The network for 'negative regulation of insulin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of insulin receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.

NameDescriptionProbabilityFunc Analog Organism
Cmklr1chemokine-like receptor 10.077
Syngr2synaptogyrin 20.075
Stat6signal transducer and activator of transcription 60.075
Plxnb2plexin B20.074
Slc4a2solute carrier family 4 (anion exchanger), member 20.065
Map3k11mitogen-activated protein kinase kinase kinase 110.064
Hist1h1ahistone cluster 1, H1a0.058
Rnf10ring finger protein 100.056
Usf2upstream transcription factor 2, c-fos interacting0.053
Cyfip2cytoplasmic FMR1 interacting protein 20.050
SnrkSNF related kinase0.049
Nfianuclear factor I/A0.047
Lzts2leucine zipper, putative tumor suppressor 20.042
Fth1ferritin, heavy polypeptide 10.037
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.037
Epn1Epsin 10.036
Gna12guanine nucleotide binding protein (G protein) alpha 120.035
Gria2glutamate receptor, ionotropic, AMPA 20.035
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.034
Eef2eukaryotic translation elongation factor 20.034
Myo1cmyosin IC0.034
Cugbp2CUG triplet repeat, RNA binding protein 20.034
Csnk1g2casein kinase 1, gamma 20.033
Hckhemopoietic cell kinase0.033
Unc13dunc-13 homolog D (C. elegans)0.033
Itpr1inositol 1,4,5-triphosphate receptor, type 10.032
Tgfbr2transforming growth factor, beta receptor II0.032
Metap2methionyl aminopeptidase 20.032
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.032
Vaspvasodilator-stimulated phosphoprotein0.031
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.030
Ryr2ryanodine receptor 2, cardiac0.030
Ptpn6protein tyrosine phosphatase, non-receptor type 60.028
Cskc-src tyrosine kinase0.026
Smad7SMAD family member 70.026
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.025
Pip4k2aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.025
Pkn2protein kinase N20.024
Tnip1TNFAIP3 interacting protein 10.024
Myh9myosin, heavy chain 9, non-muscle0.024
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.023
Gria3glutamate receptor, ionotrophic, AMPA 30.023
Fam134afamily with sequence similarity 134, member A0.023
Dlgap1discs, large (Drosophila) homolog-associated protein 10.023
Slasrc-like adaptor0.022
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.022
Plcb1phospholipase C, beta 1 (phosphoinositide-specific)0.022
Cd37CD37 molecule0.022
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.021
Unc5bunc-5 homolog B (C. elegans)0.020
Cxcl10chemokine (C-X-C motif) ligand 100.020
Anapc5anaphase-promoting complex subunit 50.020
Myo1emyosin IE0.019
Git1G protein-coupled receptor kinase interacting ArfGAP 10.019
Sirpasignal-regulatory protein alpha0.019
Phka1phosphorylase kinase, alpha 10.019
Ambpalpha-1-microglobulin/bikunin precursor0.019
Serbp1Serpine1 mRNA binding protein 10.018
Socs2suppressor of cytokine signaling 20.018
Adrbk1adrenergic, beta, receptor kinase 10.018
Slfn2schlafen 20.017
Clcn4-2chloride channel 4-20.017
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.017
Sbno2strawberry notch homolog 2 (Drosophila)0.017
Rpl7aribosomal protein L7a0.016
Stat3signal transducer and activator of transcription 30.016
Arrdc1arrestin domain containing 10.016
Nup88nucleoporin 880.016
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.016
Gpc1glypican 10.016
Jak3Janus kinase 30.016
Kif1bkinesin family member 1B0.016
Cx3cl1chemokine (C-X3-C motif) ligand 10.015
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.015
Foxg1forkhead box G10.015
Arhgap4Rho GTPase activating protein 40.015
Rps6ka1ribosomal protein S6 kinase polypeptide 10.015
Fliiflightless I homolog (Drosophila)0.015
Lmnalamin A0.015
Mxd1max dimerization protein 10.015
Pctk1PCTAIRE protein kinase 10.015
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.015
Fgafibrinogen alpha chain0.015
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.015
Tcfe2atranscription factor E2a0.015
Tpt1tumor protein, translationally-controlled 10.015
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.014
Map2microtubule-associated protein 20.014
Nek9NIMA (never in mitosis gene a)- related kinase 90.014
Fnbp1formin binding protein 10.014
Sort1sortilin 10.014
Cttnbp2cortactin binding protein 20.014
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.014
Akap1A kinase (PRKA) anchor protein 10.014
Actbactin, beta0.014
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.014
Tgfb1transforming growth factor, beta 10.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PtenCG5671 gene product from transcript CG5671-RB0.293
Pi3K92ECG4141 gene product from transcript CG4141-RB0.269
Cdc42CG12530 gene product from transcript CG12530-RA0.186
RhebCG1081 gene product from transcript CG1081-RA0.160
chicoCG5686 gene product from transcript CG5686-RB0.127
InRInsulin-like receptor0.117
CaMKIICalcium/calmodulin-dependent protein kinase II0.104
CG14815CG14815 gene product from transcript CG14815-RA0.064
Akt1CG4006 gene product from transcript CG4006-RA0.064
IdeInsulin degrading metalloproteinase0.062
B4CG9239 gene product from transcript CG9239-RA0.061
rictorrapamycin-insensitive companion of Tor0.059
inaDinactivation no afterpotential D0.048
ThorCG8846 gene product from transcript CG8846-RA0.043
LnkCG17367 gene product from transcript CG17367-RC0.037
sec5CG8843 gene product from transcript CG8843-RA0.035
pashapartner of drosha0.033
CG8443CG8443 gene product from transcript CG8443-RA0.031
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.030
Fak56DFocal Adhesion Kinase0.027
Ilp2Insulin-like peptide 20.027
Tsc1CG6147 gene product from transcript CG6147-RA0.025
MadMothers against dpp0.023
Coq2Coenzyme Q biosynthesis protein 20.022
slikSterile20-like kinase0.022
unc-13CG2999 gene product from transcript CG2999-RA0.020
Sox14Sox box protein 140.019
nrv1nervana 10.019
Atg4Autophagy-specific gene 40.017
trptransient receptor potential0.017
Vap-33-1CG5014 gene product from transcript CG5014-RB0.016
htshu li tai shao0.016
Sop2Suppressor of profilin 20.015
CG7565CG7565 gene product from transcript CG7565-RA0.014
Dhc64CDynein heavy chain 64C0.013
CG14937CG14937 gene product from transcript CG14937-RA0.013
Klp64DKinesin-like protein at 64D0.013
skpACG16983 gene product from transcript CG16983-RD0.013
FatpFatty acid (long chain) transport protein0.013
Sin3ACG8815 gene product from transcript CG8815-RC0.013
RanBPMRan-binding protein M0.013
Pk61CProtein kinase 61C0.013
HLH106Helix loop helix protein 1060.013
enokenoki mushroom0.012
NFATNFAT homolog0.010
SmoxSmad on X0.010
CG12428CG12428 gene product from transcript CG12428-RB0.010
ari-2ariadne 20.010
CG3308CG3308 gene product from transcript CG3308-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
INSRinsulin receptor0.784
PTPN1protein tyrosine phosphatase, non-receptor type 10.677
NCOA1nuclear receptor coactivator 10.365
MAPK14mitogen-activated protein kinase 140.296
FYNFYN oncogene related to SRC, FGR, YES0.242
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.111
GRB10growth factor receptor-bound protein 100.098
IGF1Rinsulin-like growth factor 1 receptor0.088
IRS2insulin receptor substrate 20.085
IRS1insulin receptor substrate 10.081
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.075
PTPN11protein tyrosine phosphatase, non-receptor type 110.069
CREBBPCREB binding protein0.055
MAPTmicrotubule-associated protein tau0.055
SH2B1SH2B adaptor protein 10.048
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.042
BTRCbeta-transducin repeat containing0.038
CUL1cullin 10.036
FBXW11F-box and WD repeat domain containing 110.033
TSC2tuberous sclerosis 20.032
GHRgrowth hormone receptor0.022
MAPK1mitogen-activated protein kinase 10.021
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.021
ITSN1intersectin 1 (SH3 domain protein)0.021
MAPK3mitogen-activated protein kinase 30.020
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.020
LCKlymphocyte-specific protein tyrosine kinase0.020
IL1RAPinterleukin 1 receptor accessory protein0.019
SORBS3sorbin and SH3 domain containing 30.018
PLCG1phospholipase C, gamma 10.017
NOXA1NADPH oxidase activator 10.017
TSC1tuberous sclerosis 10.017
EGFRepidermal growth factor receptor0.017
ARandrogen receptor0.015
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.014
NCF1neutrophil cytosolic factor 10.013
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.013
JAK2Janus kinase 20.012
RASA1RAS p21 protein activator (GTPase activating protein) 10.012
STAT5Bsignal transducer and activator of transcription 5B0.012
SKP1S-phase kinase-associated protein 10.011
MAP3K5mitogen-activated protein kinase kinase kinase 50.011
CAV1caveolin 1, caveolae protein, 22kDa0.010
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ldb3LIM domain binding 30.998
Leprleptin receptor0.998
FynFyn proto-oncogene0.992
Jak2Janus kinase 20.991
Cdkn1bcyclin-dependent kinase inhibitor 1B0.963
Insrinsulin receptor0.895
Tsc1tuberous sclerosis 10.845
Tsc2tuberous sclerosis 20.819
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.794
SrcRous sarcoma oncogene0.705
Igf1rinsulin-like growth factor I receptor0.659
Nf2neurofibromatosis 20.645
Il1binterleukin 1 beta0.622
Apcadenomatosis polyposis coli0.608
Cishcytokine inducible SH2-containing protein0.601
Tekendothelial-specific receptor tyrosine kinase0.569
Akt1thymoma viral proto-oncogene 10.527
Grb2growth factor receptor bound protein 20.493
Bcl2B-cell leukemia/lymphoma 20.463
Efnb2ephrin B20.433
Irs2insulin receptor substrate 20.433
Actn2actinin alpha 20.382
Ptprcprotein tyrosine phosphatase, receptor type, C0.379
Dok2docking protein 20.371
Dok1docking protein 10.367
Prkcbprotein kinase C, beta0.341
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.334
Kitkit oncogene0.332
Tnftumor necrosis factor0.324
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.317
Socs2suppressor of cytokine signaling 20.314
Efnb1ephrin B10.313
Nf1neurofibromatosis 10.290
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.282
Lcklymphocyte protein tyrosine kinase0.274
Ctnnb1catenin (cadherin associated protein), beta 10.274
Pim1proviral integration site 10.266
Prkceprotein kinase C, epsilon0.260
Vhlvon Hippel-Lindau tumor suppressor0.252
Inpp5dinositol polyphosphate-5-phosphatase D0.242
Jak1Janus kinase 10.228
Gsk3bglycogen synthase kinase 3 beta0.213
Ptpn11protein tyrosine phosphatase, non-receptor type 110.213
Ptk2PTK2 protein tyrosine kinase 20.206
Plcg1phospholipase C, gamma 10.198
Ppargperoxisome proliferator activated receptor gamma0.197
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.196
Fmr1fragile X mental retardation syndrome 1 homolog0.190
Fcgr2bFc receptor, IgG, low affinity IIb0.190
Fxr1fragile X mental retardation gene 1, autosomal homolog0.189
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.186
Nedd4neural precursor cell expressed, developmentally down-regulated 40.184
Xpaxeroderma pigmentosum, complementation group A0.178
Enahenabled homolog (Drosophila)0.176
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.168
Fbxw7F-box and WD-40 domain protein 70.166
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.163
Ptk2bPTK2 protein tyrosine kinase 2 beta0.158
Il1ainterleukin 1 alpha0.156
Casp4caspase 4, apoptosis-related cysteine peptidase0.156
NsfN-ethylmaleimide sensitive fusion protein0.150
Stat5bsignal transducer and activator of transcription 5B0.148
Pag1phosphoprotein associated with glycosphingolipid microdomains 10.143
CblCasitas B-lineage lymphoma0.138
Stat5asignal transducer and activator of transcription 5A0.133
Cd28CD28 antigen0.122
RoraRAR-related orphan receptor alpha0.121
Tnip1TNFAIP3 interacting protein 10.119
TcraT-cell receptor alpha chain0.116
Il6stinterleukin 6 signal transducer0.108
Rint1RAD50 interactor 10.105
Irak4interleukin-1 receptor-associated kinase 40.101
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.092
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.085
Gnb2guanine nucleotide binding protein (G protein), beta 20.084
Rassf5Ras association (RalGDS/AF-6) domain family member 50.083
Ikzf1IKAROS family zinc finger 10.080
Tbk1TANK-binding kinase 10.079
Arandrogen receptor0.077
Clockcircadian locomotor output cycles kaput0.075
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.073
Crb2crumbs homolog 2 (Drosophila)0.070
Stat3signal transducer and activator of transcription 30.070
Csnk1g2casein kinase 1, gamma 20.069
Prkciprotein kinase C, iota0.068
Irs1insulin receptor substrate 10.066
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.066
Cenpc1centromere protein C10.066
Cand1cullin associated and neddylation disassociated 10.062
Cul5cullin 50.061
Akt2thymoma viral proto-oncogene 20.059
Fbxl20F-box and leucine-rich repeat protein 200.059
BrafBraf transforming gene0.058
Prkcaprotein kinase C, alpha0.058
Notch1Notch gene homolog 1 (Drosophila)0.057
Prkcdprotein kinase C, delta0.056
Wipf1WAS/WASL interacting protein family, member 10.055
Spin1spindlin 10.054
MefvMediterranean fever0.053
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism