The network for 'enzyme linked receptor protein signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

enzyme linked receptor protein signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
egl-15Protein EGL-150.913
nhr-67Protein NHR-670.585
vab-3Protein VAB-30.548
elt-6Protein ELT-60.522
sem-5Protein SEM-50.514
sma-6Protein SMA-60.490
bar-1Protein BAR-10.453
egl-8Protein EGL-80.446
let-60Protein LET-600.446
egl-18Protein EGL-180.418
egl-13Protein EGL-130.413
pry-1Protein PRY-10.411
che-2Protein CHE-20.384
eps-8Protein EPS-80.374
hlh-30Protein HLH-300.343
daf-1Protein DAF-10.340
unc-6Protein UNC-60.320
hlh-2Protein HLH-20.317
unc-9Protein UNC-90.303
plc-1Protein PLC-10.273
che-13Protein CHE-130.213
unc-94Protein UNC-940.203
dlk-1Protein DLK-10.198
daf-2Protein DAF-20.184
ccch-1Protein CCCH-10.178
pkg-1Protein PKG-10.174
par-5Protein PAR-50.166
pxf-1Protein PXF-10.164
oac-46Protein OAC-460.158
tax-4Protein TAX-40.156
che-3Protein CHE-30.150
osm-3Protein OSM-30.148
unc-73Protein UNC-730.147
dnc-2Protein DNC-20.143
glo-4Protein GLO-40.131
odr-3Protein ODR-30.130
peb-1Protein PEB-10.129
unc-83Protein UNC-830.128
itr-1Protein ITR-10.128
pha-4Protein PHA-40.126
akt-1Protein AKT-10.126
lag-1Protein LAG-10.125
daf-11Protein DAF-110.125
osm-6Protein OSM-60.125
nipi-3Protein NIPI-30.125
inx-3Protein INX-30.122
ceh-20Protein CEH-200.116
mes-4Protein MES-40.115
unc-52Protein UNC-520.110
egl-27Protein EGL-270.109
gcy-22Protein GCY-220.103
osm-5Protein OSM-50.102
nhr-25Protein NHR-250.101
cam-1Protein CAM-10.095
ten-1Protein TEN-10.094
brp-1Protein BRP-10.092
egl-30Protein EGL-300.090
cids-2Protein CIDS-20.087
ape-1Protein APE-10.086
ceh-44Protein CEH-440.085
miz-1Protein MIZ-10.084
pat-3Protein PAT-30.083
mig-2Protein MIG-20.082
nas-38Protein NAS-380.079
cki-1Protein CKI-10.079
unc-104Protein UNC-1040.078
hlh-1Protein HLH-10.078
flt-1Protein FLT-10.078
sel-12Protein SEL-120.078
unc-43Protein UNC-430.077
pdfr-1Protein PDFR-10.073
trcs-2Protein TRCS-20.072
erd-2Protein ERD-20.071
hlh-14Protein HLH-140.070
egl-44Protein EGL-440.069
tag-123Protein TAG-1230.069
lin-29Protein LIN-290.068
CELE_F54D5.5Protein F54D5.50.067
nhr-45Protein NHR-450.067
rme-4Protein RME-40.066
efl-3Protein EFL-30.066
sax-3Protein SAX-30.065
mbk-2Protein MBK-20.065
exc-5Protein EXC-50.064
tag-196Protein TAG-1960.064
tag-320Protein TAG-3200.064
ing-3Protein ING-30.064
frm-7Protein FRM-70.064
daf-7Protein DAF-70.064
wrn-1Protein WRN-10.063
unc-62Protein UNC-620.063
CELE_Y69A2AR.28Protein Y69A2AR.280.063
lin-1Protein LIN-10.063
ttm-1Protein TTM-10.061
T28F4.1Protein T28F4.10.061
C14B9.2Protein C14B9.20.060
daf-19Protein DAF-190.059
faah-1Protein FAAH-10.058
lin-25Protein LIN-250.058
daf-4Protein DAF-40.057
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf8afibroblast growth factor 8 a0.993
sox9aSRY-box containing gene 9a0.983
shhasonic hedgehog a0.967
ntlano tail a0.947
plcg1phospholipase C, gamma 10.940
tbx1T-box 10.928
fgf3fibroblast growth factor 30.926
ndr2nodal-related 20.905
gli2aGLI-Kruppel family member GLI2a0.896
bmp4bone morphogenetic protein 40.888
bmp2abone morphogenetic protein 2a0.883
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.858
bmp2bbone morphogenetic protein 2b0.830
pcdh18bprotocadherin 18b0.813
wnt4awingless-type MMTV integration site family, member 4a0.729
wnt2bbwingless-type MMTV integration site family, member 2Bb0.722
tbx16T-box gene 160.703
gli1GLI-Kruppel family member 10.688
vcanaversican a0.674
dusp6dual specificity phosphatase 60.661
fn1fibronectin 10.656
raraaretinoic acid receptor, alpha a0.647
hey1hairy/enhancer-of-split related with YRPW motif 10.640
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.613
s1pr2sphingosine-1-phosphate receptor 20.611
notch1anotch homolog 1a0.609
efnb2aephrin B2a0.592
ventventral expressed homeobox0.589
gpc4glypican 40.586
notch3notch homolog 30.580
gbx2gastrulation brain homeo box 20.578
fzd10frizzled homolog 100.570
ephb4beph receptor B4b0.564
smad9MAD homolog 9 (Drosophila)0.559
esr1estrogen receptor 10.526
trim33tripartite motif-containing 330.522
wnt5bwingless-type MMTV integration site family, member 5b0.519
tie1endothelium-specific receptor tyrosine kinase 10.511
gata4GATA-binding protein 40.510
foxa3forkhead box A30.509
rag1recombination activating gene 10.501
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.498
runx2brunt-related transcription factor 2b0.497
spns2spinster homolog 2 (Drosophila)0.490
fstafollistatin a0.478
wnt10awingless-type MMTV integration site family, member 10a0.467
fbn2bfibrillin 2b0.466
sox7SRY-box containing gene 70.465
foxi1forkhead box I10.461
bmp7abone morphogenetic protein 7a0.460
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.456
fgfr1bfibroblast growth factor receptor 1b0.454
igf1rbinsulin-like growth factor 1b receptor0.454
nanos3nanos homolog 30.449
zbtb4zinc finger and BTB domain containing 40.447
tbx2aT-box gene 2a0.444
sox19aSRY-box containing gene 19a0.435
wnt8bwingless-type MMTV integration site family, member 8b0.431
wnt11rwingless-type MMTV integration site family, member 11, related0.417
sec23aSec23 homolog A (S. cerevisiae)0.414
cmybtranscription factor cmyb0.400
tll1tolloid-like 10.398
wnt11wingless-type MMTV integration site family, member 110.397
pomcaproopiomelanocortin a0.396
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.395
egr1early growth response 10.391
neo1neogenin 10.388
nog2noggin 20.385
fras1Fraser syndrome 10.379
ptch2patched 20.377
ghragrowth hormone receptor a0.376
dccdeleted in colorectal carcinoma0.375
eomesaeomesodermin homolog a0.374
esr2aestrogen receptor 2a0.373
wnt9awingless-type MMTV integration site family, member 9A0.363
pkd2polycystic kidney disease 20.363
rarabretinoic acid receptor, alpha b0.354
fgfr2fibroblast growth factor receptor 20.351
hoxa13ahomeo box A13a0.345
spry4sprouty (Drosophila) homolog 40.343
hhiphedgehog interacting protein0.333
tp53bp2tumor protein p53 binding protein, 20.326
cdh5cadherin 50.326
fmr1fragile X mental retardation 10.323
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.322
nrp2bneuropilin 2b0.319
hs6st2heparan sulfate 6-O-sulfotransferase 20.317
mecomMDS1 and EVI1 complex locus0.317
trpv6transient receptor potential cation channel, subfamily V, member 60.315
tbx18T-box 180.315
gbx1gastrulation brain homeobox 10.312
ptk2.1protein tyrosine kinase 2a0.312
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EcREcdysone receptor0.996
drkdownstream of receptor kinase0.993
EgfrEpidermal growth factor receptor0.984
l(2)gllethal (2) giant larvae0.983
InRInsulin-like receptor0.975
phlpole hole0.957
mbcmyoblast city0.940
Atg1Autophagy-specific gene 10.937
eyaeyes absent0.936
sogshort gastrulation0.934
argosCG4531 gene product from transcript CG4531-RA0.921
cicubitus interruptus0.912
Rac1CG2248 gene product from transcript CG2248-RA0.911
Ras85DRas oncogene at 85D0.887
chicoCG5686 gene product from transcript CG5686-RB0.881
bowlbrother of odd with entrails limited0.828
JraJun-related antigen0.810
Src42ASrc oncogene at 42A0.793
Stat92ESignal-transducer and activator of transcription protein at 92E0.785
Bre1CG10542 gene product from transcript CG10542-RA0.753
C3GCG42328 gene product from transcript CG42328-RC0.750
ash2absent, small, or homeotic discs 20.748
LanB1CG7123 gene product from transcript CG7123-RA0.743
Rab5Rab-protein 50.742
aopanterior open0.718
par-1CG8201 gene product from transcript CG8201-RA0.701
stumpsCG31317 gene product from transcript CG31317-RC0.701
sosine oculis0.692
witwishful thinking0.685
rictorrapamycin-insensitive companion of Tor0.683
fkhfork head0.656
DadDaughters against dpp0.641
Rab7Rab-protein 70.625
spensplit ends0.622
hipkhomeodomain interacting protein kinase0.608
Akt1CG4006 gene product from transcript CG4006-RA0.605
PtenCG5671 gene product from transcript CG5671-RB0.604
eveeven skipped0.601
salmspalt major0.591
S6kRPS6-p70-protein kinase0.579
mewmultiple edematous wings0.576
Dsor1Downstream of raf10.575
Su(dx)Suppressor of deltex0.563
NFATNFAT homolog0.553
cv-ccrossveinless c0.553
ebiCG4063 gene product from transcript CG4063-RA0.551
Fas2Fasciclin 20.540
Socs36ESuppressor of cytokine signaling at 36E0.540
Mef2Myocyte enhancer factor 20.537
E(spl)Enhancer of split0.529
Hsc70-4Heat shock protein cognate 40.521
myoglianinCG1838 gene product from transcript CG1838-RD0.495
Kr-h1Kruppel homolog 10.491
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
SHC1SHC (Src homology 2 domain containing) transforming protein 11.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
GRB2growth factor receptor-bound protein 21.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1.000
PTPN1protein tyrosine phosphatase, non-receptor type 11.000
FYNFYN oncogene related to SRC, FGR, YES1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
JUNjun proto-oncogene1.000
PTPN11protein tyrosine phosphatase, non-receptor type 111.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
PLCG1phospholipase C, gamma 11.000
ABL1c-abl oncogene 1, non-receptor tyrosine kinase1.000
BCAR1breast cancer anti-estrogen resistance 11.000
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)1.000
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like1.000
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)1.000
SMAD3SMAD family member 31.000
METmet proto-oncogene (hepatocyte growth factor receptor)1.000
LCKlymphocyte-specific protein tyrosine kinase1.000
GRB7growth factor receptor-bound protein 70.999
FOSFBJ murine osteosarcoma viral oncogene homolog0.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
SMAD4SMAD family member 40.999
PTK2PTK2 protein tyrosine kinase 20.999
CREBBPCREB binding protein0.999
ESR1estrogen receptor 10.998
CAV1caveolin 1, caveolae protein, 22kDa0.998
FN1fibronectin 10.998
SMAD2SMAD family member 20.998
DUSP1dual specificity phosphatase 10.997
MAPK8mitogen-activated protein kinase 80.997
SMAD1SMAD family member 10.997
SMURF1SMAD specific E3 ubiquitin protein ligase 10.996
IRS1insulin receptor substrate 10.996
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.996
SMAD7SMAD family member 70.996
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.994
SKILSKI-like oncogene0.993
FGFR2fibroblast growth factor receptor 20.993
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.992
MAPK1mitogen-activated protein kinase 10.992
SMURF2SMAD specific E3 ubiquitin protein ligase 20.992
GRB10growth factor receptor-bound protein 100.989
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.989
INSRinsulin receptor0.987
TGFB1transforming growth factor, beta 10.986
MMP14matrix metallopeptidase 14 (membrane-inserted)0.985
MAPK14mitogen-activated protein kinase 140.985
APPamyloid beta (A4) precursor protein0.985
SYKspleen tyrosine kinase0.984
FGF1fibroblast growth factor 1 (acidic)0.984
FHL2four and a half LIM domains 20.982
NCK1NCK adaptor protein 10.982
SOCS1suppressor of cytokine signaling 10.981
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.979
SHC2SHC (Src homology 2 domain containing) transforming protein 20.978
SP1Sp1 transcription factor0.977
PDCD6IPprogrammed cell death 6 interacting protein0.976
MAP2K4mitogen-activated protein kinase kinase 40.974
SH3KBP1SH3-domain kinase binding protein 10.972
PTPN6protein tyrosine phosphatase, non-receptor type 60.971
ARandrogen receptor0.969
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.968
GSK3Bglycogen synthase kinase 3 beta0.966
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.959
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.956
GHRgrowth hormone receptor0.955
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.955
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.952
TP53tumor protein p530.949
DLG1discs, large homolog 1 (Drosophila)0.947
IGF1Rinsulin-like growth factor 1 receptor0.946
NCK2NCK adaptor protein 20.942
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.942
TGFBR1transforming growth factor, beta receptor 10.941
SOCS3suppressor of cytokine signaling 30.941
SIRT1sirtuin 10.940
FGFR1fibroblast growth factor receptor 10.939
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.937
PRKCAprotein kinase C, alpha0.935
ATF2activating transcription factor 20.933
VAV1vav 1 guanine nucleotide exchange factor0.928
FLNAfilamin A, alpha0.924
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.922
PTK2BPTK2B protein tyrosine kinase 2 beta0.921
NCOA1nuclear receptor coactivator 10.919
APCadenomatous polyposis coli0.912
GAB1GRB2-associated binding protein 10.910
ATF3activating transcription factor 30.909
EP300E1A binding protein p3000.900
MAP3K5mitogen-activated protein kinase kinase kinase 50.898
WWP2WW domain containing E3 ubiquitin protein ligase 20.893
COL6A2collagen, type VI, alpha 20.891
THBS1thrombospondin 10.882
LTBP2latent transforming growth factor beta binding protein 20.882
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grm5glutamate receptor, metabotropic 50.811
Gata6GATA binding protein 60.754
Jak2Janus kinase 20.743
S1pr2sphingosine-1-phosphate receptor 20.741
Smad3SMAD family member 30.725
Irs1insulin receptor substrate 10.722
Grb2growth factor receptor bound protein 20.711
Fgfr2fibroblast growth factor receptor 20.688
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.667
Sirpasignal-regulatory protein alpha0.663
Akt1v-akt murine thymoma viral oncogene homolog 10.616
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.612
Irf2interferon regulatory factor 20.607
Egfrepidermal growth factor receptor0.591
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.575
Ppardperoxisome proliferator-activated receptor delta0.574
Jak1Janus kinase 10.548
Flt1FMS-related tyrosine kinase 10.519
Col5a2collagen, type V, alpha 20.507
Dusp1dual specificity phosphatase 10.498
Ghrgrowth hormone receptor0.493
Metmet proto-oncogene0.487
Smad7SMAD family member 70.469
Ednraendothelin receptor type A0.465
Ddr2discoidin domain receptor tyrosine kinase 20.462
Rararetinoic acid receptor, alpha0.457
Trim47tripartite motif-containing 470.449
Cishcytokine inducible SH2-containing protein0.448
Itgb1integrin, beta 10.442
Pecam1platelet/endothelial cell adhesion molecule 10.428
Egr1early growth response 10.426
Prdm2PR domain containing 2, with ZNF domain0.426
Phkg1phosphorylase kinase, gamma 10.425
Rac1ras-related C3 botulinum toxin substrate 10.414
RorbRAR-related orphan receptor B0.409
Stk10serine/threonine kinase 100.402
Agtr1aangiotensin II receptor, type 1a0.390
Efnb1ephrin B10.386
Btg2BTG family, member 20.376
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.372
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.368
Bmp6bone morphogenetic protein 60.357
Prrx1paired related homeobox 10.351
Foxs1forkhead box S10.348
Slco2a1solute carrier organic anion transporter family, member 2a10.345
Egr2early growth response 20.344
Sox17SRY (sex determining region Y)-box 170.342
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.333
Gna12guanine nucleotide binding protein (G protein) alpha 120.330
Syt8synaptotagmin VIII0.322
Robo1roundabout homolog 1 (Drosophila)0.316
Cntfrciliary neurotrophic factor receptor0.310
Fstl1follistatin-like 10.308
Cpxm2carboxypeptidase X (M14 family), member 20.297
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.297
Dusp6dual specificity phosphatase 60.295
Smad1SMAD family member 10.292
Snap91synaptosomal-associated protein 910.291
Olfml2bolfactomedin-like 2B0.285
Insrinsulin receptor0.284
Lnpepleucyl/cystinyl aminopeptidase0.281
Glg1golgi apparatus protein 10.281
Col1a1collagen, type I, alpha 10.280
Gcm1glial cells missing homolog 1 (Drosophila)0.280
Lims1LIM and senescent cell antigen-like domains 10.279
Gria2glutamate receptor, ionotropic, AMPA 20.278
Acvr1activin A receptor, type I0.274
Stat5bsignal transducer and activator of transcription 5B0.272
Tgfb3transforming growth factor, beta 30.270
Tgfbr3transforming growth factor, beta receptor III0.264
Bcl2B-cell CLL/lymphoma 20.256
Inpp5dinositol polyphosphate-5-phosphatase D0.253
Pde4bphosphodiesterase 4B, cAMP specific0.253
Ryr2ryanodine receptor 2, cardiac0.253
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.252
Ptpn11protein tyrosine phosphatase, non-receptor type 110.251
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.245
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.244
Usf2upstream transcription factor 2, c-fos interacting0.243
Irx4iroquois homeobox 40.239
Nr4a1nuclear receptor subfamily 4, group A, member 10.239
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.239
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.239
Wipf1WAS/WASL interacting protein family, member 10.238
Hpcal4hippocalcin-like 40.237
Ptafrplatelet-activating factor receptor0.236
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.235
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.234
Rassf5Ras association (RalGDS/AF-6) domain family member 50.233
Il1r1interleukin 1 receptor, type I0.228
Atf3activating transcription factor 30.228
Loxlysyl oxidase0.227
Arntaryl hydrocarbon receptor nuclear translocator0.227
Zfp36zinc finger protein 360.226
Timp2TIMP metallopeptidase inhibitor 20.225
Fgfr1Fibroblast growth factor receptor 10.225
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism