The network for 'proteolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

NameDescriptionProbabilityFunc Analog Organism
rpn-7Protein RPN-70.567
pas-4Protein PAS-40.542
rpn-12Protein RPN-120.477
rpt-3Protein RPT-30.413
rpn-3Protein RPN-30.380
rpt-2Protein RPT-20.366
pas-1Protein PAS-10.336
rpt-5Protein RPT-50.304
npl-4.2Protein NPL-4.20.291
pas-2Protein PAS-20.212
rpt-4Protein RPT-40.196
pbs-6Protein PBS-60.190
taf-5Protein TAF-50.186
rpn-2Protein RPN-20.180
imb-2Protein IMB-20.172
stam-1Protein STAM-10.161
pbs-2Protein PBS-20.160
kle-2Protein KLE-20.149
F56D2.6Protein F56D2.60.140
rpn-6.1Protein RPN-6.10.134
rad-26Protein RAD-260.132
tba-2Protein TBA-20.128
cul-2Protein CUL-20.121
daf-21Protein DAF-210.120
cpr-4Protein CPR-40.120
atg-18Protein ATG-180.119
dpy-30Protein DPY-300.118
rpn-9Protein RPN-90.117
ttyh-1Protein TTYH-10.115
hda-1Protein HDA-10.115
ubq-1Protein UBQ-10.115
pbs-5Protein PBS-50.114
rnr-1Protein RNR-10.114
atx-3Protein ATX-30.111
ubc-25Protein UBC-250.104
kin-3Protein KIN-30.104
rpn-10Protein RPN-100.103
rpt-1Protein RPT-10.102
CELE_C25A1.4Protein C25A1.40.102
F36D4.5Protein F36D4.50.100
pbs-1Protein PBS-10.096
E04D5.1Protein E04D5.10.096
rpt-6Protein RPT-60.090
pas-6Protein PAS-60.088
F46F11.6Protein F46F11.60.088
atp-2Protein ATP-20.084
egl-18Protein EGL-180.082
fzy-1Protein FZY-10.082
pbs-4Protein PBS-40.082
pde-4Protein PDE-40.079
Y54E5A.7Protein Y54E5A.70.078
cra-1Protein CRA-10.077
zen-4Protein ZEN-40.077
npp-22Protein NPP-220.076
pup-2Protein PUP-20.075
cul-1Protein CUL-10.074
cdc-48.2Protein CDC-48.20.073
pas-3Protein PAS-30.073
bar-1Protein BAR-10.073
prp-31Protein PRP-310.072
guk-1Protein GUK-10.072
pkc-3Protein PKC-30.072
gsy-1Protein GSY-10.070
T22F3.2Protein T22F3.20.070
pbs-3Protein PBS-30.070
CELE_C24H12.5Protein C24H12.50.069
cam-1Protein CAM-10.069
sel-2Protein SEL-20.065
ebp-2Protein EBP-20.065
zyg-9Protein ZYG-90.065
lag-1Protein LAG-10.064
trap-2Protein TRAP-20.064
csn-5Protein CSN-50.064
bir-1Protein BIR-10.064
R11A8.7Protein R11A8.70.063
B0041.5Protein B0041.50.063
npl-4.1Protein NPL-4.10.061
vps-53Protein VPS-530.059
hrdl-1Protein HRDL-10.059
nipi-3Protein NIPI-30.059
CELE_R11H6.2Protein R11H6.20.059
cki-2Protein CKI-20.059
bub-1Protein BUB-10.058
ric-3Protein RIC-30.057
ubr-1Protein UBR-10.057
pas-5Protein PAS-50.056
W04B5.3Protein W04B5.30.056
hpo-9Protein HPO-90.055
dcr-1Protein DCR-10.055
atg-13Protein ATG-130.055
smc-3Protein SMC-30.054
hsp-4Protein HSP-40.054
hrp-1Protein HRP-10.054
noca-1Protein NOCA-10.053
mtm-3Protein MTM-30.053
his-42Protein HIS-420.053
rod-1Protein ROD-10.053
rpa-2Protein RPA-20.052
C31E10.6Protein C31E10.60.051
hgrs-1Protein HGRS-10.051
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cfl2lcofilin 2, like0.530
psmb1proteasome (prosome, macropain) subunit, beta type, 10.337
psma6aproteasome (prosome, macropain) subunit, alpha type, 6a0.320
tfatransferrin-a0.291
psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.280
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.264
baxabcl2-associated X protein, a0.260
fn1fibronectin 10.259
psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.243
fbp1bfructose-1,6-bisphosphatase 1b0.232
psmb3proteasome (prosome, macropain) subunit, beta type, 30.208
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.172
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.158
sulf2lsulfatase 2, like0.158
cnn2calponin 20.152
osr1odd-skipped related 1 (Drosophila)0.140
cdt1chromatin licensing and DNA replication factor 10.137
ctsl1bcathepsin L, 1 b0.132
si:rp71-45k5.4si:rp71-45k5.40.129
psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.128
furinafurin (paired basic amino acid cleaving enzyme) a0.125
bcl2l10BCL2-like 10 (apoptosis facilitator)0.125
psmc3proteasome (prosome, macropain) 26S subunit, ATPase, 30.124
fstl1bfollistatin-like 1b0.120
pitx3paired-like homeodomain transcription factor 30.119
hhiphedgehog interacting protein0.119
rxrbbretinoid x receptor, beta b0.119
inspreproinsulin0.113
ext1bexostoses (multiple) 1b0.112
cpa5carboxypeptidase A50.112
ctsbacathepsin B, a0.105
szlsizzled0.105
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.105
ela2lelastase 2 like0.102
psmd4bproteasome (prosome, macropain) 26S subunit, non-ATPase, 4b0.101
gro2groucho 20.101
adipor1badiponectin receptor 1b0.096
stc1lstanniocalcin 1, like0.095
psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.091
mcl1bmyeloid cell leukemia sequence 1b0.089
txnrd1thioredoxin reductase 10.086
wif1wnt inhibitory factor 10.086
ck2bcasein kinase 2 beta0.084
bhmtbetaine-homocysteine methyltransferase0.082
fgfr1afibroblast growth factor receptor 1a0.082
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.082
btg2B-cell translocation gene 20.081
sgpl1sphingosine-1-phosphate lyase 10.077
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.076
hspa5heat shock protein 50.073
ctszcathepsin Z0.072
psma2proteasome (prosome, macropain) subunit, alpha type, 20.072
furinbfurin (paired basic amino acid cleaving enzyme) b0.071
plk1polo-like kinase 1 (Drosophila)0.070
psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.067
maxmyc-associated factor X0.066
psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.065
olfml3bolfactomedin-like 3b0.063
dab1adisabled homolog 1a (Drosophila)0.063
si:ch211-212m21.5si:ch211-212m21.50.063
ef1aelongation factor 1-alpha0.062
sdcbpsyndecan binding protein (syntenin)0.060
fggfibrinogen, gamma polypeptide0.060
psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.058
zgc:193613zgc:1936130.058
psma8proteasome (prosome, macropain) subunit, alpha type, 80.057
ihhaIndian hedgehog homolog a0.057
optcopticin0.056
glud1aglutamate dehydrogenase 1a0.055
fabp10afatty acid binding protein 10a, liver basic0.055
smarcb1aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a0.055
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.055
eif1axbeukaryotic translation initiation factor 1A, X-linked, b0.055
gcm2glial cells missing homolog 2 (Drosophila)0.054
s1pr2sphingosine-1-phosphate receptor 20.054
ctrlchymotrypsin-like0.053
zgc:86903zgc:869030.053
tram1translocating chain-associating membrane protein 10.053
psmb5proteasome (prosome, macropain) subunit, beta type, 50.053
pitrm1pitrilysin metalloproteinase 10.053
rag1recombination activating gene 10.053
il8interleukin 80.052
psmb7proteasome (prosome, macropain) subunit, beta type, 70.052
chchd10coiled-coil-helix-coiled-coil-helix domain containing 100.051
slc3a2solute carrier family 3, member 20.051
tp53bp2tumor protein p53 binding protein, 20.050
vcpvalosin containing protein0.050
uqcrc2bubiquinol-cytochrome c reductase core protein IIb0.050
sulf1sulfatase 10.049
zgc:92775zgc:927750.048
cpb1carboxypeptidase B1 (tissue)0.047
tnfrsfatumor necrosis factor receptor superfamily, member a0.047
kpna4karyopherin alpha 4 (importin alpha 3)0.047
lyzlysozyme0.046
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.045
zgc:56200zgc:562000.045
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.045
orc1origin recognition complex, subunit 10.045
ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.045
usp5ubiquitin specific protease 50.044
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.976
Prosbeta1Proteasome beta1 subunit0.966
Akt1CG4006 gene product from transcript CG4006-RA0.962
Rpt1CG1341 gene product from transcript CG1341-RA0.943
Rpn2CG11888 gene product from transcript CG11888-RA0.916
CG13349CG13349 gene product from transcript CG13349-RA0.900
Pros54Proteasome 54kD subunit0.900
Pros29Proteasome 29kD subunit0.869
Prosbeta3Proteasome beta3 subunit0.859
Pros26Proteasome 26kD subunit0.848
Rpn7CG5378 gene product from transcript CG5378-RA0.819
CSN5COP9 complex homolog subunit 50.812
Prosbeta2Proteasome beta2 subunit0.805
CG12321CG12321 gene product from transcript CG12321-RA0.796
Prosbeta5Proteasome beta5 subunit0.794
Rpn1CG7762 gene product from transcript CG7762-RA0.774
nejnejire0.769
Rpt4CG3455 gene product from transcript CG3455-RA0.707
p53CG33336 gene product from transcript CG33336-RB0.697
Rpn5CG1100 gene product from transcript CG1100-RA0.693
Rpt3CG16916 gene product from transcript CG16916-RA0.686
Mov34CG3416 gene product from transcript CG3416-RA0.681
jarjaguar0.663
Pi3K92ECG4141 gene product from transcript CG4141-RB0.658
tshteashirt0.656
ththread0.648
tefutelomere fusion0.644
CG2046CG2046 gene product from transcript CG2046-RA0.637
Tak1TGF-beta activated kinase 10.624
Tbp-1Tat-binding protein-10.623
cindrCIN85 and CD2AP orthologue0.622
pucpuckered0.616
Rpn9CG10230 gene product from transcript CG10230-RB0.603
NacalphaNascent polypeptide associated complex protein alpha subunit0.593
smosmoothened0.592
RalaRas-related protein0.555
CG8155CG8155 gene product from transcript CG8155-RA0.541
swmsecond mitotic wave missing0.535
CycECyclin E0.514
UbcD2Ubiquitin conjugating enzyme 20.510
CG9772CG9772 gene product from transcript CG9772-RB0.500
Prosalpha7Proteasome alpha7 subunit0.500
Mi-2CG8103 gene product from transcript CG8103-RA0.489
CG8531CG8531 gene product from transcript CG8531-RA0.488
Pros45CG1489 gene product from transcript CG1489-RA0.481
Ras85DRas oncogene at 85D0.477
Rpn3Regulatory particle non-ATPase 30.475
Prosbeta7Proteasome beta7 subunit0.474
Rac1CG2248 gene product from transcript CG2248-RA0.466
Rpn11CG18174 gene product from transcript CG18174-RA0.464
Cul-3Cullin-30.459
MiroMitochondrial Rho0.458
Pros35Proteasome 35kD subunit0.455
ykiyorkie0.444
Prosalpha5Proteasome alpha5 subunit0.441
wtswarts0.439
Rpn6Proteasome p44.5 subunit0.432
Dcp-1Death caspase-10.426
jingCG9397 gene product from transcript CG9397-RI0.425
CG11347CG11347 gene product from transcript CG11347-RE0.409
Pros28.1Proteasome 28kD subunit 10.403
CG7818CG7818 gene product from transcript CG7818-RA0.396
caspcaspar0.390
DhodDihydroorotate dehydrogenase0.389
gwlgreatwall0.381
CG5384CG5384 gene product from transcript CG5384-RA0.380
Hsp83Heat shock protein 830.372
tsrtwinstar0.371
rstroughest0.367
rinrasputin0.365
CG8979CG8979 gene product from transcript CG8979-RC0.364
giggigas0.362
pumpumilio0.360
ph-ppolyhomeotic proximal0.358
RpL15Ribosomal protein L150.350
frtzfritz0.329
Su(var)205Suppressor of variegation 2050.321
agoarchipelago0.319
stumpsCG31317 gene product from transcript CG31317-RC0.311
Ulp1CG12359 gene product from transcript CG12359-RA0.308
nbsCG6754 gene product from transcript CG6754-RC0.307
rprreaper0.301
CSN8COP9 complex homolog subunit 80.301
Aos1CG12276 gene product from transcript CG12276-RA0.300
CkIalphaCasein kinase Ialpha0.297
p47CG11139 gene product from transcript CG11139-RA0.295
cathDCG1548 gene product from transcript CG1548-RA0.293
RhoGEF2CG9635 gene product from transcript CG9635-RF0.285
grimCG4345 gene product from transcript CG4345-RA0.285
TER94CG2331 gene product from transcript CG2331-RA0.284
dshdishevelled0.282
debcldeath executioner Bcl-2 homologue0.279
dldorsal0.275
chicchickadee0.274
parkparkin0.274
CG4030CG4030 gene product from transcript CG4030-RA0.271
scribscribbled0.261
bchsblue cheese0.257
G-salpha60AG protein salpha 60A0.252
fl(2)dfemale lethal d0.252
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psma3proteasome (prosome, macropain) subunit, alpha type 30.647
Psma5proteasome (prosome, macropain) subunit, alpha type 50.616
Psmb3proteasome (prosome, macropain) subunit, beta type 30.602
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.601
Taok1TAO kinase 10.473
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.466
Anxa1annexin A10.436
Hsph1heat shock 105/110 protein 10.405
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.403
Psmb6proteasome (prosome, macropain) subunit, beta type 60.397
Mapre1microtubule-associated protein, RP/EB family, member 10.395
S100a8S100 calcium binding protein A80.353
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.333
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.327
Lamc1laminin, gamma 10.309
Anxa4annexin A40.283
Vimvimentin0.278
Fn1fibronectin 10.274
Psmb4proteasome (prosome, macropain) subunit, beta type 40.273
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.254
FosFBJ osteosarcoma oncogene0.243
Psma1proteasome (prosome, macropain) subunit, alpha type 10.224
Psmb2proteasome (prosome, macropain) subunit, beta type 20.221
Hpxhemopexin0.220
Dctn4dynactin 40.220
Jak1Janus kinase 10.216
S100a10S100 calcium binding protein A100.209
Psme2proteasome (prosome, macropain) activator subunit 20.201
Eef2eukaryotic translation elongation factor 20.196
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.195
Fgafibrinogen alpha chain0.194
Ccl5chemokine (C-C motif) ligand 50.188
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.187
Nr4a3nuclear receptor subfamily 4, group A, member 30.185
Psma7proteasome (prosome, macropain) subunit, alpha type 70.183
Pdia4protein disulfide isomerase family A, member 40.182
Fgfr2fibroblast growth factor receptor 20.177
Psmb7proteasome (prosome, macropain) subunit, beta type 70.168
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.168
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.168
Psmb1proteasome (prosome, macropain) subunit, beta type 10.166
Bgnbiglycan0.166
Enpp3ectonucleotide pyrophosphatase/phosphodiesterase 30.166
Casp3caspase 30.163
Ifitm3interferon induced transmembrane protein 30.162
Iappislet amyloid polypeptide0.159
Pdclphosducin-like0.154
Nek9NIMA (never in mitosis gene a)- related kinase 90.153
Cpa3carboxypeptidase A3, mast cell0.153
Vcpvalosin-containing protein0.152
P22k15cystatin related protein 20.150
Usf2upstream transcription factor 2, c-fos interacting0.149
Pgk1phosphoglycerate kinase 10.143
LOC100361261rCG23560-like0.143
Smad4SMAD family member 40.141
Cficomplement factor I0.140
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.139
Pyypeptide YY (mapped)0.139
Ctsacathepsin A0.135
Pfn1profilin 10.134
Psma4proteasome (prosome, macropain) subunit, alpha type 40.134
Mdm2Mdm2 p53 binding protein homolog (mouse)0.133
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.133
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.132
Acp5acid phosphatase 5, tartrate resistant0.132
Myo1bmyosin Ib0.129
Smad1SMAD family member 10.129
Mbl1mannose-binding lectin (protein A) 10.129
Clic4chloride intracellular channel 40.127
LOC691259hypothetical protein LOC6912590.127
Ppt1palmitoyl-protein thioesterase 10.125
Pkn2protein kinase N20.121
Cryba1crystallin, beta A10.121
Rasgrp4RAS guanyl releasing protein 40.120
Psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.120
Csnk1dcasein kinase 1, delta0.119
Ahsgalpha-2-HS-glycoprotein0.119
Gfm1G elongation factor, mitochondrial 10.119
Cma1chymase 1, mast cell0.118
Sycnsyncollin0.118
Psma6proteasome (prosome, macropain) subunit, alpha type 60.118
Lamp2lysosomal-associated membrane protein 20.117
Dnase1l3deoxyribonuclease 1-like 30.115
Stip1stress-induced phosphoprotein 10.114
Adam10ADAM metallopeptidase domain 100.114
Cd3gCD3 molecule, gamma0.114
Mapk1mitogen activated protein kinase 10.113
Psmd8proteasome (prosome, macropain) 26S subunit, non-ATPase, 80.113
Ldb3LIM domain binding 30.113
Atp6v1fATPase, H transporting, lysosomal V1 subunit F0.112
Tpi1triosephosphate isomerase 10.112
Ppp1r2protein phosphatase 1, regulatory (inhibitor) subunit 20.111
Col1a1collagen, type I, alpha 10.111
C9complement component 90.111
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.110
B2mbeta-2 microglobulin0.110
Mcpt8mast cell protease 80.110
Arpc1bactin related protein 2/3 complex, subunit 1B0.108
Muskmuscle, skeletal, receptor tyrosine kinase0.108
Syngr2synaptogyrin 20.107
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC48Cdc48p0.999
RPT1Rpt1p0.997
RAD23Rad23p0.996
UBP6Ubp6p0.993
RPN12Rpn12p0.992
HRD1Hrd1p0.991
ECM29Ecm29p0.987
PPH22Pph22p0.978
RPN10Rpn10p0.975
RPT3Rpt3p0.972
PRE2Pre2p0.961
RPT4Rpt4p0.960
NPL4Npl4p0.949
RPN11Rpn11p0.948
RPT6Rpt6p0.947
PRE1Pre1p0.946
KAR2Kar2p0.941
UFD2Ufd2p0.937
SCJ1Scj1p0.932
RPT2Rpt2p0.929
RPN9Rpn9p0.928
RPN6Rpn6p0.926
RPT5Rpt5p0.922
DSK2Dsk2p0.914
RPN3Rpn3p0.891
PRE9Pre9p0.890
RPN2Rpn2p0.878
SHP1Shp1p0.860
UFD4Ufd4p0.857
KSP1Ksp1p0.823
UBC4Ubc4p0.818
APC5Apc5p0.810
PUP2Pup2p0.809
RPN8Rpn8p0.767
PRE7Pre7p0.765
CDC16Cdc16p0.763
VID28Vid28p0.761
CDC4Cdc4p0.759
PRE10Pre10p0.755
MND2Mnd2p0.754
SWM1Swm1p0.743
APP1App1p0.731
MGR1Mgr1p0.719
PRE6Pre6p0.714
NOP6Nop6p0.713
UFD1Ufd1p0.710
PMT1Pmt1p0.706
CDC23Cdc23p0.704
HSP82Hsp82p0.702
CDC27Cdc27p0.695
RKR1Rkr1p0.682
GFA1Gfa1p0.655
MAD2Mad2p0.649
SIT4Sit4p0.646
RPN5Rpn5p0.642
OTU1Otu1p0.642
SKP1Skp1p0.641
PUP1Pup1p0.639
FYV10Fyv10p0.637
PRE8Pre8p0.619
PRE5Pre5p0.616
DOC1Doc1p0.613
UBR1Ubr1p0.613
VPS27Vps27p0.602
SSE1Sse1p0.597
YDJ1Ydj1p0.588
PRE4Pre4p0.566
APC2Apc2p0.564
PPH21Pph21p0.563
YLR257Whypothetical protein0.561
DER1Der1p0.559
APC9Apc9p0.557
RPN7Rpn7p0.547
PUP3Pup3p0.533
UBC13Ubc13p0.525
CDC34Cdc34p0.517
GLC8Glc8p0.514
DOA4Doa4p0.509
PRE3Pre3p0.498
UBX3Ubx3p0.494
HRD3Hrd3p0.493
MUB1Mub1p0.492
ELC1Elc1p0.489
CDC20Cdc20p0.489
TPK2Tpk2p0.482
FES1Fes1p0.482
APC1Apc1p0.478
LAG2Lag2p0.468
MDN1Mdn1p0.463
USA1Usa1p0.459
BMH2Bmh2p0.457
CDC26Cdc26p0.453
CHL4Chl4p0.434
CSM1Csm1p0.434
UBX2Ubx2p0.427
RPN13Rpn13p0.427
SEC61Sec61p0.426
DDI1Ddi1p0.426
SCL1Scl1p0.420
APC4Apc4p0.414