The network for 'negative regulation of response to external stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of response to external stimulus

Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.

NameDescriptionProbabilityFunc Analog Organism
lin-25Protein LIN-250.035
egl-27Protein EGL-270.030
acdh-3Protein ACDH-30.023
egl-18Protein EGL-180.023
pqn-62Protein PQN-620.022
egl-5Protein EGL-50.022
rpn-10Protein RPN-100.022
F02D8.4Protein F02D8.40.022
F14B8.4Protein F14B8.40.021
nhr-67Protein NHR-670.021
osm-5Protein OSM-50.021
CELE_C27A7.1Protein C27A7.10.021
gsr-1Protein GSR-10.021
T03F7.7Protein T03F7.70.021
hlh-11Protein HLH-110.020
C06E8.5Protein C06E8.50.020
bbs-8Protein BBS-80.020
sel-7Protein SEL-70.020
Y43E12A.2Protein Y43E12A.20.019
eor-2Protein EOR-20.019
C09E7.7Protein C09E7.70.019
pde-4Protein PDE-40.018
F45E4.5Protein F45E4.50.018
pxd-1Protein PXD-10.018
ztf-15Protein ZTF-150.018
pbs-5Protein PBS-50.018
C32D5.1Protein C32D5.10.018
F55G1.15Protein F55G1.150.018
cam-1Protein CAM-10.018
irx-1Protein IRX-10.017
che-13Protein CHE-130.017
ten-1Protein TEN-10.017
gei-4Protein GEI-40.017
T28D6.6Protein T28D6.60.017
che-2Protein CHE-20.017
ugt-57Protein UGT-570.017
nphp-1Protein NPHP-10.017
vab-3Protein VAB-30.017
rgs-5Protein RGS-50.017
CELE_T04H1.2Protein T04H1.20.017
mig-38Protein MIG-380.017
T05A12.4Protein T05A12.40.017
lag-2Protein LAG-20.016
CELE_Y44A6D.3Protein Y44A6D.30.016
flh-2Protein FLH-20.016
ZC434.9Protein ZC434.90.016
let-60Protein LET-600.016
che-11Protein CHE-110.016
lbp-5Protein LBP-50.016
sma-6Protein SMA-60.016
pde-2Protein PDE-20.016
ceh-22Protein CEH-220.016
F25H5.8Protein F25H5.80.016
pept-3Protein PEPT-30.016
mab-23Protein MAB-230.016
K05F1.6Protein K05F1.60.016
hsp-43Protein HSP-430.016
brp-1Protein BRP-10.016
Y37A1A.3Protein Y37A1A.30.016
ttr-15Protein TTR-150.016
cyn-7Protein CYN-70.016
sdc-2Protein SDC-20.016
drap-1Protein DRAP-10.016
dhs-21Protein DHS-210.016
pek-1Protein PEK-10.016
frm-3Protein FRM-30.015
F59E12.9Protein F59E12.90.015
ceh-6Protein CEH-60.015
egl-44Protein EGL-440.015
unc-29Protein UNC-290.015
daf-9Protein DAF-90.015
W01F3.1Protein W01F3.10.015
Y40C5A.1Protein Y40C5A.10.015
ttr-2Protein TTR-20.015
ZK593.3Protein ZK593.30.015
K03E6.7Protein K03E6.70.015
osm-12Protein OSM-120.015
pbs-6Protein PBS-60.015
CELE_Y67H2A.5Protein Y67H2A.50.015
sel-2Protein SEL-20.015
srp-7Protein SRP-70.015
clk-2Protein CLK-20.015
lis-1Protein LIS-10.015
zyg-8Protein ZYG-80.015
odr-3Protein ODR-30.015
nac-1Protein NAC-10.015
apc-2Protein APC-20.015
fozi-1Protein FOZI-10.015
nas-32Protein NAS-320.015
F29B9.8Protein F29B9.80.015
orc-1Protein ORC-10.015
rpl-16Protein RPL-160.015
ogt-1Protein OGT-10.014
hil-2Protein HIL-20.014
cdh-3Protein CDH-30.014
mek-2Protein MEK-20.014
CELE_F07H5.6Protein F07H5.60.014
soc-2Protein SOC-20.014
maea-1Protein MAEA-10.014
CELE_ZC204.12Protein ZC204.120.014
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.149
nrp1aneuropilin 1a0.110
cdh1cadherin 1, epithelial0.102
myf5myogenic factor 50.055
bmp2abone morphogenetic protein 2a0.048
mapk8bmitogen-activated protein kinase 8b0.042
tagln2transgelin 20.038
dab1adisabled homolog 1a (Drosophila)0.036
nrp2bneuropilin 2b0.034
egr1early growth response 10.026
ahr2aryl hydrocarbon receptor 20.026
tp63tumor protein p630.025
slc30a7solute carrier family 30 (zinc transporter), member 70.024
foxa1forkhead box A10.024
ncor2nuclear receptor co-repressor 20.023
atf3activating transcription factor 30.023
itih2inter-alpha (globulin) inhibitor H20.022
tbx2bT-box 2b0.022
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.022
snai1asnail homolog 1a (Drosophila)0.022
drd2ldopamine receptor D2 like0.021
kal1bKallmann syndrome 1b sequence0.021
fn1bfibronectin 1b0.020
pld1aphospholipase D1a0.020
epha4aeph receptor A4a0.020
ahcyS-adenosylhomocysteine hydrolase0.018
foxp2forkhead box P20.017
esrrgaestrogen-related receptor gamma a0.017
krt18keratin 180.016
hsp47heat shock protein 470.016
mmp2matrix metalloproteinase 20.016
efnb3bephrin B3b0.016
lrrc33leucine rich repeat containing 330.016
ptgs2aprostaglandin-endoperoxide synthase 2a0.015
dab1bdisabled homolog 1b (Drosophila)0.015
cxcr4bchemokine (C-X-C motif), receptor 4b0.015
pcdh18bprotocadherin 18b0.015
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.015
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.014
aldh8a1aldehyde dehydrogenase 8 family, member A10.013
aqp3aaquaporin 3a0.013
sulf1sulfatase 10.012
fabp3fatty acid binding protein 3, muscle and heart0.012
roraaRAR-related orphan receptor A, paralog a0.012
tcf7transcription factor 7 (T-cell specific, HMG-box)0.012
nccrp1nonspecific cytotoxic cell receptor protein 10.012
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.012
rhagRhesus blood group-associated glycoprotein0.012
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.012
kal1aKallmann syndrome 1a sequence0.012
prdm5PR domain containing 50.012
efnb2aephrin B2a0.012
mmp9matrix metalloproteinase 90.012
adra2badrenergic, alpha-2B-, receptor0.011
prdm16PR domain containing 160.011
LOC799612prolactin 20.011
c9complement component 90.011
adipoqladiponectin, C1Q and collagen domain containing, like0.011
gatmglycine amidinotransferase (L-arginine:glycine amidinotransferase)0.011
cldniclaudin i0.011
fgf3fibroblast growth factor 30.011
vephventricular zone expressed PH domain protein0.011
slit1bslit homolog 1b (Drosophila)0.011
crip2cysteine-rich protein 20.011
sox7SRY-box containing gene 70.011
mxtx2mix-type homeobox gene 20.010
znf703zinc finger protein 7030.010
fgfr3fibroblast growth factor receptor 30.010
aldh1a3aldehyde dehydrogenase 1 family, member A30.010
sema6dlsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like0.010
aplnraapelin receptor a0.010
pcdh2acprotocadherin 2 alpha c0.010
brpf1bromodomain and PHD finger containing, 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.848
Ptp69DProtein tyrosine phosphatase 69D0.345
Pi3K92ECG4141 gene product from transcript CG4141-RB0.299
GNBP3Gram-negative bacteria binding protein 30.297
Mpk2CG5475 gene product from transcript CG5475-RB0.247
foxoforkhead box, sub-group O0.199
grassGram-positive Specific Serine protease0.193
PGRP-SAPeptidoglycan recognition protein SA0.162
Sema-1bCG6446 gene product from transcript CG6446-RA0.128
PGRP-LBPeptidoglycan recognition protein LB0.118
SPESpatzle-Processing Enzyme0.118
Wnt5Wnt oncogene analog 50.098
Tsp42EdTetraspanin 42Ed0.084
pirkpoor Imd response upon knock-in0.073
CG14864CG14864 gene product from transcript CG14864-RB0.065
drkdownstream of receptor kinase0.064
CG5794CG5794 gene product from transcript CG5794-RB0.060
imdimmune deficiency0.057
CG4822CG4822 gene product from transcript CG4822-RB0.047
PvrPDGF- and VEGF-receptor related0.046
PGRP-SDCG7496 gene product from transcript CG7496-RA0.044
Sp7Serine protease 70.043
CG33960CG33960 gene product from transcript CG33960-RB0.042
CG17528CG17528 gene product from transcript CG17528-RC0.041
aopanterior open0.039
PGRP-LCPeptidoglycan recognition protein LC0.039
GripGlutamate receptor binding protein0.038
CG5346CG5346 gene product from transcript CG5346-RA0.036
phlpole hole0.035
JraJun-related antigen0.035
CG18594CG18594 gene product from transcript CG18594-RA0.034
CG15917CG15917 gene product from transcript CG15917-RA0.033
PGRP-LFPeptidoglycan recognition protein LF0.031
ird5immune response deficient 50.031
CG9184CG9184 gene product from transcript CG9184-RB0.030
DreddDeath related ced-3/Nedd2-like protein0.029
eaterCG6124 gene product from transcript CG6124-RB0.028
Tsp42EfTetraspanin 42Ef0.028
Lectin-galC1Galactose-specific C-type lectin0.028
Tpr2Tetratricopeptide repeat protein 20.028
Map205Microtubule-associated protein 2050.027
MEP-1CG1244 gene product from transcript CG1244-RG0.027
CG12004CG12004 gene product from transcript CG12004-RC0.027
CG42863CG42863 gene product from transcript CG42863-RB0.026
EphrinCG1862 gene product from transcript CG1862-RA0.026
upd2unpaired 20.026
IrcImmune-regulated catalase0.026
Traf4TNF-receptor-associated factor 40.026
HmgDHigh mobility group protein D0.025
CG9568CG9568 gene product from transcript CG9568-RA0.024
Atg13Autophagy-specific gene 130.024
Gadd45CG11086 gene product from transcript CG11086-RA0.024
VGlutVesicular glutamate transporter0.024
UtxCG5640 gene product from transcript CG5640-RD0.023
Fas2Fasciclin 20.022
unc-5CG8166 gene product from transcript CG8166-RA0.022
bbgbig bang0.022
sleslender lobes0.022
ninaAneither inactivation nor afterpotential A0.022
CG31004CG31004 gene product from transcript CG31004-RC0.021
jingCG9397 gene product from transcript CG9397-RI0.021
CG12424CG12424 gene product from transcript CG12424-RC0.020
cpocouch potato0.020
MrtfMyocardin-related transcription factor0.020
Rab2Rab-protein 20.020
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.020
Adf1Adh transcription factor 10.019
Spn1Serine protease inhibitor 10.019
p38bCG7393 gene product from transcript CG7393-RA0.019
Spn5Serine protease inhibitor 50.018
l(1)G0289lethal (1) G02890.018
CG9743CG9743 gene product from transcript CG9743-RA0.018
pgant5polypeptide GalNAc transferase 50.018
wbwing blister0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.979
JUNjun proto-oncogene0.942
MAPK1mitogen-activated protein kinase 10.921
FGFR2fibroblast growth factor receptor 20.918
TEKTEK tyrosine kinase, endothelial0.835
C1QAcomplement component 1, q subcomponent, A chain0.786
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.758
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.746
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.704
MDM2Mdm2 p53 binding protein homolog (mouse)0.697
JAG1jagged 10.697
CCR5chemokine (C-C motif) receptor 50.696
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.680
VEGFAvascular endothelial growth factor A0.669
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.647
FGAfibrinogen alpha chain0.614
FN1fibronectin 10.599
IFIT1interferon-induced protein with tetratricopeptide repeats 10.579
IL4Rinterleukin 4 receptor0.579
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.547
FOSFBJ murine osteosarcoma viral oncogene homolog0.512
CXCL12chemokine (C-X-C motif) ligand 120.478
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.472
IFIT2interferon-induced protein with tetratricopeptide repeats 20.434
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.405
FGBfibrinogen beta chain0.401
JUNBjun B proto-oncogene0.398
PLAUplasminogen activator, urokinase0.393
CCL2chemokine (C-C motif) ligand 20.374
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.366
IFIT3interferon-induced protein with tetratricopeptide repeats 30.356
INSRinsulin receptor0.344
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.322
NRP1neuropilin 10.321
DICER1dicer 1, ribonuclease type III0.321
TNFAIP3tumor necrosis factor, alpha-induced protein 30.318
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.316
EGR1early growth response 10.312
TBXA2Rthromboxane A2 receptor0.303
DUSP1dual specificity phosphatase 10.294
CASP8caspase 8, apoptosis-related cysteine peptidase0.290
PLATplasminogen activator, tissue0.287
COL3A1collagen, type III, alpha 10.281
NEDD4neural precursor cell expressed, developmentally down-regulated 40.278
KNG1kininogen 10.272
SMAD4SMAD family member 40.272
APOEapolipoprotein E0.269
DPP4dipeptidyl-peptidase 40.259
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.258
TAL1T-cell acute lymphocytic leukemia 10.255
IFIT5interferon-induced protein with tetratricopeptide repeats 50.245
PTPN1protein tyrosine phosphatase, non-receptor type 10.239
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.238
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.231
NOTCH1notch 10.227
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.225
IER2immediate early response 20.225
TRADDTNFRSF1A-associated via death domain0.220
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.217
MAP2K1mitogen-activated protein kinase kinase 10.216
HLA-DRB5major histocompatibility complex, class II, DR beta 50.207
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.204
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.204
C1QCcomplement component 1, q subcomponent, C chain0.200
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.197
CAV1caveolin 1, caveolae protein, 22kDa0.196
NR0B1nuclear receptor subfamily 0, group B, member 10.193
C3complement component 30.192
CASP10caspase 10, apoptosis-related cysteine peptidase0.189
CCL8chemokine (C-C motif) ligand 80.182
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.177
IL2RBinterleukin 2 receptor, beta0.175
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.175
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.174
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.173
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.166
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.162
CFLARCASP8 and FADD-like apoptosis regulator0.162
PDGFCplatelet derived growth factor C0.161
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.159
PYCARDPYD and CARD domain containing0.155
ICAM1intercellular adhesion molecule 10.151
TNFtumor necrosis factor0.144
PTENphosphatase and tensin homolog0.143
FGF2fibroblast growth factor 2 (basic)0.140
SMURF2SMAD specific E3 ubiquitin protein ligase 20.137
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.136
CXCL9chemokine (C-X-C motif) ligand 90.135
HLA-DRB4major histocompatibility complex, class II, DR beta 40.135
TRAF2TNF receptor-associated factor 20.133
MASP2mannan-binding lectin serine peptidase 20.133
HLA-DMBmajor histocompatibility complex, class II, DM beta0.130
CYLDcylindromatosis (turban tumor syndrome)0.130
C1QBcomplement component 1, q subcomponent, B chain0.127
APOC1apolipoprotein C-I0.126
CCL4chemokine (C-C motif) ligand 40.126
TMEM173transmembrane protein 1730.124
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pzppregnancy-zone protein0.388
Iappislet amyloid polypeptide0.251
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.229
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.210
Lgals3lectin, galactoside-binding, soluble, 30.173
Adora2aadenosine A2a receptor0.152
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.146
Il1r1interleukin 1 receptor, type I0.135
Hcrtr1hypocretin (orexin) receptor 10.135
Dccdeleted in colorectal carcinoma0.126
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.123
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.123
Dio1deiodinase, iodothyronine, type I0.121
Smgbneonatal submandibular gland protein B0.109
Ctla4cytotoxic T-lymphocyte-associated protein 40.100
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.099
Aspgasparaginase homolog (S. cerevisiae)0.098
Uhmk1U2AF homology motif (UHM) kinase 10.095
Ppypancreatic polypeptide0.090
Syt8synaptotagmin VIII0.086
Gna15guanine nucleotide binding protein, alpha 150.086
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.086
Adam1aa disintegrin and metallopeptidase domain 1a0.085
S100a6S100 calcium binding protein A60.084
Twist2twist homolog 2 (Drosophila)0.082
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.079
F2rl1coagulation factor II (thrombin) receptor-like 10.079
Cdx2caudal type homeo box 20.079
Ncr1natural cytotoxicity triggering receptor 10.076
Fshbfollicle stimulating hormone, beta polypeptide0.076
Olr1496olfactory receptor 14960.075
Apoa2apolipoprotein A-II0.075
Cd4Cd4 molecule0.072
Rnase4ribonuclease, RNase A family 40.072
Csn1s1casein alpha s10.072
Il12binterleukin 12B0.071
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.069
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.069
Cd5Cd5 molecule0.068
Pnliprp1pancreatic lipase-related protein 10.067
Krt31keratin 310.066
Gzmkgranzyme K0.066
Tlr4toll-like receptor 40.064
Ppyr1pancreatic polypeptide receptor 10.064
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.063
Notch3Notch homolog 3 (Drosophila)0.061
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.059
Ctshcathepsin H0.059
Csrp1cysteine and glycine-rich protein 10.059
Fgf7fibroblast growth factor 70.058
B2mbeta-2 microglobulin0.058
Tas2r118taste receptor, type 2, member 1180.057
Psbpc1prostatic steroid binding protein C10.053
Haao3-hydroxyanthranilate 3,4-dioxygenase0.053
Chrna6cholinergic receptor, nicotinic, alpha 60.052
C1scomplement component 1, s subcomponent0.052
Adora3adenosine A3 receptor0.052
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.052
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.051
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.051
Cpb1carboxypeptidase B1 (tissue)0.051
Reg3gregenerating islet-derived 3 gamma0.050
Apohapolipoprotein H (beta-2-glycoprotein I)0.050
Cxcr5chemokine (C-X-C motif) receptor 50.049
Grm6glutamate receptor, metabotropic 60.048
Necab2N-terminal EF-hand calcium binding protein 20.046
Mmp12matrix metallopeptidase 120.046
Cd9CD9 molecule0.046
Rup2urinary protein 20.046
Nos3nitric oxide synthase 3, endothelial cell0.045
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.045
Adam7ADAM metallopeptidase domain 70.045
Il13interleukin 130.045
Crhr2corticotropin releasing hormone receptor 20.045
LOC686432hypothetical protein LOC6864320.045
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.044
Galr3galanin receptor 30.044
Neurog1neurogenin 10.042
Prss3protease, serine, 30.042
Galgalanin prepropeptide0.042
Glra1glycine receptor, alpha 10.042
Nfibnuclear factor I/B0.042
Rhbdl1rhomboid, veinlet-like 1 (Drosophila)0.042
Gucy2dguanylate cyclase 2d0.042
Scnn1bsodium channel, nonvoltage-gated 1, beta0.041
Acrv1acrosomal vesicle protein 10.041
Drd2dopamine receptor D20.040
Ifitm2interferon induced transmembrane protein 20.040
Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 30.040
Nr1i2nuclear receptor subfamily 1, group I, member 20.040
Tff3trefoil factor 3, intestinal0.040
Anxa1annexin A10.040
Cpn1carboxypeptidase N, polypeptide 10.039
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism