The network for 'thymus development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

thymus development

The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
klf4Kruppel-like factor 40.367
ikzf1IKAROS family zinc finger 1 (Ikaros)0.224
wu:fv91b12wu:fv91b120.222
nrp1aneuropilin 1a0.213
efnb2aephrin B2a0.206
sox9aSRY-box containing gene 9a0.164
nrp2bneuropilin 2b0.155
pcnaproliferating cell nuclear antigen0.147
cmybtranscription factor cmyb0.098
rag1recombination activating gene 10.087
runx3runt-related transcription factor 30.074
hoxb3ahomeo box B3a0.069
nkx3.2NK3 homeobox 20.069
tal1T-cell acute lymphocytic leukemia 10.067
hhexhematopoietically expressed homeobox0.064
cdh2cadherin 2, neuronal0.062
nrp1bneuropilin 1b0.060
gata3GATA-binding protein 30.058
cacnb4bcalcium channel, voltage-dependent, beta 4b subunit0.055
dopey1dopey family member 10.050
foxi1forkhead box I10.050
il7rinterleukin 7 receptor0.046
dnttdeoxynucleotidyltransferase, terminal0.046
twist1atwist1a0.045
prickle2prickle-like 2 (Drosophila)0.045
aldh1a2aldehyde dehydrogenase 1 family, member A20.044
pdlim4PDZ and LIM domain 40.044
skianuclear oncoprotein skia0.035
foxn4forkhead box N40.035
pcdh8protocadherin 80.035
rag2recombination activating gene 20.034
foxn1forkhead box N10.034
tbx1T-box 10.034
tgfb3transforming growth factor, beta 30.033
top3atopoisomerase (DNA) III alpha0.032
ephb4beph receptor B4b0.030
jag1bjagged 1b0.030
ighzimmunoglobulin heavy constant zeta0.029
fgf10afibroblast growth factor 10a0.027
eya1eyes absent homolog 10.027
nav3neuron navigator 30.027
nrp2aneuropilin 2a0.026
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.026
rargaretinoic acid receptor gamma a0.025
msh6mutS homolog 6 (E. coli)0.025
pold1polymerase (DNA directed), delta 1, catalytic subunit0.025
uroduroporphyrinogen decarboxylase0.025
cacnb4acalcium channel, voltage-dependent, beta 4a subunit0.024
ptprfprotein tyrosine phosphatase, receptor type, F0.022
pitx2paired-like homeodomain transcription factor 20.022
smad1MAD homolog 1 (Drosophila)0.021
pif1PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)0.021
egr1early growth response 10.021
six4bsine oculis homeobox homolog 4b0.021
tbx2aT-box gene 2a0.020
csf1racolony stimulating factor 1 receptor, a0.018
mpxmyeloid-specific peroxidase0.018
hbbe3hemoglobin beta embryonic-30.018
nkx2.7NK2 transcription factor related 70.018
stc1lstanniocalcin 1, like0.018
znfl2azinc finger-like gene 2a0.018
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.018
mecomMDS1 and EVI1 complex locus0.018
hoxb2ahomeo box B2a0.018
igfbp3insulin-like growth factor binding protein 30.017
ccna2cyclin A20.017
tcf21transcription factor 210.017
myod1myogenic differentiation 10.017
trpm7transient receptor potential cation channel, subfamily M, member 70.017
sema3dsemaphorin 3d0.016
angpt1angiopoietin 10.016
znf703zinc finger protein 7030.016
crestincrestin0.016
pax2apaired box gene 2a0.016
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.016
polmpolymerase (DNA directed), mu0.016
msxemuscle segment homeobox E0.015
lzts2aleucine zipper, putative tumor suppressor 2a0.015
foxa2forkhead box A20.015
smoc1SPARC related modular calcium binding 10.015
six2asine oculis-related homeobox 2a0.015
si:dkeyp-117h8.4si:dkeyp-117h8.40.015
hoxa2bhomeo box A2b0.015
irx5airoquois homeobox protein 5a0.015
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.015
hdac4histone deacetylase 40.015
chrm2acholinergic receptor, muscarinic 2a0.014
vephventricular zone expressed PH domain protein0.014
thtyrosine hydroxylase0.014
mbtps1membrane-bound transcription factor protease, site 10.014
spry1sprouty homolog 1 (Drosophila)0.014
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.014
gata6GATA-binding protein 60.014
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.014
pnxposterior neuron-specific homeobox0.014
sox9bSRY-box containing gene 9b0.013
evx1even-skipped homeobox 10.013
bmp2bbone morphogenetic protein 2b0.013
rybpaRING1 and YY1 binding protein a0.013
eporerythropoietin receptor0.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.999
CASP8caspase 8, apoptosis-related cysteine peptidase0.994
PSEN1presenilin 10.988
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.956
BADBCL2-associated agonist of cell death0.948
VEGFAvascular endothelial growth factor A0.939
FGF10fibroblast growth factor 100.892
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.834
BCL2L1BCL2-like 10.828
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.769
POU5F1POU class 5 homeobox 10.748
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.723
FASFas (TNF receptor superfamily, member 6)0.614
FLNBfilamin B, beta0.603
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.588
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.586
TGFB1transforming growth factor, beta 10.552
NR2E3nuclear receptor subfamily 2, group E, member 30.547
FGF1fibroblast growth factor 1 (acidic)0.542
MEIS1Meis homeobox 10.520
MEIS2Meis homeobox 20.501
KPNA1karyopherin alpha 1 (importin alpha 5)0.476
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.449
ARandrogen receptor0.404
PSEN2presenilin 2 (Alzheimer disease 4)0.349
MEOX1mesenchyme homeobox 10.325
FGF7fibroblast growth factor 70.310
CDK9cyclin-dependent kinase 90.273
MED12mediator complex subunit 120.270
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.264
BCL2B-cell CLL/lymphoma 20.254
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.230
FKBP1AFK506 binding protein 1A, 12kDa0.187
LDB1LIM domain binding 10.186
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.179
FGF8fibroblast growth factor 8 (androgen-induced)0.174
CTBP1C-terminal binding protein 10.169
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.166
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.156
FGFR1fibroblast growth factor receptor 10.151
NCOR1nuclear receptor corepressor 10.151
NLKnemo-like kinase0.148
CSNK1G1casein kinase 1, gamma 10.147
ATXN3ataxin 30.144
SIN3ASIN3 homolog A, transcription regulator (yeast)0.141
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.139
GATA4GATA binding protein 40.139
TCF4transcription factor 40.136
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.135
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.133
ECSITECSIT homolog (Drosophila)0.125
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.124
MBD4methyl-CpG binding domain protein 40.121
BAXBCL2-associated X protein0.120
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.118
SEC24DSEC24 family, member D (S. cerevisiae)0.113
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.109
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.107
EP300E1A binding protein p3000.107
TGFB3transforming growth factor, beta 30.102
ZNF331zinc finger protein 3310.102
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.102
RBL1retinoblastoma-like 1 (p107)0.101
DCAF8DDB1 and CUL4 associated factor 80.097
BAK1BCL2-antagonist/killer 10.094
PKP4plakophilin 40.092
CD320CD320 molecule0.089
BIDBH3 interacting domain death agonist0.089
GLIS2GLIS family zinc finger 20.088
PRPF31PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)0.086
HDAC3histone deacetylase 30.085
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.084
FGFR3fibroblast growth factor receptor 30.083
FOXC1forkhead box C10.081
HNF4Ahepatocyte nuclear factor 4, alpha0.076
ACANaggrecan0.076
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.075
FGF3fibroblast growth factor 30.075
PGFplacental growth factor0.075
RIC8Aresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)0.074
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.073
SRIsorcin0.072
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.072
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.071
SIM2single-minded homolog 2 (Drosophila)0.069
HIC1hypermethylated in cancer 10.069
LEF1lymphoid enhancer-binding factor 10.069
DNAJB2DnaJ (Hsp40) homolog, subfamily B, member 20.067
SIX6SIX homeobox 60.066
TGIF1TGFB-induced factor homeobox 10.065
GTF3C1general transcription factor IIIC, polypeptide 1, alpha 220kDa0.065
INHBBinhibin, beta B0.065
HOXA9homeobox A90.065
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.065
CTNND1catenin (cadherin-associated protein), delta 10.065
WNT1wingless-type MMTV integration site family, member 10.064
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.064
EYA2eyes absent homolog 2 (Drosophila)0.064
TCF21transcription factor 210.063
MYBBP1AMYB binding protein (P160) 1a0.063
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.957
Isl1ISL1 transcription factor, LIM/homeodomain0.939
Foxg1forkhead box G10.928
Hoxa1homeobox A10.904
Hoxd3homeobox D30.869
Ptenphosphatase and tensin homolog0.862
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.861
Neurod1neurogenic differentiation 10.837
Trp53transformation related protein 530.826
Ascl1achaete-scute complex homolog 1 (Drosophila)0.808
Ikzf1IKAROS family zinc finger 10.798
Tcfap2atranscription factor AP-2, alpha0.742
Cd19CD19 antigen0.732
Notch1Notch gene homolog 1 (Drosophila)0.692
Ephb2Eph receptor B20.687
Fgfr2fibroblast growth factor receptor 20.683
Pbx1pre B-cell leukemia transcription factor 10.641
Fgf10fibroblast growth factor 100.638
Nkx2-1NK2 homeobox 10.620
Bcl2B-cell leukemia/lymphoma 20.602
Shhsonic hedgehog0.593
Hoxa2homeobox A20.555
Bmpr1abone morphogenetic protein receptor, type 1A0.519
Eya1eyes absent 1 homolog (Drosophila)0.508
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.501
Tgfbr2transforming growth factor, beta receptor II0.482
Gata4GATA binding protein 40.469
Pax8paired box gene 80.467
Tbx3T-box 30.465
Tlx3T-cell leukemia, homeobox 30.436
Kiss1KiSS-1 metastasis-suppressor0.425
Rargretinoic acid receptor, gamma0.417
Lef1lymphoid enhancer binding factor 10.410
Hoxa13homeobox A130.404
Neurog2neurogenin 20.399
Prph2peripherin 20.388
Dlx1distal-less homeobox 10.365
Pax3paired box gene 30.337
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.325
Gbx2gastrulation brain homeobox 20.295
Emx1empty spiracles homolog 1 (Drosophila)0.292
Dab1disabled homolog 1 (Drosophila)0.292
Meis2Meis homeobox 20.292
Hoxb3homeobox B30.287
Pax1paired box gene 10.286
Neurog1neurogenin 10.284
Smad6MAD homolog 6 (Drosophila)0.283
Fgf8fibroblast growth factor 80.274
Pitx1paired-like homeodomain transcription factor 10.268
Hes1hairy and enhancer of split 1 (Drosophila)0.267
Snai1snail homolog 1 (Drosophila)0.267
Efnb1ephrin B10.264
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.249
Ebf2early B-cell factor 20.249
Efnb2ephrin B20.248
Fgf5fibroblast growth factor 50.246
Tcf21transcription factor 210.244
Myogmyogenin0.232
Bnc1basonuclin 10.231
Hoxb4homeobox B40.227
Dhhdesert hedgehog0.225
Efna2ephrin A20.225
Prrx1paired related homeobox 10.223
Casp8caspase 80.220
Ptpn11protein tyrosine phosphatase, non-receptor type 110.220
Dll4delta-like 4 (Drosophila)0.220
Otx2orthodenticle homolog 2 (Drosophila)0.219
Alx3aristaless-like homeobox 30.216
Fgfr1fibroblast growth factor receptor 10.206
Vegfavascular endothelial growth factor A0.202
Sox2SRY-box containing gene 20.199
Socs1suppressor of cytokine signaling 10.196
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.194
Fgf15fibroblast growth factor 150.193
Notch2Notch gene homolog 2 (Drosophila)0.192
Gata3GATA binding protein 30.189
Dlx5distal-less homeobox 50.187
Ptk2PTK2 protein tyrosine kinase 20.185
Hoxd13homeobox D130.181
Gata6GATA binding protein 60.178
Lhx5LIM homeobox protein 50.177
Pax2paired box gene 20.176
Rag2recombination activating gene 20.176
Zfpm2zinc finger protein, multitype 20.174
Jag1jagged 10.168
Pitx2paired-like homeodomain transcription factor 20.162
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.160
MecomMDS1 and EVI1 complex locus0.156
Hoxa11homeobox A110.155
Nr5a1nuclear receptor subfamily 5, group A, member 10.150
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.148
Lhx6LIM homeobox protein 60.146
Tbx2T-box 20.144
Wnt3awingless-related MMTV integration site 3A0.144
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.143
Tcfap2btranscription factor AP-2 beta0.140
Hoxb1homeobox B10.140
Chd7chromodomain helicase DNA binding protein 70.138
Hoxb5homeobox B50.135
Ror2receptor tyrosine kinase-like orphan receptor 20.135
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism