7fatty acid binding protein 7, brain0.020
CALYcalcyon neuron-specific vesicular protein0.020
LASS1LAG1 homolog, ceramide synthase 10.020
NTRK3neurotrophic tyrosine kinase, receptor, type 30.020
THY1Thy-1 cell surface antigen0.020
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.019
FBXL7F-box and leucine-rich repeat protein 70.019
CD93CD93 molecule0.019
LBX1ladybird homeobox 10.019
KRT14keratin 140.019
NPYneuropeptide Y0.019
ELF5E74-like factor 5 (ets domain transcription factor)0.019
NPY2Rneuropeptide Y receptor Y20.018
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.018
TRILTLR4 interactor with leucine-rich repeats0.018
ECM2extracellular matrix protein 2, female organ and adipocyte specific0.018
ZG16zymogen granule protein 16 homolog (rat)0.018
RGS5regulator of G-protein signaling 50.018
PRRX1paired related homeobox 10.018
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.017
CNTFRciliary neurotrophic factor receptor0.017
HAVCR1hepatitis A virus cellular receptor 10.017
FGF18fibroblast growth factor 180.017
IL33interleukin 330.017
IGF1insulin-like growth factor 1 (somatomedin C)0.016
LRRN2leucine rich repeat neuronal 20.016
TM4SF1transmembrane 4 L six family member 10.016
KCNJ8potassium inwardly-rectifying channel, subfamily J, member 80.016
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.016
NKX2-8NK2 homeobox 80.016
GJA1gap junction protein, alpha 1, 43kDa0.015
HCN2hyperpolarization activated cyclic nucleotide-gated potassium channel 20.015
KIF1Akinesin family member 1A0.015
CALCAcalcitonin-related polypeptide alpha0.015
GPX7glutathione peroxidase 70.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bbs4Bardet-Biedl syndrome 4 (human)0.637
Acvr1activin A receptor, type 10.513
Ece1endothelin converting enzyme 10.461
Vegfavascular endothelial growth factor A0.272
Prrx1paired related homeobox 10.261
Rargretinoic acid receptor, gamma0.175
Agtr1aangiotensin II receptor, type 1a0.086
Sox9SRY-box containing gene 90.081
Prrx2paired related homeobox 20.077
Tbx1T-box 10.074
Eya1eyes absent 1 homolog (Drosophila)0.069
Rarbretinoic acid receptor, beta0.067
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.066
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.053
Foxi3forkhead box I30.048
Foxc2forkhead box C20.048
Tgfb2transforming growth factor, beta 20.041
Bbs9Bardet-Biedl syndrome 9 (human)0.038
Fgfr1fibroblast growth factor receptor 10.037
Bbs1Bardet-Biedl syndrome 1 (human)0.036
Smosmoothened homolog (Drosophila)0.035
Bmp4bone morphogenetic protein 40.034
Foxc1forkhead box C10.033
Ren1renin 1 structural0.029
Hoxa3homeobox A30.027
Hand2heart and neural crest derivatives expressed transcript 20.025
Nrp1neuropilin 10.021
Rararetinoic acid receptor, alpha0.017
Plxnd1plexin D10.017
Ednraendothelin receptor type A0.014
Tcfap2atranscription factor AP-2, alpha0.014
Pbx1pre B-cell leukemia transcription factor 10.014
Arl6ADP-ribosylation factor-like 60.013
Hoxa1homeobox A10.012
Mkl2MKL/myocardin-like 20.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism