The network for 'negative regulation of ion transmembrane transporter activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ion transmembrane transporter activity

Any process that stops or reduces the activity of an ion transporter.

NameDescriptionProbabilityFunc Analog Organism
efn-2Protein EFN-20.463
inx-12Protein INX-120.445
unc-7Protein UNC-70.381
vab-3Protein VAB-30.362
unc-36Protein UNC-360.211
eat-4Protein EAT-40.205
ger-1Protein GER-10.112
egl-19Protein EGL-190.110
T23G4.3Protein T23G4.30.103
sdz-28Protein SDZ-280.097
R148.4Protein R148.40.085
inx-4Protein INX-40.082
vha-7Protein VHA-70.082
mec-2Protein MEC-20.075
ifd-1Protein IFD-10.074
syg-1Protein SYG-10.071
glr-5Protein GLR-50.069
inx-8Protein INX-80.064
hrg-4Protein HRG-40.060
K10D6.2Protein K10D6.20.058
CELE_Y75B12B.1Protein Y75B12B.10.056
C48B4.8Protein C48B4.80.054
unc-115Protein UNC-1150.049
che-3Protein CHE-30.047
unc-9Protein UNC-90.047
ZC247.2Protein ZC247.20.047
unc-86Protein UNC-860.045
inx-5Protein INX-50.044
CELE_F17C11.12Protein F17C11.120.044
dyb-1Protein DYB-10.043
CELE_C27A7.6Protein C27A7.60.043
nmgp-1Protein NMGP-10.042
vha-16Protein VHA-160.042
F39G3.5Protein F39G3.50.037
inx-13Protein INX-130.036
nhr-143Protein NHR-1430.035
cah-2Protein CAH-20.034
crp-1Protein CRP-10.032
glr-1Protein GLR-10.032
fard-1Protein FARD-10.032
tag-256Protein TAG-2560.029
R03H10.2Protein R03H10.20.029
C15C8.3Protein C15C8.30.029
lov-1Protein LOV-10.029
clc-3Protein CLC-30.029
acy-1Protein ACY-10.028
sul-2Protein SUL-20.026
gcy-28Protein GCY-280.026
CELE_M176.5Protein M176.50.026
unc-42Protein UNC-420.025
ser-2Protein SER-20.025
rad-51Protein RAD-510.024
nhr-31Protein NHR-310.024
vha-15Protein VHA-150.024
acl-14Protein ACL-140.024
C14A4.6Protein C14A4.60.024
che-2Protein CHE-20.024
ape-1Protein APE-10.024
CELE_K02E7.6Protein K02E7.60.023
CELE_F53A3.1Protein F53A3.10.023
che-1Protein CHE-10.023
aat-2Protein AAT-20.023
upp-1Protein UPP-10.023
srv-1Protein SRV-10.023
nhr-91Protein NHR-910.023
unc-1Protein UNC-10.023
inx-17Protein INX-170.023
C03A3.1Protein C03A3.10.022
K01A2.9Protein K01A2.90.022
twk-26Protein TWK-260.022
CELE_Y14H12B.2Protein Y14H12B.20.022
C49A9.5Protein C49A9.50.022
Y87G2A.11Protein Y87G2A.110.022
C46C11.3Protein C46C11.30.022
slo-1Protein SLO-10.021
hrg-3Protein HRG-30.021
CELE_C49C3.10Protein C49C3.100.021
C08G9.2Protein C08G9.20.021
tbh-1Protein TBH-10.021
CELE_F40F9.5Protein F40F9.50.021
CELE_F46C3.2Protein F46C3.20.021
F54B11.7Protein F54B11.70.020
K03B8.6Protein K03B8.60.020
vha-17Protein VHA-170.020
ZK1053.4Protein ZK1053.40.020
C46G7.2Protein C46G7.20.020
CELE_Y44A6D.3Protein Y44A6D.30.020
unc-8Protein UNC-80.020
daf-10Protein DAF-100.019
CELE_Y39E4B.5Protein Y39E4B.50.019
otpl-3Protein OTPL-30.019
ZK470.1Protein ZK470.10.019
T27A1.5Protein T27A1.50.018
T02E9.5Protein T02E9.50.018
erm-1Protein ERM-10.018
npr-1Protein NPR-10.018
mec-1Protein MEC-10.018
tba-6Protein TBA-60.017
R11G1.6Protein R11G1.60.017
T10B10.8Protein T10B10.80.017
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.982
GSTM2glutathione S-transferase mu 2 (muscle)0.964
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.677
CAB39calcium binding protein 390.332
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.303
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.228
GSTM4glutathione S-transferase mu 40.214
WWP1WW domain containing E3 ubiquitin protein ligase 10.191
SMURF2SMAD specific E3 ubiquitin protein ligase 20.187
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.164
TGFBR1transforming growth factor, beta receptor 10.120
FBXL15F-box and leucine-rich repeat protein 150.111
PDLIM1PDZ and LIM domain 10.098
CALM1calmodulin 1 (phosphorylase kinase, delta)0.093
ACVR1Bactivin A receptor, type IB0.082
NEDD4neural precursor cell expressed, developmentally down-regulated 40.075
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.075
GSTM3glutathione S-transferase mu 3 (brain)0.074
CRHcorticotropin releasing hormone0.069
MYOZ1myozenin 10.044
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.043
PKD1polycystic kidney disease 1 (autosomal dominant)0.043
ZFYVE9zinc finger, FYVE domain containing 90.042
SMAD5SMAD family member 50.041
TGFB1transforming growth factor, beta 10.041
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.039
SMAD4SMAD family member 40.039
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.037
ADORA2Aadenosine A2a receptor0.037
SMAD1SMAD family member 10.036
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.036
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.036
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.032
MMP12matrix metallopeptidase 12 (macrophage elastase)0.032
SMAD7SMAD family member 70.032
CAPN2calpain 2, (m/II) large subunit0.029
ANKRD13Aankyrin repeat domain 13A0.029
PSEN2presenilin 2 (Alzheimer disease 4)0.028
GLRXglutaredoxin (thioltransferase)0.028
NEDD9neural precursor cell expressed, developmentally down-regulated 90.028
TBC1D10ATBC1 domain family, member 10A0.027
POU5F1POU class 5 homeobox 10.027
CAPZBcapping protein (actin filament) muscle Z-line, beta0.027
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.026
CXXC5CXXC finger protein 50.024
PDCD6programmed cell death 60.024
RHOAras homolog gene family, member A0.023
CAPNS1calpain, small subunit 10.021
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.021
TIMP2TIMP metallopeptidase inhibitor 20.020
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.020
WNK4WNK lysine deficient protein kinase 40.019
PKM2pyruvate kinase, muscle0.019
GNG2guanine nucleotide binding protein (G protein), gamma 20.018
MMP10matrix metallopeptidase 10 (stromelysin 2)0.017
GNG5guanine nucleotide binding protein (G protein), gamma 50.017
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.016
CYLDcylindromatosis (turban tumor syndrome)0.016
TUBA1Atubulin, alpha 1a0.015
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.015
PGK1phosphoglycerate kinase 10.014
TRPC1transient receptor potential cation channel, subfamily C, member 10.014
PRELPproline/arginine-rich end leucine-rich repeat protein0.014
THBS2thrombospondin 20.014
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.014
SOX7SRY (sex determining region Y)-box 70.014
FGFR1fibroblast growth factor receptor 10.013
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.013
PDCD6IPprogrammed cell death 6 interacting protein0.013
OTUB1OTU domain, ubiquitin aldehyde binding 10.013
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.012
EPORerythropoietin receptor0.012
CALCOCO2calcium binding and coiled-coil domain 20.012
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.012
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.012
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.012
MYH9myosin, heavy chain 9, non-muscle0.011
CLIC1chloride intracellular channel 10.011
CCL7chemokine (C-C motif) ligand 70.011
WWP2WW domain containing E3 ubiquitin protein ligase 20.011
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.011
GRIA4glutamate receptor, ionotrophic, AMPA 40.011
INHBAinhibin, beta A0.011
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.011
MAP2K1mitogen-activated protein kinase kinase 10.010
SMAD6SMAD family member 60.010
TRIM63tripartite motif containing 630.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Slc34a1solute carrier family 34 (sodium phosphate), member 10.399
Dmddystrophin, muscular dystrophy0.062
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.028
Ldb3LIM domain binding 30.025
Dtnadystrobrevin alpha0.018
Ryr2ryanodine receptor 2, cardiac0.018
Nos1nitric oxide synthase 1, neuronal0.014
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.644
LOC100362824caveolin 2-like0.569
Eef1a2eukaryotic translation elongation factor 1 alpha 20.071
Scarb1scavenger receptor class B, member 10.067
Git1G protein-coupled receptor kinase interacting ArfGAP 10.065
Efhd2EF-hand domain family, member D20.059
Lim2lens intrinsic membrane protein 20.058
Pygmphosphorylase, glycogen, muscle0.054
Actc1actin, alpha, cardiac muscle 10.052
Csnk1dcasein kinase 1, delta0.052
Myl1myosin, light chain 10.046
Zg16zymogen granule protein 160.045
Nckap1NCK-associated protein 10.041
Myf6myogenic factor 60.041
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.040
Cdh22cadherin 220.038
Cav3caveolin 30.038
Cdc25acell division cycle 25 homolog A (S. pombe)0.038
RGD1307752similar to RIKEN cDNA 1110008F130.038
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.035
Cav2caveolin 20.034
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.032
Psgb1pregnancy-specific beta 1-glycoprotein0.032
Pftk1PFTAIRE protein kinase 10.032
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.029
Strnstriatin, calmodulin binding protein0.029
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.027
Csrp3cysteine and glycine-rich protein 30.027
Olr1361olfactory receptor 13610.027
Cplx1complexin 10.027
Adra1aadrenergic, alpha-1A-, receptor0.027
Actn4actinin alpha 40.026
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.023
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.023
Tnni1troponin I type 1 (skeletal, slow)0.021
Esr2estrogen receptor 2 (ER beta)0.021
Galr2galanin receptor 20.021
Appamyloid beta (A4) precursor protein0.021
Vps52vacuolar protein sorting 52 homolog (S. cerevisiae)0.021
Mapk3mitogen activated protein kinase 30.021
Aipl1aryl hydrocarbon receptor-interacting protein-like 10.020
Gja1gap junction protein, alpha 10.019
MosMoloney sarcoma oncogene0.019
Gstm1glutathione S-transferase mu 10.019
Dgkzdiacylglycerol kinase zeta0.019
Nrapnebulin-related anchoring protein0.019
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.018
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.018
Muskmuscle, skeletal, receptor tyrosine kinase0.018
Myh9myosin, heavy chain 9, non-muscle0.018
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.017
Tpm3tropomyosin 3, gamma0.017
Ifnginterferon gamma0.016
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.016
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.016
Cited4Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 40.016
Smpxsmall muscle protein, X-linked0.016
Pgam2phosphoglycerate mutase 2 (muscle)0.015
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.015
VapaVAMP (vesicle-associated membrane protein)-associated protein A0.015
Fgf8fibroblast growth factor 80.015
Foxc2forkhead box C20.015
Myh2myosin, heavy chain 2, skeletal muscle, adult0.014
Ckmcreatine kinase, muscle0.014
LOC100360587hypothetical protein LOC1003605870.014
Ltb4r2leukotriene B4 receptor 20.014
Myoz2myozenin 20.014
Tmem72transmembrane protein 720.014
Smap2small ArfGAP20.014
Adcy5adenylate cyclase 50.014
Itpkainositol 1,4,5-trisphosphate 3-kinase A0.014
Fbxl22F-box and leucine-rich repeat protein 220.013
Crybb3crystallin, beta B30.013
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.013
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.013
Nexnnexilin (F actin binding protein)0.012
Barhl2BarH-like homeobox 20.012
Kykyphoscoliosis peptidase0.012
Tpc1808tropic 18080.012
Rbp3retinol binding protein 3, interstitial0.012
Pgs1phosphatidylglycerophosphate synthase 10.012
Ola1Obg-like ATPase 10.012
Mfrpmembrane frizzled-related protein0.012
Rpl3lribosomal protein L3-like0.011
Trim28tripartite motif-containing 280.011
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.011
Plb1phospholipase B10.011
Tmprss11dtransmembrane protease, serine 11d0.011
Aqp2aquaporin 2 (collecting duct)0.011
Ntsr2neurotensin receptor 20.011
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.011
Pitpnaphosphatidylinositol transfer protein, alpha0.011
Fitm1fat storage-inducing transmembrane protein 10.011
Slc6a18solute carrier family 6, member 180.011
Bst1bone marrow stromal cell antigen 10.011
Clcn1chloride channel 10.011
Cntn2contactin 2 (axonal)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism