IMP: Integrative Multi-species Prediction

The network for 'embryo development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

Caenorhabditis elegans

Name	Description	Probability
mom-2	Protein MOM-2	0.998
egl-18	Protein EGL-18	0.997
rnr-1	Protein RNR-1	0.997
pal-1	Protein PAL-1	0.994
dlc-1	Protein DLC-1	0.994
nhr-2	Protein NHR-2	0.991
scc-1	Protein SCC-1	0.990
his-45	Protein HIS-45	0.990
eef-1A.1	Protein EEF-1A.1	0.989
mes-3	Protein MES-3	0.989
his-64	Protein HIS-64	0.989
F01G4.6	Protein F01G4.6	0.989
prp-3	Protein PRP-3	0.989
swd-2.2	Protein SWD-2.2	0.987
mcm-7	Protein MCM-7	0.987
stip-1	Protein STIP-1	0.984
sas-5	Protein SAS-5	0.984
vab-3	Protein VAB-3	0.983
san-1	Protein SAN-1	0.983
his-46	Protein HIS-46	0.983
npp-11	Protein NPP-11	0.982
hcp-3	Protein HCP-3	0.982
dao-5	Protein DAO-5	0.982
rars-1	Protein RARS-1	0.981
let-99	Protein LET-99	0.981
par-5	Protein PAR-5	0.981
tag-170	Protein TAG-170	0.980
his-68	Protein HIS-68	0.980
rpl-4	Protein RPL-4	0.980
mrps-18B	Protein MRPS-18B	0.978
mig-5	Protein MIG-5	0.978
skr-2	Protein SKR-2	0.977
skr-7	Protein SKR-7	0.977
cam-1	Protein CAM-1	0.976
icd-1	Protein ICD-1	0.975
tba-1	Protein TBA-1	0.974
pch-2	Protein PCH-2	0.974
elt-6	Protein ELT-6	0.973
asb-2	Protein ASB-2	0.972
hsp-1	Protein HSP-1	0.972
his-16	Protein HIS-16	0.972
aos-1	Protein AOS-1	0.970
klp-16	Protein KLP-16	0.969
rbx-1	Protein RBX-1	0.969
pab-1	Protein PAB-1	0.968
flh-1	Protein FLH-1	0.968
his-5	Protein HIS-5	0.968
his-62	Protein HIS-62	0.965
npp-1	Protein NPP-1	0.965
bir-1	Protein BIR-1	0.964
hcp-4	Protein HCP-4	0.964
mig-6	Protein MIG-6	0.963
abce-1	Protein ABCE-1	0.961
ndc-80	Protein NDC-80	0.961
fkb-6	Protein FKB-6	0.961
spn-4	Protein SPN-4	0.960
patr-1	Protein PATR-1	0.959
apc-11	Protein APC-11	0.959
epg-8	Protein EPG-8	0.958
ubc-12	Protein UBC-12	0.957
F53B7.3	Protein F53B7.3	0.957
T11G6.8	Protein T11G6.8	0.956
snr-5	Protein SNR-5	0.956
C44E4.4	Protein C44E4.4	0.953
ran-1	Protein RAN-1	0.953
pqn-59	Protein PQN-59	0.953
bub-1	Protein BUB-1	0.952
ptr-2	Protein PTR-2	0.952
pos-1	Protein POS-1	0.952
rack-1	Protein RACK-1	0.951
rpl-7	Protein RPL-7	0.951
W08E12.7	Protein W08E12.7	0.951
mel-11	Protein MEL-11	0.951
prg-1	Protein PRG-1	0.950
sbds-1	Protein SBDS-1	0.950
unc-37	Protein UNC-37	0.950
ify-1	Protein IFY-1	0.949
dsh-2	Protein DSH-2	0.949
hcp-1	Protein HCP-1	0.948
his-1	Protein HIS-1	0.948
lsy-22	Protein LSY-22	0.948
mat-3	Protein MAT-3	0.946
pfd-1	Protein PFD-1	0.946
mcm-6	Protein MCM-6	0.945
npp-15	Protein NPP-15	0.944
Y110A7A.4	Protein Y110A7A.4	0.944
dhfr-1	Protein DHFR-1	0.944
H28O16.1	Protein H28O16.1	0.944
hpo-35	Protein HPO-35	0.943
dlat-1	Protein DLAT-1	0.942
pat-4	Protein PAT-4	0.942
hda-1	Protein HDA-1	0.941
his-31	Protein HIS-31	0.941
Y47D3A.29	Protein Y47D3A.29	0.941
nap-1	Protein NAP-1	0.941
brc-1	Protein BRC-1	0.940
skn-1	Protein SKN-1	0.939
rad-50	Protein RAD-50	0.939
CELE_F19F10.9	Protein F19F10.9	0.938
wdr-46	Protein WDR-46	0.937

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Danio rerio

Name	Description	Probability	Func Analog Organism

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Drosophila melanogaster

Name	Description	Probability	Func Analog Organism

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Homo sapiens

Name	Description	Probability
SRSF1	serine/arginine-rich splicing factor 1	0.997
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.996
TP53	tumor protein p53	0.993
EGFR	epidermal growth factor receptor	0.991
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.990
FN1	fibronectin 1	0.989
HDAC1	histone deacetylase 1	0.989
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.979
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.976
HDAC2	histone deacetylase 2	0.973
BRCA1	breast cancer 1, early onset	0.972
UBC	ubiquitin C	0.971
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.971
ICT1	immature colon carcinoma transcript 1	0.968
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.965
C1QBP	complement component 1, q subcomponent binding protein	0.965
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.964
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.962
SMAD2	SMAD family member 2	0.949
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.946
ILF3	interleukin enhancer binding factor 3, 90kDa	0.946
SMAD4	SMAD family member 4	0.937
SMAD3	SMAD family member 3	0.936
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.936
ATF2	activating transcription factor 2	0.933
DHX15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.926
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.916
MAPK14	mitogen-activated protein kinase 14	0.914
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.909
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.906
RPS6	ribosomal protein S6	0.904
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.893
SRSF7	serine/arginine-rich splicing factor 7	0.891
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.886
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.873
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.870
RPL6	ribosomal protein L6	0.868
TCP1	t-complex 1	0.867
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.859
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.855
EP300	E1A binding protein p300	0.855
APC	adenomatous polyposis coli	0.838
CSNK2B	casein kinase 2, beta polypeptide	0.835
JUN	jun proto-oncogene	0.831
SRPK2	SRSF protein kinase 2	0.830
SRSF2	serine/arginine-rich splicing factor 2	0.829
ESR1	estrogen receptor 1	0.824
CUL3	cullin 3	0.822
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.813
PCGF2	polycomb group ring finger 2	0.809
CREBBP	CREB binding protein	0.808
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.799
SRSF3	serine/arginine-rich splicing factor 3	0.783
MRPL3	mitochondrial ribosomal protein L3	0.776
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.773
RPS8	ribosomal protein S8	0.771
RPL14	ribosomal protein L14	0.755
PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	0.750
PGK1	phosphoglycerate kinase 1	0.746
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.738
PHB	prohibitin	0.737
TARDBP	TAR DNA binding protein	0.736
SRPK1	SRSF protein kinase 1	0.716
IQGAP1	IQ motif containing GTPase activating protein 1	0.715
RB1	retinoblastoma 1	0.708
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.706
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.702
PSMB5	proteasome (prosome, macropain) subunit, beta type, 5	0.702
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.696
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.695
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.693
RHOA	ras homolog gene family, member A	0.692
FLNA	filamin A, alpha	0.691
RFC4	replication factor C (activator 1) 4, 37kDa	0.684
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.671
COL1A1	collagen, type I, alpha 1	0.669
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.669
PSEN1	presenilin 1	0.665
CDK2	cyclin-dependent kinase 2	0.662
CYC1	cytochrome c-1	0.660
MCM3	minichromosome maintenance complex component 3	0.649
SF3B1	splicing factor 3b, subunit 1, 155kDa	0.648
NCOR1	nuclear receptor corepressor 1	0.643
EIF4A3	eukaryotic translation initiation factor 4A3	0.643
FGFR1	fibroblast growth factor receptor 1	0.639
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.632
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.630
NUDC	nuclear distribution gene C homolog (A. nidulans)	0.625
EPS15	epidermal growth factor receptor pathway substrate 15	0.621
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.612
RPS4X	ribosomal protein S4, X-linked	0.608
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.606
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.606
DAXX	death-domain associated protein	0.603
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.603
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.600
NDUFS3	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	0.598
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.589
SEC23A	Sec23 homolog A (S. cerevisiae)	0.588
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.584

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Mus musculus

Name	Description	Probability	Func Analog Organism

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Rattus norvegicus

Name	Description	Probability
Tgfbr2	transforming growth factor, beta receptor II	0.264
Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.224
Smad7	SMAD family member 7	0.187
Psgb1	pregnancy-specific beta 1-glycoprotein	0.186
Sirpa	signal-regulatory protein alpha	0.149
Slc5a1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.130
Col12a1	collagen, type XII, alpha 1	0.126
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.118
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.110
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.110
Irs1	insulin receptor substrate 1	0.100
Cald1	caldesmon 1	0.097
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.095
Trim47	tripartite motif-containing 47	0.086
Eln	elastin	0.082
Tcfe2a	transcription factor E2a	0.079
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.079
Myh9	myosin, heavy chain 9, non-muscle	0.078
Actb	actin, beta	0.076
Tars	threonyl-tRNA synthetase	0.075
Nek9	NIMA (never in mitosis gene a)- related kinase 9	0.073
Sdc3	syndecan 3	0.073
Col5a2	collagen, type V, alpha 2	0.073
Lamc1	laminin, gamma 1	0.073
Dusp1	dual specificity phosphatase 1	0.072
Fgfr2	fibroblast growth factor receptor 2	0.072
Met	met proto-oncogene	0.071
Bcl2	B-cell CLL/lymphoma 2	0.071
Egr2	early growth response 2	0.071
Rhob	ras homolog gene family, member B	0.071
Rara	retinoic acid receptor, alpha	0.070
Fn1	fibronectin 1	0.069
Flt1	FMS-related tyrosine kinase 1	0.069
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.068
Acvr1	activin A receptor, type I	0.066
Tpm3	tropomyosin 3, gamma	0.064
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.061
Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.060
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.059
Col1a2	collagen, type I, alpha 2	0.058
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.058
Foxd3	forkhead box D3	0.057
Myo1b	myosin Ib	0.056
Jak1	Janus kinase 1	0.056
Neurog1	neurogenin 1	0.056
Tubb5	tubulin, beta 5	0.055
Hoxb7	homeo box B7	0.054
Clic4	chloride intracellular channel 4	0.053
Tp53	tumor protein p53	0.052
Foxc2	forkhead box C2	0.052
Flna	filamin A, alpha	0.051
Dchs1	dachsous 1 (Drosophila)	0.051
Akt1	v-akt murine thymoma viral oncogene homolog 1	0.051
Krt18	keratin 18	0.051
Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.051
Rhoa	ras homolog gene family, member A	0.050
Wdr26	WD repeat domain 26	0.050
Sfrs2	splicing factor, arginine/serine-rich 2	0.049
Prrx1	paired related homeobox 1	0.049
Dapk3	death-associated protein kinase 3	0.049
Sox17	SRY (sex determining region Y)-box 17	0.049
Gast	gastrin	0.049
Acta2	smooth muscle alpha-actin	0.049
Rap1b	RAP1B, member of RAS oncogene family	0.048
Grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.048
Psma4	proteasome (prosome, macropain) subunit, alpha type 4	0.048
Abi1	abl-interactor 1	0.048
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.048
Junb	jun B proto-oncogene	0.047
Myo1e	myosin IE	0.047
Bgn	biglycan	0.046
Ptprc	protein tyrosine phosphatase, receptor type, C	0.046
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.046
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.045
Kl	Klotho	0.045
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.045
Dlg1	discs, large homolog 1 (Drosophila)	0.045
Timp3	TIMP metallopeptidase inhibitor 3	0.045
Lig3	ligase III, DNA, ATP-dependent	0.043
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.043
Dact3	dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)	0.043
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.043
Aqp2	aquaporin 2 (collecting duct)	0.043
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.042
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.042
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.041
Bmp6	bone morphogenetic protein 6	0.041
Nab1	Ngfi-A binding protein 1	0.041
Ccnb2	cyclin B2	0.041
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.041
Chrng	cholinergic receptor, nicotinic, gamma	0.041
Cand1	cullin-associated and neddylation-dissociated 1	0.040
Runx1	runt-related transcription factor 1	0.040
Jun	Jun oncogene	0.039
Gja5	gap junction protein, alpha 5	0.039
Prkch	protein kinase C, eta	0.039
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.039
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.039
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.039
Ins2	insulin 2	0.039

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Saccharomyces cerevisiae

Name	Description	Probability	Func Analog Organism