The network for 'protein k63 linked ubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein k63 linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.

NameDescriptionProbabilityFunc Analog Organism
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.018
Sp110SP110 nuclear body protein0.015
Dnm1ldynamin 1-like0.015
Maoamonoamine oxidase A0.014
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.012
Rnf146ring finger protein 1460.012
Dtx3ldeltex 3-like (Drosophila)0.012
Rbm18RNA binding motif protein 180.011
Ppm1bprotein phosphatase 1B, magnesium dependent, beta isoform0.011
Prkar1aprotein kinase, cAMP-dependent, regulatory, type I, alpha0.011
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.010
Tbpl1TATA box binding protein-like 10.010
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ilf2interleukin enhancer binding factor 20.071
psmd4bproteasome (prosome, macropain) 26S subunit, non-ATPase, 4b0.061
arpp19acAMP-regulated phosphoprotein 19a0.054
tcea1transcription elongation factor A (SII), 10.049
srrm1serine/arginine repetitive matrix 10.045
snx6sorting nexin 60.040
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.038
nola1nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)0.036
rap1aRAP1A, member of RAS oncogene family0.033
ddx39aaDEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa0.030
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.028
elof1elongation factor 1 homolog (S. cerevisiae)0.028
srsf1aserine/arginine-rich splicing factor 1a0.028
dnaja2lDnaJ (Hsp40) homolog, subfamily A, member 2, like0.027
srmspermidine synthase0.026
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.025
rab1aRAB1A, member RAS oncogene family0.023
strapserine/threonine kinase receptor associated protein0.022
psmd11bproteasome (prosome, macropain) 216S subunit, non-ATPase, 11b0.022
rab5aaRAB5A, member RAS oncogene family, a0.022
sf3a3splicing factor 3a, subunit 30.022
tia1lcytotoxic granule-associated RNA binding protein 1, like0.020
snx12sorting nexin 120.020
psmd11aproteasome (prosome, macropain) 216S subunit, non-ATPase, 11a0.020
sap30bpSAP30 binding protein and SAP30 binding protein0.019
arglu1aarginine and glutamate rich 1a0.019
tomm40translocase of outer mitochondrial membrane 40 homolog (yeast)0.019
etf1eukaryotic translation termination factor 10.019
hp1bp3heterochromatin protein 1, binding protein 30.019
api5apoptosis inhibitor 50.018
sfswapsplicing factor, suppressor of white-apricot homolog (Drosophila)0.018
adrm1badhesion regulating molecule 1b0.018
dynlrb1dynein, light chain, roadblock-type 10.018
lztfl1leucine zipper transcription factor-like 10.018
g3bp1GTPase activating protein (SH3 domain) binding protein 10.018
erhenhancer of rudimentary homolog (Drosophila)0.017
wdr5WD repeat domain 50.017
ncoa2nuclear receptor coactivator 20.017
ube2naubiquitin-conjugating enzyme E2Na0.017
lmnb1lamin B10.017
atat1alpha tubulin acetyltransferase 10.016
cand1cullin-associated and neddylation-dissociated 10.016
pggt1bprotein geranylgeranyltransferase type I, beta subunit0.016
lman2lectin, mannose-binding 20.016
caprin1acell cycle associated protein 1a0.016
h3f3cH3 histone, family 3C0.016
fam195bfamily with sequence similarity 195, member B0.016
hnrnpa0lheterogeneous nuclear ribonucleoprotein A0, like0.016
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.016
pfn2lprofilin 2 like0.016
smndc1survival motor neuron domain containing 10.016
praf2PRA1 domain family, member 20.015
nononon-POU domain containing, octamer-binding0.015
morc2MORC family CW-type zinc finger 20.015
atxn3ataxin 30.015
srsf4serine/arginine-rich splicing factor 40.014
exoc7exocyst complex component 70.014
cnihcornichon homolog (Drosophila)0.014
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.014
srp68signal recognition particle 680.014
ck2bcasein kinase 2 beta0.014
cbx5chromobox homolog 5 (HP1 alpha homolog, Drosophila)0.014
safbscaffold attachment factor B0.014
znf207azinc finger protein 207, a0.014
ube2nbubiquitin-conjugating enzyme E2Nb0.014
eif4heukaryotic translation initiation factor 4h0.014
mmgt1membrane magnesium transporter 10.013
seh1lSEH1-like (S. cerevisiae)0.013
tada3ltranscriptional adaptor 3 (NGG1 homolog, yeast)-like0.013
sp4sp4 transcription factor0.013
sp5Sp5 transcription factor0.013
smarce1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.013
wdr45lwdr45 like0.013
zfrzinc finger RNA binding protein0.013
ube2q1ubiquitin-conjugating enzyme E2Q (putative) 10.012
pfdn2prefoldin subunit 20.012
ubinataxin-1 ubiquitin-like interacting protein0.012
insrainsulin receptor a0.012
polr2glpolymerase (RNA) II (DNA directed) polypeptide G-like0.012
vps26bvacuolar protein sorting 26 homolog B0.012
ck2a1casein kinase 2 alpha 10.012
tfip11tuftelin interacting protein 110.012
dpm3dolichyl-phosphate mannosyltransferase polypeptide 30.012
usp5ubiquitin specific protease 50.012
smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.012
eif4e1ceukaryotic translation initiation factor 4E family member 1c0.012
yy1bYY1 transcription factor b0.011
ppil4peptidylprolyl isomerase (cyclophilin)-like 40.011
hnrnph1lheterogeneous nuclear ribonucleoprotein H1, like0.011
gdi2GDP dissociation inhibitor 20.011
dopey1dopey family member 10.011
ube2q2ubiquitin-conjugating enzyme E2Q family member 20.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG32581CG32581 gene product from transcript CG32581-RB0.021
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)1.000
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)1.000
UBE2V1ubiquitin-conjugating enzyme E2 variant 11.000
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)1.000
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.999
RNF11ring finger protein 110.998
ZNRF1zinc and ring finger 10.979
SMURF2SMAD specific E3 ubiquitin protein ligase 20.973
ARIH2ariadne homolog 2 (Drosophila)0.962
BIRC3baculoviral IAP repeat containing 30.941
TRAF3TNF receptor-associated factor 30.905
RNF5ring finger protein 50.877
DTX3Ldeltex 3-like (Drosophila)0.851
SMURF1SMAD specific E3 ubiquitin protein ligase 10.835
TRAF6TNF receptor-associated factor 60.800
TRAF2TNF receptor-associated factor 20.670
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.661
TRIM39tripartite motif containing 390.661
BIRC2baculoviral IAP repeat containing 20.605
UBE2E1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)0.594
UBE2L3ubiquitin-conjugating enzyme E2L 30.592
RNF168ring finger protein 1680.584
UBE2E2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)0.547
TRIM43tripartite motif containing 430.500
UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.474
UBCubiquitin C0.432
RNF111ring finger protein 1110.431
TRIM27tripartite motif containing 270.412
OTUB1OTU domain, ubiquitin aldehyde binding 10.373
XIAPX-linked inhibitor of apoptosis0.352
FBXW11F-box and WD repeat domain containing 110.352
TRAF1TNF receptor-associated factor 10.349
TRIM32tripartite motif containing 320.301
CUL1cullin 10.286
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.282
MARCH7membrane-associated ring finger (C3HC4) 70.269
UBA1ubiquitin-like modifier activating enzyme 10.269
ANKRD28ankyrin repeat domain 280.263
MED15mediator complex subunit 150.257
DZIP3DAZ interacting protein 3, zinc finger0.234
ZMYND11zinc finger, MYND-type containing 110.223
ZRANB1zinc finger, RAN-binding domain containing 10.215
ZNF746zinc finger protein 7460.181
DAXXdeath-domain associated protein0.174
RNF185ring finger protein 1850.164
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.147
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.143
UBE2Mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.141
RIPK2receptor-interacting serine-threonine kinase 20.136
TNFAIP3tumor necrosis factor, alpha-induced protein 30.128
UBE2E3ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)0.122
WWP2WW domain containing E3 ubiquitin protein ligase 20.116
WWP1WW domain containing E3 ubiquitin protein ligase 10.116
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.107
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.107
AMFRautocrine motility factor receptor0.103
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.102
UBR1ubiquitin protein ligase E3 component n-recognin 10.099
CD40CD40 molecule, TNF receptor superfamily member 50.099
RNF10ring finger protein 100.097
RHOAras homolog gene family, member A0.087
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.085
MARCH5membrane-associated ring finger (C3HC4) 50.085
UBE2Wubiquitin-conjugating enzyme E2W (putative)0.080
RNF2ring finger protein 20.071
MDM4Mdm4 p53 binding protein homolog (mouse)0.070
FBXL15F-box and leucine-rich repeat protein 150.067
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.066
TRIM5tripartite motif containing 50.064
ZNF263zinc finger protein 2630.063
TRADDTNFRSF1A-associated via death domain0.061
SKP1S-phase kinase-associated protein 10.060
RNF14ring finger protein 140.060
ING2inhibitor of growth family, member 20.058
RANGAP1Ran GTPase activating protein 10.057
ANKRD13Aankyrin repeat domain 13A0.056
RNF114ring finger protein 1140.054
RNF126ring finger protein 1260.051
RNF4ring finger protein 40.047
BFARbifunctional apoptosis regulator0.047
PMLpromyelocytic leukemia0.045
TRIM26tripartite motif containing 260.043
USP15ubiquitin specific peptidase 150.043
NUMBLnumb homolog (Drosophila)-like0.042
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.042
HN1hematological and neurological expressed 10.041
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.041
RNF130ring finger protein 1300.039
UBE3Aubiquitin protein ligase E3A0.037
RYBPRING1 and YY1 binding protein0.036
NEDD4neural precursor cell expressed, developmentally down-regulated 40.036
FAF2Fas associated factor family member 20.036
BTRCbeta-transducin repeat containing0.036
UBOX5U-box domain containing 50.035
RLIMring finger protein, LIM domain interacting0.035
MID1midline 1 (Opitz/BBB syndrome)0.035
TP53BP1tumor protein p53 binding protein 10.035
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.035
ZNF473zinc finger protein 4730.034
RNPS1RNA binding protein S1, serine-rich domain0.034
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Map3k7mitogen-activated protein kinase kinase kinase 70.473
Traf6TNF receptor-associated factor 60.297
Ube2nubiquitin-conjugating enzyme E2N0.055
Trim30dtripartite motif-containing 30D0.051
Mbd3methyl-CpG binding domain protein 30.050
Tnfaip3tumor necrosis factor, alpha-induced protein 30.042
Rnf11ring finger protein 110.037
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.036
Cd40CD40 antigen0.035
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.033
Usp9xubiquitin specific peptidase 9, X chromosome0.030
Irak1interleukin-1 receptor-associated kinase 10.021
Trim30atripartite motif-containing 30A0.020
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.020
Traf2TNF receptor-associated factor 20.017
Irak3interleukin-1 receptor-associated kinase 30.017
Ifi44interferon-induced protein 440.016
Wbp1WW domain binding protein 10.016
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.015
Cyldcylindromatosis (turban tumor syndrome)0.014
Trafd1TRAF type zinc finger domain containing 10.014
Adrm1adhesion regulating molecule 10.013
Kpna1karyopherin (importin) alpha 10.013
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.012
Parp14poly (ADP-ribose) polymerase family, member 140.012
Mavsmitochondrial antiviral signaling protein0.012
Birc3baculoviral IAP repeat-containing 30.012
CflarCASP8 and FADD-like apoptosis regulator0.011
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.011
Trim12atripartite motif-containing 12A0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism