The network for 'muscle structure development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle structure development

The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

NameDescriptionProbabilityFunc Analog Organism
twk-18Protein TWK-180.677
myo-3Protein MYO-30.571
epi-1Protein EPI-10.565
hlh-1Protein HLH-10.542
mig-6Protein MIG-60.511
cysl-1Protein CYSL-10.487
vab-3Protein VAB-30.442
pha-4Protein PHA-40.430
unc-112Protein UNC-1120.399
his-64Protein HIS-640.371
F39G3.5Protein F39G3.50.369
pat-6Protein PAT-60.367
pat-4Protein PAT-40.366
his-1Protein HIS-10.355
sgcb-1Protein SGCB-10.315
mlc-2Protein MLC-20.310
lam-2Protein LAM-20.308
slo-1Protein SLO-10.304
sem-5Protein SEM-50.304
pat-2Protein PAT-20.300
php-3Protein PHP-30.294
inx-4Protein INX-40.272
sel-7Protein SEL-70.272
egl-18Protein EGL-180.271
T28F4.1Protein T28F4.10.270
unc-15Protein UNC-150.269
inx-5Protein INX-50.266
CELE_Y24F12A.1Protein Y24F12A.10.242
insc-1Protein INSC-10.235
unc-45Protein UNC-450.229
unc-43Protein UNC-430.226
unc-73Protein UNC-730.224
spd-1Protein SPD-10.224
sqt-1Protein SQT-10.222
sma-6Protein SMA-60.221
tbx-8Protein TBX-80.218
T28B4.1Protein T28B4.10.218
nlg-1Protein NLG-10.217
ain-1Protein AIN-10.217
C53B4.4Protein C53B4.40.211
lev-11Protein LEV-110.208
ceh-34Protein CEH-340.207
ace-3Protein ACE-30.202
unc-6Protein UNC-60.200
spc-1Protein SPC-10.199
tag-232Protein TAG-2320.198
cka-2Protein CKA-20.197
hmp-1Protein HMP-10.196
egl-46Protein EGL-460.196
F54C8.4Protein F54C8.40.195
pat-10Protein PAT-100.195
ret-1Protein RET-10.194
dhp-2Protein DHP-20.193
npp-7Protein NPP-70.191
CELE_C01G6.5Protein C01G6.50.190
bre-1Protein BRE-10.187
T25F10.6Protein T25F10.60.186
C54E4.2Protein C54E4.20.186
mat-3Protein MAT-30.185
C06G3.5Protein C06G3.50.185
fkh-2Protein FKH-20.185
che-2Protein CHE-20.184
eat-6Protein EAT-60.183
egl-13Protein EGL-130.183
eat-18Protein EAT-180.183
C44C1.1Protein C44C1.10.183
irx-1Protein IRX-10.183
CELE_C17H12.13Protein C17H12.130.179
pat-3Protein PAT-30.179
pac-1Protein PAC-10.177
act-2Protein ACT-20.176
D1044.2Protein D1044.20.175
bar-1Protein BAR-10.175
tag-260Protein TAG-2600.175
zip-7Protein ZIP-70.174
aex-5Protein AEX-50.173
mec-2Protein MEC-20.170
unc-27Protein UNC-270.170
set-18Protein SET-180.168
lin-37Protein LIN-370.166
his-31Protein HIS-310.166
him-8Protein HIM-80.166
C50E3.5Protein C50E3.50.165
mtk-1Protein MTK-10.165
ttm-5Protein TTM-50.164
lin-11Protein LIN-110.161
zer-1Protein ZER-10.161
unc-98Protein UNC-980.161
ZK524.4Protein ZK524.40.161
unc-7Protein UNC-70.160
vha-8Protein VHA-80.157
unc-60Protein UNC-600.156
ceh-18Protein CEH-180.155
crn-7Protein CRN-70.155
idh-1Protein IDH-10.155
plp-1Protein PLP-10.155
cfim-2Protein CFIM-20.153
ncx-1Protein NCX-10.153
mig-38Protein MIG-380.151
egl-27Protein EGL-270.151
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ttnatitin a1.000
smyd1bSET and MYND domain containing 1b1.000
unc45bunc-45 homolog B (C. elegans)0.999
cdh2cadherin 2, neuronal0.999
myod1myogenic differentiation 10.998
tbx1T-box 10.992
mef2camyocyte enhancer factor 2ca0.990
tbx2bT-box 2b0.988
hsp90a.1heat shock protein 90-alpha 10.987
pdlim7PDZ and LIM domain 70.985
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.981
myf5myogenic factor 50.980
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.972
lamc1laminin, gamma 10.971
tnnc1btroponin C type 1b (slow)0.970
lama4laminin, alpha 40.969
tpm4tropomyosin 40.960
gdf6agrowth differentiation factor 6a0.958
wnt5bwingless-type MMTV integration site family, member 5b0.948
tbx5aT-box 5a0.945
wnt11rwingless-type MMTV integration site family, member 11, related0.936
dag1dystroglycan 10.934
flncbfilamin C, gamma b (actin binding protein 280)0.930
fn1fibronectin 10.927
actn2actinin, alpha 20.924
alcamaactivated leukocyte cell adhesion molecule a0.923
tnni1btroponin I, skeletal, slow b0.915
tnni2a.4troponin I, skeletal, fast 2a.40.912
hoxd4ahomeo box D4a0.902
gli1GLI-Kruppel family member 10.900
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.886
mef2dmyocyte enhancer factor 2d0.883
mef2cbmyocyte enhancer factor 2cb0.878
rx2retinal homeobox gene 20.871
tnni1altroponin I, skeletal, slow like0.863
ryr1bryanodine receptor 1b (skeletal)0.859
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.857
hey2hairy/enhancer-of-split related with YRPW motif 20.852
bmp4bone morphogenetic protein 40.849
ndr2nodal-related 20.847
shhasonic hedgehog a0.839
smyhc1slow myosin heavy chain 10.836
mbnl2muscleblind-like 2 (Drosophila)0.835
myf6myogenic factor 60.829
lama2laminin, alpha 20.828
csrnp1bcysteine-serine-rich nuclear protein 1b0.821
snai1asnail homolog 1a (Drosophila)0.819
tbx18T-box 180.804
tp73tumor protein p730.803
actn1actinin, alpha 10.802
aldh1a2aldehyde dehydrogenase 1 family, member A20.797
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.786
tbx20T-box 200.780
vmhcventricular myosin heavy chain0.778
scn4absodium channel, voltage-gated, type IV, alpha, b0.778
myhz2myosin, heavy polypeptide 2, fast muscle specific0.774
rxrbbretinoid x receptor, beta b0.768
jam3bjunctional adhesion molecule 3b0.768
nkx2.5NK2 transcription factor related 50.761
pitx2paired-like homeodomain transcription factor 20.751
cmlc1cardiac myosin light chain-10.745
lef1lymphocyte enhancer binding factor 10.742
lamb1alaminin, beta 1a0.740
lamb2laminin, beta 2 (laminin S)0.737
rx3retinal homeobox gene 30.736
ilkintegrin linked kinase0.733
snai1bsnail homolog 1b (Drosophila)0.721
bocbrother of CDO0.717
pcdh8protocadherin 80.712
spry4sprouty (Drosophila) homolog 40.710
foxd3forkhead box D30.704
actn3aactinin alpha 3a0.698
tbx24T-box 240.694
mibmind bomb0.694
gata3GATA-binding protein 30.693
tbx2aT-box gene 2a0.692
fgf3fibroblast growth factor 30.691
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.691
atp1a2aATPase, Na+/K+ transporting, alpha 2a polypeptide0.684
desmadesmin a0.679
fgf10afibroblast growth factor 10a0.672
actn3bactinin alpha 3b0.671
gro1groucho 10.671
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.654
hspb1heat shock protein, alpha-crystallin-related, 10.641
flot1bflotillin 1b0.634
pax7apaired box gene 7a0.632
six1asine oculis homeobox homolog 1a0.631
dmrt2adoublesex and mab-3 related transcription factor 2a0.624
gapdhglyceraldehyde-3-phosphate dehydrogenase0.619
six4bsine oculis homeobox homolog 4b0.612
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.611
fgfr2fibroblast growth factor receptor 20.609
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Mef2Myocyte enhancer factor 21.000
AtpalphaNa pump alpha subunit1.000
snssticks and stones1.000
MhcMyosin heavy chain1.000
cicubitus interruptus0.999
Rac1CG2248 gene product from transcript CG2248-RA0.999
LanB2Laminin B20.999
eyaeyes absent0.999
Rho1CG8416 gene product from transcript CG8416-RB0.998
Zasp52Z band alternatively spliced PDZ-motif protein 520.998
rolsrolling pebbles0.998
howheld out wings0.996
Fmr1CG6203 gene product from transcript CG6203-RC0.995
BicDBicaudal D0.993
mbcmyoblast city0.992
slmbsupernumerary limbs0.990
MicalMolecule interacting with CasL0.989
shotshort stop0.989
ewgerect wing0.988
DadDaughters against dpp0.988
Actnalpha actinin0.988
Mlp84BMuscle LIM protein at 84B0.987
Arp66BActin-related protein 66B0.983
Rya-r44FRyanodine receptor 44F0.981
Vrp1Verprolin 10.977
LanALaminin A0.972
MadMothers against dpp0.967
Ras85DRas oncogene at 85D0.965
LanB1CG7123 gene product from transcript CG7123-RA0.960
ThorCG8846 gene product from transcript CG8846-RA0.952
abd-Aabdominal A0.943
wupAwings up A0.942
Adf1Adh transcription factor 10.938
S6kRPS6-p70-protein kinase0.935
Btk29ABtk family kinase at 29A0.929
Rac2CG8556 gene product from transcript CG8556-RA0.925
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.923
kirrekin of irre0.915
Atg1Autophagy-specific gene 10.892
Gyc76CGuanylyl cyclase at 76C0.889
Pi3K92ECG4141 gene product from transcript CG4141-RB0.888
SmD3Small ribonucleoprotein particle protein SmD30.887
zfh1Zn finger homeodomain 10.887
Vap-33-1CG5014 gene product from transcript CG5014-RB0.880
DscamDown syndrome cell adhesion molecule0.880
stmAstambha A0.873
CG42247CG42247 gene product from transcript CG42247-RC0.856
DlicDynein light intermediate chain0.855
nkdnaked cuticle0.850
stumpsCG31317 gene product from transcript CG31317-RC0.840
twProtein O-mannosyltransferase 20.839
blowblown fuse0.827
PyKPyruvate kinase0.825
GripGlutamate receptor binding protein0.822
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GRB2growth factor receptor-bound protein 21.000
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
CREBBPCREB binding protein1.000
EGFRepidermal growth factor receptor1.000
TRIM63tripartite motif containing 630.998
QKIquaking homolog, KH domain RNA binding (mouse)0.998
ACTBactin, beta0.998
EP300E1A binding protein p3000.998
ESR1estrogen receptor 10.997
SMAD3SMAD family member 30.997
FLNAfilamin A, alpha0.995
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.994
JUNjun proto-oncogene0.991
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.991
CAV1caveolin 1, caveolae protein, 22kDa0.990
RB1retinoblastoma 10.986
MYH9myosin, heavy chain 9, non-muscle0.985
FYNFYN oncogene related to SRC, FGR, YES0.984
FN1fibronectin 10.979
ARandrogen receptor0.969
RUNX1runt-related transcription factor 10.968
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.964
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.962
TAL1T-cell acute lymphocytic leukemia 10.958
SMAD2SMAD family member 20.958
RBPMSRNA binding protein with multiple splicing0.950
SHC1SHC (Src homology 2 domain containing) transforming protein 10.948
GSK3Bglycogen synthase kinase 3 beta0.944
MYOD1myogenic differentiation 10.943
SIN3ASIN3 homolog A, transcription regulator (yeast)0.930
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.923
NCOA3nuclear receptor coactivator 30.915
RARAretinoic acid receptor, alpha0.914
JAG1jagged 10.912
FHL2four and a half LIM domains 20.906
AKT1v-akt murine thymoma viral oncogene homolog 10.904
ILKintegrin-linked kinase0.900
NCOR1nuclear receptor corepressor 10.895
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.886
SIRT1sirtuin 10.884
FGFR2fibroblast growth factor receptor 20.880
ACTN1actinin, alpha 10.875
PTRFpolymerase I and transcript release factor0.870
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.867
TPM1tropomyosin 1 (alpha)0.866
RBBP4retinoblastoma binding protein 40.860
FGF1fibroblast growth factor 1 (acidic)0.858
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.850
TNNI1troponin I type 1 (skeletal, slow)0.831
KRT18keratin 180.829
SMN1survival of motor neuron 1, telomeric0.818
PAX3paired box 30.796
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.796
APCadenomatous polyposis coli0.796
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.793
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.788
CTGFconnective tissue growth factor0.785
NCOR2nuclear receptor corepressor 20.784
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.780
TNNC1troponin C type 1 (slow)0.773
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.769
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.766
NR4A1nuclear receptor subfamily 4, group A, member 10.763
ERBB2IPerbb2 interacting protein0.757
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.757
FLNCfilamin C, gamma0.744
TNNT3troponin T type 3 (skeletal, fast)0.735
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.727
IQGAP1IQ motif containing GTPase activating protein 10.712
NCAM1neural cell adhesion molecule 10.709
MEF2Cmyocyte enhancer factor 2C0.698
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.696
EPAS1endothelial PAS domain protein 10.680
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.678
IGFBP5insulin-like growth factor binding protein 50.672
IL4Rinterleukin 4 receptor0.665
NCK2NCK adaptor protein 20.651
NOTCH3notch 30.633
CFL1cofilin 1 (non-muscle)0.629
HIPK2homeodomain interacting protein kinase 20.625
ITSN1intersectin 1 (SH3 domain protein)0.616
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.600
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.594
VHLvon Hippel-Lindau tumor suppressor0.582
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.582
SMAD1SMAD family member 10.575
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.575
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.568
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.561
SMYD1SET and MYND domain containing 10.559
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.553
HDAC3histone deacetylase 30.540
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr1early growth response 10.519
Myh9myosin, heavy chain 9, non-muscle0.451
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.358
Actc1actin, alpha, cardiac muscle 10.337
Acta2smooth muscle alpha-actin0.313
Hoxb7homeo box B70.267
Cav1caveolin 1, caveolae protein0.259
Actbactin, beta0.256
Fgf7fibroblast growth factor 70.222
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.222
Metmet proto-oncogene0.205
Gja5gap junction protein, alpha 50.202
Irs1insulin receptor substrate 10.202
Rararetinoic acid receptor, alpha0.199
Actn4actinin alpha 40.197
Fgfr2fibroblast growth factor receptor 20.175
Tgfbr2transforming growth factor, beta receptor II0.171
Prrx1paired related homeobox 10.170
Emp1epithelial membrane protein 10.169
Calcrlcalcitonin receptor-like0.163
Tpm4tropomyosin 40.162
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.155
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.154
Acta1actin, alpha 1, skeletal muscle0.153
Dchs1dachsous 1 (Drosophila)0.146
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.144
Tgfbr3transforming growth factor, beta receptor III0.141
Pfn1profilin 10.140
Flnafilamin A, alpha0.140
Krt18keratin 180.138
Igfbp5insulin-like growth factor binding protein 50.138
Nos3nitric oxide synthase 3, endothelial cell0.138
Ckmcreatine kinase, muscle0.137
Agtr2angiotensin II receptor, type 20.136
Clic4chloride intracellular channel 40.132
S100a6S100 calcium binding protein A60.132
FosFBJ osteosarcoma oncogene0.131
Fxyd1FXYD domain-containing ion transport regulator 10.128
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.128
Col12a1collagen, type XII, alpha 10.127
Mybpc1myosin binding protein C, slow type0.127
Testintestin gene0.124
Syt8synaptotagmin VIII0.122
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.122
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.120
Tnni1troponin I type 1 (skeletal, slow)0.119
Ncr1natural cytotoxicity triggering receptor 10.117
Cd4Cd4 molecule0.117
Gna12guanine nucleotide binding protein (G protein) alpha 120.113
Ccnd3cyclin D30.112
Col10a1collagen, type X, alpha 10.110
Dccdeleted in colorectal carcinoma0.110
S100a8S100 calcium binding protein A80.110
Arf6ADP-ribosylation factor 60.109
Sod3superoxide dismutase 3, extracellular0.109
Ahraryl hydrocarbon receptor0.109
Galr3galanin receptor 30.108
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.107
S100a9S100 calcium binding protein A90.106
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.106
Ldb3LIM domain binding 30.105
LOC683626similar to limb-bud and heart0.104
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.104
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.104
Csnk1g2casein kinase 1, gamma 20.102
Lamc1laminin, gamma 10.101
Hoxc4homeo box C40.101
S100a11S100 calcium binding protein A11 (calizzarin)0.100
Smad3SMAD family member 30.099
Nr4a2nuclear receptor subfamily 4, group A, member 20.097
Cav3caveolin 30.095
Myo1bmyosin Ib0.094
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.093
Hspb2heat shock protein beta 20.092
Slit3slit homolog 3 (Drosophila)0.092
Haao3-hydroxyanthranilate 3,4-dioxygenase0.092
Rxrgretinoid X receptor gamma0.092
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.092
Tubb5tubulin, beta 50.091
Tcfe2atranscription factor E2a0.090
Myl1myosin, light chain 10.089
Apoa5apolipoprotein A-V0.088
Cgaglycoprotein hormones, alpha polypeptide0.087
Smad7SMAD family member 70.087
Dusp6dual specificity phosphatase 60.087
Scn5asodium channel, voltage-gated, type V, alpha subunit0.086
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.086
Grik3glutamate receptor, ionotropic, kainate 30.084
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.084
Cdk2cyclin dependent kinase 20.084
Lphn2latrophilin 20.084
Cckbrcholecystokinin B receptor0.083
Tagln2transgelin 20.083
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism