The network for 'regulation of ryanodine sensitive calcium release channel activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of ryanodine sensitive calcium release channel activity

Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

NameDescriptionProbabilityFunc Analog Organism
Calm1calmodulin 10.739
Pgam1phosphoglycerate mutase 1 (brain)0.441
Tuba1ctubulin, alpha 1C0.323
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.213
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.212
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.173
Dynll1dynein light chain LC8-type 10.121
Sub1SUB1 homolog (S. cerevisiae)0.089
Hn1hematological and neurological expressed 10.064
Actc1actin, alpha, cardiac muscle 10.062
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.057
Hsbp1heat shock factor binding protein 10.055
Asphaspartate-beta-hydroxylase0.051
Calm2calmodulin 20.042
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.038
Phka1phosphorylase kinase, alpha 10.037
Myl1myosin, light chain 10.033
Ak1adenylate kinase 10.032
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.031
Fkbp1aFK506 binding protein 1a0.030
Tubb2atubulin, beta 2a0.026
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.026
Smpxsmall muscle protein, X-linked0.024
Stmn1stathmin 10.024
Nme1non-metastatic cells 1, protein (NM23A) expressed in0.023
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.021
Tsc22d1TSC22 domain family, member 10.021
Prnpprion protein0.018
Cap2CAP, adenylate cyclase-associated protein, 2 (yeast)0.018
Cav3caveolin 30.018
Utrnutrophin0.016
Rab1bRAB1B, member RAS oncogene family0.016
Ndufc1NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 10.015
Ldb3LIM domain binding 30.015
HrasHarvey rat sarcoma virus oncogene0.014
Csrp3cysteine and glycine-rich protein 30.012
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.012
Dad1defender against cell death 10.012
Actg1actin, gamma 10.012
Gstk1glutathione S-transferase kappa 10.012
Nptnneuroplastin0.011
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.011
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 11.000
GSTM2glutathione S-transferase mu 2 (muscle)0.999
GSTM4glutathione S-transferase mu 40.983
DTNAdystrobrevin, alpha0.418
KIAA1683KIAA16830.220
ACVR1Bactivin A receptor, type IB0.204
GSTM3glutathione S-transferase mu 3 (brain)0.146
MYO10myosin X0.096
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.094
ARF3ADP-ribosylation factor 30.069
TGFBR1transforming growth factor, beta receptor 10.064
CFL1cofilin 1 (non-muscle)0.059
PDCD6programmed cell death 60.051
PKD1polycystic kidney disease 1 (autosomal dominant)0.049
PSEN2presenilin 2 (Alzheimer disease 4)0.032
CAPN2calpain 2, (m/II) large subunit0.031
TBCBtubulin folding cofactor B0.030
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.030
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.030
CAPZBcapping protein (actin filament) muscle Z-line, beta0.028
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.028
SYNMsynemin, intermediate filament protein0.025
AKAP6A kinase (PRKA) anchor protein 60.025
TRAPPC1trafficking protein particle complex 10.025
TRPC1transient receptor potential cation channel, subfamily C, member 10.024
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.024
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.019
DTNBdystrobrevin, beta0.018
CLTBclathrin, light chain B0.018
FKBP1AFK506 binding protein 1A, 12kDa0.018
MAPK4mitogen-activated protein kinase 40.016
CALCOCO2calcium binding and coiled-coil domain 20.016
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.016
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.015
RALBP1ralA binding protein 10.014
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.013
ARPC1Aactin related protein 2/3 complex, subunit 1A, 41kDa0.013
AP2M1adaptor-related protein complex 2, mu 1 subunit0.012
SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)0.012
ILKintegrin-linked kinase0.011
NOP10NOP10 ribonucleoprotein homolog (yeast)0.011
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.011
GSTM5glutathione S-transferase mu 50.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.741
Dag1dystroglycan 10.581
Gja1gap junction protein, alpha 10.253
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.246
Cep290centrosomal protein 2900.167
Meox2mesenchyme homeobox 20.159
Smyd1SET and MYND domain containing 10.157
Cys1cystin 10.142
Scn5asodium channel, voltage-gated, type V, alpha0.125
Bicc1bicaudal C homolog 1 (Drosophila)0.114
Ryr2ryanodine receptor 2, cardiac0.110
Ift140intraflagellar transport 140 homolog (Chlamydomonas)0.106
Pkd2polycystic kidney disease 20.079
Il6stinterleukin 6 signal transducer0.075
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.061
Ttntitin0.059
Iduaiduronidase, alpha-L-0.056
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.054
Usp13ubiquitin specific peptidase 13 (isopeptidase T-3)0.053
Hspg2perlecan (heparan sulfate proteoglycan 2)0.052
Morf4l2mortality factor 4 like 20.048
Casq2calsequestrin 20.041
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.038
Tgfb2transforming growth factor, beta 20.038
Dtnadystrobrevin alpha0.037
Invsinversin0.034
Scn1asodium channel, voltage-gated, type I, alpha0.033
Frmd5FERM domain containing 50.032
Cav3caveolin 30.029
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.029
Notch2Notch gene homolog 2 (Drosophila)0.029
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.028
En2engrailed 20.026
Mks1Meckel syndrome, type 10.024
Ldb3LIM domain binding 30.024
Macf1microtubule-actin crosslinking factor 10.024
Arpc3actin related protein 2/3 complex, subunit 30.022
Fktnfukutin0.022
Prkccprotein kinase C, gamma0.022
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.021
Syncsyncoilin0.021
Sgcbsarcoglycan, beta (dystrophin-associated glycoprotein)0.021
Nr3c1nuclear receptor subfamily 3, group C, member 10.020
Calm1calmodulin 10.020
Myl3myosin, light polypeptide 30.019
Rgs14regulator of G-protein signaling 140.019
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.016
Mtl5metallothionein-like 5, testis-specific (tesmin)0.016
Alpk3alpha-kinase 30.016
Slc30a3solute carrier family 30 (zinc transporter), member 30.016
Pkd1polycystic kidney disease 1 homolog0.016
Leng8leukocyte receptor cluster (LRC) member 80.015
Art3ADP-ribosyltransferase 30.015
Fbn1fibrillin 10.015
Tmem107transmembrane protein 1070.015
Mef2cmyocyte enhancer factor 2C0.015
Popdc2popeye domain containing 20.014
Pygmmuscle glycogen phosphorylase0.014
Actg1actin, gamma, cytoplasmic 10.013
RictorRPTOR independent companion of MTOR, complex 20.013
Txlnbtaxilin beta0.013
Acracrosin prepropeptide0.013
Ptprnprotein tyrosine phosphatase, receptor type, N0.013
Arpc4actin related protein 2/3 complex, subunit 40.013
Nos1nitric oxide synthase 1, neuronal0.012
Sept7septin 70.012
Yipf7Yip1 domain family, member 70.012
Mstnmyostatin0.012
Fgfr3fibroblast growth factor receptor 30.012
Galntl1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 10.012
Pacsin1protein kinase C and casein kinase substrate in neurons 10.012
Hspb3heat shock protein 30.012
Gnao1guanine nucleotide binding protein, alpha O0.012
Ccdc39coiled-coil domain containing 390.012
Pax7paired box gene 70.011
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.011
Srpk3serine/arginine-rich protein specific kinase 30.011
Arf1ADP-ribosylation factor 10.011
Tmsb4xthymosin, beta 4, X chromosome0.011
Itgb1integrin beta 1 (fibronectin receptor beta)0.011
Col19a1collagen, type XIX, alpha 10.011
Casq1calsequestrin 10.011
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.010
Rgs7regulator of G protein signaling 70.010
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.010
Ptproprotein tyrosine phosphatase, receptor type, O0.010
Fkbp9FK506 binding protein 90.010
Capn3calpain 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism