The network for 'positive regulation of protein binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein binding

Any process that activates or increases the frequency, rate or extent of protein binding.

NameDescriptionProbabilityFunc Analog Organism
Hsph1heat shock 105/110 protein 10.993
Stip1stress-induced phosphoprotein 10.899
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.869
Hspa8heat shock protein 80.770
Hspd1heat shock protein 1 (chaperonin)0.569
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.142
St13suppression of tumorigenicity 130.113
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.105
Rhoaras homolog gene family, member A0.039
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.036
Rabac1Rab acceptor 1 (prenylated)0.029
Ttc33tetratricopeptide repeat domain 330.028
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.028
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.026
Arf1ADP-ribosylation factor 10.023
Picalmphosphatidylinositol binding clathrin assembly protein0.023
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.022
Prkar1aprotein kinase, cAMP-dependent, regulatory, type I, alpha0.022
Rab7aRAB7A, member RAS oncogene family0.018
Bmpr2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.016
Vps41vacuolar protein sorting 41 homolog (S. cerevisiae)0.016
Ptafrplatelet-activating factor receptor0.016
Prdx6peroxiredoxin 60.015
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.014
Icam2intercellular adhesion molecule 20.013
Skp1S-phase kinase-associated protein 10.012
Sptbn1spectrin, beta, non-erythrocytic 10.012
Ptgfrnprostaglandin F2 receptor negative regulator0.012
Actg1actin, gamma 10.011
Arid5bAT rich interactive domain 5B (Mrf1 like)0.011
Plcg1phospholipase C, gamma 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
howheld out wings0.021
hipkhomeodomain interacting protein kinase0.017
Gprk2G protein-coupled receptor kinase 20.014
Cdlc2Cytoplasmic dynein light chain 20.014
Gef26CG9491 gene product from transcript CG9491-RB0.013
CG4168CG4168 gene product from transcript CG4168-RA0.013
Apc2Adenomatous polyposis coli tumor suppressor homolog 20.012
Smg5CG8954 gene product from transcript CG8954-RA0.012
CG1347CG1347 gene product from transcript CG1347-RB0.012
elavembryonic lethal abnormal vision0.012
Nrx-IVNeurexin IV0.011
aPKCatypical protein kinase C0.010
AnceAngiotensin converting enzyme0.010
ChcClathrin heavy chain0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.720
BMPR1Abone morphogenetic protein receptor, type IA0.572
ZNF260zinc finger protein 2600.540
CREBBPCREB binding protein0.337
IRAK2interleukin-1 receptor-associated kinase 20.318
BIRC3baculoviral IAP repeat containing 30.283
SPTBspectrin, beta, erythrocytic0.278
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.246
RIPK2receptor-interacting serine-threonine kinase 20.234
TICAM2toll-like receptor adaptor molecule 20.225
TRAF6TNF receptor-associated factor 60.224
IRAK1interleukin-1 receptor-associated kinase 10.222
ZMYND11zinc finger, MYND-type containing 110.209
SMURF1SMAD specific E3 ubiquitin protein ligase 10.207
STK3serine/threonine kinase 30.148
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.143
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.141
TERF1telomeric repeat binding factor (NIMA-interacting) 10.125
CD40CD40 molecule, TNF receptor superfamily member 50.124
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.115
MYD88myeloid differentiation primary response gene (88)0.106
PKD2polycystic kidney disease 2 (autosomal dominant)0.104
ZNF420zinc finger protein 4200.104
HOOK2hook homolog 2 (Drosophila)0.104
TCF4transcription factor 40.101
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 90.101
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.099
MAPRE2microtubule-associated protein, RP/EB family, member 20.093
SMAD3SMAD family member 30.091
TGFB1transforming growth factor, beta 10.090
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.090
LRP6low density lipoprotein receptor-related protein 60.089
HDAC4histone deacetylase 40.080
ZNF12zinc finger protein 120.079
SMAD7SMAD family member 70.072
SMAD1SMAD family member 10.072
STK4serine/threonine kinase 40.071
ACVR1Bactivin A receptor, type IB0.070
SELSselenoprotein S0.066
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.063
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.062
FZD1frizzled homolog 1 (Drosophila)0.059
RASSF5Ras association (RalGDS/AF-6) domain family member 50.057
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.057
ZNF83zinc finger protein 830.056
TRAF3TNF receptor-associated factor 30.054
RASSF1Ras association (RalGDS/AF-6) domain family member 10.052
ZNF432zinc finger protein 4320.051
PELI3pellino homolog 3 (Drosophila)0.047
ANK1ankyrin 1, erythrocytic0.047
ZNF84zinc finger protein 840.047
SPTBN1spectrin, beta, non-erythrocytic 10.046
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.046
HSPA8heat shock 70kDa protein 80.044
ZNF571zinc finger protein 5710.042
MTORmechanistic target of rapamycin (serine/threonine kinase)0.042
TRADDTNFRSF1A-associated via death domain0.042
RFX1regulatory factor X, 1 (influences HLA class II expression)0.041
FSTL1follistatin-like 10.041
MAVSmitochondrial antiviral signaling protein0.041
PSEN1presenilin 10.040
TNFRSF9tumor necrosis factor receptor superfamily, member 90.040
ZNF585Azinc finger protein 585A0.038
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.038
TGFBR1transforming growth factor, beta receptor 10.035
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.034
MMP12matrix metallopeptidase 12 (macrophage elastase)0.032
BIRC2baculoviral IAP repeat containing 20.031
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.031
SYVN1synovial apoptosis inhibitor 1, synoviolin0.031
RBM12BRNA binding motif protein 12B0.030
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.030
ATF5activating transcription factor 50.029
NUMBLnumb homolog (Drosophila)-like0.029
SAV1salvador homolog 1 (Drosophila)0.027
MBOAT7membrane bound O-acyltransferase domain containing 70.027
ZNF569zinc finger protein 5690.026
RASSF3Ras association (RalGDS/AF-6) domain family member 30.026
ARRB2arrestin, beta 20.026
ZNF529zinc finger protein 5290.025
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.025
LRP5low density lipoprotein receptor-related protein 50.025
EP300E1A binding protein p3000.025
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.024
SPAG9sperm associated antigen 90.024
HDAC9histone deacetylase 90.023
ING2inhibitor of growth family, member 20.023
FAM65Afamily with sequence similarity 65, member A0.023
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.023
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.023
AKT1v-akt murine thymoma viral oncogene homolog 10.023
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.023
RIN1Ras and Rab interactor 10.022
ABCC1ATP-binding cassette, sub-family C (CFTR/MRP), member 10.021
RAP1ARAP1A, member of RAS oncogene family0.021
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.021
ZFP30zinc finger protein 30 homolog (mouse)0.021
ARandrogen receptor0.021
SOD1superoxide dismutase 1, soluble0.021
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.501
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.320
Hdac7histone deacetylase 70.311
Arrb1arrestin, beta 10.268
Rargretinoic acid receptor, gamma0.207
Meox2mesenchyme homeobox 20.195
Dag1dystroglycan 10.195
Fgfr1fibroblast growth factor receptor 10.172
Atf4activating transcription factor 40.144
Inpp5dinositol polyphosphate-5-phosphatase D0.121
Axin1axin 10.113
Hdac4histone deacetylase 40.097
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.096
Spnb2spectrin beta 20.086
Mpripmyosin phosphatase Rho interacting protein0.085
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.080
Lrp6low density lipoprotein receptor-related protein 60.077
Macf1microtubule-actin crosslinking factor 10.074
Ptenphosphatase and tensin homolog0.068
SrcRous sarcoma oncogene0.063
Mef2dmyocyte enhancer factor 2D0.057
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.056
Arrb2arrestin, beta 20.052
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.050
Mdm2transformed mouse 3T3 cell double minute 20.043
Trp53transformation related protein 530.042
Lrp5low density lipoprotein receptor-related protein 50.042
Rassf5Ras association (RalGDS/AF-6) domain family member 50.041
Nrp1neuropilin 10.040
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.040
Ncoa1nuclear receptor coactivator 10.039
Kif3akinesin family member 3A0.038
Ctnnb1catenin (cadherin associated protein), beta 10.035
Plxna1plexin A10.035
Bmp7bone morphogenetic protein 70.034
Ifnar1interferon (alpha and beta) receptor 10.033
Mecp2methyl CpG binding protein 20.033
Foxo3forkhead box O30.032
Hdac5histone deacetylase 50.032
Fgfr2fibroblast growth factor receptor 20.032
Epb4.1l2erythrocyte protein band 4.1-like 20.032
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.031
Epn1epsin 10.030
Spnb1spectrin beta 10.030
Nf1neurofibromatosis 10.030
SnrkSNF related kinase0.029
Skiski sarcoma viral oncogene homolog (avian)0.029
Lamc1laminin, gamma 10.028
Smad3MAD homolog 3 (Drosophila)0.028
Gsk3aglycogen synthase kinase 3 alpha0.028
Add1adducin 1 (alpha)0.027
Ncoa2nuclear receptor coactivator 20.027
FynFyn proto-oncogene0.027
Phldb1pleckstrin homology-like domain, family B, member 10.026
DaxxFas death domain-associated protein0.026
Vegfavascular endothelial growth factor A0.026
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.026
Ncoa3nuclear receptor coactivator 30.025
Plcb3phospholipase C, beta 30.025
Rac1RAS-related C3 botulinum substrate 10.025
Sipa1signal-induced proliferation associated gene 10.025
Rock2Rho-associated coiled-coil containing protein kinase 20.025
Klf7Kruppel-like factor 7 (ubiquitous)0.024
Prkchprotein kinase C, eta0.024
Hivep1human immunodeficiency virus type I enhancer binding protein 10.023
Sos2son of sevenless homolog 2 (Drosophila)0.023
St3gal2ST3 beta-galactoside alpha-2,3-sialyltransferase 20.023
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.023
Cys1cystin 10.023
Fmnl3formin-like 30.022
Pnpla6patatin-like phospholipase domain containing 60.022
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.022
Rararetinoic acid receptor, alpha0.022
Cul9cullin 90.022
Vcpvalosin containing protein0.022
Fhl5four and a half LIM domains 50.022
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.021
Slc4a1solute carrier family 4 (anion exchanger), member 10.021
Hbb-b1hemoglobin, beta adult major chain0.021
Mef2cmyocyte enhancer factor 2C0.021
Flt1FMS-like tyrosine kinase 10.020
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.020
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.020
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.020
Ctdsp2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 20.020
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.020
Ctnnd1catenin (cadherin associated protein), delta 10.020
Ank1ankyrin 1, erythroid0.019
Gtf3c1general transcription factor III C 10.019
Arhgap21Rho GTPase activating protein 210.019
Dvl2dishevelled 2, dsh homolog (Drosophila)0.019
Epha4Eph receptor A40.019
Ednraendothelin receptor type A0.019
Mef2amyocyte enhancer factor 2A0.019
Timp2tissue inhibitor of metalloproteinase 20.019
Ptk2PTK2 protein tyrosine kinase 20.019
Smosmoothened homolog (Drosophila)0.019
Dennd5aDENN/MADD domain containing 5A0.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YNL115Chypothetical protein0.010