The network for 'response to amphetamine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to amphetamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.

NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.994
Nr4a3nuclear receptor subfamily 4, group A, member 30.893
FosFBJ osteosarcoma oncogene0.836
Nr4a1nuclear receptor subfamily 4, group A, member 10.772
Ccl2chemokine (C-C motif) ligand 20.589
Egr2early growth response 20.557
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.276
Btg2BTG family, member 20.205
Adora2aadenosine A2a receptor0.200
Egr1early growth response 10.175
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.148
Drd1adopamine receptor D1A0.142
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.120
Dlg4discs, large homolog 4 (Drosophila)0.112
Ier2immediate early response 20.087
Il6interleukin 60.086
Atf3activating transcription factor 30.072
Chrnb4cholinergic receptor, nicotinic, beta 40.069
Il1r2interleukin 1 receptor, type II0.068
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.068
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.067
Fosl1fos-like antigen 10.067
Irf1interferon regulatory factor 10.064
Gucy2dguanylate cyclase 2d0.064
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.060
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.059
Gng7guanine nucleotide binding protein (G protein), gamma 70.058
Arcactivity-regulated cytoskeleton-associated protein0.056
Ccl20chemokine (C-C motif) ligand 200.054
Cox8acytochrome c oxidase subunit VIIIa0.054
FevFEV (ETS oncogene family)0.054
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.051
Sub1SUB1 homolog (S. cerevisiae)0.051
Cd14CD14 molecule0.049
Nfascneurofascin0.049
Pou2f2POU class 2 homeobox 20.047
Shox2short stature homeobox 20.045
Zfp36zinc finger protein 360.044
Calm1calmodulin 10.042
Olr1082olfactory receptor 10820.041
Dusp1dual specificity phosphatase 10.041
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.041
Cdk5r2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.039
Ptgs2prostaglandin-endoperoxide synthase 20.039
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.039
Prrxl1paired related homeobox protein-like 10.038
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.037
Timp1TIMP metallopeptidase inhibitor 10.037
LOC60591calcium-activated potassium channel beta subunit0.037
Halhistidine ammonia lyase0.036
F2rl1coagulation factor II (thrombin) receptor-like 10.036
Il1binterleukin 1 beta0.036
Stmn1stathmin 10.035
Klra22killer cell lectin-like receptor subfamily A, member 220.035
Arpp21cAMP-regulated phosphoprotein 210.034
Map3k8mitogen-activated protein kinase kinase kinase 80.033
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.033
Cyr61cysteine-rich, angiogenic inducer, 610.033
Oprm1opioid receptor, mu 10.033
Tspan7tetraspanin 70.032
Calm2calmodulin 20.032
Mylk2myosin light chain kinase 20.031
Olr1278olfactory receptor 12780.031
Krtap1-5keratin associated protein 1-50.030
Cacng3calcium channel, voltage-dependent, gamma subunit 30.030
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.030
Socs3suppressor of cytokine signaling 30.030
Dlg3discs, large homolog 3 (Drosophila)0.030
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.029
Gpr6G protein-coupled receptor 60.029
Cxcl10chemokine (C-X-C motif) ligand 100.028
Mrfap1Mof4 family associated protein 10.028
Csf1colony stimulating factor 1 (macrophage)0.028
Clstn3calsyntenin 30.028
Reg3gregenerating islet-derived 3 gamma0.028
Shank1SH3 and multiple ankyrin repeat domains 10.028
Dlgap3discs, large (Drosophila) homolog-associated protein 30.028
Pdpnpodoplanin0.028
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.027
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.027
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.027
Dio2deiodinase, iodothyronine, type II0.027
Ifitm3interferon induced transmembrane protein 30.027
Nr4a2nuclear receptor subfamily 4, group A, member 20.027
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.027
Casrcalcium-sensing receptor0.026
Cpb1carboxypeptidase B1 (tissue)0.026
Prrx1paired related homeobox 10.026
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.026
Nrxn2neurexin 20.026
Col10a1collagen, type X, alpha 10.025
Tnp2transition protein 20.025
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.025
Kcnh4potassium voltage-gated channel, subfamily H (eag-related), member 40.025
Kcnb2potassium voltage gated channel, Shab-related subfamily, member 20.025
Thtyrosine hydroxylase0.025
Tbr1T-box, brain, 10.025
Dlgap2discs, large (Drosophila) homolog-associated protein 20.025
Apcsamyloid P component, serum0.024
Sisucrase-isomaltase (alpha-glucosidase)0.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
drd2adopamine receptor D2a0.762
drd2bdopamine receptor D2b0.716
drd2ldopamine receptor D2 like0.622
crhcorticotropin releasing hormone0.534
drd3dopamine receptor D30.504
maomonoamine oxidase0.477
uts1urotensin 10.471
amy2aamylase, alpha 2A; pancreatic0.402
nlgn1neuroligin 10.398
pcp4aPurkinje cell protein 4a0.385
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.283
cpa1carboxypeptidase A1 (pancreatic)0.247
slc5a5solute carrier family 5 (sodium iodide symporter), member 50.219
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.181
ucn3lurocortin 3, like0.173
ctrlchymotrypsin-like0.163
dab1adisabled homolog 1a (Drosophila)0.150
trytrypsin0.149
oprd1aopioid receptor, delta 1a0.142
ddcdopa decarboxylase0.133
relnreelin0.129
esrrgaestrogen-related receptor gamma a0.103
hcrtr2hypocretin (orexin) receptor 20.102
ncaphnon-SMC condensin I complex, subunit H0.101
nlgn3bneuroligin 3b0.099
ryr2aryanodine receptor 2a (cardiac)0.095
srd5a2asteroid-5-alpha-reductase, alpha polypeptide 2a0.094
dio2deiodinase, iodothyronine, type II0.084
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.084
zgc:110124zgc:1101240.083
pou4f2POU domain, class 4, transcription factor 20.077
otpaorthopedia homolog a0.076
LOC100007758novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)0.072
cadm2bcell adhesion molecule 2b0.071
zgc:92041zgc:920410.070
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.070
ywhag13-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 10.069
dhfrdihydrofolate reductase0.065
sst1.1somatostatin 1, tandem duplicate 10.063
LOC100006361galanin-like0.061
hoxc12bhomeo box C12b0.061
cnr1cannabinoid receptor 10.061
pkm2apyruvate kinase, muscle, a0.058
badBCL2-antagonist of cell death0.057
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.056
pcdh17protocadherin 170.056
apoa4apolipoprotein A-IV0.055
chia.2chitinase, acidic.20.055
esrrbestrogen-related receptor beta0.055
ctrb1chymotrypsinogen B10.054
tspotranslocator protein0.053
si:dkey-228g21.4si:dkey-228g21.40.053
si:ch211-209p5.2si:ch211-209p5.20.051
syt11asynaptotagmin XIa0.049
grm1aglutamate receptor, metabotropic 1a0.049
wu:fc51d09wu:fc51d090.049
sim1asingle-minded homolog 1a (Drosophila)0.048
crhbpcorticotropin releasing hormone binding protein0.047
ncam1bneural cell adhesion molecule 1b0.047
drd4adopamine receptor D4a0.047
cadm1bcell adhesion molecule 1b0.047
wu:fc18c07wu:fc18c070.046
cnga5cyclic nucleotide gated channel alpha 50.045
adcyap1r1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I0.045
eno3enolase 3, (beta, muscle)0.045
penkaproenkephalin a0.044
twf1btwinfilin, actin-binding protein, homolog 1b0.042
thtyrosine hydroxylase0.042
foxe1forkhead box E1 (thyroid transcription factor 2)0.041
aldocbaldolase C, fructose-bisphosphate, b0.041
lmx1aLIM homeobox transcription factor 1, alpha0.041
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.040
bdnfbrain-derived neurotrophic factor0.040
prlprolactin0.039
tbpTATA box binding protein0.039
si:dkey-24g18.2si:dkey-24g18.20.039
cpa4carboxypeptidase A40.039
rbp1bretinol binding protein 1b, cellular0.038
sagaS-antigen; retina and pineal gland (arrestin) a0.038
helthey-like transcription factor0.038
zgc:92745zgc:927450.038
gad1bglutamate decarboxylase 1b0.037
nxph1neurexophilin 10.036
agxtaalanine-glyoxylate aminotransferase a0.036
bhlha15basic helix-loop-helix family, member a150.036
nlgn2bneuroligin 2b0.036
tpi1btriosephosphate isomerase 1b0.035
ctsbacathepsin B, a0.035
arxaristaless related homeobox0.034
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.034
ela2lelastase 2 like0.034
grm5aglutamate receptor, metabotropic 5a0.034
chrna6cholinergic receptor, nicotinic, alpha 60.034
LOC568107Iodotyrosine dehalogenase 1-like0.034
zgc:77784zgc:777840.033
oxtloxytocin-like0.033
ifnphi1interferon phi 10.032
gsx1GS homeobox 10.032
mc4rmelanocortin 4 receptor0.032
lrrtm4l2leucine rich repeat transmembrane neuronal 4 like 20.032
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)1.000
Drd2dopamine receptor D20.994
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.937
Nos1nitric oxide synthase 1, neuronal0.866
Leprleptin receptor0.836
Pnpla2patatin-like phospholipase domain containing 20.736
Ptgs2prostaglandin-endoperoxide synthase 20.727
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.644
Ppargperoxisome proliferator activated receptor gamma0.606
Shc3src homology 2 domain-containing transforming protein C30.594
Cckbrcholecystokinin B receptor0.581
Sstr4somatostatin receptor 40.540
Nos2nitric oxide synthase 2, inducible0.520
FosFBJ osteosarcoma oncogene0.494
FosbFBJ osteosarcoma oncogene B0.494
Dlg4discs, large homolog 4 (Drosophila)0.475
Cav1caveolin 1, caveolae protein0.462
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.453
Ccl2chemokine (C-C motif) ligand 20.431
Lepleptin0.388
Adrb1adrenergic receptor, beta 10.248
Stat3signal transducer and activator of transcription 30.237
Cux2cut-like homeobox 20.235
Sstr1somatostatin receptor 10.233
JunbJun-B oncogene0.223
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.213
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.203
Dusp1dual specificity phosphatase 10.201
Arandrogen receptor0.192
Egr1early growth response 10.188
Prkccprotein kinase C, gamma0.186
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.166
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.159
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.142
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.135
Mmp9matrix metallopeptidase 90.134
Tgfb1transforming growth factor, beta 10.129
Grid1glutamate receptor, ionotropic, delta 10.121
Chrm1cholinergic receptor, muscarinic 1, CNS0.121
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.119
Ghrgrowth hormone receptor0.119
Sult4a1sulfotransferase family 4A, member 10.113
Hif1ahypoxia inducible factor 1, alpha subunit0.103
Cd44CD44 antigen0.102
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.097
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.095
Inpp5jinositol polyphosphate 5-phosphatase J0.093
Cacng2calcium channel, voltage-dependent, gamma subunit 20.089
Klklotho0.089
Gcgrglucagon receptor0.088
Srcin1SRC kinase signaling inhibitor 10.088
Chst2carbohydrate sulfotransferase 20.086
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.086
Slc12a5solute carrier family 12, member 50.082
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.080
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.080
Lin7blin-7 homolog B (C. elegans)0.079
Citcitron0.079
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.076
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.074
Thrbthyroid hormone receptor beta0.073
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.071
Grm2glutamate receptor, metabotropic 20.071
Sstr3somatostatin receptor 30.070
Adra1aadrenergic receptor, alpha 1a0.070
Syt7synaptotagmin VII0.069
Gpr83G protein-coupled receptor 830.068
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.067
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.067
Mbmyoglobin0.067
Thrathyroid hormone receptor alpha0.066
Cntnap1contactin associated protein-like 10.066
Atxn1ataxin 10.065
Bdkrb2bradykinin receptor, beta 20.064
Acracrosin prepropeptide0.064
Vdrvitamin D receptor0.064
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.063
Pgrprogesterone receptor0.059
Adrb2adrenergic receptor, beta 20.059
Gpr3G-protein coupled receptor 30.057
Ikzf4IKAROS family zinc finger 40.057
Sstr2somatostatin receptor 20.056
Irs2insulin receptor substrate 20.055
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.054
Npyneuropeptide Y0.053
Syn2synapsin II0.050
Thtyrosine hydroxylase0.050
Ccr2chemokine (C-C motif) receptor 20.048
Npy2rneuropeptide Y receptor Y20.048
Nr3c1nuclear receptor subfamily 3, group C, member 10.048
Bai1brain-specific angiogenesis inhibitor 10.048
Crtac1cartilage acidic protein 10.048
Slc12a1solute carrier family 12, member 10.047
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.047
Plcg1phospholipase C, gamma 10.047
Bcanbrevican0.045
Sema5bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.045
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.045
Fut2fucosyltransferase 20.044
Ren1renin 1 structural0.044
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism