The network for 'organic substance catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organic substance catabolic process

The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.

NameDescriptionProbabilityFunc Analog Organism
rpt-2Protein RPT-20.823
F56D2.6Protein F56D2.60.740
sma-6Protein SMA-60.721
dpy-4Protein DPY-40.670
vab-3Protein VAB-30.639
rpl-11.1Protein RPL-11.10.636
pas-4Protein PAS-40.624
ced-9Protein CED-90.622
unc-52Protein UNC-520.617
col-34Protein COL-340.595
lin-45Protein LIN-450.579
pkg-1Protein PKG-10.568
rpn-7Protein RPN-70.561
ape-1Protein APE-10.560
prx-5Protein PRX-50.542
ykt-6Protein YKT-60.538
gld-1Protein GLD-10.535
pbs-6Protein PBS-60.533
vav-1Protein VAV-10.517
K10C9.3Protein K10C9.30.508
egl-30Protein EGL-300.507
bre-1Protein BRE-10.506
dcr-1Protein DCR-10.503
rpt-3Protein RPT-30.503
spd-5Protein SPD-50.501
pri-2Protein PRI-20.498
pmk-1Protein PMK-10.496
csn-3Protein CSN-30.493
unc-54Protein UNC-540.484
sli-1Protein SLI-10.482
cdc-37Protein CDC-370.479
imb-2Protein IMB-20.462
egl-18Protein EGL-180.461
rnr-1Protein RNR-10.458
sem-5Protein SEM-50.457
app-1Protein APP-10.457
rsp-8Protein RSP-80.448
tba-2Protein TBA-20.444
hel-1Protein HEL-10.444
ZK1055.7Protein ZK1055.70.443
CELE_C39E9.11Protein C39E9.110.443
atg-18Protein ATG-180.443
myo-3Protein MYO-30.440
hgrs-1Protein HGRS-10.436
egl-13Protein EGL-130.434
cka-2Protein CKA-20.430
etr-1Protein ETR-10.428
alx-1Protein ALX-10.419
pdr-1Protein PDR-10.418
gpr-2Protein GPR-20.417
npp-1Protein NPP-10.416
rpl-11.2Protein RPL-11.20.414
lev-11Protein LEV-110.412
rgl-1Protein RGL-10.412
rpn-12Protein RPN-120.411
pat-10Protein PAT-100.399
unc-6Protein UNC-60.394
dpf-3Protein DPF-30.391
npp-19Protein NPP-190.387
upb-1Protein UPB-10.384
pptr-2Protein PPTR-20.383
H14E04.2Protein H14E04.20.383
col-84Protein COL-840.381
CELE_Y57G11C.3Protein Y57G11C.30.380
CELE_C25A1.4Protein C25A1.40.379
pbs-1Protein PBS-10.376
F22D3.2Protein F22D3.20.373
sqt-1Protein SQT-10.372
hcp-1Protein HCP-10.371
ubxn-4Protein UBXN-40.364
T08B2.7Protein T08B2.70.363
rpn-3Protein RPN-30.358
K01G5.5Protein K01G5.50.356
H43E16.1Protein H43E16.10.353
zfp-1Protein ZFP-10.350
atp-2Protein ATP-20.349
dpy-31Protein DPY-310.349
C42C1.4Protein C42C1.40.348
vbh-1Protein VBH-10.346
tat-1Protein TAT-10.345
kin-3Protein KIN-30.343
col-73Protein COL-730.341
pgl-1Protein PGL-10.339
csn-4Protein CSN-40.339
mig-6Protein MIG-60.338
unc-23Protein UNC-230.337
pbs-5Protein PBS-50.337
mei-1Protein MEI-10.332
D1081.8Protein D1081.80.331
dpy-13Protein DPY-130.331
CELE_C10C6.6Protein C10C6.60.331
zen-4Protein ZEN-40.330
ifa-1Protein IFA-10.330
bar-1Protein BAR-10.329
ina-1Protein INA-10.329
klp-15Protein KLP-150.326
rpl-6Protein RPL-60.324
tpxl-1Protein TPXL-10.320
kin-2Protein KIN-20.319
sec-24.1Protein SEC-24.10.319
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gro1groucho 10.271
psmb1proteasome (prosome, macropain) subunit, beta type, 10.256
smad2MAD homolog 2 (Drosophila)0.226
psmb3proteasome (prosome, macropain) subunit, beta type, 30.199
nlgn4aneuroligin 4a0.198
hspa5heat shock protein 50.198
pcnaproliferating cell nuclear antigen0.192
upf1upf1 regulator of nonsense transcripts homolog (yeast)0.189
ncor1nuclear receptor co-repressor 10.187
zgc:85866zgc:858660.178
psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.174
sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.167
maomonoamine oxidase0.167
hk1hexokinase 10.159
ccnb1cyclin B10.154
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.151
aldocbaldolase C, fructose-bisphosphate, b0.148
chdchordin0.148
pax8paired box gene 80.135
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.130
psma8proteasome (prosome, macropain) subunit, alpha type, 80.126
tnni2a.4troponin I, skeletal, fast 2a.40.126
psma6aproteasome (prosome, macropain) subunit, alpha type, 6a0.120
myhz2myosin, heavy polypeptide 2, fast muscle specific0.118
plxnb2aplexin b2a0.111
pgam2phosphoglycerate mutase 2 (muscle)0.111
psma1proteasome (prosome, macropain) subunit, alpha type, 10.109
zgc:92775zgc:927750.108
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.107
ctsccathepsin C0.107
sox9bSRY-box containing gene 9b0.106
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.106
tnnt3btroponin T3b, skeletal, fast0.105
dhfrdihydrofolate reductase0.103
yap1Yes-associated protein 10.098
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.098
ctsbacathepsin B, a0.098
psen1presenilin 10.098
arnt2aryl hydrocarbon receptor nuclear translocator 20.096
apoa4apolipoprotein A-IV0.092
sass6spindle assembly 6 homolog (C. elegans)0.086
gpibglucose phosphate isomerase b0.085
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.085
aurkbaurora kinase B0.082
cyp2y3cytochrome P450, family 2, subfamily Y, polypeptide 30.079
desmadesmin a0.077
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.075
cand1cullin-associated and neddylation-dissociated 10.074
cdh23cadherin-like 230.074
cnot8CCR4-NOT transcription complex, subunit 80.074
nrg2aneuregulin 2a0.073
tram1translocating chain-associating membrane protein 10.072
mycbp2MYC binding protein 20.072
psmd4bproteasome (prosome, macropain) 26S subunit, non-ATPase, 4b0.071
suv39h1bsuppressor of variegation 3-9 homolog 1b0.070
psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.070
snai1asnail homolog 1a (Drosophila)0.069
rangap1Ran GTPase activating protein 10.068
yrkYes-related kinase0.067
psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.066
rae1RAE1 RNA export 1 homolog (S. pombe)0.066
s1pr2sphingosine-1-phosphate receptor 20.066
crabp2acellular retinoic acid binding protein 2, a0.065
atp1b3bATPase, Na+/K+ transporting, beta 3b polypeptide0.065
chukconserved helix-loop-helix ubiquitous kinase0.064
zbtb4zinc finger and BTB domain containing 40.064
vcpvalosin containing protein0.064
dusp1dual specificity phosphatase 10.064
zgc:101661zgc:1016610.063
uqcrc2bubiquinol-cytochrome c reductase core protein IIb0.063
supt6hsuppressor of Ty 6 homolog0.062
jag1bjagged 1b0.062
usp5ubiquitin specific protease 50.061
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.061
tph1btryptophan hydroxylase 1b0.061
hoxd4ahomeo box D4a0.060
itgb1bintegrin, beta 1b0.060
sox32SRY-box containing gene 320.060
msh2mutS homolog 2 (E. coli)0.059
bms1lBMS1-like, ribosome assembly protein (yeast)0.058
sema3aasemaphorin 3aa0.058
sec61al1Sec61 alpha like 10.058
prkciprotein kinase C, iota0.058
gna12guanine nucleotide binding protein (G protein) alpha 120.057
bsdc1BSD domain containing 10.057
psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.057
psmb5proteasome (prosome, macropain) subunit, beta type, 50.057
chia.2chitinase, acidic.20.056
flot1flotillin 10.056
psmb2proteasome (prosome, macropain) subunit, beta type, 20.056
ruvbl2RuvB-like 2 (E. coli)0.055
si:dkey-24l11.7si:dkey-24l11.70.055
mtpmicrosomal triglyceride transfer protein0.054
psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.054
hhiphedgehog interacting protein0.054
ndufs4NADH dehydrogenase (ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase)0.053
myogmyogenin0.053
nadl1.2neural adhesion molecule L1.20.053
ncbp2nuclear cap binding protein subunit 20.052
olfm1aolfactomedin 1a0.052
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.995
saxsaxophone0.921
Syx7Syntaxin 70.845
mspsmini spindles0.813
NNotch0.804
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.771
EcREcdysone receptor0.731
Sema-1aCG18405 gene product from transcript CG18405-RD0.682
dcodiscs overgrown0.682
slmbsupernumerary limbs0.656
rlrolled0.652
Aos1CG12276 gene product from transcript CG12276-RA0.631
LamLamin0.608
tefutelomere fusion0.590
nejnejire0.574
Hel25EHelicase at 25E0.571
InRInsulin-like receptor0.563
Src64BSrc oncogene at 64B0.551
CycECyclin E0.551
rad50CG6339 gene product from transcript CG6339-RD0.521
cpacapping protein alpha0.517
piepineapple eye0.505
Ras85DRas oncogene at 85D0.504
Top1Topoisomerase 10.502
Rho1CG8416 gene product from transcript CG8416-RB0.498
Mi-2CG8103 gene product from transcript CG8103-RA0.488
Rpn11CG18174 gene product from transcript CG18174-RA0.481
ptcpatched0.480
Dcr-2Dicer-20.478
drkdownstream of receptor kinase0.477
Rac1CG2248 gene product from transcript CG2248-RA0.468
agoarchipelago0.466
Lis-1Lissencephaly-10.460
tsrtwinstar0.458
dosdaughter of sevenless0.454
awdabnormal wing discs0.447
Rpt1CG1341 gene product from transcript CG1341-RA0.446
SNF1ASNF1A/AMP-activated protein kinase0.438
cenG1Acentaurin gamma 1A0.438
Su(var)205Suppressor of variegation 2050.438
Dhc64CDynein heavy chain 64C0.427
RelRelish0.420
MadMothers against dpp0.414
Mov34CG3416 gene product from transcript CG3416-RA0.410
Ada2bCG9638 gene product from transcript CG9638-RA0.409
jebjelly belly0.407
RhebCG1081 gene product from transcript CG1081-RA0.399
nctnicastrin0.395
CakiCalcium/calmodulin-dependent protein kinase0.391
eIF-4EEukaryotic initiation factor 4E0.386
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.386
CG8155CG8155 gene product from transcript CG8155-RA0.371
UbcD2Ubiquitin conjugating enzyme 20.370
shgshotgun0.368
Kr-h1Kruppel homolog 10.368
DlicDynein light intermediate chain0.366
CkIIalphaCasein kinase II alpha subunit0.364
FhosCG42610 gene product from transcript CG42610-RC0.363
par-6CG5884 gene product from transcript CG5884-RA0.354
CatCatalase0.354
wupAwings up A0.351
CG6617CG6617 gene product from transcript CG6617-RA0.351
EnoEnolase0.348
CG9772CG9772 gene product from transcript CG9772-RB0.347
alpha-Catalpha Catenin0.346
betaTub60Dbeta-Tubulin at 60D0.343
twstwins0.339
CG7998CG7998 gene product from transcript CG7998-RA0.339
TalCG2827 gene product from transcript CG2827-RA0.338
trioCG18214 gene product from transcript CG18214-RA0.332
Rpd3CG7471 gene product from transcript CG7471-RA0.332
sqhspaghetti squash0.330
PakPAK-kinase0.329
ArgkArginine kinase0.329
brpbruchpilot0.323
Ugt35aUDP-glycosyltransferase 35a0.315
CkIalphaCasein kinase Ialpha0.315
G-oalpha47AG protein oalpha 47A0.314
CamCalmodulin0.313
rinrasputin0.313
PknProtein kinase related to protein kinase N0.313
p53CG33336 gene product from transcript CG33336-RB0.308
Rpt4CG3455 gene product from transcript CG3455-RA0.307
BRWD3CG31132 gene product from transcript CG31132-RA0.306
scnyscrawny0.306
Rab1Rab-protein 10.305
Tak1TGF-beta activated kinase 10.303
Nedd8CG10679 gene product from transcript CG10679-RA0.299
unc-104CG8566 gene product from transcript CG8566-RB0.298
E(z)Enhancer of zeste0.295
CkIIbetaCasein kinase II beta subunit0.295
maskmultiple ankyrin repeats single KH domain0.293
giggigas0.291
Uba1Ubiquitin activating enzyme 10.288
benbendless0.287
cltcricklet0.287
ifinflated0.286
Rcd1Reduction in Cnn dots 10.283
Eip63EEcdysone-induced protein 63E0.283
Yp1Yolk protein 10.282
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.875
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.857
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.838
Ldhalactate dehydrogenase A0.786
Pkm2pyruvate kinase, muscle0.777
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.706
Acadvlacyl-Coenzyme A dehydrogenase, very long chain0.700
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.673
Rxrgretinoid X receptor gamma0.673
Acaa2acetyl-Coenzyme A acyltransferase 20.672
Aldoaaldolase A, fructose-bisphosphate0.662
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.646
LOC293989cytochrome P450-like0.641
Psma5proteasome (prosome, macropain) subunit, alpha type 50.641
Stxbp1syntaxin binding protein 10.632
Lamp2lysosomal-associated membrane protein 20.610
Mapre1microtubule-associated protein, RP/EB family, member 10.608
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.598
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.561
Anxa2annexin A20.549
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.548
Car5acarbonic anhydrase 5a, mitochondrial0.521
Tpi1triosephosphate isomerase 10.521
Psma3proteasome (prosome, macropain) subunit, alpha type 30.518
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.504
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.503
Cd8bCD8b molecule0.503
Psmb3proteasome (prosome, macropain) subunit, beta type 30.488
Eef2eukaryotic translation elongation factor 20.486
Pebp1phosphatidylethanolamine binding protein 10.485
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.470
Myo1bmyosin Ib0.466
Prlprolactin0.452
Prkchprotein kinase C, eta0.450
Gja1gap junction protein, alpha 10.446
Tpm3tropomyosin 3, gamma0.433
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.417
Cpt2carnitine palmitoyltransferase 20.411
Acox1acyl-Coenzyme A oxidase 1, palmitoyl0.411
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.398
Gna15guanine nucleotide binding protein, alpha 150.398
Rgs19regulator of G-protein signaling 190.394
Acta2smooth muscle alpha-actin0.392
Klf6Kruppel-like factor 60.392
Pfn1profilin 10.389
Psme2proteasome (prosome, macropain) activator subunit 20.387
Shank2SH3 and multiple ankyrin repeat domains 20.386
Mgst2microsomal glutathione S-transferase 20.382
Ripk3receptor-interacting serine-threonine kinase 30.381
Ctbschitobiase, di-N-acetyl-0.380
Adrbk1adrenergic, beta, receptor kinase 10.379
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.373
Crotcarnitine O-octanoyltransferase0.373
Ctsbcathepsin B0.371
Acsl1acyl-CoA synthetase long-chain family member 10.364
Nr0b2nuclear receptor subfamily 0, group B, member 20.362
Camk4calcium/calmodulin-dependent protein kinase IV0.358
Tkttransketolase0.357
Litaflipopolysaccharide-induced TNF factor0.354
Psma7proteasome (prosome, macropain) subunit, alpha type 70.352
Igf2insulin-like growth factor 20.351
Cyfip1cytoplasmic FMR1 interacting protein 10.349
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.348
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.341
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.338
Stip1stress-induced phosphoprotein 10.337
Cd302CD302 molecule0.335
Anxa1annexin A10.331
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.330
Dctn4dynactin 40.330
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.328
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.319
Cmklr1chemokine-like receptor 10.318
Csnk1dcasein kinase 1, delta0.304
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.304
A1i3alpha-1-inhibitor III0.303
Psmb4proteasome (prosome, macropain) subunit, beta type 40.302
Myo1dmyosin ID0.298
Pja2praja 2, RING-H2 motif containing0.297
Rab1bRAB1B, member RAS oncogene family0.295
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.292
Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 30.292
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.291
Pdcd10programmed cell death 100.287
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.284
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.283
Il13interleukin 130.282
Ube2iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.279
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.278
Pahphenylalanine hydroxylase0.277
Lgals3lectin, galactoside-binding, soluble, 30.276
Cfl1cofilin 1, non-muscle0.276
Pros1protein S (alpha)0.275
Nntnicotinamide nucleotide transhydrogenase0.275
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.274
Anxa4annexin A40.273
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.272
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.271
Csnk2bcasein kinase 2, beta polypeptide0.270
Glud1glutamate dehydrogenase 10.270
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism