The network for 'negative regulation of cd4 positive alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cd4 positive alpha beta t cell activation

Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CCR5chemokine (C-C motif) receptor 50.999
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.995
CCL4chemokine (C-C motif) ligand 40.946
IL8interleukin 80.896
IL2RGinterleukin 2 receptor, gamma0.881
CCL2chemokine (C-C motif) ligand 20.730
CXCL9chemokine (C-X-C motif) ligand 90.725
CCL13chemokine (C-C motif) ligand 130.588
DPP4dipeptidyl-peptidase 40.498
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.460
IL1Binterleukin 1, beta0.388
IDEinsulin-degrading enzyme0.382
CCR7chemokine (C-C motif) receptor 70.382
CCL8chemokine (C-C motif) ligand 80.340
CCL22chemokine (C-C motif) ligand 220.227
CCL5chemokine (C-C motif) ligand 50.227
IL7Rinterleukin 7 receptor0.206
CCR1chemokine (C-C motif) receptor 10.192
IL6interleukin 6 (interferon, beta 2)0.186
CXCL2chemokine (C-X-C motif) ligand 20.163
CXCL10chemokine (C-X-C motif) ligand 100.160
CCR4chemokine (C-C motif) receptor 40.148
CXCL3chemokine (C-X-C motif) ligand 30.134
CCL11chemokine (C-C motif) ligand 110.129
CXCL13chemokine (C-X-C motif) ligand 130.124
CCL3chemokine (C-C motif) ligand 30.121
CXCL11chemokine (C-X-C motif) ligand 110.117
CCL7chemokine (C-C motif) ligand 70.107
SOCS3suppressor of cytokine signaling 30.094
VCAM1vascular cell adhesion molecule 10.089
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.082
CCL19chemokine (C-C motif) ligand 190.080
PCDH9protocadherin 90.078
SIN3ASIN3 homolog A, transcription regulator (yeast)0.076
SELEselectin E0.073
TNFtumor necrosis factor0.065
CD40CD40 molecule, TNF receptor superfamily member 50.061
CD83CD83 molecule0.060
RGS1regulator of G-protein signaling 10.060
ICAM1intercellular adhesion molecule 10.059
NCOR2nuclear receptor corepressor 20.058
TNFAIP3tumor necrosis factor, alpha-induced protein 30.056
FPR3formyl peptide receptor 30.055
TNFRSF9tumor necrosis factor receptor superfamily, member 90.053
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.052
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.052
IL10interleukin 100.049
AKT2v-akt murine thymoma viral oncogene homolog 20.047
ATP2B1ATPase, Ca++ transporting, plasma membrane 10.046
CH25Hcholesterol 25-hydroxylase0.045
MAP4K3mitogen-activated protein kinase kinase kinase kinase 30.044
IFNGinterferon, gamma0.042
DARCDuffy blood group, chemokine receptor0.041
EBI3Epstein-Barr virus induced 30.041
ARRB1arrestin, beta 10.041
IL1RNinterleukin 1 receptor antagonist0.040
MMP12matrix metallopeptidase 12 (macrophage elastase)0.039
HDAC9histone deacetylase 90.039
IL13interleukin 130.038
IRF4interferon regulatory factor 40.038
EPORerythropoietin receptor0.037
CXCL5chemokine (C-X-C motif) ligand 50.037
IL18RAPinterleukin 18 receptor accessory protein0.036
CCR3chemokine (C-C motif) receptor 30.033
IL2RBinterleukin 2 receptor, beta0.032
HDAC5histone deacetylase 50.032
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.031
CCL21chemokine (C-C motif) ligand 210.030
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.030
INHBAinhibin, beta A0.029
IL3interleukin 3 (colony-stimulating factor, multiple)0.029
MSCmusculin0.028
CCL3L3chemokine (C-C motif) ligand 3-like 30.027
PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)0.027
CCL17chemokine (C-C motif) ligand 170.026
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.026
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.026
ZC3H12Azinc finger CCCH-type containing 12A0.025
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.024
NR4A3nuclear receptor subfamily 4, group A, member 30.024
XCL2chemokine (C motif) ligand 20.024
CSF1colony stimulating factor 1 (macrophage)0.023
XCL1chemokine (C motif) ligand 10.023
CD69CD69 molecule0.023
KDM2Alysine (K)-specific demethylase 2A0.023
STAT4signal transducer and activator of transcription 40.022
IL1R2interleukin 1 receptor, type II0.022
CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)0.021
LAMP3lysosomal-associated membrane protein 30.021
UBDubiquitin D0.020
IDO1indoleamine 2,3-dioxygenase 10.020
BATFbasic leucine zipper transcription factor, ATF-like0.020
CCL1chemokine (C-C motif) ligand 10.020
CCL20chemokine (C-C motif) ligand 200.019
NNMTnicotinamide N-methyltransferase0.018
BCL2A1BCL2-related protein A10.018
RGS16regulator of G-protein signaling 160.018
DDX6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.017
SLAMF8SLAM family member 80.017
GADD45Bgrowth arrest and DNA-damage-inducible, beta0.017
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.938
Stat3signal transducer and activator of transcription 30.815
Rc3h1RING CCCH (C3H) domains 10.799
Leprleptin receptor0.623
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.615
FasFas (TNF receptor superfamily member 6)0.505
Jak2Janus kinase 20.448
Stat5asignal transducer and activator of transcription 5A0.328
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.298
Stat6signal transducer and activator of transcription 60.206
Socs1suppressor of cytokine signaling 10.192
Socs3suppressor of cytokine signaling 30.162
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.122
Bcl3B-cell leukemia/lymphoma 30.117
Cishcytokine inducible SH2-containing protein0.095
Il6stinterleukin 6 signal transducer0.092
Ifnginterferon gamma0.091
Foxp3forkhead box P30.051
Cul5cullin 50.046
Il4rainterleukin 4 receptor, alpha0.045
Prdm1PR domain containing 1, with ZNF domain0.041
Map3k14mitogen-activated protein kinase kinase kinase 140.040
Socs2suppressor of cytokine signaling 20.034
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.034
Tnftumor necrosis factor0.034
Batfbasic leucine zipper transcription factor, ATF-like0.033
Rc3h2ring finger and CCCH-type zinc finger domains 20.030
Sh2b1SH2B adaptor protein 10.029
Creb1cAMP responsive element binding protein 10.024
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.024
Arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.023
Ptprcprotein tyrosine phosphatase, receptor type, C0.023
Pim1proviral integration site 10.022
Tnip1TNFAIP3 interacting protein 10.019
Il3rainterleukin 3 receptor, alpha chain0.019
Hhexhematopoietically expressed homeobox0.018
Il6interleukin 60.018
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.018
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.018
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.017
Mipol1mirror-image polydactyly gene 1 homolog (human)0.017
Cd80CD80 antigen0.017
Rag1recombination activating gene 10.017
2310014H01RikRIKEN cDNA 2310014H01 gene0.015
Csf1rcolony stimulating factor 1 receptor0.015
Socs5suppressor of cytokine signaling 50.015
Cd40lgCD40 ligand0.014
Plcg1phospholipase C, gamma 10.014
Ebf3early B-cell factor 30.013
Zfp61zinc finger protein 610.012
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.011
Ifngr2interferon gamma receptor 20.011
Dppa5adevelopmental pluripotency associated 5A0.011
Il2interleukin 20.011
Wdr26WD repeat domain 260.011
Zbtb37zinc finger and BTB domain containing 370.010
Robo3roundabout homolog 3 (Drosophila)0.010
Cd40CD40 antigen0.010
4933426M11RikRIKEN cDNA 4933426M11 gene0.010
Il4interleukin 40.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism