The network for 'cell surface receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.989
vab-3Protein VAB-30.895
osm-5Protein OSM-50.877
pha-4Protein PHA-40.820
atn-1Protein ATN-10.800
unc-62Protein UNC-620.799
mig-2Protein MIG-20.796
hlh-2Protein HLH-20.793
let-60Protein LET-600.746
pkg-1Protein PKG-10.728
lag-1Protein LAG-10.713
nhr-67Protein NHR-670.692
che-3Protein CHE-30.686
goa-1Protein GOA-10.674
unc-52Protein UNC-520.670
hmg-1.2Protein HMG-1.20.664
egl-30Protein EGL-300.664
brp-1Protein BRP-10.650
eef-1A.1Protein EEF-1A.10.607
mom-2Protein MOM-20.607
unc-6Protein UNC-60.588
cam-1Protein CAM-10.583
lin-17Protein LIN-170.545
apl-1Protein APL-10.543
igcm-3Protein IGCM-30.525
hlh-1Protein HLH-10.503
daf-11Protein DAF-110.503
pdfr-1Protein PDFR-10.501
let-607Protein LET-6070.493
eat-4Protein EAT-40.483
unc-37Protein UNC-370.470
unc-7Protein UNC-70.469
daf-7Protein DAF-70.462
sma-6Protein SMA-60.462
egl-13Protein EGL-130.451
che-13Protein CHE-130.444
egl-15Protein EGL-150.430
egl-5Protein EGL-50.429
magi-1Protein MAGI-10.423
unc-9Protein UNC-90.422
cst-2Protein CST-20.419
vab-10Protein VAB-100.419
syg-1Protein SYG-10.408
ina-1Protein INA-10.399
pry-1Protein PRY-10.397
soc-2Protein SOC-20.397
vab-1Protein VAB-10.395
unc-120Protein UNC-1200.391
egl-8Protein EGL-80.389
mod-1Protein MOD-10.388
mig-5Protein MIG-50.371
ceh-20Protein CEH-200.361
cal-4Protein CAL-40.358
flh-1Protein FLH-10.356
che-2Protein CHE-20.353
bar-1Protein BAR-10.352
gsk-3Protein GSK-30.349
pat-6Protein PAT-60.347
plc-1Protein PLC-10.339
lmn-1Protein LMN-10.338
glr-4Protein GLR-40.338
daf-2Protein DAF-20.331
unc-79Protein UNC-790.329
tag-297Protein TAG-2970.309
pat-3Protein PAT-30.307
pxf-1Protein PXF-10.307
cids-2Protein CIDS-20.306
akt-1Protein AKT-10.306
lin-25Protein LIN-250.293
zyg-8Protein ZYG-80.291
ima-3Protein IMA-30.290
frm-7Protein FRM-70.290
hlh-30Protein HLH-300.282
par-5Protein PAR-50.281
hmp-2Protein HMP-20.278
daf-1Protein DAF-10.275
T28F4.1Protein T28F4.10.273
npp-7Protein NPP-70.272
ceh-18Protein CEH-180.271
zyg-9Protein ZYG-90.269
lin-29Protein LIN-290.268
dop-1Protein DOP-10.267
nipi-3Protein NIPI-30.267
gpb-1Protein GPB-10.266
asd-1Protein ASD-10.264
lin-11Protein LIN-110.263
abts-3Protein ABTS-30.261
tax-6Protein TAX-60.261
osm-3Protein OSM-30.261
aat-1Protein AAT-10.260
F13H6.1Protein F13H6.10.259
che-14Protein CHE-140.258
cit-1.1Protein CIT-1.10.258
unc-129Protein UNC-1290.257
cki-1Protein CKI-10.257
tam-1Protein TAM-10.254
sel-7Protein SEL-70.252
ham-1Protein HAM-10.250
sma-9Protein SMA-90.250
rig-6Protein RIG-60.249
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin1.000
gli1GLI-Kruppel family member 10.999
ntlano tail a0.997
cdh1cadherin 1, epithelial0.995
tbx1T-box 10.993
bmp2bbone morphogenetic protein 2b0.993
ndr2nodal-related 20.993
shhasonic hedgehog a0.991
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.982
ptch1patched 10.980
ephb4beph receptor B4b0.978
twist1atwist1a0.976
pitx3paired-like homeodomain transcription factor 30.971
lef1lymphocyte enhancer binding factor 10.970
fn1fibronectin 10.969
dladeltaA0.967
pcdh18bprotocadherin 18b0.963
fgf3fibroblast growth factor 30.961
dusp6dual specificity phosphatase 60.953
irx3airoquois homeobox protein 3a0.952
tyrtyrosinase0.943
fgf8afibroblast growth factor 8 a0.938
il17rdinterleukin 17 receptor D0.935
alcambactivated leukocyte cell adhesion molecule b0.934
notch1anotch homolog 1a0.919
mibmind bomb0.907
prdm1aPR domain containing 1a, with ZNF domain0.895
fzd10frizzled homolog 100.894
her6hairy-related 60.892
tgfb3transforming growth factor, beta 30.888
wnt5bwingless-type MMTV integration site family, member 5b0.887
wnt4awingless-type MMTV integration site family, member 4a0.886
bmp2abone morphogenetic protein 2a0.881
wnt11rwingless-type MMTV integration site family, member 11, related0.881
dlddeltaD0.873
ephb3aeph receptor B3a0.872
wnt2bbwingless-type MMTV integration site family, member 2Bb0.868
snai1asnail homolog 1a (Drosophila)0.867
smosmoothened homolog (Drosophila)0.867
smad1MAD homolog 1 (Drosophila)0.864
wnt3wingless-type MMTV integration site family, member 30.860
dccdeleted in colorectal carcinoma0.859
gscgoosecoid0.854
dlx5adistal-less homeobox gene 5a0.849
lft2lefty20.833
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.830
lmx1b.1LIM homeobox transcription factor 1, beta 10.828
rspo1R-spondin homolog (Xenopus laevis)0.822
junjun proto-oncogene0.820
lft1lefty10.819
tbx5aT-box 5a0.818
tp53tumor protein p530.815
btg2B-cell translocation gene 20.808
snai1bsnail homolog 1b (Drosophila)0.807
s1pr2sphingosine-1-phosphate receptor 20.805
crabp2acellular retinoic acid binding protein 2, a0.803
vegfcvascular endothelial growth factor c0.803
twist2twist20.800
runx2brunt-related transcription factor 2b0.798
six3bsine oculis homeobox homolog 3b0.795
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.794
flt4fms-related tyrosine kinase 40.793
otx2orthodenticle homolog 20.793
sox1aSRY-box containing gene 1a0.787
rarabretinoic acid receptor, alpha b0.784
nanos3nanos homolog 30.781
pax8paired box gene 80.780
gli2aGLI-Kruppel family member GLI2a0.778
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.769
yrkYes-related kinase0.764
eve1even-skipped-like10.764
tac1tachykinin 10.760
egr1early growth response 10.758
edn1endothelin 10.755
kitakit receptor a0.755
axin2axin 2 (conductin, axil)0.753
gro1groucho 10.752
tbx16T-box gene 160.750
tbx6T-box gene 60.746
hoxd4ahomeo box D4a0.736
vegfaavascular endothelial growth factor Aa0.735
wnt2wingless-type MMTV integration site family member 20.730
pou5f1POU domain, class 5, transcription factor 10.730
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.729
fbn2bfibrillin 2b0.729
ctsl1bcathepsin L, 1 b0.728
her8ahairy-related 8a0.727
pea3ETS-domain transcription factor pea30.721
rargaretinoic acid receptor gamma a0.720
nrp2bneuropilin 2b0.719
wlswntless homolog (Drosophila)0.715
dzip1DAZ interacting protein 10.710
col5a1procollagen, type V, alpha 10.710
csrp1acysteine and glycine-rich protein 1a0.708
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.707
esr2aestrogen receptor 2a0.703
adra2aadrenergic, alpha-2A-, receptor0.702
sulf2sulfatase 20.700
gdf6agrowth differentiation factor 6a0.697
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.696
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
STE4Ste4p0.961
STE12Ste12p0.888
STE2Ste2p0.835
CLA4Cla4p0.672
STE20Ste20p0.669
STE5Ste5p0.668
FUS3Fus3p0.528
APP1App1p0.511
PBS2Pbs2p0.475
BCK1Bck1p0.440
PRK1Prk1p0.432
CKA2Cka2p0.348
FAR1Far1p0.316
SSK2Ssk2p0.304
HOF1Hof1p0.275
STE7Ste7p0.266
SSK1Ssk1p0.244
MYO5Myo5p0.238
BOI2Boi2p0.184
ERP4Erp4p0.180
CKB2Ckb2p0.173
ERV25Erv25p0.166
ROM2Rom2p0.159
VRP1Vrp1p0.155
RIX1Rix1p0.153
CDC24Cdc24p0.152
KSS1Kss1p0.149
KDX1Kdx1p0.147
PKH2Pkh2p0.146
IZH4Izh4p0.131
RHO1Rho1p0.117
STP22Stp22p0.114
MRS6Mrs6p0.112
MF(ALPHA)1Mf(alpha)1p0.111
MSI1Msi1p0.110
END3End3p0.109
STE18Ste18p0.109
MDS3Mds3p0.108
BCK2Bck2p0.105
PAF1Paf1p0.104
YOL087Chypothetical protein0.102
RSC8Rsc8p0.095
GIC2Gic2p0.088
SDS22Sds22p0.087
SLG1Slg1p0.087
PAN1Pan1p0.083
DID4Did4p0.083
MF(ALPHA)2Mf(alpha)2p0.083
AGA2Aga2p0.080
VPS4Vps4p0.079
ECM27Ecm27p0.078
RAS2Ras2p0.077
STE3Ste3p0.077
VPS36Vps36p0.077
DBF2Dbf2p0.076
GIS1Gis1p0.075
PSP2Psp2p0.074
SUP35Sup35p0.072
ARP2Arp2p0.072
NSR1Nsr1p0.071
PYK2Pyk2p0.070
YAP1801hypothetical protein0.069
SST2Sst2p0.068
YPT10Ypt10p0.068
STE50Ste50p0.068
ACT1Act1p0.065
SWI1Swi1p0.064
MFA1Mfa1p0.064
STI1Sti1p0.063
TPK2Tpk2p0.063
YPT1Ypt1p0.063
STE11Ste11p0.061
CDC34Cdc34p0.061
MSG5Msg5p0.058
VPS16Vps16p0.058
YGL036Whypothetical protein0.057
ERP5Erp5p0.056
TFB4Tfb4p0.055
AIM3Aim3p0.054
GLO3Glo3p0.054
SIR2Sir2p0.053
PEP5Pep5p0.053
GIC1Gic1p0.052
VPS24Vps24p0.052
PPZ1Ppz1p0.052
NUP170Nup170p0.052
AQR1Aqr1p0.051
GPA1Gpa1p0.050
YNL024Chypothetical protein0.049
DIA2Dia2p0.049
UGO1Ugo1p0.048
LHS1Lhs1p0.048
GSC2Gsc2p0.048
RSC2Rsc2p0.048
MFA2Mfa2p0.047
YCL042Whypothetical protein0.047
PPQ1Ppq1p0.047
YBL086Chypothetical protein0.047
GCS1Gcs1p0.046
MBR1Mbr1p0.046