The network for 'regulation of cation channel activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cation channel activity

Any process that modulates the frequency, rate or extent of cation channel activity.

NameDescriptionProbabilityFunc Analog Organism
glr-5Protein GLR-50.621
unc-7Protein UNC-70.588
efn-2Protein EFN-20.540
inx-4Protein INX-40.517
inx-12Protein INX-120.501
unc-9Protein UNC-90.463
inx-5Protein INX-50.452
che-3Protein CHE-30.447
syg-1Protein SYG-10.443
itr-1Protein ITR-10.368
mec-2Protein MEC-20.315
F39G3.5Protein F39G3.50.246
inx-13Protein INX-130.237
egl-30Protein EGL-300.236
sdz-28Protein SDZ-280.202
inx-8Protein INX-80.197
inx-6Protein INX-60.197
che-2Protein CHE-20.189
egl-19Protein EGL-190.167
CELE_Y75B12B.1Protein Y75B12B.10.163
hrg-4Protein HRG-40.146
R07E4.3Protein R07E4.30.144
R13A5.9Protein R13A5.90.134
unc-29Protein UNC-290.130
unc-86Protein UNC-860.126
CELE_C27A7.6Protein C27A7.60.120
srv-1Protein SRV-10.119
inx-17Protein INX-170.116
plc-3Protein PLC-30.116
eat-4Protein EAT-40.115
tag-256Protein TAG-2560.110
unc-36Protein UNC-360.104
inx-9Protein INX-90.104
K10D3.4Protein K10D3.40.098
nlg-1Protein NLG-10.093
tbh-1Protein TBH-10.092
ncs-2Protein NCS-20.091
C08G9.2Protein C08G9.20.087
let-23Protein LET-230.087
C15C8.3Protein C15C8.30.086
C49A9.5Protein C49A9.50.082
mec-1Protein MEC-10.080
pes-2.1Protein PES-2.10.080
lev-8Protein LEV-80.079
vha-17Protein VHA-170.072
gcy-28Protein GCY-280.071
erm-1Protein ERM-10.070
unc-47Protein UNC-470.070
ugt-57Protein UGT-570.067
R148.4Protein R148.40.067
bus-17Protein BUS-170.064
flr-4Protein FLR-40.062
CELE_F17C11.12Protein F17C11.120.062
tbb-4Protein TBB-40.060
col-165Protein COL-1650.059
cka-2Protein CKA-20.057
lin-11Protein LIN-110.057
Y4C6A.3Protein Y4C6A.30.056
daf-10Protein DAF-100.056
gpb-1Protein GPB-10.055
CELE_Y39B6A.40Protein Y39B6A.400.054
vha-7Protein VHA-70.054
T27A3.6Protein T27A3.60.054
klo-1Protein KLO-10.053
CELE_Y39E4B.5Protein Y39E4B.50.051
R90.1Protein R90.10.050
C06E4.2Protein C06E4.20.048
daf-6Protein DAF-60.047
klp-3Protein KLP-30.047
C47D12.5Protein C47D12.50.046
igcm-1Protein IGCM-10.046
rig-3Protein RIG-30.046
ceh-26Protein CEH-260.045
acl-14Protein ACL-140.045
unc-42Protein UNC-420.045
ger-1Protein GER-10.045
epi-1Protein EPI-10.044
lron-1Protein LRON-10.043
hrg-3Protein HRG-30.042
R02F2.4Protein R02F2.40.041
mdh-2Protein MDH-20.041
C48B4.8Protein C48B4.80.039
jnk-1Protein JNK-10.039
R11G1.6Protein R11G1.60.039
CELE_Y64G10A.7Protein Y64G10A.70.038
inx-18Protein INX-180.038
iglr-1Protein IGLR-10.038
swd-2.1Protein SWD-2.10.037
ZK470.1Protein ZK470.10.037
F29B9.8Protein F29B9.80.036
eat-6Protein EAT-60.036
ncx-7Protein NCX-70.036
F33H2.8Protein F33H2.80.035
egg-2Protein EGG-20.035
vab-3Protein VAB-30.034
rad-51Protein RAD-510.034
B0035.13Protein B0035.130.034
C25A8.4Protein C25A8.40.033
osm-6Protein OSM-60.033
mam-8Protein MAM-80.033
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG42629CG42629 gene product from transcript CG42629-RB0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.987
GSTM2glutathione S-transferase mu 2 (muscle)0.899
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.879
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.716
S100BS100 calcium binding protein B0.695
TBX5T-box 50.569
CALM1calmodulin 1 (phosphorylase kinase, delta)0.513
KIAA1683KIAA16830.407
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.325
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.295
GSTM4glutathione S-transferase mu 40.258
DTNAdystrobrevin, alpha0.183
GSTM3glutathione S-transferase mu 3 (brain)0.175
ACVR1Bactivin A receptor, type IB0.164
TGFBR1transforming growth factor, beta receptor 10.162
TRIM29tripartite motif containing 290.150
CRHcorticotropin releasing hormone0.144
ORAI1ORAI calcium release-activated calcium modulator 10.131
CAPNS1calpain, small subunit 10.129
PKD1polycystic kidney disease 1 (autosomal dominant)0.116
RYR2ryanodine receptor 2 (cardiac)0.091
PDCD6programmed cell death 60.086
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.077
ADORA2Aadenosine A2a receptor0.076
MED31mediator complex subunit 310.076
MPDZmultiple PDZ domain protein0.070
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.066
AKAP6A kinase (PRKA) anchor protein 60.062
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.058
GLRXglutaredoxin (thioltransferase)0.056
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.052
MMP12matrix metallopeptidase 12 (macrophage elastase)0.051
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.049
AKT1v-akt murine thymoma viral oncogene homolog 10.048
ZFYVE9zinc finger, FYVE domain containing 90.046
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.046
EPORerythropoietin receptor0.046
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.040
TIMP2TIMP metallopeptidase inhibitor 20.040
GNG5guanine nucleotide binding protein (G protein), gamma 50.039
MYO10myosin X0.036
DTNBdystrobrevin, beta0.035
ARF3ADP-ribosylation factor 30.035
SH3BP2SH3-domain binding protein 20.035
TGFB1transforming growth factor, beta 10.033
MTORmechanistic target of rapamycin (serine/threonine kinase)0.031
SMAD2SMAD family member 20.031
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.030
TRPC1transient receptor potential cation channel, subfamily C, member 10.030
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.030
THBS1thrombospondin 10.029
S100A10S100 calcium binding protein A100.029
MAPK4mitogen-activated protein kinase 40.029
MMP10matrix metallopeptidase 10 (stromelysin 2)0.028
RAB27ARAB27A, member RAS oncogene family0.028
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.028
MAP1Amicrotubule-associated protein 1A0.028
PSEN2presenilin 2 (Alzheimer disease 4)0.027
GNG2guanine nucleotide binding protein (G protein), gamma 20.027
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.027
FOXD3forkhead box D30.026
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.026
CAPN2calpain 2, (m/II) large subunit0.026
RHOAras homolog gene family, member A0.026
CAPZBcapping protein (actin filament) muscle Z-line, beta0.026
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.026
CHRNA4cholinergic receptor, nicotinic, alpha 40.026
DRD2dopamine receptor D20.026
ZMYND11zinc finger, MYND-type containing 110.025
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.025
ATOX1ATX1 antioxidant protein 1 homolog (yeast)0.023
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.023
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.023
GPRASP1G protein-coupled receptor associated sorting protein 10.023
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.022
DIAPH1diaphanous homolog 1 (Drosophila)0.022
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.022
WWP2WW domain containing E3 ubiquitin protein ligase 20.022
HTR1A5-hydroxytryptamine (serotonin) receptor 1A0.022
GFAPglial fibrillary acidic protein0.022
P2RX6purinergic receptor P2X, ligand-gated ion channel, 60.021
HTR45-hydroxytryptamine (serotonin) receptor 40.021
PTGER1prostaglandin E receptor 1 (subtype EP1), 42kDa0.021
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.021
THBS2thrombospondin 20.021
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.021
FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)0.021
SMURF2SMAD specific E3 ubiquitin protein ligase 20.021
SHC3SHC (Src homology 2 domain containing) transforming protein 30.020
SLC2A4solute carrier family 2 (facilitated glucose transporter), member 40.020
ARPC1Aactin related protein 2/3 complex, subunit 1A, 41kDa0.020
RHBDL1rhomboid, veinlet-like 1 (Drosophila)0.020
OXToxytocin, prepropeptide0.020
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.020
AQP7aquaporin 70.020
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.020
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.019
LHBluteinizing hormone beta polypeptide0.019
TEFthyrotrophic embryonic factor0.019
FKBP1AFK506 binding protein 1A, 12kDa0.019
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.609
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.605
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.604
Shhsonic hedgehog0.601
Ikbkginhibitor of kappaB kinase gamma0.554
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.514
Nodalnodal0.465
Gata4GATA binding protein 40.464
Homer1homer homolog 1 (Drosophila)0.460
Grm1glutamate receptor, metabotropic 10.448
Chukconserved helix-loop-helix ubiquitous kinase0.393
Tbx5T-box 50.381
Nos1nitric oxide synthase 1, neuronal0.314
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.296
Sox9SRY-box containing gene 90.285
Cckbrcholecystokinin B receptor0.283
Scn5asodium channel, voltage-gated, type V, alpha0.275
Rac1RAS-related C3 botulinum substrate 10.265
Grb10growth factor receptor bound protein 100.259
Hand2heart and neural crest derivatives expressed transcript 20.253
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.246
Ryr2ryanodine receptor 2, cardiac0.240
Zfpm2zinc finger protein, multitype 20.216
Smyd1SET and MYND domain containing 10.210
Htr75-hydroxytryptamine (serotonin) receptor 70.209
Dtnadystrobrevin alpha0.170
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.168
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.159
Shc3src homology 2 domain-containing transforming protein C30.158
Ttntitin0.154
Nognoggin0.154
Rxraretinoid X receptor alpha0.150
Hspg2perlecan (heparan sulfate proteoglycan 2)0.148
Fgf10fibroblast growth factor 100.146
Fgf5fibroblast growth factor 50.143
Inpp5jinositol polyphosphate 5-phosphatase J0.135
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.135
Smad4MAD homolog 4 (Drosophila)0.131
Chrm1cholinergic receptor, muscarinic 1, CNS0.126
Wt1Wilms tumor 1 homolog0.126
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.126
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.120
Cux2cut-like homeobox 20.119
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.118
Foxg1forkhead box G10.117
Srcin1SRC kinase signaling inhibitor 10.117
Hrh1histamine receptor H10.112
Fgf8fibroblast growth factor 80.111
Pou3f4POU domain, class 3, transcription factor 40.107
Pax6paired box gene 60.105
Cntn2contactin 20.104
Gja5gap junction protein, alpha 50.104
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.103
Plcb1phospholipase C, beta 10.103
Ghgrowth hormone0.102
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.100
Gata6GATA binding protein 60.100
Pitx2paired-like homeodomain transcription factor 20.099
Epb4.9erythrocyte protein band 4.90.099
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.098
Smad6MAD homolog 6 (Drosophila)0.093
Itpr1inositol 1,4,5-trisphosphate receptor 10.092
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.091
Stim2stromal interaction molecule 20.091
Gja1gap junction protein, alpha 10.091
Foxh1forkhead box H10.090
Myl3myosin, light polypeptide 30.087
Crhr2corticotropin releasing hormone receptor 20.086
Gnao1guanine nucleotide binding protein, alpha O0.085
Stx1bsyntaxin 1B0.084
Mtl5metallothionein-like 5, testis-specific (tesmin)0.083
Casq2calsequestrin 20.082
Tbx3T-box 30.079
Stim1stromal interaction molecule 10.079
Kif5akinesin family member 5A0.078
Jag1jagged 10.077
Hand1heart and neural crest derivatives expressed transcript 10.076
Map3k7mitogen-activated protein kinase kinase kinase 70.076
Grid1glutamate receptor, ionotropic, delta 10.075
Fktnfukutin0.074
Lhx6LIM homeobox protein 60.074
Pthlhparathyroid hormone-like peptide0.072
Pitx1paired-like homeodomain transcription factor 10.072
Ikbkbinhibitor of kappaB kinase beta0.072
Il16interleukin 160.070
Kcnk3potassium channel, subfamily K, member 30.070
Bmpr1abone morphogenetic protein receptor, type 1A0.069
Cyldcylindromatosis (turban tumor syndrome)0.069
Chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.069
Smad7MAD homolog 7 (Drosophila)0.069
Slc12a5solute carrier family 12, member 50.068
Dag1dystroglycan 10.068
Nr3c1nuclear receptor subfamily 3, group C, member 10.066
Ascl1achaete-scute complex homolog 1 (Drosophila)0.066
Fgf22fibroblast growth factor 220.065
Btrcbeta-transducin repeat containing protein0.064
Eporerythropoietin receptor0.064
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.064
Adam23a disintegrin and metallopeptidase domain 230.064
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.063
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a6S100 calcium binding protein A60.608
Anxa2annexin A20.312
Fgf14fibroblast growth factor 140.254
LOC100362824caveolin 2-like0.235
Cripcysteine-rich intestinal protein0.175
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.152
Spt1salivary protein 10.127
Anxa1annexin A10.102
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.089
Pdynprodynorphin0.069
Adrb1adrenergic, beta-1-, receptor0.069
Fgf7fibroblast growth factor 70.066
Cacng8calcium channel, voltage-dependent, gamma subunit 80.066
RGD1565859RGD15658590.062
Strnstriatin, calmodulin binding protein0.062
Tspotranslocator protein0.060
Gria1glutamate receptor, ionotropic, AMPA 10.059
S100a10S100 calcium binding protein A100.059
Calm1calmodulin 10.057
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.057
Itpr1inositol 1,4,5-triphosphate receptor, type 10.053
Lgals3lectin, galactoside-binding, soluble, 30.052
Plp2proteolipid protein 2 (colonic epithelium-enriched)0.051
Scn2bsodium channel, voltage-gated, type II, beta0.050
Arnt2aryl hydrocarbon receptor nuclear translocator 20.049
Asphaspartate-beta-hydroxylase0.048
Dmddystrophin0.046
Ntsr2neurotensin receptor 20.046
Cav1caveolin 1, caveolae protein0.045
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.045
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.045
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.041
Fgf8fibroblast growth factor 80.041
Mobpmyelin-associated oligodendrocyte basic protein0.040
LOC688549hypothetical protein LOC6885490.040
Myoz1myozenin 10.039
Lim2lens intrinsic membrane protein 20.039
Gfra2GDNF family receptor alpha 20.039
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.038
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.038
AhnakAHNAK nucleoprotein0.038
Gpr6G protein-coupled receptor 60.037
Egr3early growth response 30.036
Grm2glutamate receptor, metabotropic 20.035
Neu2sialidase 2 (cytosolic sialidase)0.035
Lifrleukemia inhibitory factor receptor alpha0.033
Pygmphosphorylase, glycogen, muscle0.033
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.033
Sub1SUB1 homolog (S. cerevisiae)0.032
Esr2estrogen receptor 2 (ER beta)0.032
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.032
Drd3dopamine receptor D30.031
Muskmuscle, skeletal, receptor tyrosine kinase0.031
Rgs8regulator of G-protein signaling 80.030
Clec11aC-type lectin domain family 11, member a0.030
Ppardperoxisome proliferator-activated receptor delta0.030
Gzmfgranzyme F0.030
Anxa5annexin A50.029
Cnga1cyclic nucleotide gated channel alpha 10.029
Acracrosin0.029
Gcm1glial cells missing homolog 1 (Drosophila)0.029
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.029
Phkg1phosphorylase kinase, gamma 10.029
Ccr2chemokine (C-C motif) receptor 20.028
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.027
LOC286980putative pheromone receptor (Go-VN13B)0.027
RGD1562234similar to S100 calcium-binding protein, ventral prostate0.027
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.026
Tnni1troponin I type 1 (skeletal, slow)0.025
Gpr88G-protein coupled receptor 880.025
Nox1NADPH oxidase 10.025
Tnnt3troponin T type 3 (skeletal, fast)0.025
Hpcal4hippocalcin-like 40.025
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.025
Cdh6cadherin 60.025
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.025
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.024
Chrngcholinergic receptor, nicotinic, gamma0.024
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.024
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.024
Syt6synaptotagmin VI0.024
Odf4outer dense fiber of sperm tails 40.024
Scn5asodium channel, voltage-gated, type V, alpha subunit0.024
Sycnsyncollin0.023
Timp1TIMP metallopeptidase inhibitor 10.023
Irx4iroquois homeobox 40.023
LOC60591calcium-activated potassium channel beta subunit0.023
Ckmcreatine kinase, muscle0.023
KlKlotho0.023
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.022
Prrx1paired related homeobox 10.022
Gucy2eguanylate cyclase 2E0.022
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.022
Syt9synaptotagmin IX0.022
Kcnab3potassium voltage-gated channel, shaker-related subfamily, beta member 30.022
Rph3arabphilin 3A0.022
Rims1regulating synaptic membrane exocytosis 10.021
Fxyd1FXYD domain-containing ion transport regulator 10.021
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.021
Sncgsynuclein, gamma (breast cancer-specific protein 1)0.021
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism