The network for 'lateral inhibition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lateral inhibition

Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.

NameDescriptionProbabilityFunc Analog Organism
ttm-4Protein TTM-40.014
unc-73Protein UNC-730.014
C05C10.2Protein C05C10.20.013
cdl-1Protein CDL-10.013
ccdc-47Protein CCDC-470.013
Y42H9B.3Protein Y42H9B.30.013
grl-4Protein GRL-40.013
sel-10Protein SEL-100.012
lin-40Protein LIN-400.012
F11E6.7Protein F11E6.70.012
mex-5Protein MEX-50.012
ifa-1Protein IFA-10.012
kin-10Protein KIN-100.012
sas-4Protein SAS-40.012
mig-2Protein MIG-20.012
zyg-8Protein ZYG-80.012
smg-7Protein SMG-70.012
npp-2Protein NPP-20.011
mdf-2Protein MDF-20.011
smu-2Protein SMU-20.011
tag-315Protein TAG-3150.011
rfc-2Protein RFC-20.011
syg-2Protein SYG-20.011
ifb-2Protein IFB-20.011
nhr-31Protein NHR-310.011
sas-5Protein SAS-50.011
cam-1Protein CAM-10.011
F12F6.1Protein F12F6.10.011
rnr-1Protein RNR-10.011
taf-6.1Protein TAF-6.10.011
pqn-51Protein PQN-510.011
rpa-1Protein RPA-10.011
sel-8Protein SEL-80.011
mcm-4Protein MCM-40.011
par-5Protein PAR-50.011
nhr-55Protein NHR-550.011
pxf-1Protein PXF-10.011
ttll-4Protein TTLL-40.011
trr-1Protein TRR-10.011
cco-1Protein CCO-10.011
B0205.9Protein B0205.90.011
cas-2Protein CAS-20.010
CELE_C12D8.1Protein C12D8.10.010
F25B5.2Protein F25B5.20.010
pct-1Protein PCT-10.010
zfp-3Protein ZFP-30.010
C16B8.3Protein C16B8.30.010
H06I04.1Protein H06I04.10.010
ocam-1Protein OCAM-10.010
toe-4Protein TOE-40.010
F22D3.2Protein F22D3.20.010
lag-1Protein LAG-10.010
csn-3Protein CSN-30.010
dpy-26Protein DPY-260.010
CELE_Y41D4B.6Protein Y41D4B.60.010
F38E9.5Protein F38E9.50.010
vps-36Protein VPS-360.010
F13B12.1Protein F13B12.10.010
lag-2Protein LAG-20.010
ubc-3Protein UBC-30.010
mls-2Protein MLS-20.010
kin-19Protein KIN-190.010
F17B5.6Protein F17B5.60.010
CELE_F46F2.3Protein F46F2.30.010
san-1Protein SAN-10.010
pos-1Protein POS-10.010
ant-1.1Protein ANT-1.10.010
T19H12.2Protein T19H12.20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
jag1bjagged 1b0.748
jag2jagged 20.715
hlxb9lahomeo box HB9 like a0.635
kdrlkinase insert domain receptor like0.632
emx3empty spiracles homeobox 30.578
gro1groucho 10.547
etv2ets variant gene 20.487
notch3notch homolog 30.432
notch2notch homolog 20.413
lmx1b.1LIM homeobox transcription factor 1, beta 10.400
tbx2bT-box 2b0.381
lhx1aLIM homeobox 1a0.374
akt2v-akt murine thymoma viral oncogene homolog 20.358
hgfahepatocyte growth factor a0.354
notch1anotch homolog 1a0.349
inka1ainduced in neural crest by AP2, 1a0.330
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.313
tp53tumor protein p530.313
ascl1aachaete-scute complex-like 1a (Drosophila)0.306
sox3SRY-box containing gene 30.296
ephb4beph receptor B4b0.295
snai1asnail homolog 1a (Drosophila)0.291
pou3f1POU class 3 homeobox 10.287
alcambactivated leukocyte cell adhesion molecule b0.281
sema3aasemaphorin 3aa0.270
sema3fbsemaphorin 3fb0.269
her6hairy-related 60.267
ccm2cerebral cavernous malformation 20.267
barhl1.2BarH-like 1.20.254
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.253
foxp2forkhead box P20.249
hlxb9lbhomeo box HB9 like b0.249
cdh1cadherin 1, epithelial0.248
sox19aSRY-box containing gene 19a0.247
wtipWilms tumor 1 interacting protein0.242
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.241
efnb2aephrin B2a0.239
grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.238
fzd5frizzled homolog 50.237
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.236
gdf6agrowth differentiation factor 6a0.233
tal1T-cell acute lymphocytic leukemia 10.224
wnt5bwingless-type MMTV integration site family, member 5b0.223
dzip1DAZ interacting protein 10.217
stmn1bstathmin 1b0.208
olig2oligodendrocyte lineage transcription factor 20.207
gpiaglucose phosphate isomerase a0.203
her1hairy-related 10.202
ubl7ubiquitin-like 70.201
gpc4glypican 40.195
cops3COP9 constitutive photomorphogenic homolog subunit 30.192
plcg1phospholipase C, gamma 10.190
ptp4a1protein tyrosine phosphatase type IVA, member 10.184
mfn2mitofusin 20.180
ebf3early B-cell factor 30.178
cap1Cap1 CAP, adenylate cyclase-associated protein 10.177
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.174
foxn1forkhead box N10.168
vaspvasodilator-stimulated phosphoprotein0.166
mapk14amitogen-activated protein kinase 14a0.165
chpfchondroitin polymerizing factor0.162
LOC565459tight junction protein ZO-1-like0.155
fn1fibronectin 10.154
hsp47heat shock protein 470.154
racgap1Rac GTPase-activating protein 10.154
wlswntless homolog (Drosophila)0.153
vegfabvascular endothelial growth factor Ab0.153
dab1bdisabled homolog 1b (Drosophila)0.151
ptprebprotein tyrosine phosphatase, receptor type, E, b0.150
nrarpanotch-regulated ankyrin repeat protein a0.150
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.143
pgk1phosphoglycerate kinase 10.142
spon1bspondin 1b0.137
ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.136
mllt11myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 110.135
rbl1retinoblastoma-like 1 (p107)0.132
bmp4bone morphogenetic protein 40.130
pitx3paired-like homeodomain transcription factor 30.130
tjp1tight junction protein 1 (zona occludens 1)0.130
col11a1bcollagen type XI alpha-1b and collagen, type XI, alpha 1b0.126
hoxa13bhomeo box A13b0.126
gyltl1bglycosyltransferase-like 1b0.125
ednraendothelin receptor type A0.124
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.122
slit2slit (Drosophila) homolog 20.121
smarcb1aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a0.120
cdk8cyclin-dependent kinase 80.117
ptpreaprotein tyrosine phosphatase, receptor type, E, a0.115
hnf1bbHNF1 homeobox Bb0.113
wt1bwilms tumor 1b0.112
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
dltdiscs lost0.978
MadMothers against dpp0.966
Su(H)Suppressor of Hairless0.953
Ras85DRas oncogene at 85D0.902
Tab2TAK1-associated binding protein 20.878
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.872
Sema-2aCG4700 gene product from transcript CG4700-RC0.850
RfC4Replication factor C subunit 40.808
Dsor1Downstream of raf10.796
Pde11Phosphodiesterase 110.760
trioCG18214 gene product from transcript CG18214-RA0.730
CG34345CG34345 gene product from transcript CG34345-RA0.722
Gnf1Germ line transcription factor 10.693
ProsapCG30483 gene product from transcript CG30483-RA0.689
E(spl)Enhancer of split0.662
S6kRPS6-p70-protein kinase0.658
CG31343CG31343 gene product from transcript CG31343-RA0.651
Fas2Fasciclin 20.650
Psf3CG2222 gene product from transcript CG2222-RA0.612
slp1sloppy paired 10.604
Lerplysosomal enzyme receptor protein0.600
Psf1CG9187 gene product from transcript CG9187-RA0.579
plexAplexin A0.573
CG42404CG42404 gene product from transcript CG42404-RC0.572
CG2183CG2183 gene product from transcript CG2183-RA0.567
CG5362CG5362 gene product from transcript CG5362-RA0.549
proPO-A1prophenol oxidase A10.541
larpLa related protein0.540
CG42369CG42369 gene product from transcript CG42369-RA0.532
CG8021CG8021 gene product from transcript CG8021-RA0.532
amosabsent MD neurons and olfactory sensilla0.519
kirrekin of irre0.519
spensplit ends0.514
Rab10Rab-protein 100.511
Top1Topoisomerase 10.501
fasfaint sausage0.497
laceCG4162 gene product from transcript CG4162-RA0.478
zfh1Zn finger homeodomain 10.474
Mcm2Minichromosome maintenance 20.458
RfC3Replication factor C subunit 30.449
CG31198CG31198 gene product from transcript CG31198-RA0.444
CG13983CG13983 gene product from transcript CG13983-RA0.420
eIF-4EEukaryotic initiation factor 4E0.415
CG8142CG8142 gene product from transcript CG8142-RA0.403
CtBPC-terminal Binding Protein0.403
Taf1TBP-associated factor 10.394
bibbig brain0.391
CG16704CG16704 gene product from transcript CG16704-RA0.384
singsingles bar0.379
snssticks and stones0.371
hipkhomeodomain interacting protein kinase0.367
CG7470CG7470 gene product from transcript CG7470-RA0.366
Tak1TGF-beta activated kinase 10.364
WASpCG1520 gene product from transcript CG1520-RA0.355
vavCG7893 gene product from transcript CG7893-RB0.343
CG4612CG4612 gene product from transcript CG4612-RA0.333
KLHL18CG3571 gene product from transcript CG3571-RA0.330
sbrsmall bristles0.323
crolcrooked legs0.319
ewgerect wing0.314
Hsc70-4Heat shock protein cognate 40.309
djdon juan0.300
l(2)k16918lethal (2) k169180.298
MtnAMetallothionein A0.297
CSN3COP9 complex homolog subunit 30.296
ik2IkappaB kinase-like 20.294
CG9772CG9772 gene product from transcript CG9772-RB0.294
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Psen1presenilin 11.000
Notch1Notch gene homolog 1 (Drosophila)1.000
Ptenphosphatase and tensin homolog0.995
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.995
Hes1hairy and enhancer of split 1 (Drosophila)0.990
Notch2Notch gene homolog 2 (Drosophila)0.989
Ctnnb1catenin (cadherin associated protein), beta 10.988
Dll1delta-like 1 (Drosophila)0.985
Id3inhibitor of DNA binding 30.972
Id1inhibitor of DNA binding 10.933
Emx1empty spiracles homolog 1 (Drosophila)0.920
Psen2presenilin 20.919
Robo1roundabout homolog 1 (Drosophila)0.911
FynFyn proto-oncogene0.893
Chd7chromodomain helicase DNA binding protein 70.885
CblCasitas B-lineage lymphoma0.834
Sox2SRY-box containing gene 20.830
Cdc25bcell division cycle 25 homolog B (S. pombe)0.813
Cdc25acell division cycle 25 homolog A (S. pombe)0.775
Grb2growth factor receptor bound protein 20.757
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.713
Emx2empty spiracles homolog 2 (Drosophila)0.706
Tcf4transcription factor 40.666
Tsc1tuberous sclerosis 10.635
Pax2paired box gene 20.624
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.622
Foxg1forkhead box G10.583
Mapk14mitogen-activated protein kinase 140.563
Jag1jagged 10.554
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.551
Lmnb1lamin B10.548
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.512
Cops6COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)0.500
Cdc25ccell division cycle 25 homolog C (S. pombe)0.493
Rb1retinoblastoma 10.491
Nf2neurofibromatosis 20.490
Tcf3transcription factor 30.440
Wizwidely-interspaced zinc finger motifs0.428
Prkg1protein kinase, cGMP-dependent, type I0.425
UncxUNC homeobox0.399
Cops3COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)0.393
Nr5a1nuclear receptor subfamily 5, group A, member 10.376
Ptk7PTK7 protein tyrosine kinase 70.373
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.358
Otx1orthodenticle homolog 1 (Drosophila)0.357
Lmnb2lamin B20.357
Slit3slit homolog 3 (Drosophila)0.355
Otx2orthodenticle homolog 2 (Drosophila)0.354
Efnb2ephrin B20.344
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.329
Smad1MAD homolog 1 (Drosophila)0.324
Dll4delta-like 4 (Drosophila)0.321
Mib1mindbomb homolog 1 (Drosophila)0.318
Skor1SKI family transcriptional corepressor 10.318
Kpna3karyopherin (importin) alpha 30.313
Egfl7EGF-like domain 70.309
Ikzf1IKAROS family zinc finger 10.308
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.293
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.271
Slit2slit homolog 2 (Drosophila)0.270
Foxc1forkhead box C10.265
Ptf1apancreas specific transcription factor, 1a0.263
Polr2kpolymerase (RNA) II (DNA directed) polypeptide K0.263
Jag2jagged 20.263
Ptp4a2protein tyrosine phosphatase 4a20.260
Ncapgnon-SMC condensin I complex, subunit G0.259
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.259
Brd4bromodomain containing 40.258
Arhgap1Rho GTPase activating protein 10.257
Efnb1ephrin B10.253
Appamyloid beta (A4) precursor protein0.245
Pofut1protein O-fucosyltransferase 10.242
Ddah2dimethylarginine dimethylaminohydrolase 20.242
Prkcdprotein kinase C, delta0.239
Atp11cATPase, class VI, type 11C0.238
Cpeb3cytoplasmic polyadenylation element binding protein 30.234
Lrrc40leucine rich repeat containing 400.231
Cops5COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)0.230
Lig1ligase I, DNA, ATP-dependent0.229
Ube2cubiquitin-conjugating enzyme E2C0.228
Syvn1synovial apoptosis inhibitor 1, synoviolin0.228
Gsk3bglycogen synthase kinase 3 beta0.228
Lhx9LIM homeobox protein 90.227
Lin7clin-7 homolog C (C. elegans)0.225
Fgfr1fibroblast growth factor receptor 10.225
Kitlkit ligand0.223
NrarpNotch-regulated ankyrin repeat protein0.222
Cdt1chromatin licensing and DNA replication factor 10.221
Wnt4wingless-related MMTV integration site 40.217
Dlg1discs, large homolog 1 (Drosophila)0.215
Fzd2frizzled homolog 2 (Drosophila)0.212
Gps1G protein pathway suppressor 10.208
Cox5acytochrome c oxidase, subunit Va0.206
Rrm2ribonucleotide reductase M20.206
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.204
Rrm1ribonucleotide reductase M10.199
Smurf2SMAD specific E3 ubiquitin protein ligase 20.196
Ptrfpolymerase I and transcript release factor0.196
Usp9xubiquitin specific peptidase 9, X chromosome0.192
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism