The network for 'twitch skeletal muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

twitch skeletal muscle contraction

A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation.

NameDescriptionProbabilityFunc Analog Organism
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.489
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.477
Myh7myosin, heavy chain 7, cardiac muscle, beta0.343
Actc1actin, alpha, cardiac muscle 10.330
Pgam2phosphoglycerate mutase 2 (muscle)0.257
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.251
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.204
Ckmcreatine kinase, muscle0.148
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.145
Actn2actinin alpha 20.135
Cox8bcytochrome c oxidase, subunit VIIIb0.087
Mybpc1myosin binding protein C, slow type0.078
Myoz2myozenin 20.068
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.066
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.060
Casq2calsequestrin 2 (cardiac muscle)0.055
Trim54tripartite motif-containing 540.048
Tnni2troponin I type 2 (skeletal, fast)0.048
Myom1myomesin 10.041
Acta1actin, alpha 1, skeletal muscle0.040
Myh2myosin, heavy chain 2, skeletal muscle, adult0.038
Tnni3troponin I type 3 (cardiac)0.030
Rpl3lribosomal protein L3-like0.030
Hspb2heat shock protein beta 20.028
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.026
Csrp3cysteine and glycine-rich protein 30.026
Myl1myosin, light chain 10.026
Cav3caveolin 30.022
Car3carbonic anhydrase 30.017
Cacng1calcium channel, voltage-dependent, gamma subunit 10.016
Capn3calpain 30.015
Fabp3fatty acid binding protein 3, muscle and heart0.014
Amhanti-Mullerian hormone0.014
Tnnc1troponin C type 1 (slow)0.011
LOC100360919Immunoglobulin lambda-like polypeptide 1-like0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myhz2myosin, heavy polypeptide 2, fast muscle specific0.998
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.979
myhc4myosin heavy chain 40.819
tnnc1btroponin C type 1b (slow)0.796
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.783
smyd1bSET and MYND domain containing 1b0.571
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.470
actn3aactinin alpha 3a0.470
myf6myogenic factor 60.440
tnni1altroponin I, skeletal, slow like0.429
mylz2myosin, light polypeptide 2, skeletal muscle0.342
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.218
smyhc1slow myosin heavy chain 10.178
tnni2a.4troponin I, skeletal, fast 2a.40.170
ryr1bryanodine receptor 1b (skeletal)0.165
tnnt1troponin T1, skeletal, slow0.122
actn3bactinin alpha 3b0.111
smyhc2slow myosin heavy chain 20.105
lamb2laminin, beta 2 (laminin S)0.080
ryr3ryanodine receptor 30.059
tnnt3atroponin T3a, skeletal, fast0.057
vgll2bvestigial like 2b0.056
hsp90a.1heat shock protein 90-alpha 10.054
tnni1btroponin I, skeletal, slow b0.054
lama2laminin, alpha 20.053
tnnt3btroponin T3b, skeletal, fast0.039
myl1myosin, light chain 1, alkali; skeletal, fast0.031
actn2actinin, alpha 20.031
ryr1aryanodine receptor 1a (skeletal)0.029
lbx2ladybird homeobox homolog 2 (Drosophila)0.024
smyhc1lslow myosin heavy chain 1, like0.023
stac3SH3 and cysteine rich domain 30.023
smyhc3slow myosin heavy chain 30.021
flncbfilamin C, gamma b (actin binding protein 280)0.020
tpm2tropomyosin 2 (beta)0.016
flncafilamin C, gamma a (actin binding protein 280)0.016
pdlim5PDZ and LIM domain 50.016
ckmt2creatine kinase, mitochondrial 2 (sarcomeric)0.013
ckmacreatine kinase, muscle a0.013
popdc2popeye domain containing 20.013
tnnc2troponin C type 2 (fast)0.012
acta1bactin, alpha 1b, skeletal muscle0.012
LOC566040protein notum homolog0.011
jam2ajunctional adhesion molecule 2a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TNNI1troponin I type 1 (skeletal, slow)0.924
TNNC1troponin C type 1 (slow)0.916
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.532
TRIM63tripartite motif containing 630.336
TNNT3troponin T type 3 (skeletal, fast)0.283
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.207
MYH7myosin, heavy chain 7, cardiac muscle, beta0.197
ACTA1actin, alpha 1, skeletal muscle0.176
ACTN2actinin, alpha 20.161
MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow0.157
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.154
CKMcreatine kinase, muscle0.132
TNNI2troponin I type 2 (skeletal, fast)0.125
LDB3LIM domain binding 30.120
MYL2myosin, light chain 2, regulatory, cardiac, slow0.117
TNNC2troponin C type 2 (fast)0.076
MYBPC1myosin binding protein C, slow type0.070
ACTN3actinin, alpha 30.058
MYBPC2myosin binding protein C, fast type0.057
MYOZ1myozenin 10.053
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.042
TNNT2troponin T type 2 (cardiac)0.040
TCAPtitin-cap (telethonin)0.039
SRPK3SRSF protein kinase 30.036
MYL4myosin, light chain 4, alkali; atrial, embryonic0.033
MYOZ2myozenin 20.032
CLCN1chloride channel 1, skeletal muscle0.027
SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)0.027
MYH1myosin, heavy chain 1, skeletal muscle, adult0.026
TNNI3troponin I type 3 (cardiac)0.024
CAV3caveolin 30.024
OSBP2oxysterol binding protein 20.023
FBP2fructose-1,6-bisphosphatase 20.023
PYGMphosphorylase, glycogen, muscle0.022
MYL1myosin, light chain 1, alkali; skeletal, fast0.021
PGAM2phosphoglycerate mutase 2 (muscle)0.018
TMEM98transmembrane protein 980.017
MYH2myosin, heavy chain 2, skeletal muscle, adult0.015
RPL3Lribosomal protein L3-like0.015
PLEKHF1pleckstrin homology domain containing, family F (with FYVE domain) member 10.015
CASQ1calsequestrin 1 (fast-twitch, skeletal muscle)0.014
HRChistidine rich calcium binding protein0.013
RAPSNreceptor-associated protein of the synapse0.013
HAP1huntingtin-associated protein 10.013
TNNT1troponin T type 1 (skeletal, slow)0.012
RYR1ryanodine receptor 1 (skeletal)0.012
ZNF768zinc finger protein 7680.012
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.011
CA3carbonic anhydrase III, muscle specific0.011
ACTC1actin, alpha, cardiac muscle 10.011
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.011
ANK1ankyrin 1, erythrocytic0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism