The network for 'cuticle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cuticle development

The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.

NameDescriptionProbabilityFunc Analog Organism
rol-8Protein ROL-80.607
dpy-4Protein DPY-40.538
col-73Protein COL-730.473
col-144Protein COL-1440.472
col-157Protein COL-1570.466
wrt-6Protein WRT-60.444
rol-6Protein ROL-60.410
sqt-1Protein SQT-10.393
col-146Protein COL-1460.386
egl-18Protein EGL-180.340
aagr-4Protein AAGR-40.315
sqt-2Protein SQT-20.313
col-145Protein COL-1450.305
col-17Protein COL-170.295
col-8Protein COL-80.276
dpy-13Protein DPY-130.260
col-119Protein COL-1190.246
col-92Protein COL-920.244
col-181Protein COL-1810.227
col-142Protein COL-1420.225
col-114Protein COL-1140.217
col-133Protein COL-1330.214
col-93Protein COL-930.214
CELE_E01G4.6Protein E01G4.60.212
col-138Protein COL-1380.207
col-154Protein COL-1540.204
col-49Protein COL-490.199
alh-3Protein ALH-30.199
col-111Protein COL-1110.194
col-140Protein COL-1400.192
col-160Protein COL-1600.192
col-38Protein COL-380.189
col-71Protein COL-710.189
col-107Protein COL-1070.189
ifb-2Protein IFB-20.188
col-141Protein COL-1410.184
col-180Protein COL-1800.183
col-2Protein COL-20.178
col-173Protein COL-1730.170
col-43Protein COL-430.164
col-178Protein COL-1780.163
col-79Protein COL-790.161
bli-2Protein BLI-20.155
col-166Protein COL-1660.154
col-149Protein COL-1490.151
atn-1Protein ATN-10.150
col-109Protein COL-1090.149
col-156Protein COL-1560.148
col-143Protein COL-1430.146
gck-2Protein GCK-20.144
col-184Protein COL-1840.140
dpy-9Protein DPY-90.140
elt-6Protein ELT-60.137
dig-1Protein DIG-10.134
fat-2Protein FAT-20.132
T03D8.6Protein T03D8.60.132
col-66Protein COL-660.131
col-122Protein COL-1220.131
C14F11.4Protein C14F11.40.130
col-98Protein COL-980.127
col-63Protein COL-630.123
F27C1.2Protein F27C1.20.123
col-58Protein COL-580.122
col-117Protein COL-1170.121
dpy-5Protein DPY-50.119
col-120Protein COL-1200.119
T19A5.3Protein T19A5.30.115
unc-23Protein UNC-230.111
col-84Protein COL-840.111
C34E7.4Protein C34E7.40.110
col-129Protein COL-1290.110
col-125Protein COL-1250.109
col-130Protein COL-1300.109
lin-13Protein LIN-130.108
col-14Protein COL-140.107
col-103Protein COL-1030.106
nas-37Protein NAS-370.105
col-90Protein COL-900.104
C05C8.7Protein C05C8.70.103
nab-1Protein NAB-10.102
kin-2Protein KIN-20.102
col-159Protein COL-1590.098
pmt-1Protein PMT-10.098
bli-1Protein BLI-10.097
col-94Protein COL-940.096
cat-1Protein CAT-10.096
hlh-2Protein HLH-20.094
clec-63Protein CLEC-630.094
ribo-1Protein RIBO-10.094
col-77Protein COL-770.094
col-118Protein COL-1180.093
col-54Protein COL-540.092
C06G1.1Protein C06G1.10.091
col-91Protein COL-910.090
mup-4Protein MUP-40.089
abu-13Protein ABU-130.089
T27A10.6Protein T27A10.60.088
dpy-7Protein DPY-70.086
lir-1Protein LIR-10.086
col-127Protein COL-1270.085
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.991
EcREcdysone receptor0.980
knkknickkopf0.978
grhgrainy head0.919
dshdishevelled0.867
wolwollknaeuel0.847
GugGrunge0.714
vermvermiform0.691
opaodd paired0.688
NNotch0.670
MadMothers against dpp0.646
kkvkrotzkopf verkehrt0.620
piopiopio0.601
Cyp12d1-pCG30489 gene product from transcript CG30489-RA0.594
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.543
dibdisembodied0.540
sroshroud0.539
sec23CG1250 gene product from transcript CG1250-RA0.538
mtgmind the gap0.524
rtvretroactive0.521
fwfurrowed0.521
mysmyospheroid0.500
snssticks and stones0.500
tsrtwinstar0.478
spospook0.471
MegalinCG42611 gene product from transcript CG42611-RA0.468
TwdlLTweedleL0.467
ghoghost0.438
UsfCG17592 gene product from transcript CG17592-RB0.432
Pink1PTEN-induced putative kinase 10.425
hephemipterous0.421
porporcupine0.396
Cyp12d1-dCG33503 gene product from transcript CG33503-RA0.395
TwdlETweedleE0.389
Mes2CG11100 gene product from transcript CG11100-RB0.384
UbxUltrabithorax0.375
plepale0.367
rokRho-kinase0.346
Cpr64AdCuticular protein 64Ad0.338
DdcDopa decarboxylase0.321
btlbreathless0.319
CatsupCatecholamines up0.317
SerSerrate0.310
yyellow0.307
fufused0.305
mmymummy0.302
shashavenoid0.295
mwhmultiple wing hairs0.293
Sec61betaCG10130 gene product from transcript CG10130-RA0.292
BicDBicaudal D0.291
Src42ASrc oncogene at 42A0.286
serpserpentine0.276
TwdlCTweedleC0.276
varivaricose0.269
slprslipper0.268
dsdachsous0.261
Npc1bNiemann-Pick type C-1b0.250
TalCG2827 gene product from transcript CG2827-RA0.248
slouslouch0.247
pydpolychaetoid0.245
SNF1ASNF1A/AMP-activated protein kinase0.240
Wnt2Wnt oncogene analog 20.232
mminiature0.232
bsblistered0.231
jebjelly belly0.230
SasSialic acid phosphate synthase0.226
RalaRas-related protein0.225
fredfriend of echinoid0.222
eaeaster0.221
dpdumpy0.212
snasnail0.207
l(2)gllethal (2) giant larvae0.204
nejnejire0.204
dispdispatched0.199
CrebACyclic-AMP response element binding protein A0.198
CG5933CG5933 gene product from transcript CG5933-RA0.193
sadshadow0.192
shdshade0.187
Hr38Hormone receptor-like in 380.186
Apc2Adenomatous polyposis coli tumor suppressor homolog 20.184
domedomeless0.180
CG18766CG18766 gene product from transcript CG18766-RB0.171
Rac1CG2248 gene product from transcript CG2248-RA0.162
inx2innexin 20.161
pucpuckered0.159
stnBstoned B0.157
Myo31DFMyosin 31DF0.156
kugkugelei0.149
nyonyobe0.149
simsingle-minded0.149
Stat92ESignal-transducer and activator of transcription protein at 92E0.148
rtrotated abdomen0.148
Gcn2CG1609 gene product from transcript CG1609-RA0.146
loqsloquacious0.143
oddodd skipped0.141
cicubitus interruptus0.139
TwdlBTweedleB0.138
CG14667CG14667 gene product from transcript CG14667-RA0.136
kirrekin of irre0.132
rkrickets0.131
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NOTCH3notch 30.811
WIPF1WAS/WASL interacting protein family, member 10.808
NOTCH1notch 10.701
SUFUsuppressor of fused homolog (Drosophila)0.557
ZNF496zinc finger protein 4960.484
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.341
GFI1Bgrowth factor independent 1B transcription repressor0.231
NR4A2nuclear receptor subfamily 4, group A, member 20.227
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.208
VHLvon Hippel-Lindau tumor suppressor0.206
STK36serine/threonine kinase 360.180
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.122
WASLWiskott-Aldrich syndrome-like0.102
CTNNBIP1catenin, beta interacting protein 10.092
APCadenomatous polyposis coli0.087
TCEAL5transcription elongation factor A (SII)-like 50.079
HES1hairy and enhancer of split 1, (Drosophila)0.075
ZNF331zinc finger protein 3310.070
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.067
TCF4transcription factor 40.053
ACTA2actin, alpha 2, smooth muscle, aorta0.052
TRPM6transient receptor potential cation channel, subfamily M, member 60.050
JUPjunction plakoglobin0.049
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.049
SUZ12suppressor of zeste 12 homolog (Drosophila)0.049
RPL27Aribosomal protein L27a0.048
FXYD3FXYD domain containing ion transport regulator 30.044
CTTNcortactin0.043
IQGAP1IQ motif containing GTPase activating protein 10.041
RPL13ribosomal protein L130.040
NR4A3nuclear receptor subfamily 4, group A, member 30.038
PDE4Dphosphodiesterase 4D, cAMP-specific0.038
PBX1pre-B-cell leukemia homeobox 10.037
NOTCH2notch 20.035
DSPdesmoplakin0.035
EGR2early growth response 20.035
MYL9myosin, light chain 9, regulatory0.033
TRPM7transient receptor potential cation channel, subfamily M, member 70.033
RCN3reticulocalbin 3, EF-hand calcium binding domain0.032
SIK1salt-inducible kinase 10.031
PEX26peroxisomal biogenesis factor 260.031
SKIv-ski sarcoma viral oncogene homolog (avian)0.031
ACTN1actinin, alpha 10.031
LTBP4latent transforming growth factor beta binding protein 40.030
EGR3early growth response 30.030
SNX9sorting nexin 90.029
FBXW11F-box and WD repeat domain containing 110.028
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.028
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.026
NCOA2nuclear receptor coactivator 20.026
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.026
BAIAP2BAI1-associated protein 20.026
GAS7growth arrest-specific 70.025
GLI1GLI family zinc finger 10.025
ASCC2activating signal cointegrator 1 complex subunit 20.024
GNMTglycine N-methyltransferase0.024
FBLN1fibulin 10.023
CORO1Ccoronin, actin binding protein, 1C0.023
MID1IP1MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))0.022
CNN1calponin 1, basic, smooth muscle0.022
RGS2regulator of G-protein signaling 2, 24kDa0.022
AP1M2adaptor-related protein complex 1, mu 2 subunit0.021
CD2CD2 molecule0.021
CNN2calponin 20.021
HSPG2heparan sulfate proteoglycan 20.021
BCL2B-cell CLL/lymphoma 20.021
WDYHV1WDYHV motif containing 10.020
GLIS3GLIS family zinc finger 30.020
AGRNagrin0.019
EIF3Leukaryotic translation initiation factor 3, subunit L0.019
QPRTquinolinate phosphoribosyltransferase0.019
BTKBruton agammaglobulinemia tyrosine kinase0.018
GLI3GLI family zinc finger 30.018
FASLGFas ligand (TNF superfamily, member 6)0.018
GLIS2GLIS family zinc finger 20.018
PKP3plakophilin 30.017
ACTC1actin, alpha, cardiac muscle 10.017
CBX7chromobox homolog 70.017
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.017
EZRezrin0.017
ZNF512Bzinc finger protein 512B0.017
EEF2eukaryotic translation elongation factor 20.017
BCL2L11BCL2-like 11 (apoptosis facilitator)0.017
MYL6myosin, light chain 6, alkali, smooth muscle and non-muscle0.017
CD83CD83 molecule0.017
PRSS8protease, serine, 80.016
SPRR3small proline-rich protein 30.016
TPM4tropomyosin 40.016
BTRCbeta-transducin repeat containing0.016
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.016
FERMT2fermitin family member 20.016
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.016
PABPC1poly(A) binding protein, cytoplasmic 10.016
SPTBN1spectrin, beta, non-erythrocytic 10.015
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.015
ARRB1arrestin, beta 10.015
PRPF6PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)0.015
KLK7kallikrein-related peptidase 70.015
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.015
JAG2jagged 20.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism