The network for 'negative regulation of gene expression' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.832
hlh-2Protein HLH-20.723
egl-18Protein EGL-180.717
vab-3Protein VAB-30.614
nhr-2Protein NHR-20.585
hcp-3Protein HCP-30.477
attf-2Protein ATTF-20.457
CELE_W03F9.10Protein W03F9.100.450
zip-7Protein ZIP-70.430
W04D2.6Protein W04D2.60.411
nhr-34Protein NHR-340.391
tbx-8Protein TBX-80.387
mab-5Protein MAB-50.376
his-16Protein HIS-160.366
his-1Protein HIS-10.366
lsy-22Protein LSY-220.337
nhr-67Protein NHR-670.333
ubq-1Protein UBQ-10.332
unc-62Protein UNC-620.327
mcm-4Protein MCM-40.321
lin-53Protein LIN-530.319
eor-1Protein EOR-10.315
pri-2Protein PRI-20.312
cec-5Protein CEC-50.306
his-68Protein HIS-680.297
egl-13Protein EGL-130.288
his-45Protein HIS-450.287
daf-1Protein DAF-10.286
cfim-2Protein CFIM-20.277
klp-19Protein KLP-190.276
dcr-1Protein DCR-10.269
cacn-1Protein CACN-10.269
lin-35Protein LIN-350.268
atg-2Protein ATG-20.268
itx-1Protein ITX-10.266
his-5Protein HIS-50.265
lin-40Protein LIN-400.263
CELE_C17E4.6Protein C17E4.60.259
his-48Protein HIS-480.254
rsr-2Protein RSR-20.251
elt-6Protein ELT-60.250
zag-1Protein ZAG-10.250
hlh-1Protein HLH-10.249
unc-37Protein UNC-370.247
mes-3Protein MES-30.244
H06I04.3Protein H06I04.30.240
lin-12Protein LIN-120.239
CELE_C25A1.4Protein C25A1.40.238
his-61Protein HIS-610.238
skp-1Protein SKP-10.237
hrp-1Protein HRP-10.237
rpb-6Protein RPB-60.237
F33D11.10Protein F33D11.100.237
egl-46Protein EGL-460.235
fkh-2Protein FKH-20.232
cul-2Protein CUL-20.231
egg-6Protein EGG-60.230
his-52Protein HIS-520.229
smc-3Protein SMC-30.229
bar-1Protein BAR-10.229
mcm-7Protein MCM-70.227
alg-2Protein ALG-20.226
egl-44Protein EGL-440.226
snr-2Protein SNR-20.224
pry-1Protein PRY-10.222
egl-27Protein EGL-270.221
ccr-4Protein CCR-40.219
T28C6.7Protein T28C6.70.218
ceh-32Protein CEH-320.216
ceh-27Protein CEH-270.215
F39B2.1Protein F39B2.10.214
epn-1Protein EPN-10.213
mbk-1Protein MBK-10.212
lsy-2Protein LSY-20.212
hum-5Protein HUM-50.210
mat-3Protein MAT-30.210
T27A3.7Protein T27A3.70.209
lmn-1Protein LMN-10.207
psa-3Protein PSA-30.206
mep-1Protein MEP-10.205
bet-1Protein BET-10.204
let-502Protein LET-5020.204
snrp-200Protein SNRP-2000.203
capg-1Protein CAPG-10.201
his-42Protein HIS-420.199
his-29Protein HIS-290.199
klp-16Protein KLP-160.196
lin-11Protein LIN-110.194
hda-1Protein HDA-10.194
K07B1.7Protein K07B1.70.194
unc-73Protein UNC-730.193
rpn-2Protein RPN-20.193
dlc-1Protein DLC-10.193
npp-4Protein NPP-40.191
lin-66Protein LIN-660.188
mdf-2Protein MDF-20.186
npp-19Protein NPP-190.185
gls-1Protein GLS-10.184
jmjd-2Protein JMJD-20.184
mex-5Protein MEX-50.184
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.944
ndr2nodal-related 20.942
tp53tumor protein p530.937
dlx2adistal-less homeobox gene 2a0.874
shhasonic hedgehog a0.859
whsc1Wolf-Hirschhorn syndrome candidate 10.845
ef1aelongation factor 1-alpha0.838
gata6GATA-binding protein 60.817
chdchordin0.811
isl1islet10.804
tbx1T-box 10.804
fgf3fibroblast growth factor 30.798
robo3roundabout homolog 30.793
snai1bsnail homolog 1b (Drosophila)0.789
hnf1baHNF1 homeobox Ba0.767
otx1borthodenticle homolog 1b0.756
gli1GLI-Kruppel family member 10.736
tfap2atranscription factor AP-2 alpha0.735
sox19aSRY-box containing gene 19a0.707
dlx3bdistal-less homeobox gene 3b0.699
runx2brunt-related transcription factor 2b0.691
nclnucleolin0.670
jag2jagged 20.658
piwil1piwi-like 1 (Drosophila)0.657
gro1groucho 10.649
lhx1aLIM homeobox 1a0.645
foxb1.1forkhead box B1.10.638
mab21l2mab-21-like 20.637
sox32SRY-box containing gene 320.628
nr2e1nuclear receptor subfamily 2, group E, member 10.626
foxa3forkhead box A30.574
kctd15apotassium channel tetramerisation domain containing 15a0.566
tbx6T-box gene 60.561
twist3twist30.555
dusp6dual specificity phosphatase 60.555
klf4Kruppel-like factor 40.536
meis2.1myeloid ecotropic viral integration site 2.10.533
pou3f2POU class 3 homeobox 20.531
sox9bSRY-box containing gene 9b0.526
eya1eyes absent homolog 10.519
tbx18T-box 180.515
fn1fibronectin 10.482
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.476
sesn1sestrin 10.476
flhfloating head0.474
gscgoosecoid0.473
slit3slit (Drosophila) homolog 30.466
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.463
wnt1wingless-type MMTV integration site family, member 10.457
nkx2.5NK2 transcription factor related 50.454
zic1zic family member 1 (odd-paired homolog, Drosophila)0.447
her15.1hairy and enhancer of split-related 15.10.438
tfebtranscription factor EB0.433
neo1neogenin 10.432
gbx2gastrulation brain homeo box 20.427
spry4sprouty (Drosophila) homolog 40.420
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.413
sall1asal-like 1a (Drosophila)0.384
pkd2polycystic kidney disease 20.382
six3asine oculis homeobox homolog 3a0.382
hmgb1ahigh-mobility group box 1a0.377
aldh1a2aldehyde dehydrogenase 1 family, member A20.373
dlx5adistal-less homeobox gene 5a0.371
gata4GATA-binding protein 40.366
myf5myogenic factor 50.365
foxi1forkhead box I10.361
prox1prospero-related homeobox gene 10.358
pitx2paired-like homeodomain transcription factor 20.352
ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39b0.347
cdc25cell division cycle 25 homolog0.345
hoxa13ahomeo box A13a0.344
zgc:55461zgc:554610.334
osr2odd-skipped related 2 (Drosophila)0.334
mcoln1mucolipin 10.333
mespamesoderm posterior a0.330
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.329
ihhaIndian hedgehog homolog a0.324
znf703zinc finger protein 7030.324
bmp2bbone morphogenetic protein 2b0.323
ewsr1bEwing sarcoma breakpoint region 1b0.322
smyd2aSET and MYND domain containing 2a0.321
dctdopachrome tautomerase0.317
barx1BarH-like homeobox 10.313
pdlim7PDZ and LIM domain 70.309
tp73tumor protein p730.309
pax8paired box gene 80.303
mecomMDS1 and EVI1 complex locus0.300
rarabretinoic acid receptor, alpha b0.298
irx4biroquois homeobox protein 4b0.297
plagl2pleiomorphic adenoma gene-like 20.293
fgf19fibroblast growth factor 190.292
sox3SRY-box containing gene 30.290
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.289
hoxb1bhomeo box B1b0.287
ptgs2aprostaglandin-endoperoxide synthase 2a0.286
ranras-related nuclear protein0.285
her7hairy and enhancer of split related-70.284
foxa1forkhead box A10.282
mcl1amyeloid cell leukemia sequence 1a0.281
fgfr3fibroblast growth factor receptor 30.281
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
IswiImitation SWI1.000
PcPolycomb0.999
CtBPC-terminal Binding Protein0.999
Snr1Snf5-related 10.999
dcodiscs overgrown0.994
CTCFCG8591 gene product from transcript CG8591-RA0.993
Su(var)205Suppressor of variegation 2050.992
slmbsupernumerary limbs0.992
phylphyllopod0.987
dallydivision abnormally delayed0.986
E(spl)Enhancer of split0.986
Su(H)Suppressor of Hairless0.986
Mi-2CG8103 gene product from transcript CG8103-RA0.986
CycBCyclin B0.984
Fmr1CG6203 gene product from transcript CG6203-RC0.983
pr-set7CG3307 gene product from transcript CG3307-RC0.980
gppgrappa0.978
hephemipterous0.977
PclPolycomblike0.976
His2AvHistone H2A variant0.975
mormoira0.969
NNotch0.969
smt3CG4494 gene product from transcript CG4494-RA0.968
shnschnurri0.966
nejnejire0.966
Rpd3CG7471 gene product from transcript CG7471-RA0.965
piwiCG6122 gene product from transcript CG6122-RA0.964
MadMothers against dpp0.958
DadDaughters against dpp0.958
UbxUltrabithorax0.955
Sir2CG5216 gene product from transcript CG5216-RA0.955
Spt5CG7626 gene product from transcript CG7626-RA0.954
fufused0.953
growlCG14648 gene product from transcript CG14648-RA0.952
Pp1-87BProtein phosphatase 1 at 87B0.951
slp1sloppy paired 10.947
E(var)3-9Enhancer of variegation 3-90.945
D1D1 chromosomal protein0.943
nubnubbin0.939
arrarrow0.936
stysprouty0.935
osaCG7467 gene product from transcript CG7467-RD0.933
Su(var)3-7Suppressor of variegation 3-70.926
Taf1TBP-associated factor 10.924
sbbscribbler0.920
loqsloquacious0.918
ninaEneither inactivation nor afterpotential E0.916
gsbgooseberry0.916
mtsmicrotubule star0.915
stisticky0.915
CkIIalphaCasein kinase II alpha subunit0.915
BEAF-32Boundary element-associated factor of 32kD0.915
rinrasputin0.912
hthhomothorax0.909
nmonemo0.909
hkbhuckebein0.908
tsrtwinstar0.906
dsxdoublesex0.904
Acf1ATP-dependent chromatin assembly factor large subunit0.904
atoatonal0.901
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.898
drprdraper0.893
hbshibris0.889
tlltailless0.883
eygeyegone0.881
edechinoid0.876
p53CG33336 gene product from transcript CG33336-RB0.875
Trim9CG31721 gene product from transcript CG31721-RB0.875
hephhephaestus0.872
SmrSmrter0.871
kelkelch0.866
HLHmdeltaE(spl) region transcript mdelta0.865
Suv4-20CG13363 gene product from transcript CG13363-RA0.856
SceSex combs extra0.855
Bap55Brahma associated protein 55kD0.855
AblAbl tyrosine kinase0.854
KrKruppel0.848
sosine oculis0.848
grogroucho0.847
osoutstretched0.843
Pkc98EProtein C kinase 98E0.841
abd-Aabdominal A0.838
poloCG12306 gene product from transcript CG12306-RA0.830
E2f2E2F transcription factor 20.825
CG7971CG7971 gene product from transcript CG7971-RC0.823
Doc2Dorsocross20.823
ushu-shaped0.821
escextra sexcombs0.821
snasnail0.818
vvlventral veins lacking0.816
discodisconnected0.815
effeffete0.813
Akt1CG4006 gene product from transcript CG4006-RA0.811
nkdnaked cuticle0.811
hbhunchback0.811
LIMK1LIM-kinase10.809
spn-Espindle E0.809
Abd-BAbdominal B0.804
wgwingless0.803
lidlittle imaginal discs0.803
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.831
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.658
Nedd4neural precursor cell expressed, developmentally down-regulated 40.569
Metmet proto-oncogene0.540
S100a10S100 calcium binding protein A100.522
FosFBJ osteosarcoma oncogene0.491
Smad7SMAD family member 70.479
JunJun oncogene0.453
Hoxc4homeo box C40.436
Tcfe2atranscription factor E2a0.424
Rhobras homolog gene family, member B0.411
Pgam1phosphoglycerate mutase 1 (brain)0.407
Eif4heukaryotic translation initiation factor 4H0.404
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.384
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.375
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.366
Myh9myosin, heavy chain 9, non-muscle0.356
Socs3suppressor of cytokine signaling 30.354
Iappislet amyloid polypeptide0.353
Ier2immediate early response 20.353
Vimvimentin0.347
Fgfr2fibroblast growth factor receptor 20.342
Errfi1ERBB receptor feedback inhibitor 10.342
Tgfbr2transforming growth factor, beta receptor II0.339
Plb1phospholipase B10.331
Asgr1asialoglycoprotein receptor 10.316
Nfibnuclear factor I/B0.315
Ttc36tetratricopeptide repeat domain 360.307
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.305
Itih4inter alpha-trypsin inhibitor, heavy chain 40.303
Sfrs1splicing factor, arginine/serine-rich 10.302
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.297
Dynll1dynein light chain LC8-type 10.295
Sirpasignal-regulatory protein alpha0.295
Gja1gap junction protein, alpha 10.295
Nfyanuclear transcription factor-Y alpha0.294
Epn1Epsin 10.293
Hspb1heat shock protein 10.282
Usf2upstream transcription factor 2, c-fos interacting0.274
DbpD site of albumin promoter (albumin D-box) binding protein0.272
Arf6ADP-ribosylation factor 60.271
Klf9Kruppel-like factor 90.270
Gjb4gap junction protein, beta 40.269
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.264
Stat3signal transducer and activator of transcription 30.262
Ifitm3interferon induced transmembrane protein 30.257
Tcf4transcription factor 40.257
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.257
Pcnaproliferating cell nuclear antigen0.256
Casp2caspase 20.254
Onecut1one cut homeobox 10.250
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.249
Creb1cAMP responsive element binding protein 10.247
Pgk1phosphoglycerate kinase 10.246
Kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.245
Pon1paraoxonase 10.244
Id1inhibitor of DNA binding 10.241
Sox4SRY (sex determining region Y)-box 40.241
Cyth1cytohesin 10.240
Shox2short stature homeobox 20.237
Tmpothymopoietin0.231
Lhx5LIM homeobox 50.230
Lgals3lectin, galactoside-binding, soluble, 30.229
Fggfibrinogen gamma chain0.228
Marcksmyristoylated alanine rich protein kinase C substrate0.227
Hnrnprheterogeneous nuclear ribonucleoprotein R0.225
Zfand6zinc finger, AN1-type domain 60.217
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.214
Ptpn1protein tyrosine phosphatase, non-receptor type 10.210
Arpc1bactin related protein 2/3 complex, subunit 1B0.209
S100a6S100 calcium binding protein A60.208
Mgpmatrix Gla protein0.208
Anxa2annexin A20.208
Hnrnpa0heterogeneous nuclear ribonucleoprotein A00.208
Pim1pim-1 oncogene0.206
Calm2calmodulin 20.201
Hes1hairy and enhancer of split 1 (Drosophila)0.198
Hoxb7homeo box B70.197
Ptmsparathymosin0.197
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.197
Nfianuclear factor I/A0.195
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.194
Purbpurine rich element binding protein B0.194
Egr1early growth response 10.194
Fabp5fatty acid binding protein 5, epidermal0.193
Cdk2cyclin dependent kinase 20.192
Cd80Cd80 molecule0.192
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.190
Timp1TIMP metallopeptidase inhibitor 10.190
Ahraryl hydrocarbon receptor0.189
Stat6signal transducer and activator of transcription 60.188
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.188
Dlg1discs, large homolog 1 (Drosophila)0.185
Csnk1g2casein kinase 1, gamma 20.184
Klf4Kruppel-like factor 4 (gut)0.183
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.182
Tp53tumor protein p530.182
Foxi2forkhead box I20.181
Nr2f6nuclear receptor subfamily 2, group F, member 60.179
Procprotein C0.178
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SIN3Sin3p0.985
RPD3Rpd3p0.984
CKA2Cka2p0.984
SIR2Sir2p0.980
GLC7Glc7p0.973
HDA1Hda1p0.967
RXT2Rxt2p0.936
HHF1Hhf1p0.933
GAL11Gal11p0.922
RAP1Rap1p0.919
CTI6Cti6p0.913
ASF1Asf1p0.912
SIR4Sir4p0.905
HMO1Hmo1p0.902
SUM1Sum1p0.898
RLF2Rlf2p0.893
SNF1Snf1p0.886
SIN4Sin4p0.882
ZDS2Zds2p0.867
CDC14Cdc14p0.867
SET1Set1p0.844
RSC2Rsc2p0.841
ORC2Orc2p0.838
RGR1Rgr1p0.835
RCO1Rco1p0.831
FKH1Fkh1p0.828
RNR4Rnr4p0.820
SAS2Sas2p0.819
BMH2Bmh2p0.818
HTB1Htb1p0.810
PLC1Plc1p0.808
HTZ1Htz1p0.794
ROX3Rox3p0.778
NPL3Npl3p0.778
ISW1Isw1p0.767
HAT1Hat1p0.767
CYC8Cyc8p0.766
HHT1Hht1p0.761
GCN5Gcn5p0.752
SDS3Sds3p0.747
SGV1Sgv1p0.746
SIR3Sir3p0.717
CCR4Ccr4p0.716
FKH2Fkh2p0.711
YTA7Yta7p0.707
RTF1Rtf1p0.705
CKA1Cka1p0.701
SET3Set3p0.696
UME1Ume1p0.695
CHL1Chl1p0.688
YAK1Yak1p0.684
RNR2Rnr2p0.679
PGD1Pgd1p0.673
SPT10Spt10p0.672
PPH3Pph3p0.657
CDC6Cdc6p0.654
MED2Med2p0.654
UBP8Ubp8p0.647
RIF1Rif1p0.629
UBP10Ubp10p0.627
HTB2Htb2p0.627
RPN4Rpn4p0.625
PHO4Pho4p0.622
PPH21Pph21p0.620
ISW2Isw2p0.618
ORC5Orc5p0.615
DHH1Dhh1p0.615
NRG1Nrg1p0.607
SRM1Srm1p0.605
DEP1Dep1p0.604
KSP1Ksp1p0.603
SRB4Srb4p0.596
ARX1Arx1p0.593
HOG1Hog1p0.591
SMC3Smc3p0.586
ORC6Orc6p0.586
HDA3Hda3p0.584
LSM1Lsm1p0.584
TAF6Taf6p0.578
GCR2Gcr2p0.577
CTF18Ctf18p0.577
BUB3Bub3p0.577
TID3Tid3p0.569
SSN3Ssn3p0.564
BCK1Bck1p0.564
CDC55Cdc55p0.563
REG1Reg1p0.561
SAS4Sas4p0.553
TIF4632Tif4632p0.550
PUB1Pub1p0.548
CTK1Ctk1p0.539
CDC45Cdc45p0.534
SNF5Snf5p0.532
RTT106Rtt106p0.531
HHF2Hhf2p0.521
SWE1Swe1p0.521
HAT2Hat2p0.518
GSY2Gsy2p0.515
SWI3Swi3p0.515
SSE1Sse1p0.512