The network for 'regulation of phospholipase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of phospholipase activity

Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

NameDescriptionProbabilityFunc Analog Organism
Lgals3lectin, galactoside-binding, soluble, 30.176
Rnase4ribonuclease, RNase A family 40.066
Gna12guanine nucleotide binding protein (G protein) alpha 120.054
Rap1bRAP1B, member of RAS oncogene family0.051
Anxa2annexin A20.043
Akt2v-akt murine thymoma viral oncogene homolog 20.043
Ccnd3cyclin D30.042
Anxa5annexin A50.031
Eef2eukaryotic translation elongation factor 20.028
Csf1colony stimulating factor 1 (macrophage)0.028
Hist1h1ahistone cluster 1, H1a0.026
S100a10S100 calcium binding protein A100.026
Cdk7cyclin-dependent kinase 70.025
Gcgroup specific component0.023
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.023
Slco2b1solute carrier organic anion transporter family, member 2b10.022
Itpr1inositol 1,4,5-triphosphate receptor, type 10.022
Cgaglycoprotein hormones, alpha polypeptide0.022
Mep1ameprin 1 alpha0.021
Cd68Cd68 molecule0.021
Spp2secreted phosphoprotein 20.020
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.020
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.020
Gucy1b3guanylate cyclase 1, soluble, beta 30.019
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.018
Dock8dedicator of cytokinesis 80.017
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.016
Arl11ADP-ribosylation factor-like 110.016
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.016
Adora3adenosine A3 receptor0.015
Map3k3mitogen activated protein kinase kinase kinase 30.015
Slc22a7solute carrier family 22 (organic anion transporter), member 70.015
Arpc1bactin related protein 2/3 complex, subunit 1B0.015
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.015
Klrd1killer cell lectin-like receptor, subfamily D, member 10.015
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.014
Chiachitinase, acidic0.014
Mpeg1macrophage expressed 10.014
Gja1gap junction protein, alpha 10.014
Apoc4apolipoprotein C-IV0.014
Apoa5apolipoprotein A-V0.014
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.014
Igf2insulin-like growth factor 20.014
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.014
Itgb1integrin, beta 10.013
Tgfbr2transforming growth factor, beta receptor II0.013
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.013
Il1rl1interleukin 1 receptor-like 10.013
Esr2estrogen receptor 2 (ER beta)0.013
Ggt5gamma-glutamyltransferase 50.013
Itgamintegrin, alpha M0.013
Scamp2secretory carrier membrane protein 20.013
Il9rinterleukin 9 receptor0.012
Arf4ADP-ribosylation factor 40.012
Ttc3tetratricopeptide repeat domain 30.012
Tmed2transmembrane emp24 domain trafficking protein 20.012
Pik3c2gphosphoinositide-3-kinase, class 2, gamma polypeptide0.012
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.012
Cd4Cd4 molecule0.012
Capn2calpain 20.012
Anxa1annexin A10.012
Cd151CD151 molecule (Raph blood group)0.012
Zg16zymogen granule protein 160.011
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.011
Folr2folate receptor 2 (fetal)0.011
Fgfr2fibroblast growth factor receptor 20.011
Grk4G protein-coupled receptor kinase 40.011
Sirpasignal-regulatory protein alpha0.011
Itih3inter-alpha trypsin inhibitor, heavy chain 30.011
Lim2lens intrinsic membrane protein 20.011
Prlhrprolactin releasing hormone receptor0.011
Vat1vesicle amine transport protein 1 homolog (T californica)0.011
Gucy1a3guanylate cyclase 1, soluble, alpha 30.011
Myadmmyeloid-associated differentiation marker0.011
Sod3superoxide dismutase 3, extracellular0.011
Vipvasoactive intestinal peptide0.011
Cntn1contactin 10.011
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.011
TekTEK tyrosine kinase, endothelial0.011
Hk1hexokinase 10.010
Ctsl1cathepsin L10.010
Mapk3mitogen activated protein kinase 30.010
Cpb1carboxypeptidase B1 (tissue)0.010
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.010
Cd48Cd48 molecule0.010
Ptprcprotein tyrosine phosphatase, receptor type, C0.010
RGD1560925similar to 2610034M16Rik protein0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.815
fgfr2fibroblast growth factor receptor 20.446
sema3aasemaphorin 3aa0.328
notch3notch homolog 30.247
sulf1sulfatase 10.127
nr2f2nuclear receptor subfamily 2, group F, member 20.104
tcf12transcription factor 120.082
fstl1bfollistatin-like 1b0.073
dlg2discs, large (Drosophila) homolog 20.073
tie2endothelium-specific receptor tyrosine kinase 20.058
LOC100007758novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)0.055
lhx2bLIM homeobox 2b0.055
meis2.2myeloid ecotropic viral integration site 2.20.051
LOC796684hypothetical protein LOC7966840.044
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.043
mpzmyelin protein zero0.042
esr2bestrogen receptor 2b0.041
gnasGNAS complex locus0.040
her6hairy-related 60.039
rhoubras homolog gene family, member Ub0.037
fgf8bfibroblast growth factor 8 b0.036
phf21aPHD finger protein 21A0.036
henmt1HEN1 methyltransferase homolog 1 (Arabidopsis)0.035
socs3asuppressor of cytokine signaling 3a0.033
fgfr1bfibroblast growth factor receptor 1b0.033
msi1musashi homolog 1 (Drosophila)0.031
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.028
otpborthopedia homolog b0.028
oclnboccludin b0.026
efnb2aephrin B2a0.026
gna11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)0.026
gna13bguanine nucleotide binding protein (G protein), alpha 13b0.026
aldh1l1aldehyde dehydrogenase 1 family, member L10.024
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.024
fshbfollicle stimulating hormone, beta polypeptide0.023
nr4a1nuclear receptor subfamily 4, group A, member 10.023
lrrtm1leucine rich repeat transmembrane neuronal 10.023
adoa2-aminoethanethiol (cysteamine) dioxygenase a0.023
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.023
LOC100003514protein kinase C alpha type-like0.022
gli3GLI-Kruppel family member GLI30.022
apoa1bpapolipoprotein A-I binding protein0.022
prkcqprotein kinase C, theta0.022
gro2groucho 20.022
myh11amyosin, heavy polypeptide 11, smooth muscle a0.022
grn1granulin 10.021
six3asine oculis homeobox homolog 3a0.021
fabp1b.1fatty acid binding protein 1b, tandem duplicate 10.021
dlg1discs, large (Drosophila) homolog 10.021
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.021
cnga5cyclic nucleotide gated channel alpha 50.021
pitx3paired-like homeodomain transcription factor 30.021
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.020
phox2apaired-like homeobox 2a0.020
pacsin3protein kinase C and casein kinase substrate in neurons 30.020
pkzprotein kinase containing Z-DNA binding domains0.020
sfrp5secreted frizzled-related protein 50.019
ntrk2bneurotrophic tyrosine kinase, receptor, type 2b0.019
fabp11afatty acid binding protein 11a0.018
tgfb1atransforming growth factor, beta 1a0.018
wt1bwilms tumor 1b0.018
zbtb16azinc finger and BTB domain containing 16a0.018
foxe1forkhead box E1 (thyroid transcription factor 2)0.018
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.017
dlg4discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)0.017
rnasel2ribonuclease like 20.017
rorcaRAR-related orphan receptor C a0.017
grk7aG-protein-coupled receptor kinase 7a0.017
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.016
bmp7bbone morphogenetic protein 7b0.016
rbm4.1RNA binding motif protein 4.10.016
v2rl1vomeronasal 2 receptor, l10.016
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.016
zfp36l1azinc finger protein 36, C3H type-like 1a0.016
LOC100149007zinc finger protein 319-like0.016
tas2r202taste receptor, type 2, member 2020.016
bmpr1bbbone morphogenetic protein receptor, type 1bb0.016
pard3par-3 partitioning defective 3 homolog (C. elegans)0.016
terttelomerase reverse transcriptase0.015
il8interleukin 80.015
plekhg5apleckstrin homology domain containing, family G (with RhoGef domain) member 5a0.015
acp5bacid phosphatase 5b, tartrate resistant0.015
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.015
tac1tachykinin 10.015
vtg2vitellogenin 20.015
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.015
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.015
slc26a3solute carrier family 26, member 30.015
pink1PTEN induced putative kinase 10.015
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
zfh1Zn finger homeodomain 10.035
Ggamma1G protein gamma 10.029
Arc-p34CG10954 gene product from transcript CG10954-RA0.028
Src42ASrc oncogene at 42A0.023
inaCinactivation no afterpotential C0.023
Rac2CG8556 gene product from transcript CG8556-RA0.023
stumpsCG31317 gene product from transcript CG31317-RC0.020
drkdownstream of receptor kinase0.020
CkIalphaCasein kinase Ialpha0.020
Tre1trapped in endoderm-10.019
nrv3nervana 30.017
DokDownstream of kinase0.016
CG15080CG15080 gene product from transcript CG15080-RA0.016
Ggamma30AG protein gamma30A0.014
NFATNFAT homolog0.014
Octbeta2RCG33976 gene product from transcript CG33976-RA0.014
CG11242CG11242 gene product from transcript CG11242-RA0.013
Wnt2Wnt oncogene analog 20.013
Rya-r44FRyanodine receptor 44F0.012
p120ctnAdherens junction protein p1200.012
RASSF8CG5053 gene product from transcript CG5053-RA0.012
Src64BSrc oncogene at 64B0.012
slikSterile20-like kinase0.012
Plc21CPhospholipase C at 21C0.012
wbwing blister0.012
CG17082CG17082 gene product from transcript CG17082-RD0.011
ScgbetaSarcoglycan beta0.011
DlicDynein light intermediate chain0.011
lqfliquid facets0.011
flowerCG6151 gene product from transcript CG6151-RA0.010
howheld out wings0.010
Arf79FADP ribosylation factor 79F0.010
m6E(spl) region transcript m60.010
mewmultiple edematous wings0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGF1fibroblast growth factor 1 (acidic)0.998
FGFR1fibroblast growth factor receptor 10.983
PLCG1phospholipase C, gamma 10.877
ARRB1arrestin, beta 10.810
CCR5chemokine (C-C motif) receptor 50.698
MAPTmicrotubule-associated protein tau0.653
CTGFconnective tissue growth factor0.531
FGFR2fibroblast growth factor receptor 20.517
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.502
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.412
MPDZmultiple PDZ domain protein0.379
CXCL9chemokine (C-X-C motif) ligand 90.324
CCL2chemokine (C-C motif) ligand 20.250
CCL4chemokine (C-C motif) ligand 40.234
S100A10S100 calcium binding protein A100.216
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.215
ARFIP2ADP-ribosylation factor interacting protein 20.209
RNASE4ribonuclease, RNase A family, 40.206
SPRR2Asmall proline-rich protein 2A0.176
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.162
VCAM1vascular cell adhesion molecule 10.151
ANGangiogenin, ribonuclease, RNase A family, 50.137
GAB1GRB2-associated binding protein 10.135
ANXA5annexin A50.134
CDH5cadherin 5, type 2 (vascular endothelium)0.103
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.091
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.089
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.085
CRPC-reactive protein, pentraxin-related0.081
RAB1ARAB1A, member RAS oncogene family0.077
ANXA1annexin A10.072
KDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 20.061
BCAR1breast cancer anti-estrogen resistance 10.058
DARCDuffy blood group, chemokine receptor0.057
CCL8chemokine (C-C motif) ligand 80.054
ANXA2annexin A20.054
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.053
RLN3relaxin 30.050
IL6interleukin 6 (interferon, beta 2)0.049
CCL5chemokine (C-C motif) ligand 50.046
CCL7chemokine (C-C motif) ligand 70.044
FGAfibrinogen alpha chain0.042
GSK3Bglycogen synthase kinase 3 beta0.041
SOS1son of sevenless homolog 1 (Drosophila)0.041
SELEselectin E0.039
PDGFCplatelet derived growth factor C0.038
CALM1calmodulin 1 (phosphorylase kinase, delta)0.038
ARF4ADP-ribosylation factor 40.037
LRP1low density lipoprotein receptor-related protein 10.037
ITGB5integrin, beta 50.036
ARRDC3arrestin domain containing 30.036
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.036
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.035
CCR1chemokine (C-C motif) receptor 10.035
CCR7chemokine (C-C motif) receptor 70.035
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.034
IL10interleukin 100.034
VEGFAvascular endothelial growth factor A0.034
CCL13chemokine (C-C motif) ligand 130.033
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.033
IL1Binterleukin 1, beta0.031
FYBFYN binding protein0.031
CCL3chemokine (C-C motif) ligand 30.030
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.029
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.029
CTSBcathepsin B0.028
TMED2transmembrane emp24 domain trafficking protein 20.028
TIMP3TIMP metallopeptidase inhibitor 30.027
ARCN1archain 10.027
CCR3chemokine (C-C motif) receptor 30.027
KITLGKIT ligand0.026
CCL22chemokine (C-C motif) ligand 220.026
TRAM1translocation associated membrane protein 10.025
SHC2SHC (Src homology 2 domain containing) transforming protein 20.025
FGFR3fibroblast growth factor receptor 30.025
EEF2eukaryotic translation elongation factor 20.024
IL7Rinterleukin 7 receptor0.023
C4orf14chromosome 4 open reading frame 140.022
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.022
REEP5receptor accessory protein 50.021
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.021
APPamyloid beta (A4) precursor protein0.021
EMP1epithelial membrane protein 10.021
CXCL13chemokine (C-X-C motif) ligand 130.021
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.021
PGFplacental growth factor0.020
FGBfibrinogen beta chain0.020
IFNGinterferon, gamma0.019
RIN1Ras and Rab interactor 10.019
SHBSrc homology 2 domain containing adaptor protein B0.019
EGFRepidermal growth factor receptor0.019
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.019
AGTR1angiotensin II receptor, type 10.019
CARD11caspase recruitment domain family, member 110.018
HPGDShematopoietic prostaglandin D synthase0.018
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.018
ADORA3adenosine A3 receptor0.018
CPA3carboxypeptidase A3 (mast cell)0.018
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr1fibroblast growth factor receptor 10.666
Fgfr2fibroblast growth factor receptor 20.581
Prrx1paired related homeobox 10.501
Lrp6low density lipoprotein receptor-related protein 60.456
Fgfr3fibroblast growth factor receptor 30.315
Ctnnb1catenin (cadherin associated protein), beta 10.288
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.256
CblCasitas B-lineage lymphoma0.250
Dok1docking protein 10.154
Ptk2PTK2 protein tyrosine kinase 20.154
Gli3GLI-Kruppel family member GLI30.151
Runx2runt related transcription factor 20.146
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.116
Sox9SRY-box containing gene 90.099
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.094
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.092
Leprleptin receptor0.092
Gsk3bglycogen synthase kinase 3 beta0.092
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.085
Ptch1patched homolog 10.078
Bmp4bone morphogenetic protein 40.075
Gli2GLI-Kruppel family member GLI20.061
Psen1presenilin 10.060
Agtr1aangiotensin II receptor, type 1a0.058
Acvr1activin A receptor, type 10.056
Zeb1zinc finger E-box binding homeobox 10.055
Fgfrl1fibroblast growth factor receptor-like 10.054
Ren1renin 1 structural0.051
Tbx3T-box 30.049
WasWiskott-Aldrich syndrome homolog (human)0.047
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.045
Ednrbendothelin receptor type B0.042
Vangl2vang-like 2 (van gogh, Drosophila)0.038
Ptprbprotein tyrosine phosphatase, receptor type, B0.038
Smosmoothened homolog (Drosophila)0.037
Rab6RAB6, member RAS oncogene family0.036
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.036
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.033
Ldlrlow density lipoprotein receptor0.033
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.032
Bmp2bone morphogenetic protein 20.032
Apcadenomatosis polyposis coli0.029
Ctgfconnective tissue growth factor0.028
Itgb2integrin beta 20.027
Ror2receptor tyrosine kinase-like orphan receptor 20.027
Duox2dual oxidase 20.025
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.025
Vegfavascular endothelial growth factor A0.024
BlnkB-cell linker0.023
Meox2mesenchyme homeobox 20.023
Trp53transformation related protein 530.023
Prrx2paired related homeobox 20.022
Pick1protein interacting with C kinase 10.022
FynFyn proto-oncogene0.022
Selpselectin, platelet0.021
Foxc1forkhead box C10.021
Foxc2forkhead box C20.020
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.020
Sellselectin, lymphocyte0.020
Apaf1apoptotic peptidase activating factor 10.019
Folr2folate receptor 2 (fetal)0.018
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.018
Msx1homeobox, msh-like 10.018
Sox11SRY-box containing gene 110.018
Fzd2frizzled homolog 2 (Drosophila)0.017
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.017
Vdrvitamin D receptor0.017
Bmp5bone morphogenetic protein 50.017
Axin1axin 10.016
FybFYN binding protein0.016
Tgfb2transforming growth factor, beta 20.016
Ctskcathepsin K0.016
Ptenphosphatase and tensin homolog0.016
Itgb1integrin beta 1 (fibronectin receptor beta)0.016
Ptpreprotein tyrosine phosphatase, receptor type, E0.016
Cd86CD86 antigen0.016
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.016
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.016
Bcar1breast cancer anti-estrogen resistance 10.016
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.015
Tenc1tensin like C1 domain-containing phosphatase0.015
Ctswcathepsin W0.014
Pdgfbplatelet derived growth factor, B polypeptide0.014
Lama5laminin, alpha 50.014
Angptl4angiopoietin-like 40.014
Fgafibrinogen alpha chain0.014
Tnfrsf11btumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)0.014
Hcls1hematopoietic cell specific Lyn substrate 10.013
Fn1fibronectin 10.013
Dll1delta-like 1 (Drosophila)0.013
Bdkrb2bradykinin receptor, beta 20.013
Cybbcytochrome b-245, beta polypeptide0.013
Col1a1collagen, type I, alpha 10.013
Gja1gap junction protein, alpha 10.013
Ncr1natural cytotoxicity triggering receptor 10.013
Ikzf1IKAROS family zinc finger 10.012
Thrathyroid hormone receptor alpha0.012
Itgaxintegrin alpha X0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism