The network for 'specification of organ identity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

specification of organ identity

The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.

NameDescriptionProbabilityFunc Analog Organism
Unc5bunc-5 homolog B (C. elegans)0.180
Cxxc4CXXC finger 40.129
Shox2short stature homeobox 20.076
Arntaryl hydrocarbon receptor nuclear translocator0.056
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.048
MrgprfMAS-related GPR, member F0.043
Glg1golgi apparatus protein 10.043
Smad7SMAD family member 70.041
LOC246267resection-induced TPI (rs11)0.038
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.035
Prrx1paired related homeobox 10.033
F13a1coagulation factor XIII, A1 polypeptide0.032
Sardhsarcosine dehydrogenase0.031
Syt9synaptotagmin IX0.029
Metmet proto-oncogene0.029
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.028
Oprm1opioid receptor, mu 10.028
Chrnb4cholinergic receptor, nicotinic, beta 40.027
Olfml2bolfactomedin-like 2B0.026
Irs1insulin receptor substrate 10.026
RY2G5potential ligand-binding protein0.026
Clcn4-2chloride channel 4-20.026
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.025
Slc14a1solute carrier family 14 (urea transporter), member 10.025
Sv2csynaptic vesicle glycoprotein 2c0.025
Gna12guanine nucleotide binding protein (G protein) alpha 120.025
Axin1axin 10.024
Nek9NIMA (never in mitosis gene a)- related kinase 90.024
RGD1309821similar to KIAA1161 protein0.024
Clcnkbchloride channel Kb0.024
Bmp3bone morphogenetic protein 30.023
Sdc3syndecan 30.023
Nkd1naked cuticle homolog 1 (Drosophila)0.023
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.023
Hoxc4homeo box C40.023
Cpxm2carboxypeptidase X (M14 family), member 20.023
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.023
Grm8glutamate receptor, metabotropic 80.022
Sod3superoxide dismutase 3, extracellular0.022
Adrb1adrenergic, beta-1-, receptor0.022
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.021
Fzd2frizzled homolog 2 (Drosophila)0.021
Strnstriatin, calmodulin binding protein0.021
Foxc2forkhead box C20.021
SnrkSNF related kinase0.021
Otx1orthodenticle homeobox 10.021
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.021
Scn5asodium channel, voltage-gated, type V, alpha subunit0.021
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.021
Six3SIX homeobox 30.021
Gtf2a1general transcription factor IIA, 10.021
Notch2Notch homolog 2 (Drosophila)0.020
Leprleptin receptor0.020
Kcnip1Kv channel-interacting protein 10.020
Mep1bmeprin 1 beta0.020
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.020
Myo1cmyosin IC0.020
Tgfb2transforming growth factor, beta 20.020
Cercamcerebral endothelial cell adhesion molecule0.020
Folh1folate hydrolase 10.020
Ctrb1chymotrypsinogen B10.020
Kykyphoscoliosis peptidase0.020
Lims1LIM and senescent cell antigen-like domains 10.019
Znf503zinc finger protein 5030.019
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.019
Ptgfrprostaglandin F receptor0.019
Gfra1GDNF family receptor alpha 10.019
Acvr1activin A receptor, type I0.019
Adamts13ADAM metallopeptidase with thrombospondin type 1 motif, 130.019
Akt2v-akt murine thymoma viral oncogene homolog 20.019
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.019
Pde7bphosphodiesterase 7B0.019
Robo1roundabout homolog 1 (Drosophila)0.019
Pou2f3POU class 2 homeobox 30.019
Tgfbr2transforming growth factor, beta receptor II0.018
Pclopiccolo (presynaptic cytomatrix protein)0.018
Nefmneurofilament, medium polypeptide0.018
Nr2f2nuclear receptor subfamily 2, group F, member 20.018
Prap1proline-rich acidic protein 10.018
Ucn2urocortin 20.018
Phkg1phosphorylase kinase, gamma 10.017
Mycsmyc-like oncogene, s-myc protein0.017
Myh9myosin, heavy chain 9, non-muscle0.017
Cst12cystatin 120.017
A2bp1ataxin 2 binding protein 10.017
Itpr2inositol 1,4,5-triphosphate receptor, type 20.017
LOC687536similar to Forkhead box protein F1 (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1) (FREAC-1) (Hepatocyte nuclear factor 3 forkhead homolog 8) (HFH-8)0.017
Ccdc102acoiled-coil domain containing 102A0.017
Ednraendothelin receptor type A0.017
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.017
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.017
Nxph3neurexophilin 30.017
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.016
Tbr1T-box, brain, 10.016
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.016
Ryr2ryanodine receptor 2, cardiac0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dlx5adistal-less homeobox gene 5a0.961
bmp4bone morphogenetic protein 40.956
tbx1T-box 10.952
dlx3bdistal-less homeobox gene 3b0.919
fgf3fibroblast growth factor 30.911
pea3ETS-domain transcription factor pea30.759
dlx2bdistal-less homeobox gene 2b0.753
tbx5aT-box 5a0.731
prdm1aPR domain containing 1a, with ZNF domain0.725
ndr2nodal-related 20.718
hoxa9bhomeo box A9b0.707
fgf10afibroblast growth factor 10a0.702
wnt5bwingless-type MMTV integration site family, member 5b0.645
hoxa11ahomeo box A11a0.519
tbx18T-box 180.480
wnt8bwingless-type MMTV integration site family, member 8b0.471
hoxd10ahomeo box D10a0.456
pax6apaired box gene 6a0.455
bmp2bbone morphogenetic protein 2b0.444
pdlim7PDZ and LIM domain 70.438
eng2bengrailed 2b0.438
neo1neogenin 10.424
atoh1aatonal homolog 1a0.414
hoxa11bhomeo box A11b0.412
wnt10awingless-type MMTV integration site family, member 10a0.399
notch3notch homolog 30.382
wlswntless homolog (Drosophila)0.381
axin1axin 10.363
gli1GLI-Kruppel family member 10.354
shhasonic hedgehog a0.342
wif1wnt inhibitory factor 10.335
dlx2adistal-less homeobox gene 2a0.334
flhfloating head0.328
fgf8afibroblast growth factor 8 a0.314
mespbmesoderm posterior b0.312
dusp6dual specificity phosphatase 60.309
hmx4H6 family homeobox 40.305
coblcordon-bleu homolog (mouse)0.299
wnt9awingless-type MMTV integration site family, member 9A0.298
myod1myogenic differentiation 10.295
fgf17fibroblast growth factor 170.286
eomesaeomesodermin homolog a0.285
alcamaactivated leukocyte cell adhesion molecule a0.280
spry1sprouty homolog 1 (Drosophila)0.268
hoxa13bhomeo box A13b0.260
oepone-eyed pinhead0.256
fgf20afibroblast growth factor 20a0.253
rereaarginine-glutamic acid dipeptide (RE) repeats a0.249
gdnfglial cell derived neurotrophic factor0.248
hoxd4ahomeo box D4a0.245
eya1eyes absent homolog 10.231
ndr1nodal-related 10.229
hoxc6ahomeo box C6a0.228
cdh2cadherin 2, neuronal0.223
prrx1apaired related homeobox 1a0.217
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.217
dlx1adistal-less homeobox gene 1a0.215
wnt11rwingless-type MMTV integration site family, member 11, related0.209
fgf8bfibroblast growth factor 8 b0.208
dlx6adistal-less homeobox gene 6a0.205
nkx2.5NK2 transcription factor related 50.193
jag1bjagged 1b0.193
gata4GATA-binding protein 40.187
hoxd13ahomeo box D13a0.183
sfrp1asecreted frizzled-related protein 1a0.182
bmp2abone morphogenetic protein 2a0.177
spry4sprouty (Drosophila) homolog 40.177
barx1BarH-like homeobox 10.172
rorbRAR-related orphan receptor B0.168
hoxa10bhomeo box A10b0.160
hmx1H6 homeo box 10.160
has2hyaluronan synthase 20.155
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.152
her1hairy-related 10.150
trim71tripartite motif-containing 710.150
wacaWW domain containing adaptor with coiled-coil a0.145
pax2apaired box gene 2a0.143
hnf1baHNF1 homeobox Ba0.143
igf1rbinsulin-like growth factor 1b receptor0.138
fgf19fibroblast growth factor 190.138
dbx1bdeveloping brain homeobox 1b0.135
myf5myogenic factor 50.130
ptch1patched 10.130
hand2heart and neural crest derivatives expressed transcript 20.127
sall4sal-like 4 (Drosophila)0.126
lhx3LIM homeobox 30.126
foxi1forkhead box I10.126
wnt4awingless-type MMTV integration site family, member 4a0.126
wnt1wingless-type MMTV integration site family, member 10.125
wnt9bwingless-type MMTV integration site family, member 9B0.125
ascl1aachaete-scute complex-like 1a (Drosophila)0.124
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.124
pitx3paired-like homeodomain transcription factor 30.123
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
eyaeyes absent0.837
MadMothers against dpp0.609
cicubitus interruptus0.591
abd-Aabdominal A0.379
grhgrainy head0.206
Lim1CG11354 gene product from transcript CG11354-RA0.195
stumpsCG31317 gene product from transcript CG31317-RC0.156
aopanterior open0.113
sogshort gastrulation0.090
EgfrEpidermal growth factor receptor0.072
CG3563CG3563 gene product from transcript CG3563-RA0.055
Su(H)Suppressor of Hairless0.052
wbwing blister0.046
Abd-BAbdominal B0.045
bab2CG9102 gene product from transcript CG9102-RA0.040
bowlbrother of odd with entrails limited0.038
Rab11Rab-protein 110.038
numbCG3779 gene product from transcript CG3779-RB0.036
CycECyclin E0.036
mxcmulti sex combs0.034
Mlp84BMuscle LIM protein at 84B0.034
sec5CG8843 gene product from transcript CG8843-RA0.033
aPKCatypical protein kinase C0.032
argosCG4531 gene product from transcript CG4531-RA0.030
Syx1ASyntaxin 1A0.029
Rab23CG2108 gene product from transcript CG2108-RA0.028
amosabsent MD neurons and olfactory sensilla0.027
dallydivision abnormally delayed0.024
NotumCG13076 gene product from transcript CG13076-RB0.024
CtBPC-terminal Binding Protein0.023
PoxnPox neuro0.022
nkdnaked cuticle0.022
blowblown fuse0.022
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGF1fibroblast growth factor 1 (acidic)1.000
FGFR1fibroblast growth factor receptor 11.000
PAX3paired box 30.999
BMPR1Abone morphogenetic protein receptor, type IA0.998
FOXD3forkhead box D30.998
LRP6low density lipoprotein receptor-related protein 60.997
FGF10fibroblast growth factor 100.996
DVL3dishevelled, dsh homolog 3 (Drosophila)0.996
NKX2-1NK2 homeobox 10.992
SOX10SRY (sex determining region Y)-box 100.991
SP1Sp1 transcription factor0.991
MEOX2mesenchyme homeobox 20.986
FGF8fibroblast growth factor 8 (androgen-induced)0.982
FGF2fibroblast growth factor 2 (basic)0.981
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.940
NOTCH1notch 10.920
AXIN1axin 10.870
DVL1dishevelled, dsh homolog 1 (Drosophila)0.861
FZD1frizzled homolog 1 (Drosophila)0.846
FGF3fibroblast growth factor 30.839
WT1Wilms tumor 10.837
SOX2SRY (sex determining region Y)-box 20.834
ARNTaryl hydrocarbon receptor nuclear translocator0.834
CTNNBIP1catenin, beta interacting protein 10.828
NCOA2nuclear receptor coactivator 20.816
PAX8paired box 80.812
WWP2WW domain containing E3 ubiquitin protein ligase 20.810
FSTL1follistatin-like 10.795
LRRK2leucine-rich repeat kinase 20.787
HOXA10homeobox A100.767
LHX1LIM homeobox 10.742
MDFIMyoD family inhibitor0.726
POU3F2POU class 3 homeobox 20.719
SOX1SRY (sex determining region Y)-box 10.706
NEDD4neural precursor cell expressed, developmentally down-regulated 40.700
PDX1pancreatic and duodenal homeobox 10.663
NCOR2nuclear receptor corepressor 20.663
HCFC1host cell factor C1 (VP16-accessory protein)0.659
PAX7paired box 70.644
OTPorthopedia homeobox0.599
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.596
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.593
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.562
ATXN1Lataxin 1-like0.534
MYST2MYST histone acetyltransferase 20.518
PAX2paired box 20.504
MAML1mastermind-like 1 (Drosophila)0.496
EP300E1A binding protein p3000.478
SPENspen homolog, transcriptional regulator (Drosophila)0.466
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.464
FOXA2forkhead box A20.457
LBX1ladybird homeobox 10.444
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.438
UTF1undifferentiated embryonic cell transcription factor 10.436
PAX6paired box 60.423
FGF7fibroblast growth factor 70.422
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.407
NCOA7nuclear receptor coactivator 70.400
TP73tumor protein p730.393
RAXretina and anterior neural fold homeobox0.379
EYA1eyes absent homolog 1 (Drosophila)0.375
FGF4fibroblast growth factor 40.358
FOXE1forkhead box E1 (thyroid transcription factor 2)0.353
HOXB5homeobox B50.350
CEP164centrosomal protein 164kDa0.346
CUX1cut-like homeobox 10.339
SOX21SRY (sex determining region Y)-box 210.336
WNT3wingless-type MMTV integration site family, member 30.331
PITX1paired-like homeodomain 10.330
TLX2T-cell leukemia homeobox 20.325
SIM2single-minded homolog 2 (Drosophila)0.323
LMX1BLIM homeobox transcription factor 1, beta0.322
HOXD13homeobox D130.316
HOXD11homeobox D110.312
HOXD10homeobox D100.308
WNT7Awingless-type MMTV integration site family, member 7A0.308
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.303
TCF4transcription factor 40.295
NOVA2neuro-oncological ventral antigen 20.293
FZD8frizzled homolog 8 (Drosophila)0.292
SIX6SIX homeobox 60.288
TBX5T-box 50.286
HDAC9histone deacetylase 90.285
FRS2fibroblast growth factor receptor substrate 20.282
HOXC11homeobox C110.277
HOXB9homeobox B90.271
DLX4distal-less homeobox 40.266
HOXA11homeobox A110.265
HOXC5homeobox C50.264
SIX2SIX homeobox 20.260
FOXG1forkhead box G10.260
CSNK1Ecasein kinase 1, epsilon0.257
VSX1visual system homeobox 10.249
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.248
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.244
MEF2Amyocyte enhancer factor 2A0.244
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.240
PSEN1presenilin 10.232
LHX3LIM homeobox 30.229
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pitx2paired-like homeodomain transcription factor 21.000
Fgfr2fibroblast growth factor receptor 20.999
Foxc1forkhead box C10.999
Gli3GLI-Kruppel family member GLI30.998
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.998
Pax3paired box gene 30.998
Fgf10fibroblast growth factor 100.996
Fgf8fibroblast growth factor 80.995
Tbx1T-box 10.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.993
Hand2heart and neural crest derivatives expressed transcript 20.993
Rargretinoic acid receptor, gamma0.993
Hoxd11homeobox D110.992
Hand1heart and neural crest derivatives expressed transcript 10.989
Vangl2vang-like 2 (van gogh, Drosophila)0.988
Hoxa1homeobox A10.987
Gli2GLI-Kruppel family member GLI20.985
Otx2orthodenticle homolog 2 (Drosophila)0.978
Pax2paired box gene 20.972
Wnt3awingless-related MMTV integration site 3A0.971
Foxc2forkhead box C20.970
Lhx1LIM homeobox protein 10.962
Dlx5distal-less homeobox 50.956
Fgfr1fibroblast growth factor receptor 10.946
Gscgoosecoid homeobox0.935
Hoxa3homeobox A30.930
Rarbretinoic acid receptor, beta0.924
Prrx1paired related homeobox 10.917
Eya1eyes absent 1 homolog (Drosophila)0.916
Sox9SRY-box containing gene 90.914
Sall4sal-like 4 (Drosophila)0.913
Msx1homeobox, msh-like 10.909
Fgfr3fibroblast growth factor receptor 30.906
Hoxa13homeobox A130.904
Alx4aristaless-like homeobox 40.891
Hoxa2homeobox A20.886
Tcfap2atranscription factor AP-2, alpha0.852
Pitx1paired-like homeodomain transcription factor 10.849
Hoxd13homeobox D130.847
Foxh1forkhead box H10.845
Retret proto-oncogene0.836
Meox2mesenchyme homeobox 20.827
Bmp4bone morphogenetic protein 40.822
Cfc1cripto, FRL-1, cryptic family 10.803
Gbx2gastrulation brain homeobox 20.785
Dvl2dishevelled 2, dsh homolog (Drosophila)0.764
Zic3zinc finger protein of the cerebellum 30.746
Ror2receptor tyrosine kinase-like orphan receptor 20.728
Dvl3dishevelled 3, dsh homolog (Drosophila)0.721
Bmp7bone morphogenetic protein 70.706
Ptk7PTK7 protein tyrosine kinase 70.669
Ctnnb1catenin (cadherin associated protein), beta 10.663
Tbx3T-box 30.631
Mesp1mesoderm posterior 10.624
Pou3f3POU domain, class 3, transcription factor 30.617
Hoxa11homeobox A110.586
Rararetinoic acid receptor, alpha0.574
Fgf3fibroblast growth factor 30.500
Insm1insulinoma-associated 10.486
Smad6MAD homolog 6 (Drosophila)0.449
Dlx2distal-less homeobox 20.447
Pax9paired box gene 90.427
Lef1lymphoid enhancer binding factor 10.426
Emx2empty spiracles homolog 2 (Drosophila)0.417
Prrx2paired related homeobox 20.412
Ednraendothelin receptor type A0.411
Hoxb3homeobox B30.406
Vangl1vang-like 1 (van gogh, Drosophila)0.402
Neurog3neurogenin 30.398
Fgf18fibroblast growth factor 180.375
Wnt6wingless-related MMTV integration site 60.374
Vegfavascular endothelial growth factor A0.359
Alx3aristaless-like homeobox 30.358
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.348
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.346
Acvr1activin A receptor, type 10.338
Myod1myogenic differentiation 10.330
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.305
Msx2homeobox, msh-like 20.301
Ptenphosphatase and tensin homolog0.301
Pax1paired box gene 10.295
Ascl1achaete-scute complex homolog 1 (Drosophila)0.294
Lmx1aLIM homeobox transcription factor 1 alpha0.283
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.283
Tcf21transcription factor 210.282
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.281
Tbx15T-box 150.274
Smad7MAD homolog 7 (Drosophila)0.264
Smosmoothened homolog (Drosophila)0.260
Wt1Wilms tumor 1 homolog0.259
Gdnfglial cell line derived neurotrophic factor0.248
Gata4GATA binding protein 40.247
Twist2twist homolog 2 (Drosophila)0.247
Chd7chromodomain helicase DNA binding protein 70.242
Nkx2-1NK2 homeobox 10.241
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism