The network for 'epithelium development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelium development

The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.938
egl-18Protein EGL-180.716
egl-27Protein EGL-270.653
soc-2Protein SOC-20.604
mab-5Protein MAB-50.567
ldb-1Protein LDB-10.557
fln-2Protein FLN-20.531
egl-46Protein EGL-460.529
hlh-2Protein HLH-20.529
sma-6Protein SMA-60.528
bar-1Protein BAR-10.516
epi-1Protein EPI-10.503
smp-1Protein SMP-10.489
unc-73Protein UNC-730.489
rig-6Protein RIG-60.470
vab-3Protein VAB-30.453
sqv-4Protein SQV-40.433
myo-3Protein MYO-30.408
ten-1Protein TEN-10.375
hlh-1Protein HLH-10.362
apl-1Protein APL-10.354
K10C3.4Protein K10C3.40.341
vab-1Protein VAB-10.327
atn-1Protein ATN-10.320
lir-1Protein LIR-10.306
nhr-67Protein NHR-670.303
plc-1Protein PLC-10.287
xpo-1Protein XPO-10.279
svh-2Protein SVH-20.274
pal-1Protein PAL-10.262
ceh-20Protein CEH-200.260
lin-17Protein LIN-170.243
elt-2Protein ELT-20.235
egl-15Protein EGL-150.220
cnd-1Protein CND-10.213
elt-6Protein ELT-60.209
syg-2Protein SYG-20.208
C49G7.1Protein C49G7.10.207
pdfr-1Protein PDFR-10.202
unc-98Protein UNC-980.201
osm-3Protein OSM-30.192
pxf-1Protein PXF-10.191
lag-1Protein LAG-10.191
lin-45Protein LIN-450.190
cpr-4Protein CPR-40.189
pry-1Protein PRY-10.186
unc-6Protein UNC-60.180
bam-2Protein BAM-20.178
imb-2Protein IMB-20.177
mes-4Protein MES-40.176
che-13Protein CHE-130.176
sma-1Protein SMA-10.173
hda-1Protein HDA-10.172
magi-1Protein MAGI-10.169
lam-2Protein LAM-20.165
unc-53Protein UNC-530.164
T28F4.1Protein T28F4.10.161
let-60Protein LET-600.159
tra-1Protein TRA-10.157
zfp-1Protein ZFP-10.157
ncam-1Protein NCAM-10.153
Y44E3A.6Protein Y44E3A.60.153
mlc-5Protein MLC-50.152
pqn-51Protein PQN-510.145
sem-5Protein SEM-50.143
bus-8Protein BUS-80.135
R10E12.2Protein R10E12.20.133
cas-1Protein CAS-10.132
ina-1Protein INA-10.130
lin-11Protein LIN-110.129
unc-40Protein UNC-400.127
C54E4.2Protein C54E4.20.127
egl-5Protein EGL-50.125
unc-32Protein UNC-320.121
sax-3Protein SAX-30.119
par-6Protein PAR-60.119
goa-1Protein GOA-10.118
vab-10Protein VAB-100.118
unc-130Protein UNC-1300.117
F33H2.3Protein F33H2.30.116
cki-1Protein CKI-10.116
mom-2Protein MOM-20.114
sdn-1Protein SDN-10.113
elc-1Protein ELC-10.111
F29B9.8Protein F29B9.80.110
lst-4Protein LST-40.109
ptp-3Protein PTP-30.109
flt-1Protein FLT-10.107
inx-3Protein INX-30.107
tag-260Protein TAG-2600.105
nhr-25Protein NHR-250.104
hmr-1Protein HMR-10.104
cdc-42Protein CDC-420.100
lit-1Protein LIT-10.100
lst-1Protein LST-10.100
lin-53Protein LIN-530.100
C07E3.3Protein C07E3.30.099
idh-1Protein IDH-10.099
lin-14Protein LIN-140.098
sgk-1Protein SGK-10.098
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
ESR1estrogen receptor 11.000
FN1fibronectin 11.000
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.998
CAV1caveolin 1, caveolae protein, 22kDa0.998
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.998
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.998
GRB2growth factor receptor-bound protein 20.997
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.996
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.996
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.995
SP1Sp1 transcription factor0.993
PTPN1protein tyrosine phosphatase, non-receptor type 10.989
MDM2Mdm2 p53 binding protein homolog (mouse)0.988
IQGAP1IQ motif containing GTPase activating protein 10.987
JAG1jagged 10.987
RARAretinoic acid receptor, alpha0.984
FGFR2fibroblast growth factor receptor 20.983
RB1retinoblastoma 10.982
PTK2PTK2 protein tyrosine kinase 20.980
THBS1thrombospondin 10.977
COL1A1collagen, type I, alpha 10.975
SMAD7SMAD family member 70.972
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.972
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.968
PTPN11protein tyrosine phosphatase, non-receptor type 110.967
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.963
NOTCH1notch 10.956
COL4A1collagen, type IV, alpha 10.952
PKP3plakophilin 30.948
FGFR1fibroblast growth factor receptor 10.937
TRIM29tripartite motif containing 290.932
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.930
RASA1RAS p21 protein activator (GTPase activating protein) 10.930
FLNAfilamin A, alpha0.926
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.925
HNF4Ahepatocyte nuclear factor 4, alpha0.922
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.914
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.910
CTGFconnective tissue growth factor0.907
ITGB4integrin, beta 40.904
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.895
NCOR2nuclear receptor corepressor 20.888
METmet proto-oncogene (hepatocyte growth factor receptor)0.888
MYOD1myogenic differentiation 10.882
COL4A2collagen, type IV, alpha 20.881
RUNX1runt-related transcription factor 10.877
ERBB2IPerbb2 interacting protein0.876
FOXA2forkhead box A20.875
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.872
ANXA1annexin A10.868
GRB7growth factor receptor-bound protein 70.864
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.863
SMAD9SMAD family member 90.863
IGFBP3insulin-like growth factor binding protein 30.863
LAD1ladinin 10.862
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.861
NR4A1nuclear receptor subfamily 4, group A, member 10.859
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.858
IGF1Rinsulin-like growth factor 1 receptor0.848
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.840
SHC1SHC (Src homology 2 domain containing) transforming protein 10.840
MYH9myosin, heavy chain 9, non-muscle0.838
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.837
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.836
KRT8keratin 80.832
NOTCH3notch 30.827
TIMP3TIMP metallopeptidase inhibitor 30.824
KLK10kallikrein-related peptidase 100.824
BMP7bone morphogenetic protein 70.813
TAL1T-cell acute lymphocytic leukemia 10.811
FERMT2fermitin family member 20.811
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.807
GJB3gap junction protein, beta 3, 31kDa0.806
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.806
PAX3paired box 30.798
KRT5keratin 50.795
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.793
BBS10Bardet-Biedl syndrome 100.787
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.784
CDX2caudal type homeobox 20.784
CDH3cadherin 3, type 1, P-cadherin (placental)0.783
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.779
TP63tumor protein p630.775
CTSAcathepsin A0.775
SRPK2SRSF protein kinase 20.773
PSEN1presenilin 10.768
CREBBPCREB binding protein0.768
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.767
SIRT1sirtuin 10.765
RHOAras homolog gene family, member A0.761
HOXB5homeobox B50.757
FMR1fragile X mental retardation 10.755
ARHGAP1Rho GTPase activating protein 10.752
SPTBN1spectrin, beta, non-erythrocytic 10.752
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ifitm3interferon induced transmembrane protein 30.617
Itgb1integrin, beta 10.606
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.523
Lims1LIM and senescent cell antigen-like domains 10.492
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.489
Anxa2annexin A20.486
Baiap2BAI1-associated protein 20.446
Cyp51cytochrome P450, family 510.445
S100a11S100 calcium binding protein A11 (calizzarin)0.439
Ascl1achaete-scute complex homolog 1 (Drosophila)0.425
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.380
Edn1endothelin 10.349
Sqlesqualene epoxidase0.338
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.330
Hand2heart and neural crest derivatives expressed 20.324
Pfn1profilin 10.303
Tcf4transcription factor 40.301
Slit3slit homolog 3 (Drosophila)0.289
Agtr1bangiotensin II receptor, type 1b0.289
Robo1roundabout homolog 1 (Drosophila)0.286
Gja5gap junction protein, alpha 50.279
Tgfbr3transforming growth factor, beta receptor III0.265
Myh9myosin, heavy chain 9, non-muscle0.260
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.247
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.246
Anxa5annexin A50.238
Cgaglycoprotein hormones, alpha polypeptide0.236
Rararetinoic acid receptor, alpha0.230
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.225
Ednrbendothelin receptor type B0.221
Tacr1tachykinin receptor 10.219
Gata6GATA binding protein 60.215
Col12a1collagen, type XII, alpha 10.210
Litaflipopolysaccharide-induced TNF factor0.207
S100a10S100 calcium binding protein A100.203
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.202
Smad7SMAD family member 70.202
Arhgap23Rho GTPase activating protein 230.199
Foxe1forkhead box E1 (thyroid transcription factor 2)0.196
Dchs1dachsous 1 (Drosophila)0.193
Atp7bATPase, Cu++ transporting, beta polypeptide0.190
RGD1304644similar to RIKEN cDNA 2310046K010.190
Bmpr1abone morphogenetic protein receptor, type IA0.189
Hbg1hemoglobin, gamma A0.188
Foxd3forkhead box D30.187
Dlg1discs, large homolog 1 (Drosophila)0.185
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.183
Foxa3forkhead box A30.176
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.175
LOC246267resection-induced TPI (rs11)0.174
Sprr1alsmall proline-rich protein 1A-like0.172
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.169
Unc5bunc-5 homolog B (C. elegans)0.168
Jak1Janus kinase 10.167
Sdcbpsyndecan binding protein0.163
Onecut1one cut homeobox 10.163
Fut1fucosyltransferase 10.162
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.162
Grm5glutamate receptor, metabotropic 50.161
Tgfbr2transforming growth factor, beta receptor II0.160
Ednraendothelin receptor type A0.160
Pde5aphosphodiesterase 5A, cGMP-specific0.160
Lama5laminin, alpha 50.157
Fstl1follistatin-like 10.157
Bmp4bone morphogenetic protein 40.156
Ageradvanced glycosylation end product-specific receptor0.154
Gja4gap junction protein, alpha 40.151
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.151
Stc1stanniocalcin 10.150
Loxl1lysyl oxidase-like 10.147
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.146
Ncam1neural cell adhesion molecule 10.144
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.143
Svs4seminal vesicle secretory protein 40.141
Sgp158proline-rich glycoprotein (sgp158)0.139
Bmp3bone morphogenetic protein 30.138
Irs1insulin receptor substrate 10.137
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.135
Nr2f2nuclear receptor subfamily 2, group F, member 20.134
Csrp1cysteine and glycine-rich protein 10.134
Dlgap1discs, large (Drosophila) homolog-associated protein 10.134
Pou3f2POU class 3 homeobox 20.133
Calcbcalcitonin-related polypeptide, beta0.131
Fgfr2fibroblast growth factor receptor 20.131
Acta2smooth muscle alpha-actin0.130
Adarb2adenosine deaminase, RNA-specific, B20.129
Runx1runt-related transcription factor 10.129
Phox2apaired-like homeobox 2a0.128
Cishcytokine inducible SH2-containing protein0.127
Syt4synaptotagmin IV0.127
FynFYN oncogene related to SRC, FGR, YES0.127
Cdk2cyclin dependent kinase 20.126
Arf6ADP-ribosylation factor 60.126
Svs1seminal vesicle secretory protein 10.126
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.125
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism