The network for 'response to corticosteroid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to corticosteroid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.

NameDescriptionProbabilityFunc Analog Organism
Anxa1annexin A10.895
Agtr1aangiotensin II receptor, type 1a0.892
Akr1c18aldo-keto reductase family 1, member C180.825
Hes3hairy and enhancer of split 3 (Drosophila)0.792
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.758
C1qccomplement component 1, q subcomponent, C chain0.755
Ccl2chemokine (C-C motif) ligand 20.748
Mgpmatrix Gla protein0.748
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.736
Mug1murinoglobulin 10.726
Cd4Cd4 molecule0.725
Mgst2microsomal glutathione S-transferase 20.690
Metmet proto-oncogene0.688
Ccnd1cyclin D10.680
RT1-BaRT1 class II, locus Ba0.669
Ptgs2prostaglandin-endoperoxide synthase 20.643
LOC100362824caveolin 2-like0.642
Cishcytokine inducible SH2-containing protein0.632
Bgnbiglycan0.629
Rarres2retinoic acid receptor responder (tazarotene induced) 20.612
Slc14a2solute carrier family 14 (urea transporter), member 20.608
Insrrinsulin receptor-related receptor0.603
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.603
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.602
Cpceruloplasmin0.594
Elnelastin0.594
Col3a1collagen, type III, alpha 10.591
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.589
Ephx1epoxide hydrolase 1, microsomal0.589
S100a10S100 calcium binding protein A100.589
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.588
Ube2d4ubiquitin-conjugating enzyme E2D 40.587
G6pcglucose-6-phosphatase, catalytic subunit0.576
Slco1a1solute carrier organic anion transporter family, member 1a10.574
Tgfbr2transforming growth factor, beta receptor II0.570
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.569
Cd14CD14 molecule0.567
Ccl20chemokine (C-C motif) ligand 200.565
Ces1ccarboxylesterase 1C0.563
Col1a2collagen, type I, alpha 20.560
Cxcl10chemokine (C-X-C motif) ligand 100.560
Procprotein C0.552
Il1binterleukin 1 beta0.551
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.550
Gfi1growth factor independent 1 transcription repressor0.545
Mchr1melanin-concentrating hormone receptor 10.524
Nr4a3nuclear receptor subfamily 4, group A, member 30.518
Cd36CD36 molecule (thrombospondin receptor)0.518
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.514
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.508
Gstm2glutathione S-transferase mu 20.507
Dcndecorin0.507
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.506
Pcolceprocollagen C-endopeptidase enhancer0.497
Gpx3glutathione peroxidase 30.495
Socs3suppressor of cytokine signaling 30.494
Col1a1collagen, type I, alpha 10.494
Slc6a1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.494
Mmp10matrix metallopeptidase 100.491
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.488
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.488
Ptch1patched homolog 1 (Drosophila)0.488
Fn1fibronectin 10.479
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.475
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.473
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.469
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.466
Ggt5gamma-glutamyltransferase 50.454
Gjb3gap junction protein, beta 30.453
Testintestin gene0.451
Spink1serine peptidase inhibitor, Kazal type 10.447
RT1-M4RT1 class Ib, locus M40.446
Il6interleukin 60.445
FcgrtFc fragment of IgG, receptor, transporter, alpha0.445
Crhbpcorticotropin releasing hormone binding protein0.445
Slco2a1solute carrier organic anion transporter family, member 2a10.443
Sod3superoxide dismutase 3, extracellular0.441
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.439
Egr2early growth response 20.439
Cpb1carboxypeptidase B1 (tissue)0.438
C5ar1complement component 5a receptor 10.434
Calcbcalcitonin-related polypeptide, beta0.432
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.431
Ccl4chemokine (C-C motif) ligand 40.426
Anxa5annexin A50.420
Vimvimentin0.417
Ttntitin0.416
Apoa4apolipoprotein A-IV0.416
LOC100362331rCG59612-like0.415
RT1-BbRT1 class II, locus Bb0.415
Il1r2interleukin 1 receptor, type II0.412
LOC293989cytochrome P450-like0.406
Idi1isopentenyl-diphosphate delta isomerase 10.403
Olfml2bolfactomedin-like 2B0.401
Calm4calmodulin 40.397
Onecut1one cut homeobox 10.396
Rnase4ribonuclease, RNase A family 40.394
Cdk2cyclin dependent kinase 20.393
Cela1chymotrypsin-like elastase family, member 10.391
Gfapglial fibrillary acidic protein0.389
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox9aSRY-box containing gene 9a0.737
col1a2collagen, type I, alpha 20.644
lmnalamin A0.583
ptgs2aprostaglandin-endoperoxide synthase 2a0.562
col1a1acollagen, type I, alpha 1a0.550
anxa1bannexin A1b0.439
thtyrosine hydroxylase0.404
col5a1procollagen, type V, alpha 10.387
alcamaactivated leukocyte cell adhesion molecule a0.340
igf2binsulin-like growth factor 2b0.321
ghrbgrowth hormone receptor b0.302
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.302
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.298
klf4aKruppel-like transcription factor 4a0.277
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.264
ncoa2nuclear receptor coactivator 20.252
epas1bendothelial PAS domain protein 1b0.243
nanos3nanos homolog 30.233
mmp9matrix metalloproteinase 90.222
apoebapolipoprotein Eb0.220
bcl2B-cell leukemia/lymphoma 20.220
ghragrowth hormone receptor a0.205
mmp2matrix metalloproteinase 20.204
trpv6transient receptor potential cation channel, subfamily V, member 60.195
zgc:85866zgc:858660.178
inhbaainhibin, beta Aa0.177
esr1estrogen receptor 10.176
igf2ainsulin-like growth factor 2a0.175
clockclock0.174
wt1bwilms tumor 1b0.170
lpar1lysophosphatidic acid receptor 10.167
shhasonic hedgehog a0.154
dlx2adistal-less homeobox gene 2a0.151
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.148
fshrfollicle stimulating hormone receptor0.144
socs3asuppressor of cytokine signaling 3a0.144
junbljun B proto-oncogene, like0.144
anxa2aannexin A2a0.142
wnt7bbwingless-type MMTV integration site family, member 7Bb0.141
sat1aspermidine/spermine N1-acetyltransferase 1a0.137
cnr1cannabinoid receptor 10.133
dlx5adistal-less homeobox gene 5a0.132
inhainhibin, alpha0.128
prmt1protein arginine methyltransferase 10.126
rag1recombination activating gene 10.125
junbjun B proto-oncogene0.125
wt1awilms tumor 1a0.124
il8interleukin 80.124
dcndecorin0.123
kiss2kisspeptin 20.121
ctsl1acathepsin L, 1 a0.121
tm4sf4transmembrane 4 L six family member 40.121
aqp1a.1aquaporin 1a, tandem duplicate 10.119
zgc:91835zgc:918350.116
vdravitamin D receptor a0.116
si:dkeyp-34c12.2si:dkeyp-34c12.20.113
starsteroidogenic acute regulatory protein0.107
zgc:175131zgc:1751310.105
krt5keratin 50.104
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.103
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.101
anxa1cannexin A1c0.100
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.098
slc8a1bsolute carrier family 8 (sodium/calcium exchanger), member 1b0.098
ptger2aprostaglandin E receptor 2a (subtype EP2)0.097
pcsk5aproprotein convertase subtilisin/kexin type 5a0.096
tnfatumor necrosis factor a (TNF superfamily, member 2)0.096
sepp1aselenoprotein P, plasma, 1a0.096
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.095
si:rp71-39b20.7si:rp71-39b20.70.094
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.091
th2tyrosine hydroxylase 20.091
eporerythropoietin receptor0.090
cx32.3connexin 32.30.089
cav1caveolin 10.089
zgc:193505zgc:1935050.089
bbc3BCL2 binding component 30.087
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.086
anxa1aannexin A1a0.085
atf3activating transcription factor 30.085
icn2ictacalcin 20.084
casrlcalcium-sensing receptor, like0.083
igfbp1ainsulin-like growth factor binding protein 1a0.082
tlr21toll-like receptor 210.081
itgb1b.2integrin, beta 1b.20.080
cpt1bcarnitine palmitoyltransferase 1B (muscle)0.079
si:ch211-195h23.3si:ch211-195h23.30.079
foxo3bforkhead box O3b0.078
wu:fb18f06wu:fb18f060.078
ucp2uncoupling protein 20.077
zgc:92030zgc:920300.076
twist1atwist1a0.076
tp63tumor protein p630.076
notch3notch homolog 30.076
krt4keratin 40.075
adra2aadrenergic, alpha-2A-, receptor0.075
pomt2protein-O-mannosyltransferase 20.074
smoc1SPARC related modular calcium binding 10.074
si:dkeyp-113d7.7si:dkeyp-113d7.70.073
col12a1collagen, type XII, alpha 10.073
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CXCL2chemokine (C-X-C motif) ligand 20.622
IL8interleukin 80.605
ANXA1annexin A10.479
ESR1estrogen receptor 10.475
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.471
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 20.385
NRP1neuropilin 10.382
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.345
JUNjun proto-oncogene0.342
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.338
RNF144Bring finger protein 144B0.333
EGFRepidermal growth factor receptor0.330
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.277
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.276
THBS1thrombospondin 10.257
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 40.236
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.231
NOSTRINnitric oxide synthase trafficker0.208
IL1R1interleukin 1 receptor, type I0.197
FOSFBJ murine osteosarcoma viral oncogene homolog0.192
NCOA1nuclear receptor coactivator 10.183
JAK2Janus kinase 20.175
CXCL3chemokine (C-X-C motif) ligand 30.160
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.157
APAF1apoptotic peptidase activating factor 10.144
CDK2cyclin-dependent kinase 20.142
IL6interleukin 6 (interferon, beta 2)0.134
SCP2sterol carrier protein 20.121
SOCS1suppressor of cytokine signaling 10.116
DUSP1dual specificity phosphatase 10.114
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.104
PLAUplasminogen activator, urokinase0.099
PTPN1protein tyrosine phosphatase, non-receptor type 10.098
NRIP1nuclear receptor interacting protein 10.092
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.089
PTPRBprotein tyrosine phosphatase, receptor type, B0.080
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.080
JUNBjun B proto-oncogene0.079
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.078
C1QAcomplement component 1, q subcomponent, A chain0.075
XIAPX-linked inhibitor of apoptosis0.074
MYD88myeloid differentiation primary response gene (88)0.062
IQGAP1IQ motif containing GTPase activating protein 10.062
TNFAIP3tumor necrosis factor, alpha-induced protein 30.060
CASP7caspase 7, apoptosis-related cysteine peptidase0.060
IER3immediate early response 30.059
ENGendoglin0.059
S100A10S100 calcium binding protein A100.057
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.055
KLHL24kelch-like 24 (Drosophila)0.052
STAT5Asignal transducer and activator of transcription 5A0.051
CCL2chemokine (C-C motif) ligand 20.051
BCL2L1BCL2-like 10.050
MAPK14mitogen-activated protein kinase 140.049
COL1A2collagen, type I, alpha 20.049
BCL2B-cell CLL/lymphoma 20.048
MDM2Mdm2 p53 binding protein homolog (mouse)0.046
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.046
PDCD6programmed cell death 60.046
BCL3B-cell CLL/lymphoma 30.045
CCND3cyclin D30.044
EP300E1A binding protein p3000.043
CCR5chemokine (C-C motif) receptor 50.042
NR4A2nuclear receptor subfamily 4, group A, member 20.041
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.041
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.041
IL10RAinterleukin 10 receptor, alpha0.040
CRHcorticotropin releasing hormone0.040
BBS1Bardet-Biedl syndrome 10.039
APOA1apolipoprotein A-I0.037
RB1retinoblastoma 10.036
CCL20chemokine (C-C motif) ligand 200.036
CRHR1corticotropin releasing hormone receptor 10.036
PLAURplasminogen activator, urokinase receptor0.036
ATF3activating transcription factor 30.036
SMAD3SMAD family member 30.035
EMP1epithelial membrane protein 10.034
RARAretinoic acid receptor, alpha0.032
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.032
PLATplasminogen activator, tissue0.031
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.030
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.029
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.029
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.029
EPORerythropoietin receptor0.029
IGFBP3insulin-like growth factor binding protein 30.028
RICTORRPTOR independent companion of MTOR, complex 20.028
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.027
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.027
MAPK8mitogen-activated protein kinase 80.027
ANXA2annexin A20.027
ARRDC3arrestin domain containing 30.027
BIDBH3 interacting domain death agonist0.026
COL3A1collagen, type III, alpha 10.025
S100A11S100 calcium binding protein A110.024
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.023
PPP5Cprotein phosphatase 5, catalytic subunit0.023
VIMvimentin0.023
FYNFYN oncogene related to SRC, FGR, YES0.023
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.022
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptgs2prostaglandin-endoperoxide synthase 20.996
Leprleptin receptor0.988
Lepleptin0.983
Trp53transformation related protein 530.960
Stat3signal transducer and activator of transcription 30.951
Ptpn11protein tyrosine phosphatase, non-receptor type 110.937
Nos3nitric oxide synthase 3, endothelial cell0.934
Esr1estrogen receptor 1 (alpha)0.909
Nos1nitric oxide synthase 1, neuronal0.903
FasFas (TNF receptor superfamily member 6)0.890
Csf1colony stimulating factor 1 (macrophage)0.740
Fshrfollicle stimulating hormone receptor0.724
Bglapbone gamma carboxyglutamate protein0.657
Ptenphosphatase and tensin homolog0.648
Lyz2lysozyme 20.615
Drd2dopamine receptor D20.604
Apoeapolipoprotein E0.562
Robo1roundabout homolog 1 (Drosophila)0.562
Col1a1collagen, type I, alpha 10.557
Egfrepidermal growth factor receptor0.527
Ren1renin 1 structural0.521
Il6stinterleukin 6 signal transducer0.505
Tgfb1transforming growth factor, beta 10.500
Cdkn1bcyclin-dependent kinase inhibitor 1B0.498
Casp4caspase 4, apoptosis-related cysteine peptidase0.434
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.387
Il1r1interleukin 1 receptor, type I0.371
Vdrvitamin D receptor0.367
Smad3MAD homolog 3 (Drosophila)0.363
Ghrgrowth hormone receptor0.347
Cdk4cyclin-dependent kinase 40.318
Ctnnb1catenin (cadherin associated protein), beta 10.311
Oprm1opioid receptor, mu 10.302
Arandrogen receptor0.287
Ccl2chemokine (C-C motif) ligand 20.257
Tlr4toll-like receptor 40.257
C1qacomplement component 1, q subcomponent, alpha polypeptide0.250
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.244
Nr3c1nuclear receptor subfamily 3, group C, member 10.244
Pomcpro-opiomelanocortin-alpha0.239
Cav1caveolin 1, caveolae protein0.239
Jag1jagged 10.230
Apcadenomatosis polyposis coli0.207
Mstnmyostatin0.202
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.202
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.200
Prlrprolactin receptor0.192
Agtr2angiotensin II receptor, type 20.188
Il6interleukin 60.183
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.178
Gja1gap junction protein, alpha 10.175
Itgb1integrin beta 1 (fibronectin receptor beta)0.172
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.172
Cd44CD44 antigen0.170
Cfhcomplement component factor h0.169
Npy1rneuropeptide Y receptor Y10.162
Insrinsulin receptor0.159
Ppargperoxisome proliferator activated receptor gamma0.155
Osmroncostatin M receptor0.154
Bcl2B-cell leukemia/lymphoma 20.149
H2-Ab1histocompatibility 2, class II antigen A, beta 10.145
Vhlvon Hippel-Lindau tumor suppressor0.144
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.143
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.142
Thbs1thrombospondin 10.140
Klf3Kruppel-like factor 3 (basic)0.135
Trim55tripartite motif-containing 550.127
Klklotho0.125
Slc12a1solute carrier family 12, member 10.125
Cdk2cyclin-dependent kinase 20.111
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.108
Nos2nitric oxide synthase 2, inducible0.102
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.102
Notch2Notch gene homolog 2 (Drosophila)0.101
Esr2estrogen receptor 2 (beta)0.100
Gata4GATA binding protein 40.094
Mmp9matrix metallopeptidase 90.093
Fbn1fibrillin 10.086
Cnr1cannabinoid receptor 1 (brain)0.083
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.081
Kitkit oncogene0.080
Galgalanin0.077
Timp1tissue inhibitor of metalloproteinase 10.076
Hif1ahypoxia inducible factor 1, alpha subunit0.075
Cyr61cysteine rich protein 610.075
Pgrprogesterone receptor0.074
Fgf10fibroblast growth factor 100.074
Spp1secreted phosphoprotein 10.069
Cxcl1chemokine (C-X-C motif) ligand 10.068
Errfi1ERBB receptor feedback inhibitor 10.067
F9coagulation factor IX0.066
Ppyr1pancreatic polypeptide receptor 10.065
Vegfavascular endothelial growth factor A0.064
H2-Eb1histocompatibility 2, class II antigen E beta0.063
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.062
BaxBCL2-associated X protein0.062
Adam17a disintegrin and metallopeptidase domain 170.060
Nupr1nuclear protein 10.058
Chrm1cholinergic receptor, muscarinic 1, CNS0.058
Npy2rneuropeptide Y receptor Y20.057
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism