The network for 'icosanoid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

icosanoid biosynthetic process

The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.

NameDescriptionProbabilityFunc Analog Organism
RT1-Db1RT1 class II, locus Db10.280
Tspotranslocator protein0.169
Anxa1annexin A10.135
Gsta3glutathione S-transferase A30.129
Il6interleukin 60.110
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.103
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.097
Anxa5annexin A50.090
Anxa2annexin A20.080
Lyz2lysozyme 20.072
S100a11S100 calcium binding protein A11 (calizzarin)0.063
RT1-BaRT1 class II, locus Ba0.062
Cd151CD151 molecule (Raph blood group)0.059
RT1-DaRT1 class II, locus Da0.058
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.057
Il18interleukin 180.056
Ctnna1catenin (cadherin associated protein), alpha 10.055
Slc14a2solute carrier family 14 (urea transporter), member 20.054
Olr416olfactory receptor 4160.052
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.052
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.050
Il17reinterleukin 17 receptor E0.043
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.041
Ggt1gamma-glutamyltransferase 10.041
Xdhxanthine dehydrogenase0.040
Ptpn14protein tyrosine phosphatase, non-receptor type 140.039
Stk39serine/threonine kinase 39, STE20/SPS1 homolog (yeast)0.039
S100a10S100 calcium binding protein A100.038
Serpinb3serine protease inhibitor B30.037
Prkcdprotein kinase C, delta0.033
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.032
Slc22a25solute carrier family 22, member 250.031
Prss1protease, serine, 1 (trypsin 1)0.030
Scnn1bsodium channel, nonvoltage-gated 1, beta0.030
Rcsd1RCSD domain containing 10.029
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.029
Fmo1flavin containing monooxygenase 10.029
S100a6S100 calcium binding protein A60.028
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.028
Ppardperoxisome proliferator-activated receptor delta0.028
Reg3gregenerating islet-derived 3 gamma0.028
Acsm5acyl-CoA synthetase medium-chain family member 50.028
Capn2calpain 20.027
C5ar1complement component 5a receptor 10.027
Abcd1ATP-binding cassette, subfamily D (ALD), member 10.027
Itgb1integrin, beta 10.025
Cd44Cd44 molecule0.024
Cyp27a1cytochrome P450, family 27, subfamily a, polypeptide 10.024
Olr1280olfactory receptor 12800.024
Cst8cystatin 8 (cystatin-related epididymal specific)0.024
Gstp1glutathione S-transferase pi 10.024
Orm1orosomucoid 10.024
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.024
Myadmmyeloid-associated differentiation marker0.024
RT1-BbRT1 class II, locus Bb0.023
Olr1082olfactory receptor 10820.023
Rag1recombination activating gene 10.023
Akr1c18aldo-keto reductase family 1, member C180.022
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.022
Cr1lcomplement component (3b/4b) receptor 1-like0.022
Gfi1growth factor independent 1 transcription repressor0.022
Ptprcprotein tyrosine phosphatase, receptor type, C0.022
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.022
Glp1rglucagon-like peptide 1 receptor0.021
Gjb3gap junction protein, beta 30.021
Il2rbinterleukin 2 receptor, beta0.020
Pla1aphospholipase A1 member A0.020
Dpep1dipeptidase 1 (renal)0.020
Rnf39ring finger protein 390.020
Pnlippancreatic lipase0.019
Arpc1bactin related protein 2/3 complex, subunit 1B0.019
Slc44a2solute carrier family 44, member 20.019
Gja5gap junction protein, alpha 50.019
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.019
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.019
Cd14CD14 molecule0.019
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.019
Ctsjcathepsin J0.018
Gstm1glutathione S-transferase mu 10.018
Ptgfrprostaglandin F receptor0.018
Il1r2interleukin 1 receptor, type II0.018
Prlhprolactin releasing hormone0.018
Ephx1epoxide hydrolase 1, microsomal0.018
Timp1TIMP metallopeptidase inhibitor 10.017
Ugt8UDP glycosyltransferase 80.017
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.017
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.017
Rgs9regulator of G-protein signaling 90.017
Enpp3ectonucleotide pyrophosphatase/phosphodiesterase 30.017
Cybrd1cytochrome b reductase 10.017
Olr1496olfactory receptor 14960.016
Gstm3glutathione S-transferase mu 30.016
Grifingalectin-related inter-fiber protein0.016
Krt4keratin 40.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
phlpole hole0.210
Fmr1CG6203 gene product from transcript CG6203-RC0.039
sesBstress-sensitive B0.028
TorTarget of rapamycin0.028
KhcKinesin heavy chain0.027
EgfrEpidermal growth factor receptor0.026
EcREcdysone receptor0.025
poloCG12306 gene product from transcript CG12306-RA0.023
CG5602CG5602 gene product from transcript CG5602-RA0.016
Bap170Brahma associated protein 170kD0.016
Ras85DRas oncogene at 85D0.016
lidlittle imaginal discs0.015
aspabnormal spindle0.015
BubR1Bub1-related kinase0.014
trioCG18214 gene product from transcript CG18214-RA0.013
mit(1)15mitotic 150.013
sbrsmall bristles0.013
Sir2CG5216 gene product from transcript CG5216-RA0.012
MED22Mediator complex subunit 220.012
dallydivision abnormally delayed0.012
trolterribly reduced optic lobes0.011
CG1677CG1677 gene product from transcript CG1677-RB0.011
BRWD3CG31132 gene product from transcript CG31132-RA0.011
Nup98Nucleoporin 980.011
Moca-cypCG1866 gene product from transcript CG1866-RA0.010
zf30CZinc finger protein 30C0.010
Fas2Fasciclin 20.010
CG32479CG32479 gene product from transcript CG32479-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GGT1gamma-glutamyltransferase 10.478
COTL1coactosin-like 1 (Dictyostelium)0.453
GGTLC1gamma-glutamyltransferase light chain 10.117
CXCR4chemokine (C-X-C motif) receptor 40.046
MAP2K4mitogen-activated protein kinase kinase 40.041
KAT2BK(lysine) acetyltransferase 2B0.038
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.032
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.027
UBASH3Bubiquitin associated and SH3 domain containing B0.026
MAPK8mitogen-activated protein kinase 80.025
GGT2gamma-glutamyltransferase 20.025
EP300E1A binding protein p3000.023
FKBP4FK506 binding protein 4, 59kDa0.022
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.020
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.020
PTPN6protein tyrosine phosphatase, non-receptor type 60.017
PDPK13-phosphoinositide dependent protein kinase-10.017
KRT5keratin 50.016
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.016
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
IRS2insulin receptor substrate 20.014
PPIDpeptidylprolyl isomerase D0.013
CARD11caspase recruitment domain family, member 110.013
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.013
CXCL2chemokine (C-X-C motif) ligand 20.012
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.012
ALOX12Barachidonate 12-lipoxygenase, 12R type0.012
HPRT1hypoxanthine phosphoribosyltransferase 10.011
PDZK1IP1PDZK1 interacting protein 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cd22CD22 antigen0.608
H2-Eb1histocompatibility 2, class II antigen E beta0.474
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.258
Ptgesprostaglandin E synthase0.189
TyrobpTYRO protein tyrosine kinase binding protein0.178
Ptgs1prostaglandin-endoperoxide synthase 10.150
Alox5arachidonate 5-lipoxygenase0.149
Ccl6chemokine (C-C motif) ligand 60.147
Cd14CD14 antigen0.121
Kitkit oncogene0.114
Fcgr3Fc receptor, IgG, low affinity III0.081
Orai1ORAI calcium release-activated calcium modulator 10.070
Tmem40transmembrane protein 400.068
Ren1renin 1 structural0.067
Ednraendothelin receptor type A0.065
Platplasminogen activator, tissue0.065
Abp1amiloride binding protein 1 (amine oxidase, copper-containing)0.065
Gp9glycoprotein 9 (platelet)0.063
Selpselectin, platelet0.059
Tbxas1thromboxane A synthase 1, platelet0.058
Hckhemopoietic cell kinase0.056
Alox5aparachidonate 5-lipoxygenase activating protein0.056
H2-Aahistocompatibility 2, class II antigen A, alpha0.055
Nfam1Nfat activating molecule with ITAM motif 10.050
Rab25RAB25, member RAS oncogene family0.049
Tlr4toll-like receptor 40.047
Latlinker for activation of T cells0.046
Inpp5dinositol polyphosphate-5-phosphatase D0.044
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.043
Pkp3plakophilin 30.042
Htra3HtrA serine peptidase 30.042
C3complement component 30.041
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.039
Bdkrb2bradykinin receptor, beta 20.039
Krt72-pskeratin 72, pseudogene0.038
Pf4platelet factor 40.038
C1qacomplement component 1, q subcomponent, alpha polypeptide0.038
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.038
H2-DMahistocompatibility 2, class II, locus DMa0.037
Ifitm6interferon induced transmembrane protein 60.037
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.035
Il6interleukin 60.035
Fcnaficolin A0.034
Il17ainterleukin 17A0.033
Itga2bintegrin alpha 2b0.033
Lgals2lectin, galactose-binding, soluble 20.033
Cbr2carbonyl reductase 20.032
Cma1chymase 1, mast cell0.030
Atf2activating transcription factor 20.030
Arntlaryl hydrocarbon receptor nuclear translocator-like0.030
C5ar1complement component 5a receptor 10.029
Dpep1dipeptidase 1 (renal)0.029
Ch25hcholesterol 25-hydroxylase0.029
Pdzk1ip1PDZK1 interacting protein 10.029
Expiextracellular proteinase inhibitor0.028
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.028
Csf1rcolony stimulating factor 1 receptor0.027
Kiss1KiSS-1 metastasis-suppressor0.027
BlkB lymphoid kinase0.027
Dok1docking protein 10.027
Ghgrowth hormone0.026
Sfrp4secreted frizzled-related protein 40.026
Krt32keratin 320.026
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.025
Thbs1thrombospondin 10.025
Trpv4transient receptor potential cation channel, subfamily V, member 40.025
Vdrvitamin D receptor0.025
C1qbcomplement component 1, q subcomponent, beta polypeptide0.025
Clic3chloride intracellular channel 30.025
Clec4nC-type lectin domain family 4, member n0.024
Slc34a1solute carrier family 34 (sodium phosphate), member 10.024
Cdh16cadherin 160.024
Mapk14mitogen-activated protein kinase 140.024
S100a8S100 calcium binding protein A8 (calgranulin A)0.023
Vpreb3pre-B lymphocyte gene 30.023
Tnfrsf17tumor necrosis factor receptor superfamily, member 170.023
Gipgastric inhibitory polypeptide0.023
A4galtalpha 1,4-galactosyltransferase0.023
Mmp8matrix metallopeptidase 80.023
Clec1bC-type lectin domain family 1, member b0.023
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.023
Ngpneutrophilic granule protein0.022
Hdchistidine decarboxylase0.022
Lyz1lysozyme 10.022
Cxcr2chemokine (C-X-C motif) receptor 20.022
Acvrl1activin A receptor, type II-like 10.022
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.021
FaslFas ligand (TNF superfamily, member 6)0.021
Rsbn1rosbin, round spermatid basic protein 10.021
Cd247CD247 antigen0.021
Lrg1leucine-rich alpha-2-glycoprotein 10.021
Htr75-hydroxytryptamine (serotonin) receptor 70.021
Padi1peptidyl arginine deiminase, type I0.021
C3ar1complement component 3a receptor 10.020
Cfdcomplement factor D (adipsin)0.020
S100a9S100 calcium binding protein A9 (calgranulin B)0.020
Itgamintegrin alpha M0.020
Ptgs2prostaglandin-endoperoxide synthase 20.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism