The network for 'signal transduction in absence of ligand' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction in absence of ligand

A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.

NameDescriptionProbabilityFunc Analog Organism
TcrbT-cell receptor beta chain0.346
Sirpasignal-regulatory protein alpha0.101
Pacs1phosphofurin acidic cluster sorting protein 10.074
Ddr1discoidin domain receptor tyrosine kinase 10.071
Epn2epsin 20.064
Ralgdsral guanine nucleotide dissociation stimulator0.053
Unc5bunc-5 homolog B (C. elegans)0.049
Ptafrplatelet-activating factor receptor0.044
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.042
Ccnd3cyclin D30.040
Hk1hexokinase 10.040
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.038
Cd86CD86 molecule0.038
Ptpn6protein tyrosine phosphatase, non-receptor type 60.038
Ppp1r9bprotein phosphatase 1, regulatory subunit 9B0.037
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.029
Ccl3chemokine (C-C motif) ligand 30.028
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.028
Ptpn7protein tyrosine phosphatase, non-receptor type 70.027
Rps6ka1ribosomal protein S6 kinase polypeptide 10.027
Hckhemopoietic cell kinase0.027
Rgs19regulator of G-protein signaling 190.026
Il2rbinterleukin 2 receptor, beta0.026
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.025
Adrbk1adrenergic, beta, receptor kinase 10.025
Mpripmyosin phosphatase Rho interacting protein0.024
Mmp12matrix metallopeptidase 120.024
Epn1Epsin 10.024
Ubtfupstream binding transcription factor, RNA polymerase I0.024
Cd14CD14 molecule0.022
Rararetinoic acid receptor, alpha0.022
Cd38CD38 molecule0.021
Prrx1paired related homeobox 10.020
Bcl2l1Bcl2-like 10.020
Gpr176G protein-coupled receptor 1760.019
Glg1golgi apparatus protein 10.019
Prdm2PR domain containing 2, with ZNF domain0.019
Map3k3mitogen activated protein kinase kinase kinase 30.019
Irf2interferon regulatory factor 20.019
Ccr5chemokine (C-C motif) receptor 50.018
Lnpepleucyl/cystinyl aminopeptidase0.018
Ptger4prostaglandin E receptor 4 (subtype EP4)0.017
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.016
Megf10multiple EGF-like domains 100.016
Usp3ubiquitin specific peptidase 30.015
Il1binterleukin 1 beta0.015
Inpp5dinositol polyphosphate-5-phosphatase D0.015
Il2rginterleukin 2 receptor, gamma0.015
Itpr2inositol 1,4,5-triphosphate receptor, type 20.015
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.015
Calcoco1calcium binding and coiled coil domain 10.015
Nr5a1nuclear receptor subfamily 5, group A, member 10.014
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.014
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.014
Prkcdprotein kinase C, delta0.014
Homer2homer homolog 2 (Drosophila)0.013
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.013
Zbp1Z-DNA binding protein 10.013
Cd37CD37 molecule0.013
Scarb1scavenger receptor class B, member 10.012
Cd53Cd53 molecule0.012
Csf1colony stimulating factor 1 (macrophage)0.012
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.012
S100a9S100 calcium binding protein A90.012
RGD1559588similar to cell surface receptor FDFACT0.011
Metmet proto-oncogene0.011
Elf1E74-like factor 10.011
Tgfb1transforming growth factor, beta 10.011
Calcrlcalcitonin receptor-like0.011
Adora2aadenosine A2a receptor0.010
Fam108a1family with sequence similarity 108, member A10.010
RGD1561143similar to cell surface receptor FDFACT0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.481
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.470
bcl2l1bcl2-like 10.461
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.448
nf1aneurofibromin 1a0.417
ptgs2aprostaglandin-endoperoxide synthase 2a0.314
mcl1amyeloid cell leukemia sequence 1a0.268
trpv6transient receptor potential cation channel, subfamily V, member 60.243
ptgdsprostaglandin D2 synthase0.215
vcanaversican a0.192
ck2bcasein kinase 2 beta0.169
bidaBH3 interacting domain death agonist0.163
LOC567131calcitonin gene-related peptide type 1 receptor-like0.161
pitx3paired-like homeodomain transcription factor 30.155
acvr2aactivin receptor IIa0.153
tgfb3transforming growth factor, beta 30.151
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.147
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.144
ptgeslprostaglandin E synthase 2-like0.142
itgb3bintegrin beta 3b0.138
tcf7transcription factor 7 (T-cell specific, HMG-box)0.133
inhainhibin, alpha0.133
bcl2B-cell leukemia/lymphoma 20.133
evx1even-skipped homeobox 10.133
six1bsine oculis homeobox homolog 1b0.130
rag1recombination activating gene 10.129
zbtb4zinc finger and BTB domain containing 40.128
mmp9matrix metalloproteinase 90.123
mcl1bmyeloid cell leukemia sequence 1b0.121
wnt9bwingless-type MMTV integration site family, member 9B0.116
nrg1neuregulin 10.115
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.114
egr2bearly growth response 2b0.109
lef1lymphocyte enhancer binding factor 10.106
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.105
mpxmyeloid-specific peroxidase0.099
lhx2bLIM homeobox 2b0.096
mfn2mitofusin 20.094
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.093
stc1lstanniocalcin 1, like0.091
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.090
pnrc2proline-rich nuclear receptor coactivator 20.085
tgfb1atransforming growth factor, beta 1a0.080
kdrlkinase insert domain receptor like0.078
dlx5adistal-less homeobox gene 5a0.077
lhx6LIM homeobox 60.075
olig1oligodendrocyte lineage transcription factor 10.075
bnc2basonuclin 20.074
nrg2aneuregulin 2a0.073
cmybtranscription factor cmyb0.071
igf1insulin-like growth factor 10.070
faslgFas ligand (TNF superfamily, member 6)0.070
scinlascinderin like a0.068
cnihcornichon homolog (Drosophila)0.068
sfrp1bsecreted frizzled-related protein 1b0.067
runx2arunt-related transcription factor 2a0.066
hmx2H6 family homeobox 20.066
cpla2cytosolic phospholipase a20.066
wnt10awingless-type MMTV integration site family, member 10a0.065
uba1ubiquitin-like modifier activating enzyme 10.065
prrx1apaired related homeobox 1a0.065
bmf1Bcl2 modifying factor 10.065
ptgs1prostaglandin-endoperoxide synthase 10.064
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.063
bc2putative breast adenocarcinoma marker0.063
adra2dbadrenergic, alpha-2D-, receptor b0.063
dusp1dual specificity phosphatase 10.063
bikBCL2-interacting killer (apoptosis-inducing)0.063
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.063
fgf20afibroblast growth factor 20a0.063
igf1rbinsulin-like growth factor 1b receptor0.063
tnfatumor necrosis factor a (TNF superfamily, member 2)0.062
tnfrsfatumor necrosis factor receptor superfamily, member a0.062
npas2neuronal PAS domain protein 20.060
lhcgrluteinizing hormone/choriogonadotropin receptor0.060
hspa12bheat shock protein 12B0.059
rcc2regulator of chromosome condensation 20.058
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.058
bglapbone gamma-carboxyglutamate (gla) protein0.057
epas1bendothelial PAS domain protein 1b0.057
calm3bcalmodulin 3b (phosphorylase kinase, delta)0.056
arf2ADP-ribosylation factor 20.056
csf1racolony stimulating factor 1 receptor, a0.054
spry1sprouty homolog 1 (Drosophila)0.053
ltkleukocyte tyrosine kinase0.053
psma6bproteasome (prosome, macropain) subunit, alpha type, 6b0.053
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.053
casp8caspase 8, apoptosis-related cysteine peptidase0.052
slc25a5solute carrier family 25 alpha, member 50.052
fstl1bfollistatin-like 1b0.052
dynlrb1dynein, light chain, roadblock-type 10.052
ppp2r1bprotein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform0.051
csnk1dbcasein kinase 1, delta b0.050
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.999
BCL2L1BCL2-like 10.995
PMLpromyelocytic leukemia0.950
BCL2L11BCL2-like 11 (apoptosis facilitator)0.883
BAXBCL2-associated X protein0.881
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.829
TAL1T-cell acute lymphocytic leukemia 10.792
BIDBH3 interacting domain death agonist0.779
HSPA1Aheat shock 70kDa protein 1A0.695
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.682
BADBCL2-associated agonist of cell death0.679
FASFas (TNF receptor superfamily, member 6)0.666
CASP10caspase 10, apoptosis-related cysteine peptidase0.611
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.594
HSPA1Bheat shock 70kDa protein 1B0.556
IL8interleukin 80.508
EGFRepidermal growth factor receptor0.468
SHC1SHC (Src homology 2 domain containing) transforming protein 10.416
CXCL2chemokine (C-X-C motif) ligand 20.325
CXCL5chemokine (C-X-C motif) ligand 50.312
IL1R1interleukin 1 receptor, type I0.273
NTRK1neurotrophic tyrosine kinase, receptor, type 10.247
CASP8caspase 8, apoptosis-related cysteine peptidase0.243
HSPB1heat shock 27kDa protein 10.220
MAP3K3mitogen-activated protein kinase kinase kinase 30.213
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.205
MAPK14mitogen-activated protein kinase 140.197
CDC37cell division cycle 37 homolog (S. cerevisiae)0.196
BCL2A1BCL2-related protein A10.186
PLCG1phospholipase C, gamma 10.182
CCL20chemokine (C-C motif) ligand 200.161
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.153
TRADDTNFRSF1A-associated via death domain0.153
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.142
AKT1v-akt murine thymoma viral oncogene homolog 10.136
MAP2K5mitogen-activated protein kinase kinase 50.130
CXCL3chemokine (C-X-C motif) ligand 30.106
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.094
IL1Binterleukin 1, beta0.090
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.083
DAXXdeath-domain associated protein0.081
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.081
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.080
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.078
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.076
BAG1BCL2-associated athanogene0.075
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.066
BAK1BCL2-antagonist/killer 10.065
CCL4chemokine (C-C motif) ligand 40.061
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.058
IL1R2interleukin 1 receptor, type II0.058
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.057
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.056
APPamyloid beta (A4) precursor protein0.055
MAP3K2mitogen-activated protein kinase kinase kinase 20.054
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.053
CHEK2CHK2 checkpoint homolog (S. pombe)0.051
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.051
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.048
CXCL10chemokine (C-X-C motif) ligand 100.046
IL6interleukin 6 (interferon, beta 2)0.044
CXCL9chemokine (C-X-C motif) ligand 90.044
RIPK3receptor-interacting serine-threonine kinase 30.044
TNFAIP6tumor necrosis factor, alpha-induced protein 60.043
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.043
CCL8chemokine (C-C motif) ligand 80.043
HSPH1heat shock 105kDa/110kDa protein 10.042
IL4Rinterleukin 4 receptor0.042
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.037
MAPK7mitogen-activated protein kinase 70.037
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.037
JUPjunction plakoglobin0.036
TP53tumor protein p530.036
BCL2L2BCL2-like 20.036
CXCL11chemokine (C-X-C motif) ligand 110.034
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.034
DIABLOdiablo, IAP-binding mitochondrial protein0.033
RIPK2receptor-interacting serine-threonine kinase 20.033
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.032
CASP7caspase 7, apoptosis-related cysteine peptidase0.031
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 20.030
XIAPX-linked inhibitor of apoptosis0.030
BIRC2baculoviral IAP repeat containing 20.030
GRB7growth factor receptor-bound protein 70.030
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.030
TRAF1TNF receptor-associated factor 10.030
IFI27interferon, alpha-inducible protein 270.029
FGF1fibroblast growth factor 1 (acidic)0.029
RNF144Bring finger protein 144B0.029
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.028
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.028
AXIN1axin 10.028
CCL2chemokine (C-C motif) ligand 20.028
BIRC3baculoviral IAP repeat containing 30.027
INSRinsulin receptor0.027
PI3peptidase inhibitor 3, skin-derived0.026
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.025
VDAC1voltage-dependent anion channel 10.024
STK11serine/threonine kinase 110.024
UBDubiquitin D0.024
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.997
Col1a1collagen, type I, alpha 10.995
Trp53transformation related protein 530.992
Kitkit oncogene0.976
Pax2paired box gene 20.962
Itgb1integrin beta 1 (fibronectin receptor beta)0.961
Ikzf1IKAROS family zinc finger 10.955
Retret proto-oncogene0.937
FasFas (TNF receptor superfamily member 6)0.935
Ptenphosphatase and tensin homolog0.902
Ifnginterferon gamma0.889
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.863
Pax3paired box gene 30.861
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.847
Leprleptin receptor0.840
BaxBCL2-associated X protein0.838
Tnfaip3tumor necrosis factor, alpha-induced protein 30.833
Ptpn11protein tyrosine phosphatase, non-receptor type 110.822
Il10interleukin 100.819
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.819
Shhsonic hedgehog0.799
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.790
Egfrepidermal growth factor receptor0.764
Zeb1zinc finger E-box binding homeobox 10.755
Bcl2B-cell leukemia/lymphoma 20.747
Tnftumor necrosis factor0.747
Fbn1fibrillin 10.741
Bmp4bone morphogenetic protein 40.704
Rb1retinoblastoma 10.690
Il1binterleukin 1 beta0.683
Ptprcprotein tyrosine phosphatase, receptor type, C0.665
Snai1snail homolog 1 (Drosophila)0.651
Cdkn1bcyclin-dependent kinase inhibitor 1B0.648
Ccr1chemokine (C-C motif) receptor 10.639
Rxraretinoid X receptor alpha0.625
Efnb2ephrin B20.611
Fgfr2fibroblast growth factor receptor 20.606
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.601
Col5a2collagen, type V, alpha 20.584
Sox10SRY-box containing gene 100.548
Tgfbr2transforming growth factor, beta receptor II0.543
Foxp3forkhead box P30.540
Cd44CD44 antigen0.506
Phox2apaired-like homeobox 2a0.489
Inpp5dinositol polyphosphate-5-phosphatase D0.458
Rararetinoic acid receptor, alpha0.449
Psen1presenilin 10.435
Hoxa11homeobox A110.432
Tbx1T-box 10.430
Lyz2lysozyme 20.420
Meox2mesenchyme homeobox 20.419
Isl1ISL1 transcription factor, LIM/homeodomain0.419
Cdk4cyclin-dependent kinase 40.407
Col3a1collagen, type III, alpha 10.407
Axin1axin 10.403
SharpinSHANK-associated RH domain interacting protein0.399
Nos3nitric oxide synthase 3, endothelial cell0.394
Tgfb1transforming growth factor, beta 10.393
Apcadenomatosis polyposis coli0.386
Vhlvon Hippel-Lindau tumor suppressor0.371
Ntf3neurotrophin 30.368
Gli3GLI-Kruppel family member GLI30.367
Hspg2perlecan (heparan sulfate proteoglycan 2)0.353
Ccr2chemokine (C-C motif) receptor 20.347
Pthlhparathyroid hormone-like peptide0.343
Foxc1forkhead box C10.331
Capn6calpain 60.319
Ciitaclass II transactivator0.316
Prrx2paired related homeobox 20.308
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.304
Adam17a disintegrin and metallopeptidase domain 170.302
C5ar1complement component 5a receptor 10.301
Selpselectin, platelet0.296
FaddFas (TNFRSF6)-associated via death domain0.286
Il6stinterleukin 6 signal transducer0.286
Smad3MAD homolog 3 (Drosophila)0.284
Wisp2WNT1 inducible signaling pathway protein 20.283
Notch1Notch gene homolog 1 (Drosophila)0.280
Lystlysosomal trafficking regulator0.278
Tgfb2transforming growth factor, beta 20.276
Kitlkit ligand0.267
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.262
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.259
Rbl1retinoblastoma-like 1 (p107)0.257
Pax8paired box gene 80.256
Elf4E74-like factor 4 (ets domain transcription factor)0.255
Il1ainterleukin 1 alpha0.253
Hoxa1homeobox A10.252
Lmnalamin A0.250
Klrg1killer cell lectin-like receptor subfamily G, member 10.247
Gata3GATA binding protein 30.247
Il18rapinterleukin 18 receptor accessory protein0.245
Postnperiostin, osteoblast specific factor0.245
Sgpl1sphingosine phosphate lyase 10.243
Il2rginterleukin 2 receptor, gamma chain0.243
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.242
Col6a1collagen, type VI, alpha 10.239
Rargretinoic acid receptor, gamma0.239
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism