The network for 'negative regulation of cation channel activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cation channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.

NameDescriptionProbabilityFunc Analog Organism
inx-5Protein INX-50.732
unc-7Protein UNC-70.612
efn-2Protein EFN-20.506
unc-9Protein UNC-90.484
clc-3Protein CLC-30.443
glr-5Protein GLR-50.423
mec-2Protein MEC-20.385
inx-12Protein INX-120.348
inx-8Protein INX-80.338
unc-36Protein UNC-360.315
inx-17Protein INX-170.290
inx-4Protein INX-40.252
eat-4Protein EAT-40.228
T23G4.3Protein T23G4.30.209
che-3Protein CHE-30.200
srv-1Protein SRV-10.185
rad-51Protein RAD-510.182
ger-1Protein GER-10.162
inx-13Protein INX-130.155
tbh-1Protein TBH-10.141
prmt-3Protein PRMT-30.134
sdz-28Protein SDZ-280.122
sng-1Protein SNG-10.121
che-1Protein CHE-10.117
che-2Protein CHE-20.117
hlh-2Protein HLH-20.116
upp-1Protein UPP-10.109
unc-86Protein UNC-860.100
CELE_C27A7.6Protein C27A7.60.096
F53B3.5Protein F53B3.50.090
pat-6Protein PAT-60.086
flr-4Protein FLR-40.077
sph-1Protein SPH-10.074
rab-3Protein RAB-30.072
C47D12.5Protein C47D12.50.069
acs-19Protein ACS-190.064
CELE_Y51A2D.14Protein Y51A2D.140.063
F39G3.5Protein F39G3.50.062
vha-17Protein VHA-170.061
tag-256Protein TAG-2560.057
inx-22Protein INX-220.055
daf-10Protein DAF-100.054
unc-1Protein UNC-10.054
daf-6Protein DAF-60.051
R148.4Protein R148.40.050
ZK470.1Protein ZK470.10.050
nhr-143Protein NHR-1430.049
vab-9Protein VAB-90.046
madd-4Protein MADD-40.044
unc-47Protein UNC-470.044
egl-19Protein EGL-190.044
unc-29Protein UNC-290.044
nhr-100Protein NHR-1000.044
R13A5.9Protein R13A5.90.041
CELE_ZC513.5Protein ZC513.50.041
R03H10.2Protein R03H10.20.040
glr-1Protein GLR-10.039
cav-1Protein CAV-10.039
nhr-91Protein NHR-910.038
F35C11.5Protein F35C11.50.038
K03B8.6Protein K03B8.60.038
ape-1Protein APE-10.037
F45E1.1Protein F45E1.10.037
CELE_M176.5Protein M176.50.037
CELE_Y75B12B.1Protein Y75B12B.10.036
acl-14Protein ACL-140.036
vha-7Protein VHA-70.036
CELE_K08E7.8Protein K08E7.80.034
CELE_F17C11.12Protein F17C11.120.030
inx-2Protein INX-20.030
T20D3.5Protein T20D3.50.029
hrg-4Protein HRG-40.029
nmgp-1Protein NMGP-10.028
C14A4.6Protein C14A4.60.028
C15C8.3Protein C15C8.30.028
sul-2Protein SUL-20.028
F47B7.1Protein F47B7.10.028
T01D1.3Protein T01D1.30.027
cav-2Protein CAV-20.027
inx-9Protein INX-90.027
mdt-28Protein MDT-280.026
gst-6Protein GST-60.026
Y87G2A.11Protein Y87G2A.110.026
CELE_C39H7.4Protein C39H7.40.026
ifd-1Protein IFD-10.025
aqp-2Protein AQP-20.025
inx-6Protein INX-60.024
noah-2Protein NOAH-20.024
bath-2Protein BATH-20.024
nphp-4Protein NPHP-40.024
lec-5Protein LEC-50.024
osm-6Protein OSM-60.024
CELE_ZK673.2Protein ZK673.20.024
hsp-12.1Protein HSP-12.10.023
R07E4.3Protein R07E4.30.023
CELE_W05H12.1Protein W05H12.10.023
nlg-1Protein NLG-10.023
T02E9.5Protein T02E9.50.023
F48E3.4Protein F48E3.40.022
gcy-28Protein GCY-280.022
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 11.000
GSTM2glutathione S-transferase mu 2 (muscle)0.802
GSTM4glutathione S-transferase mu 40.543
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.412
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.407
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.171
ADORA2Aadenosine A2a receptor0.061
CRHcorticotropin releasing hormone0.051
TGFBR1transforming growth factor, beta receptor 10.039
MMP12matrix metallopeptidase 12 (macrophage elastase)0.039
ACVR1Bactivin A receptor, type IB0.034
CALM1calmodulin 1 (phosphorylase kinase, delta)0.033
PKD1polycystic kidney disease 1 (autosomal dominant)0.032
GSTM3glutathione S-transferase mu 3 (brain)0.031
GNG5guanine nucleotide binding protein (G protein), gamma 50.027
CAPNS1calpain, small subunit 10.026
CAPN2calpain 2, (m/II) large subunit0.020
PDCD6programmed cell death 60.019
GLRXglutaredoxin (thioltransferase)0.019
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.018
THBS2thrombospondin 20.018
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.018
EPORerythropoietin receptor0.017
TGFB1transforming growth factor, beta 10.017
CAPZBcapping protein (actin filament) muscle Z-line, beta0.017
TRPC1transient receptor potential cation channel, subfamily C, member 10.014
PSEN2presenilin 2 (Alzheimer disease 4)0.013
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.013
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.012
TRAPPC1trafficking protein particle complex 10.011
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.011
ARPC1Aactin related protein 2/3 complex, subunit 1A, 41kDa0.010
ARF3ADP-ribosylation factor 30.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bicc1bicaudal C homolog 1 (Drosophila)0.772
Pkd2polycystic kidney disease 20.387
Cys1cystin 10.380
Notch2Notch gene homolog 2 (Drosophila)0.335
Invsinversin0.286
Nos1nitric oxide synthase 1, neuronal0.180
Ccr2chemokine (C-C motif) receptor 20.166
Mks1Meckel syndrome, type 10.159
Vdrvitamin D receptor0.143
Megf8multiple EGF-like-domains 80.114
Pkd1polycystic kidney disease 1 homolog0.106
Drd1adopamine receptor D1A0.100
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.099
Ift140intraflagellar transport 140 homolog (Chlamydomonas)0.083
Il6stinterleukin 6 signal transducer0.083
Esr1estrogen receptor 1 (alpha)0.082
Lepleptin0.077
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.074
Lphn1latrophilin 10.065
Nos2nitric oxide synthase 2, inducible0.060
Ptgs2prostaglandin-endoperoxide synthase 20.056
Ghrgrowth hormone receptor0.055
Thrathyroid hormone receptor alpha0.054
Ryr2ryanodine receptor 2, cardiac0.053
Meox2mesenchyme homeobox 20.048
Platplasminogen activator, tissue0.043
Nek8NIMA (never in mitosis gene a)-related expressed kinase 80.043
Pomcpro-opiomelanocortin-alpha0.042
Sox17SRY-box containing gene 170.039
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.038
Tnftumor necrosis factor0.037
Ccl2chemokine (C-C motif) ligand 20.033
Csf1colony stimulating factor 1 (macrophage)0.032
Ccdc39coiled-coil domain containing 390.032
Cd44CD44 antigen0.031
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.030
Cnr1cannabinoid receptor 1 (brain)0.030
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.027
Nos3nitric oxide synthase 3, endothelial cell0.027
Pkhd1polycystic kidney and hepatic disease 10.027
Adora2aadenosine A2a receptor0.026
Arpc3actin related protein 2/3 complex, subunit 30.025
Igf1insulin-like growth factor 10.023
Fbn1fibrillin 10.022
Bai1brain-specific angiogenesis inhibitor 10.022
Nr5a1nuclear receptor subfamily 5, group A, member 10.022
Col1a1collagen, type I, alpha 10.021
Pacsin1protein kinase C and casein kinase substrate in neurons 10.021
Leng8leukocyte receptor cluster (LRC) member 80.021
Smpd3sphingomyelin phosphodiesterase 3, neutral0.021
Snap25synaptosomal-associated protein 250.020
Ifnginterferon gamma0.020
Tmem107transmembrane protein 1070.020
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.020
Ostf1osteoclast stimulating factor 10.020
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.019
Klklotho0.019
Arhgap21Rho GTPase activating protein 210.019
WwoxWW domain-containing oxidoreductase0.019
Npy2rneuropeptide Y receptor Y20.018
Il10interleukin 100.018
Osbp2oxysterol binding protein 20.018
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.018
Cntn4contactin 40.018
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.017
Slc4a3solute carrier family 4 (anion exchanger), member 30.017
Fkbp9FK506 binding protein 90.017
Coro1bcoronin, actin binding protein 1B0.017
Il13interleukin 130.017
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.017
PacrgPARK2 co-regulated0.016
Rph3arabphilin 3A0.016
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.016
Lhx3LIM homeobox protein 30.016
Slc12a5solute carrier family 12, member 50.016
Cckbrcholecystokinin B receptor0.015
Apoeapolipoprotein E0.015
Il6interleukin 60.015
Rnf112ring finger protein 1120.014
Cdkn1bcyclin-dependent kinase inhibitor 1B0.014
Anxa7annexin A70.014
Nlrp3NLR family, pyrin domain containing 30.014
Trp53transformation related protein 530.014
Osbpl5oxysterol binding protein-like 50.014
Gabrdgamma-aminobutyric acid (GABA) A receptor, subunit delta0.014
Med12mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)0.014
Vhlvon Hippel-Lindau tumor suppressor0.014
Srcin1SRC kinase signaling inhibitor 10.013
Phf1PHD finger protein 10.013
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.013
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.013
Pitx3paired-like homeodomain transcription factor 30.013
Krt12keratin 120.013
C1ql1complement component 1, q subcomponent-like 10.013
Mc1rmelanocortin 1 receptor0.013
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.013
Dnahc11dynein, axonemal, heavy chain 110.013
D630037F22RikRIKEN cDNA D630037F22 gene0.013
Pthlhparathyroid hormone-like peptide0.012
Numa1nuclear mitotic apparatus protein 10.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.653
Cav1caveolin 1, caveolae protein0.096
Myl1myosin, light chain 10.089
Cav2caveolin 20.073
Actc1actin, alpha, cardiac muscle 10.028
Emp1epithelial membrane protein 10.026
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.024
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.022
Pdynprodynorphin0.019
MosMoloney sarcoma oncogene0.018
Gja3gap junction protein, alpha 30.015
Gstm1glutathione S-transferase mu 10.014
Csrp3cysteine and glycine-rich protein 30.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism